Incidental Mutation 'R1667:Vmn2r73'
| ID |
187281 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r73
|
| Ensembl Gene |
ENSMUSG00000070458 |
| Gene Name |
vomeronasal 2, receptor 73 |
| Synonyms |
EG620928 |
| MMRRC Submission |
039703-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R1667 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85506755-85525146 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 85506889 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 808
(C808S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076687
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077478]
|
| AlphaFold |
D3Z7M3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077478
AA Change: C808S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: C808S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
508 |
560 |
5.9e-21 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
4.4e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
99% (76/77) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgra1 |
G |
A |
7: 139,425,564 (GRCm39) |
A26T |
possibly damaging |
Het |
| Adgrg3 |
T |
A |
8: 95,760,001 (GRCm39) |
Y73* |
probably null |
Het |
| Alk |
A |
T |
17: 72,218,562 (GRCm39) |
V761E |
probably damaging |
Het |
| Ankrd13a |
T |
C |
5: 114,924,794 (GRCm39) |
V93A |
possibly damaging |
Het |
| Anks1b |
T |
C |
10: 90,347,046 (GRCm39) |
|
probably null |
Het |
| Arb2a |
T |
A |
13: 77,907,635 (GRCm39) |
M1K |
probably null |
Het |
| Ascl1 |
T |
C |
10: 87,328,655 (GRCm39) |
N99S |
probably benign |
Het |
| Atm |
A |
T |
9: 53,412,232 (GRCm39) |
L972Q |
probably damaging |
Het |
| Atp2c1 |
A |
T |
9: 105,309,996 (GRCm39) |
L566Q |
probably null |
Het |
| Bank1 |
T |
A |
3: 135,799,057 (GRCm39) |
Y629F |
probably damaging |
Het |
| Bod1l |
G |
T |
5: 41,974,118 (GRCm39) |
L2399I |
probably benign |
Het |
| Bub1b |
G |
A |
2: 118,471,670 (GRCm39) |
G1010D |
probably benign |
Het |
| Ces1b |
G |
A |
8: 93,783,532 (GRCm39) |
H563Y |
possibly damaging |
Het |
| Cfap70 |
T |
C |
14: 20,454,225 (GRCm39) |
E853G |
probably benign |
Het |
| Cfh |
T |
C |
1: 140,033,261 (GRCm39) |
E779G |
probably benign |
Het |
| Cox7c |
A |
G |
13: 86,194,003 (GRCm39) |
S7P |
probably benign |
Het |
| Cyp2c67 |
A |
G |
19: 39,632,034 (GRCm39) |
|
probably null |
Het |
| Dhx30 |
G |
T |
9: 109,914,513 (GRCm39) |
L995I |
possibly damaging |
Het |
| Dhx30 |
G |
C |
9: 109,914,514 (GRCm39) |
N957K |
possibly damaging |
Het |
| Dsc3 |
T |
C |
18: 20,124,617 (GRCm39) |
T36A |
possibly damaging |
Het |
| Dstyk |
A |
G |
1: 132,384,657 (GRCm39) |
D717G |
probably damaging |
Het |
| Dusp10 |
A |
G |
1: 183,769,055 (GRCm39) |
D7G |
probably damaging |
Het |
| E230001N04Rik |
T |
G |
17: 28,742,935 (GRCm39) |
|
noncoding transcript |
Het |
| Ece2 |
T |
C |
16: 20,456,588 (GRCm39) |
S330P |
possibly damaging |
Het |
| Frmd5 |
ATAGTGGAATTGTTCAAACTC |
ATAGTGGAATTGTTCAAACTCTAGTGGAATTGTTCAAACTC |
2: 121,379,211 (GRCm39) |
|
probably null |
Het |
| Gata3 |
T |
C |
2: 9,882,360 (GRCm39) |
H14R |
possibly damaging |
Het |
| Ggta1 |
T |
A |
2: 35,304,295 (GRCm39) |
I75F |
possibly damaging |
Het |
| Hcn1 |
A |
T |
13: 117,739,609 (GRCm39) |
I124F |
unknown |
Het |
| Herpud1 |
A |
C |
8: 95,115,994 (GRCm39) |
D53A |
probably damaging |
Het |
| Inhba |
T |
A |
13: 16,201,209 (GRCm39) |
L257Q |
possibly damaging |
Het |
| Itga10 |
C |
T |
3: 96,559,054 (GRCm39) |
|
probably benign |
Het |
| Jmy |
T |
A |
13: 93,634,878 (GRCm39) |
S313C |
