Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01903:Gm21738'

279055

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21738

Ensembl Gene

ENSMUSG00000095280

Gene Name

predicted gene, 21738

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.874) question?

Stock #

IGL01903

Quality Score

Status

Chromosome

Chromosomal Location

19415857-19418930 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19416979 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 144 (S144L)

Ref Sequence

ENSEMBL: ENSMUSP00000137127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177817]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177817
AA Change: S144L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000137127
Gene: ENSMUSG00000095280
AA Change: S144L

Domain	Start	End	E-Value	Type
internal_repeat_1	1	19	1.11e-9	PROSPERO
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	77	99	N/A	INTRINSIC
internal_repeat_1	117	135	1.11e-9	PROSPERO
transmembrane domain	152	174	N/A	INTRINSIC
low complexity region	179	195	N/A	INTRINSIC
transmembrane domain	198	220	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	T	A	3: 122,155,401		probably benign	Het
Adad1	T	A	3: 37,085,082		probably null	Het
Asxl3	T	A	18: 22,434,576	D70E	probably benign	Het
Atat1	T	A	17: 35,897,800	I380L	probably benign	Het
Ccnj	A	G	19: 40,846,010	E351G	probably damaging	Het
Clca4b	A	T	3: 144,928,259	Y132N	probably damaging	Het
Cttnbp2	A	C	6: 18,501,965	V16G	probably damaging	Het
Gcdh	A	T	8: 84,888,604	L389Q	probably damaging	Het
Ggta1	A	T	2: 35,402,557	F258Y	possibly damaging	Het
Gm10717	C	T	9: 3,025,616	S67L	probably benign	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm3696	T	A	14: 7,089,782		probably benign	Het
Gramd3	A	T	18: 56,474,029	S72C	probably damaging	Het
Hal	G	A	10: 93,500,607		probably benign	Het
Haus4	A	T	14: 54,542,429	S288T	possibly damaging	Het
Herc1	A	T	9: 66,386,872	K499*	probably null	Het
Hyou1	C	T	9: 44,381,141		probably benign	Het
Kng2	C	T	16: 22,987,790	R553Q	possibly damaging	Het
Leng9	G	A	7: 4,148,747	A310V	probably damaging	Het
Magi3	G	T	3: 104,051,210	Q520K	possibly damaging	Het
Mark1	A	G	1: 184,929,380		probably benign	Het
Mybl1	T	A	1: 9,671,576		probably null	Het
Ncapd2	A	G	6: 125,177,460	S598P	probably benign	Het
Olfr1110	A	C	2: 87,135,379		probably null	Het
Olfr126	T	C	17: 37,609,867	I295V	possibly damaging	Het
Olfr1297	T	C	2: 111,621,658	K139E	probably benign	Het
Olfr1441	G	A	19: 12,422,683	V125I	probably benign	Het
Otud6b	C	T	4: 14,818,458	E148K	probably benign	Het
Pgghg	A	G	7: 140,946,828	Q686R	probably benign	Het
Pkhd1	C	A	1: 20,198,137	C3339F	probably damaging	Het
Pla2g4a	T	C	1: 149,840,619	D697G	possibly damaging	Het
Serping1	A	T	2: 84,769,772		probably null	Het
Sfxn4	T	C	19: 60,858,680	Y55C	probably damaging	Het
Sh3bp5l	A	G	11: 58,346,038	R274G	probably damaging	Het
Snx13	A	G	12: 35,085,969	T88A	probably benign	Het
Spz1	G	T	13: 92,574,899	N356K	probably damaging	Het
Taf2	A	T	15: 55,060,016	F288L	probably benign	Het
Tti1	T	C	2: 158,000,622	E829G	probably benign	Het
Ube2z	T	C	11: 96,065,000	D92G	possibly damaging	Het
Vmn2r7	A	G	3: 64,719,443	Y142H	probably benign	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Zfp397	T	A	18: 23,960,029	N190K	probably benign	Het

Other mutations in Gm21738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Gm21738	APN	14	19418885	missense	probably benign
IGL01010:Gm21738	APN	14	19417361	missense	probably benign	0.03
IGL01018:Gm21738	APN	14	19418856	missense	probably benign	0.39
IGL01865:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01869:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01873:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01877:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01878:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01879:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01880:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01882:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01883:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01884:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01885:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01886:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01888:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01891:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01892:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01893:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01894:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01895:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01896:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01898:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01899:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01900:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01901:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01902:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01904:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01905:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01906:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01908:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01909:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01910:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01911:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01912:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01913:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01914:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01915:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01916:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01917:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01918:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01919:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01922:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01923:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01924:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01925:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01926:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01932:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01940:Gm21738	APN	14	19416979	missense	probably benign	0.01
IGL01949:Gm21738	APN	14	19416979	missense	probably benign	0.01
PIT4131001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
PIT4142001:Gm21738	UTSW	14	19417330	missense	probably benign	0.00
R0831:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R0831:Gm21738	UTSW	14	19415963	missense	probably benign
R0976:Gm21738	UTSW	14	19415963	missense	probably benign
R1029:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1146:Gm21738	UTSW	14	19415963	missense	probably benign
R1231:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1231:Gm21738	UTSW	14	19415963	missense	probably benign
R1402:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R1402:Gm21738	UTSW	14	19415963	missense	probably benign
R1638:Gm21738	UTSW	14	19418908	missense	probably benign
R1874:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R4392:Gm21738	UTSW	14	19417178	missense	probably benign
R4393:Gm21738	UTSW	14	19417178	missense	probably benign
R5049:Gm21738	UTSW	14	19415957	missense	probably benign	0.01
R5257:Gm21738	UTSW	14	19415942	missense	probably benign
R6756:Gm21738	UTSW	14	19418824	missense	possibly damaging	0.64
R6915:Gm21738	UTSW	14	19415933	missense	probably benign
V5622:Gm21738	UTSW	14	19417180	missense	probably damaging	1.00

Posted On

2015-04-16