Mutagenetix > Incidental Mutation

Incidental Mutation 'R2205:Vmn1r23'

238972

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r23

Ensembl Gene

ENSMUSG00000093376

Gene Name

vomeronasal 1 receptor 23

Synonyms

V1rc24

MMRRC Submission

040207-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.157) question?

Stock #

R2205 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

57925842-57926838 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57926619 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 58 (D58G)

Ref Sequence

ENSEMBL: ENSMUSP00000135676 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000175817]

AlphaFold

Q8R2D0

Predicted Effect

probably benign
Transcript: ENSMUST00000175817
AA Change: D58G

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000135676
Gene: ENSMUSG00000093376
AA Change: D58G

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	3.1e-57	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 96.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5330417C22Rik	C	T	3: 108,475,043 (GRCm38)	G270E	probably damaging	Het
5830473C10Rik	A	G	5: 90,569,562 (GRCm38)	T201A	possibly damaging	Het
9930111J21Rik2	C	G	11: 49,019,322 (GRCm38)	L761F	probably damaging	Het
Abca14	T	C	7: 120,247,280 (GRCm38)	S652P	probably damaging	Het
Acsl6	G	A	11: 54,324,007 (GRCm38)	G75S	probably damaging	Het
Adamts7	A	T	9: 90,180,676 (GRCm38)	K394N	probably damaging	Het
Ahdc1	A	G	4: 133,065,909 (GRCm38)	E1487G	possibly damaging	Het
Aknad1	A	G	3: 108,757,293 (GRCm38)	D406G	probably damaging	Het
Ankrd2	C	A	19: 42,044,119 (GRCm38)	A273E	probably damaging	Het
Ankrd26	T	A	6: 118,523,882 (GRCm38)	H876L	possibly damaging	Het
Arhgap35	A	T	7: 16,498,025 (GRCm38)		probably null	Het
Bag6	G	A	17: 35,144,607 (GRCm38)	G751R	probably damaging	Het
Brat1	G	A	5: 140,705,133 (GRCm38)		probably benign	Het
Cacna1h	C	T	17: 25,380,260 (GRCm38)	A1742T	probably damaging	Het
Catsperg1	G	A	7: 29,185,246 (GRCm38)	Q922*	probably null	Het
Cfap221	T	G	1: 119,936,104 (GRCm38)	Y570S	possibly damaging	Het
Cfap45	T	C	1: 172,532,161 (GRCm38)	V76A	probably benign	Het
Chil3	T	C	3: 106,164,246 (GRCm38)	D34G	probably benign	Het
Cpa1	A	G	6: 30,641,819 (GRCm38)	D214G	probably damaging	Het
Cpd	A	G	11: 76,802,244 (GRCm38)	Y739H	probably damaging	Het
Cttnbp2	T	G	6: 18,408,694 (GRCm38)	D976A	probably benign	Het
Dhrs7	A	T	12: 72,656,370 (GRCm38)	V188E	probably damaging	Het
Dpp9	A	C	17: 56,199,287 (GRCm38)	I411S	possibly damaging	Het
Fitm2	G	A	2: 163,472,596 (GRCm38)		probably benign	Het
Flnc	C	T	6: 29,459,508 (GRCm38)	P2536S	probably damaging	Het
Gm12169	A	G	11: 46,528,567 (GRCm38)	N70S	probably benign	Het
Gm6370	T	A	5: 146,493,729 (GRCm38)	D241E	probably benign	Het
Gpatch1	C	A	7: 35,291,772 (GRCm38)	D616Y	probably damaging	Het
Gpc3	T	A	X: 52,397,206 (GRCm38)	I344F	probably damaging	Het
Hmgcs2	T	A	3: 98,291,183 (GRCm38)	I134N	probably damaging	Het
Hoxb3	T	A	11: 96,345,668 (GRCm38)	S191T	probably benign	Het
Ifit1bl1	C	T	19: 34,594,341 (GRCm38)	E239K	probably benign	Het
Ints8	A	T	4: 11,225,712 (GRCm38)	M615K	possibly damaging	Het
Irak1	G	A	X: 74,017,138 (GRCm38)	T193I	probably damaging	Het
Megf8	C	T	7: 25,341,748 (GRCm38)	T1134I	probably benign	Het
Nipsnap1	C	A	11: 4,889,974 (GRCm38)	H232N	possibly damaging	Het
Nme4	A	T	17: 26,092,140 (GRCm38)	H150Q	possibly damaging	Het
Nudt5	A	T	2: 5,855,983 (GRCm38)	I22F	possibly damaging	Het
P2rx7	T	A	5: 122,681,101 (GRCm38)	Y529N	probably damaging	Het
Pdlim2	C	T	14: 70,164,779 (GRCm38)	R296H	probably damaging	Het
Pofut1	T	A	2: 153,261,247 (GRCm38)	M267K	probably damaging	Het
Rad54l2	T	C	9: 106,717,798 (GRCm38)	D320G	probably damaging	Het
Rdm1	C	A	11: 101,634,803 (GRCm38)	A225E	probably damaging	Het
Samm50	G	A	15: 84,202,314 (GRCm38)	A245T	probably benign	Het
Scfd2	A	T	5: 74,225,367 (GRCm38)	M597K	possibly damaging	Het
Shroom3	G	T	5: 92,943,086 (GRCm38)	V1151F	probably damaging	Het
Skiv2l2	T	C	13: 112,898,890 (GRCm38)	I510V	probably benign	Het
Ssh3	A	G	19: 4,269,073 (GRCm38)	L3P	probably damaging	Het
Stoml2	G	T	4: 43,030,243 (GRCm38)	Y119*	probably null	Het
Tbc1d31	A	G	15: 57,953,520 (GRCm38)	D717G	probably benign	Het
Tma7	C	A	9: 109,082,226 (GRCm38)		probably benign	Het
Tmc1	A	T	19: 20,940,905 (GRCm38)	L2M	probably benign	Het
Tmem39b	A	C	4: 129,693,923 (GRCm38)	S32A	probably benign	Het
Tnfsf14	T	C	17: 57,190,638 (GRCm38)	D198G	possibly damaging	Het
Tns3	T	C	11: 8,531,719 (GRCm38)	Y211C	probably damaging	Het
Ttc21b	C	T	2: 66,235,123 (GRCm38)	G436S	possibly damaging	Het
Ttn	T	C	2: 76,851,563 (GRCm38)		probably benign	Het
Ube3b	G	A	5: 114,389,074 (GRCm38)	V118M	probably damaging	Het
Usp34	A	G	11: 23,385,147 (GRCm38)	T1210A	probably damaging	Het
Vmn2r104	A	T	17: 20,029,821 (GRCm38)	N729K	probably benign	Het
Wdr62	T	A	7: 30,258,149 (GRCm38)		probably null	Het
Ywhah	A	G	5: 33,027,140 (GRCm38)	N229S	probably damaging	Het
Zfp651	A	G	9: 121,762,637 (GRCm38)	T8A	possibly damaging	Het
Zfyve27	C	A	19: 42,183,446 (GRCm38)	A139D	probably damaging	Het
Zmat1	A	G	X: 134,973,112 (GRCm38)	L476P	possibly damaging	Het
Zswim4	G	T	8: 84,225,869 (GRCm38)	T488N	possibly damaging	Het

