Incidental Mutation 'IGL01869:Gm21738'
ID 278955
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm21738
Ensembl Gene ENSMUSG00000095280
Gene Name predicted gene, 21738
Synonyms
Accession Numbers
Essential gene? Probably essential (E-score: 0.883) question?
Stock # IGL01869
Quality Score
Status
Chromosome 14
Chromosomal Location (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 19416979 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 144 (S144L)
Ref Sequence ENSEMBL: ENSMUSP00000137127 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177817]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

DomainStartEndE-ValueType
internal_repeat_1 1 19 1.11e-9 PROSPERO
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 77 99 N/A INTRINSIC
internal_repeat_1 117 135 1.11e-9 PROSPERO
transmembrane domain 152 174 N/A INTRINSIC
low complexity region 179 195 N/A INTRINSIC
transmembrane domain 198 220 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700026F02Rik A G 8: 71,495,689 (GRCm39) noncoding transcript Het
Adam29 T C 8: 56,324,732 (GRCm39) H574R probably damaging Het
Arap1 C A 7: 101,049,490 (GRCm39) T984K probably damaging Het
Ccdc146 A T 5: 21,521,837 (GRCm39) S396T probably benign Het
Col6a3 T C 1: 90,700,770 (GRCm39) K2587E unknown Het
Cyp3a44 A G 5: 145,727,496 (GRCm39) S278P probably damaging Het
Daw1 T G 1: 83,159,965 (GRCm39) probably benign Het
Dnah17 T C 11: 117,943,502 (GRCm39) K3200R probably benign Het
Efhd2 A G 4: 141,601,913 (GRCm39) F89S probably damaging Het
Fras1 A G 5: 96,856,642 (GRCm39) probably benign Het
Ggps1 T C 13: 14,228,979 (GRCm39) D68G probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm3604 A T 13: 62,517,954 (GRCm39) C134S probably damaging Het
Gpaa1 A G 15: 76,217,198 (GRCm39) T178A probably benign Het
Lama3 A G 18: 12,657,820 (GRCm39) N312S possibly damaging Het
Npepps T C 11: 97,126,948 (GRCm39) I437M probably damaging Het
Or10q12 A G 19: 13,746,534 (GRCm39) D276G probably benign Het
Or11i1 C T 3: 106,729,342 (GRCm39) D178N probably benign Het
Rcor1 C A 12: 111,070,193 (GRCm39) T330K possibly damaging Het
Sbno2 A G 10: 79,896,226 (GRCm39) probably null Het
Sema3g A G 14: 30,945,624 (GRCm39) E478G probably damaging Het
Smg9 A G 7: 24,115,949 (GRCm39) D280G probably damaging Het
Smtnl1 A T 2: 84,641,741 (GRCm39) *460R probably null Het
Syde1 A G 10: 78,424,753 (GRCm39) C360R possibly damaging Het
Szt2 A G 4: 118,256,268 (GRCm39) V197A possibly damaging Het
Tnrc6c T C 11: 117,646,274 (GRCm39) V1405A possibly damaging Het
Ttbk1 A G 17: 46,757,989 (GRCm39) S882P probably damaging Het
Tubgcp4 T A 2: 121,006,269 (GRCm39) H116Q possibly damaging Het
Vmn1r192 T A 13: 22,371,750 (GRCm39) N157Y probably damaging Het
Vmn1r60 C T 7: 5,547,228 (GRCm39) V291M probably benign Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Xpo5 C T 17: 46,553,133 (GRCm39) P1184L possibly damaging Het
Zfp946 T G 17: 22,673,684 (GRCm39) I146S probably benign Het
Other mutations in Gm21738
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Gm21738 APN 14 19,418,885 (GRCm38) missense probably benign
IGL01010:Gm21738 APN 14 19,417,361 (GRCm38) missense probably benign 0.03
IGL01018:Gm21738 APN 14 19,418,856 (GRCm38) missense probably benign 0.39
IGL01865:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01873:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01877:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01878:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01879:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01880:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01882:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01883:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01884:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01885:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01886:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01888:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01891:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01892:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01893:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01894:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01895:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01896:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01898:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01899:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01900:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01901:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01902:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01903:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01904:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01905:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01906:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01908:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01909:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01910:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01911:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01912:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01913:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01914:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01915:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01916:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01917:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01918:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01919:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01922:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01923:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01924:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01925:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01926:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01932:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01940:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
IGL01949:Gm21738 APN 14 19,416,979 (GRCm38) missense probably benign 0.01
PIT4131001:Gm21738 UTSW 14 19,417,330 (GRCm38) missense probably benign 0.00
PIT4142001:Gm21738 UTSW 14 19,417,330 (GRCm38) missense probably benign 0.00
R0831:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R0831:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R0976:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R1029:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R1146:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R1231:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R1231:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R1402:Gm21738 UTSW 14 19,415,963 (GRCm38) missense probably benign
R1402:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R1638:Gm21738 UTSW 14 19,418,908 (GRCm38) missense probably benign
R1874:Gm21738 UTSW 14 19,418,824 (GRCm38) missense possibly damaging 0.64
R4392:Gm21738 UTSW 14 19,417,178 (GRCm38) missense probably benign
R4393:Gm21738 UTSW 14 19,417,178 (GRCm38) missense probably benign
R5049:Gm21738 UTSW 14 19,415,957 (GRCm38) missense probably benign 0.01
R5257:Gm21738 UTSW 14 19,415,942 (GRCm38) missense probably benign
R6756:Gm21738 UTSW 14 19,418,824 (GRCm38) missense possibly damaging 0.64
R6915:Gm21738 UTSW 14 19,415,933 (GRCm38) missense probably benign
V5622:Gm21738 UTSW 14 19,417,180 (GRCm38) missense probably damaging 1.00
Posted On 2015-04-16