probably damaging |
Het |
| Lpo |
G |
A |
11: 87,698,067 (GRCm39) |
|
probably benign |
Het |
| Lsg1 |
T |
C |
16: 30,390,170 (GRCm39) |
E315G |
probably damaging |
Het |
| Lsm14a |
T |
A |
7: 34,065,079 (GRCm39) |
T167S |
possibly damaging |
Het |
| Lsmem1 |
GTACATACATACATACATACATACATACA |
GTACATACATACATACATACATACATACATACA |
12: 40,235,260 (GRCm39) |
|
probably null |
Het |
| Map3k2 |
T |
C |
18: 32,336,845 (GRCm39) |
|
probably benign |
Het |
| Mapk12 |
A |
T |
15: 89,024,344 (GRCm39) |
M81K |
probably damaging |
Het |
| Matn2 |
T |
A |
15: 34,378,878 (GRCm39) |
C305S |
probably damaging |
Het |
| Mgam |
T |
C |
6: 40,653,978 (GRCm39) |
Y844H |
possibly damaging |
Het |
| Mgat5b |
A |
G |
11: 116,838,203 (GRCm39) |
R281G |
probably benign |
Het |
| Mon1b |
T |
G |
8: 114,368,589 (GRCm39) |
C497G |
probably damaging |
Het |
| Mybbp1a |
A |
T |
11: 72,336,043 (GRCm39) |
H452L |
probably benign |
Het |
| Mybl2 |
A |
G |
2: 162,917,616 (GRCm39) |
T41A |
probably damaging |
Het |
| Ncoa5 |
A |
G |
2: 164,843,623 (GRCm39) |
V540A |
probably damaging |
Het |
| Nup93 |
T |
A |
8: 95,019,315 (GRCm39) |
V47E |
possibly damaging |
Het |
| Or10a4 |
A |
T |
7: 106,696,977 (GRCm39) |
M102L |
probably benign |
Het |
| Or5j3 |
A |
G |
2: 86,129,080 (GRCm39) |
M307V |
probably null |
Het |
| Orc6 |
T |
A |
8: 86,031,914 (GRCm39) |
C100S |
possibly damaging |
Het |
| Otogl |
G |
T |
10: 107,649,826 (GRCm39) |
Y1176* |
probably null |
Het |
| Patj |
A |
T |
4: 98,301,264 (GRCm39) |
D183V |
probably damaging |
Het |
| Pik3r3 |
A |
G |
4: 116,079,514 (GRCm39) |
T4A |
probably damaging |
Het |
| Pla2g4d |
G |
A |
2: 120,100,631 (GRCm39) |
|
probably benign |
Het |
| Pla2r1 |
A |
G |
2: 60,250,601 (GRCm39) |
I1407T |
probably benign |
Het |
| Pramel13 |
A |
T |
4: 144,119,606 (GRCm39) |
C320* |
probably null |
Het |
| Prex2 |
A |
T |
1: 11,256,981 (GRCm39) |
H1231L |
probably benign |
Het |
| Prkca |
A |
G |
11: 107,874,772 (GRCm39) |
V390A |
probably damaging |
Het |
| Psmd13 |
T |
A |
7: 140,470,522 (GRCm39) |
W255R |
probably damaging |
Het |
| Rec8 |
T |
A |
14: 55,856,253 (GRCm39) |
N37K |
probably damaging |
Het |
| Rnf207 |
C |
T |
4: 152,397,672 (GRCm39) |
E361K |
probably benign |
Het |
| Serpina3f |
T |
A |
12: 104,183,699 (GRCm39) |
L187Q |
probably damaging |
Het |
| Skint11 |
A |
T |
4: 114,051,978 (GRCm39) |
T109S |
probably damaging |
Het |
| Slc7a8 |
A |
G |
14: 54,962,306 (GRCm39) |
S443P |
probably damaging |
Het |
| Slc8b1 |
T |
A |
5: 120,659,147 (GRCm39) |
F197Y |
probably benign |
Het |
| Sox2 |
T |
C |
3: 34,704,568 (GRCm39) |
Y2H |
probably damaging |
Het |
| Speg |
T |
A |
1: 75,387,193 (GRCm39) |
|
probably benign |
Het |
| Tlr3 |
T |
C |
8: 45,853,874 (GRCm39) |
N149D |
probably benign |
Het |
| Trim60 |
A |
C |
8: 65,454,116 (GRCm39) |
D44E |
probably benign |
Het |
| Ugt1a7c |
A |
G |
1: 88,023,657 (GRCm39) |
Y272C |
probably damaging |
Het |
| Vmn1r4 |
T |
A |
6: 56,933,738 (GRCm39) |
Y81N |
probably damaging |
Het |
| Ythdf3 |
T |
C |
3: 16,259,056 (GRCm39) |
I412T |
possibly damaging |
Het |
| Zfp672 |
T |
C |
11: 58,206,921 (GRCm39) |
T467A |
possibly damaging |
Het |
| Zfp985 |
A |
T |
4: 147,668,407 (GRCm39) |
Q425L |
possibly damaging |
Het |
|
| Other mutations in Vmn2r73 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r73
|
APN |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
IGL01151:Vmn2r73
|
APN |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01408:Vmn2r73
|
APN |
7 |
