Incidental Mutation 'R1671:Zbtb26'
ID 187596
Institutional Source Beutler Lab
Gene Symbol Zbtb26
Ensembl Gene ENSMUSG00000050714
Gene Name zinc finger and BTB domain containing 26
Synonyms A630026F21Rik
MMRRC Submission 039707-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.365) question?
Stock # R1671 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 37322180-37333147 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 37326377 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 220 (T220A)
Ref Sequence ENSEMBL: ENSMUSP00000099850 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067043] [ENSMUST00000102789] [ENSMUST00000112932]
AlphaFold Q8C8S0
Predicted Effect probably benign
Transcript: ENSMUST00000067043
AA Change: T209A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000070071
Gene: ENSMUSG00000050714
AA Change: T209A

DomainStartEndE-ValueType
BTB 33 127 4.38e-12 SMART
low complexity region 169 179 N/A INTRINSIC
ZnF_C2H2 273 295 1.36e-2 SMART
ZnF_C2H2 298 320 1.4e-4 SMART
ZnF_C2H2 326 348 2.99e-4 SMART
ZnF_C2H2 354 377 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102789
AA Change: T220A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000099850
Gene: ENSMUSG00000050714
AA Change: T220A

DomainStartEndE-ValueType
BTB 44 138 4.38e-12 SMART
low complexity region 180 190 N/A INTRINSIC
ZnF_C2H2 284 306 1.36e-2 SMART
ZnF_C2H2 309 331 1.4e-4 SMART
ZnF_C2H2 337 359 2.99e-4 SMART
ZnF_C2H2 365 388 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112932
SMART Domains Protein: ENSMUSP00000108554
Gene: ENSMUSG00000066798