Other mutations in Vmn1r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01563:Vmn1r23	APN	6	57,926,076 (GRCm38)	missense	possibly damaging	0.89
IGL01980:Vmn1r23	APN	6	57,926,490 (GRCm38)	missense	probably damaging	1.00
IGL02934:Vmn1r23	APN	6	57,925,929 (GRCm38)	missense	probably benign	0.26
IGL03153:Vmn1r23	APN	6	57,925,932 (GRCm38)	missense	probably damaging	0.98
R0410:Vmn1r23	UTSW	6	57,926,190 (GRCm38)	missense	probably benign	0.11
R0452:Vmn1r23	UTSW	6	57,926,484 (GRCm38)	missense	possibly damaging	0.90
R0590:Vmn1r23	UTSW	6	57,926,364 (GRCm38)	missense	probably benign	0.43
R0647:Vmn1r23	UTSW	6	57,926,184 (GRCm38)	missense	probably benign
R0692:Vmn1r23	UTSW	6	57,926,125 (GRCm38)	nonsense	probably null
R1674:Vmn1r23	UTSW	6	57,926,061 (GRCm38)	missense	possibly damaging	0.75
R1744:Vmn1r23	UTSW	6	57,925,925 (GRCm38)	missense	possibly damaging	0.81
R1774:Vmn1r23	UTSW	6	57,926,690 (GRCm38)	missense	probably damaging	0.97
R2101:Vmn1r23	UTSW	6	57,926,452 (GRCm38)	missense	possibly damaging	0.90
R2202:Vmn1r23	UTSW	6	57,926,619 (GRCm38)	missense	probably benign	0.01
R2204:Vmn1r23	UTSW	6	57,926,619 (GRCm38)	missense	probably benign	0.01
R4282:Vmn1r23	UTSW	6	57,926,467 (GRCm38)	missense	probably benign	0.27
R4408:Vmn1r23	UTSW	6	57,926,368 (GRCm38)	missense	probably benign	0.01
R4532:Vmn1r23	UTSW	6	57,925,929 (GRCm38)	missense	probably benign	0.21
R4690:Vmn1r23	UTSW	6	57,926,025 (GRCm38)	missense	probably benign
R4700:Vmn1r23	UTSW	6	57,926,205 (GRCm38)	missense	probably benign	0.17
R4894:Vmn1r23	UTSW	6	57,926,325 (GRCm38)	missense	probably benign	0.00
R6164:Vmn1r23	UTSW	6	57,926,055 (GRCm38)	missense	possibly damaging	0.90
R6930:Vmn1r23	UTSW	6	57,926,145 (GRCm38)	missense	probably benign
R7129:Vmn1r23	UTSW	6	57,926,076 (GRCm38)	missense	possibly damaging	0.89
R7731:Vmn1r23	UTSW	6	57,926,334 (GRCm38)	missense	probably benign	0.03
R7877:Vmn1r23	UTSW	6	57,926,556 (GRCm38)	missense	probably benign
R8751:Vmn1r23	UTSW	6	57,926,467 (GRCm38)	missense	probably benign	0.27
R8809:Vmn1r23	UTSW	6	57,926,367 (GRCm38)	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- CATCTGGTTGGTCTTACTCACATTG -3'
(R):5'- TTGGAGGGTATATAACAATGTAGGC -3'

Sequencing Primer
(F):5'- GTCTTACTCACATTGTTAAAACCACC -3'
(R):5'- GACTTGGAGTCCTAGCCAATATG -3'

Posted On

2014-10-02