85,521,455 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL01505:Vmn2r73
|
APN |
7 |
85,507,267 (GRCm39) |
nonsense |
probably null |
|
|
IGL01731:Vmn2r73
|
APN |
7 |
85,506,757 (GRCm39) |
makesense |
probably null |
|
|
IGL01818:Vmn2r73
|
APN |
7 |
85,519,109 (GRCm39) |
splice site |
probably benign |
|
|
IGL02236:Vmn2r73
|
APN |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02265:Vmn2r73
|
APN |
7 |
85,520,847 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02266:Vmn2r73
|
APN |
7 |
85,525,007 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02276:Vmn2r73
|
APN |
7 |
85,518,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02284:Vmn2r73
|
APN |
7 |
85,507,123 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02380:Vmn2r73
|
APN |
7 |
85,507,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02466:Vmn2r73
|
APN |
7 |
85,522,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Vmn2r73
|
APN |
7 |
85,507,495 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03179:Vmn2r73
|
APN |
7 |
85,519,468 (GRCm39) |
missense |
probably benign |
0.04 |
|
G1Funyon:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0077:Vmn2r73
|
UTSW |
7 |
85,525,075 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0311:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R0413:Vmn2r73
|
UTSW |
7 |
85,521,087 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0494:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R1523:Vmn2r73
|
UTSW |
7 |
85,519,486 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1618:Vmn2r73
|
UTSW |
7 |
85,525,120 (GRCm39) |
nonsense |
probably null |
|
|
R1728:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1729:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Vmn2r73
|
UTSW |
7 |
85,507,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2152:Vmn2r73
|
UTSW |
7 |
85,506,936 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2395:Vmn2r73
|
UTSW |
7 |
85,506,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2415:Vmn2r73
|
UTSW |
7 |
85,521,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Vmn2r73
|
UTSW |
7 |
85,520,871 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3719:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3766:Vmn2r73
|
UTSW |
7 |
85,521,198 (GRCm39) |
missense |
probably benign |
|
|
R3838:Vmn2r73
|
UTSW |
7 |
85,507,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3890:Vmn2r73
|
UTSW |
7 |
85,507,144 (GRCm39) |
missense |
probably benign |
|
|
R4030:Vmn2r73
|
UTSW |
7 |
85,521,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4247:Vmn2r73
|
UTSW |
7 |
85,521,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4409:Vmn2r73
|
UTSW |
7 |
85,520,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4427:Vmn2r73
|
UTSW |
7 |
85,506,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4430:Vmn2r73
|
UTSW |
7 |
85,519,449 (GRCm39) |
missense |
probably benign |
|
|
R4552:Vmn2r73
|
UTSW |
7 |
85,525,055 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4779:Vmn2r73
|
UTSW |
7 |
85,520,923 (GRCm39) |
nonsense |
probably null |
|
|
R4906:Vmn2r73
|
UTSW |
7 |
85,506,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4942:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r73
|
UTSW |
7 |
85,507,155 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5344:Vmn2r73
|
UTSW |
7 |
85,525,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5478:Vmn2r73
|
UTSW |
7 |
85,518,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5527:Vmn2r73
|
UTSW |
7 |