DomainStartEndE-ValueType
BTB 33 127 2.67e-16 SMART
Blast:BTB 161 196 1e-5 BLAST
ZnF_C2H2 300 322 7.15e-2 SMART
ZnF_C2H2 325 347 1.58e-3 SMART
ZnF_C2H2 353 375 3.63e-3 SMART
ZnF_C2H2 381 404 8.81e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203522
Meta Mutation Damage Score 0.0579 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.3%
Validation Efficiency 100% (70/70)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930578I06Rik A C 14: 64,210,637 (GRCm39) L197R probably benign Het
Arglu1 A G 8: 8,733,896 (GRCm39) V140A possibly damaging Het
Arhgef28 T C 13: 98,067,542 (GRCm39) E1461G possibly damaging Het
Best3 A T 10: 116,860,573 (GRCm39) D611V possibly damaging Het
Cenpf T C 1: 189,411,341 (GRCm39) probably null Het
Cenpj A C 14: 56,802,502 (GRCm39) M21R probably damaging Het
Cltc A T 11: 86,623,421 (GRCm39) H201Q possibly damaging Het
Col28a1 A T 6: 8,083,773 (GRCm39) N561K possibly damaging Het
Cyp2c70 G A 19: 40,142,081 (GRCm39) P470L probably damaging Het
Cyp4f14 G A 17: 33,135,883 (GRCm39) probably benign Het
Ddi1 A T 9: 6,266,225 (GRCm39) V48D possibly damaging Het
Dnah11 A C 12: 117,880,523 (GRCm39) Y3866D probably damaging Het
Dnah9 A G 11: 65,818,789 (GRCm39) V3183A probably damaging Het
Elmo1 T A 13: 20,472,054 (GRCm39) probably benign Het
Fap T A 2: 62,384,179 (GRCm39) Y9F possibly damaging Het
Fbxo15 T A 18: 84,977,231 (GRCm39) S93T possibly damaging Het
Gal3st2 C T 1: 93,801,400 (GRCm39) R19C probably damaging Het
Gmnn A T 13: 24,936,054 (GRCm39) *207R probably null Het
Gucy1a1 A C 3: 82,013,529 (GRCm39) I371S probably damaging Het
H1f11-ps C A 19: 47,159,294 (GRCm39) V94L possibly damaging Het
Igsf10 G T 3: 59,235,921 (GRCm39) S1420* probably null Het
Itih5 G T 2: 10,191,782 (GRCm39) V106L probably benign Het
Itsn1 T A 16: 91,609,038 (GRCm39) I201K probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lars2 C T 9: 123,247,344 (GRCm39) T283I probably benign Het
Loxhd1 T C 18: 77,492,498 (GRCm39) I1313T probably damaging Het
Mamdc4 T A 2: 25,458,235 (GRCm39) R368* probably null Het
Mdga1 A T 17: 30,069,603 (GRCm39) Y422N probably damaging Het
Mro A T 18: 74,003,126 (GRCm39) probably benign Het
Mroh2b T C 15: 4,980,776 (GRCm39) probably null Het
Nlrp1b C A 11: 71,092,085 (GRCm39) V14L probably benign Het
Nos3 A G 5: 24,588,838 (GRCm39) D1157G probably damaging Het
Nrxn2 C A 19: 6,523,780 (GRCm39) R598S probably damaging Het
Or2av9 A T 11: 58,381,435 (GRCm39) W49R possibly damaging Het
Or4k1 T C 14: 50,377,290 (GRCm39) K269E probably damaging Het
Or52ae9 C A 7: 103,389,617 (GRCm39) A277S possibly damaging Het
Or8b101 A G 9: 38,020,428 (GRCm39) M144V probably benign Het
Otog A T 7: 45,911,210 (GRCm39) D687V probably damaging Het
Pcsk5 C T 19: 17,432,232 (GRCm39) C1461Y probably damaging Het
Raet1d A G 10: 22,238,614 (GRCm39) M1V probably null Het
Rnf6 A T 5: 146,147,998 (GRCm39) L340* probably null Het
Rsl1d1 T C 16: 11,019,245 (GRCm39) T99A probably damaging Het
Sbno1 A T 5: 124,530,130 (GRCm39) probably null Het
Sipa1l1 A G 12: 82,444,235 (GRCm39) Y982C probably damaging Het
Sorbs3 G T 14: 70,428,915 (GRCm39) R417S possibly damaging Het
Sorl1 A G 9: 41,885,296 (GRCm39) C2102R probably damaging Het
Sp140l2 C T 1: 85,235,106 (GRCm39) probably null Het
Sptbn1 T A 11: 30,092,245 (GRCm39) I494F possibly damaging Het
Tank T A 2: 61,480,097 (GRCm39) V211E probably damaging Het
Tbcd T A 11: 121,488,120 (GRCm39) D840E probably benign Het
Tg T A 15: 66,564,236 (GRCm39) C1146S possibly damaging Het
Tiam2 A T 17: 3,557,109 (GRCm39) E110V probably damaging Het
Tle4 A T 19: 14,431,103 (GRCm39) W560R probably damaging Het
Triml2 G A 8: 43,636,780 (GRCm39) R76H possibly damaging Het
Ttn T C 2: 76,541,964 (GRCm39) E25347G probably damaging Het
Ube2e2 A G 14: 18,586,889 (GRCm38) L124P probably damaging Het
Vmn2r81 A G 10: 79,103,265 (GRCm39) K153E probably benign Het
Wnt16 A T 6: 22,298,178 (GRCm39) Y348F probably damaging Het
Xpo6 A G 7: 125,707,715 (GRCm39) V897A possibly damaging Het
Zik1 A T 7: 10,224,675 (GRCm39) S141T probably damaging Het
Zkscan3 A G 13: 21,580,305 (GRCm39) Y128H possibly damaging Het
Other mutations in Zbtb26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00579:Zbtb26 APN 2 37,326,454 (GRCm39) missense possibly damaging 0.82
IGL00899:Zbtb26 APN 2 37,326,270 (GRCm39) nonsense probably null
IGL01598:Zbtb26 APN 2 37,326,283 (GRCm39) missense probably damaging 1.00
IGL01940:Zbtb26 APN 2 37,325,987 (GRCm39) missense possibly damaging 0.93
IGL02152:Zbtb26 APN 2 37,326,703 (GRCm39) missense possibly damaging 0.95
IGL02867:Zbtb26 APN 2 37,326,261 (GRCm39) missense probably benign 0.00
IGL02889:Zbtb26 APN 2 37,326,261 (GRCm39) missense probably benign 0.00
IGL03081:Zbtb26 APN 2 37,326,612 (GRCm39) missense possibly damaging 0.67
R0138:Zbtb26 UTSW 2 37,326,053 (GRCm39) missense probably benign 0.16
R0328:Zbtb26 UTSW 2 37,326,807 (GRCm39) missense possibly damaging 0.81
R0927:Zbtb26 UTSW 2 37,326,337 (GRCm39) missense possibly damaging 0.91
R1813:Zbtb26 UTSW 2 37,326,347 (GRCm39) missense possibly damaging 0.68
R1896:Zbtb26 UTSW 2 37,326,347 (GRCm39) missense possibly damaging 0.68
R2128:Zbtb26 UTSW 2 37,326,563 (GRCm39) missense probably benign 0.00
R2374:Zbtb26 UTSW 2 37,326,497 (GRCm39) missense probably benign
R4050:Zbtb26 UTSW 2 37,327,000 (GRCm39) start codon destroyed probably null 0.46
R4631:Zbtb26 UTSW 2 37,326,968 (GRCm39) missense probably benign 0.00
R4940:Zbtb26 UTSW 2 37,326,781 (GRCm39) missense probably damaging 0.98
R5071:Zbtb26 UTSW 2 37,325,941 (GRCm39) missense probably benign 0.26
R6348:Zbtb26 UTSW 2 37,325,687 (GRCm39) missense probably benign 0.43
R6962:Zbtb26 UTSW 2 37,326,106 (GRCm39) missense possibly damaging 0.71
R6990:Zbtb26 UTSW 2 37,326,557 (GRCm39) missense probably benign 0.00
R7261:Zbtb26 UTSW 2 37,326,667 (GRCm39) missense possibly damaging 0.71
R7981:Zbtb26 UTSW 2 37,326,887 (GRCm39) missense possibly damaging 0.51
R8013:Zbtb26 UTSW 2 37,327,013 (GRCm39) critical splice acceptor site probably null
R8014:Zbtb26 UTSW 2 37,327,013 (GRCm39) critical splice acceptor site probably null
R8872:Zbtb26 UTSW 2 37,326,913 (GRCm39) missense probably damaging 0.99
R8876:Zbtb26 UTSW 2 37,326,896 (GRCm39) missense probably benign
R8905:Zbtb26 UTSW 2 37,326,927 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGCCGCAGAGTAGACACATAAACAG -3'
(R):5'- AGGCTCTCCAAAGCAGGACTTACC -3'

Sequencing Primer
(F):5'- TAGTTCTCCAGGTGACGGAATAC -3'
(R):5'- CCAAAGCAGGACTTACCTTGTATTC -3'
Posted On 2014-05-09