85,507,575 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5691:Vmn2r73
|
UTSW |
7 |
85,507,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5826:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6018:Vmn2r73
|
UTSW |
7 |
85,521,875 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6082:Vmn2r73
|
UTSW |
7 |
85,507,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6111:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R6233:Vmn2r73
|
UTSW |
7 |
85,519,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6278:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R6283:Vmn2r73
|
UTSW |
7 |
85,521,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r73
|
UTSW |
7 |
85,506,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6413:Vmn2r73
|
UTSW |
7 |
85,519,544 (GRCm39) |
nonsense |
probably null |
|
|
R6782:Vmn2r73
|
UTSW |
7 |
85,519,563 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6884:Vmn2r73
|
UTSW |
7 |
85,507,213 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6921:Vmn2r73
|
UTSW |
7 |
85,507,446 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7169:Vmn2r73
|
UTSW |
7 |
85,507,663 (GRCm39) |
nonsense |
probably null |
|
|
R7206:Vmn2r73
|
UTSW |
7 |
85,522,075 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7311:Vmn2r73
|
UTSW |
7 |
85,521,192 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7650:Vmn2r73
|
UTSW |
7 |
85,521,147 (GRCm39) |
missense |
probably benign |
|
|
R7811:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8263:Vmn2r73
|
UTSW |
7 |
85,507,619 (GRCm39) |
missense |
probably benign |
|
|
R8301:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8341:Vmn2r73
|
UTSW |
7 |
85,507,128 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8500:Vmn2r73
|
UTSW |
7 |
85,519,638 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8673:Vmn2r73
|
UTSW |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8719:Vmn2r73
|
UTSW |
7 |
85,521,095 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8783:Vmn2r73
|
UTSW |
7 |
85,507,668 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8828:Vmn2r73
|
UTSW |
7 |
85,521,179 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8860:Vmn2r73
|
UTSW |
7 |
85,522,149 (GRCm39) |
splice site |
probably benign |
|
|
R9002:Vmn2r73
|
UTSW |
7 |
85,507,284 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9008:Vmn2r73
|
UTSW |
7 |
85,521,904 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9159:Vmn2r73
|
UTSW |
7 |
85,521,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9180:Vmn2r73
|
UTSW |
7 |
85,507,123 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9198:Vmn2r73
|
UTSW |
7 |
85,518,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9329:Vmn2r73
|
UTSW |
7 |
85,519,073 (GRCm39) |
missense |
probably benign |
|
|
R9448:Vmn2r73
|
UTSW |
7 |
85,522,027 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9463:Vmn2r73
|
UTSW |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
R9589:Vmn2r73
|
UTSW |
7 |
85,519,659 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0023:Vmn2r73
|
UTSW |
7 |
85,507,664 (GRCm39) |
missense |
probably benign |
0.31 |
|
Z1176:Vmn2r73
|
UTSW |
7 |
85,521,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r73
|
UTSW |
7 |
85,521,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAAAGCCAAATGCCAATTTTCAGA -3'
(R):5'- GGGCTCTATTGCTCTAGCAAGTTTCAC -3'
Sequencing Primer
(F):5'- TTGATCCAATAAACTGAGGTCCAGG -3'
(R):5'- GCTCTAGCAAGTTTCACTGTAGC -3'
|
| Posted On |
2014-05-09 |
Incidental Mutation