Mutagenetix > Incidental Mutation

Incidental Mutation 'R4733:Pkd1l2'

358968

Institutional Source

Beutler Lab

Gene Symbol

Pkd1l2

Ensembl Gene

ENSMUSG00000034416

Gene Name

polycystic kidney disease 1 like 2

Synonyms

MMRRC Submission

042023-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4733 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

116995679-117082449 bp(-) (GRCm38)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

T to A at 116995842 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000104721 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040484] [ENSMUST00000098375] [ENSMUST00000109093]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000040484

SMART Domains

Protein: ENSMUSP00000037131
Gene: ENSMUSG00000034424

Domain	Start	End	E-Value	Type
Pfam:GCV_H	48	168	1.2e-51	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000098375

SMART Domains

Protein: ENSMUSP00000095977
Gene: ENSMUSG00000034416

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CLECT	26	152	1.56e-21	SMART
Pfam:Gal_Lectin	168	250	1.8e-18	PFAM
PKD	260	341	3.84e-1	SMART
low complexity region	496	507	N/A	INTRINSIC
Pfam:REJ	510	886	1.8e-13	PFAM
low complexity region	1050	1060	N/A	INTRINSIC
GPS	1278	1327	1.61e-11	SMART
transmembrane domain	1346	1365	N/A	INTRINSIC
LH2	1390	1509	6.05e-13	SMART
transmembrane domain	1552	1574	N/A	INTRINSIC
transmembrane domain	1589	1611	N/A	INTRINSIC
transmembrane domain	1815	1837	N/A	INTRINSIC
transmembrane domain	1852	1874	N/A	INTRINSIC
transmembrane domain	1940	1962	N/A	INTRINSIC
Pfam:PKD_channel	1980	2403	6.4e-107	PFAM
Pfam:Ion_trans	2187	2396	2.5e-12	PFAM
low complexity region	2441	2458	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000109093

SMART Domains

Protein: ENSMUSP00000104721
Gene: ENSMUSG00000034416

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CLECT	26	152	1.56e-21	SMART
Pfam:Gal_Lectin	168	250	6.9e-19	PFAM
PKD	260	341	3.84e-1	SMART
low complexity region	496	507	N/A	INTRINSIC
Pfam:REJ	519	883	7e-11	PFAM
low complexity region	1051	1061	N/A	INTRINSIC
GPS	1279	1328	1.61e-11	SMART
transmembrane domain	1347	1366	N/A	INTRINSIC
LH2	1391	1510	6.05e-13	SMART
transmembrane domain	1553	1575	N/A	INTRINSIC
transmembrane domain	1590	1612	N/A	INTRINSIC
transmembrane domain	1816	1838	N/A	INTRINSIC
transmembrane domain	1853	1875	N/A	INTRINSIC
transmembrane domain	1941	1963	N/A	INTRINSIC
Pfam:PKD_channel	1981	2403	5.9e-106	PFAM
Pfam:Ion_trans	2138	2409	3.4e-12	PFAM
low complexity region	2442	2459	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000162548

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 94.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 180 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700128F08Rik	T	A	9: 8,222,173 (GRCm38)		noncoding transcript	Het
3110035E14Rik	T	C	1: 9,606,976 (GRCm38)	S24P	probably benign	Het
4933409G03Rik	A	G	2: 68,614,721 (GRCm38)		probably benign	Het
Acan	T	C	7: 79,098,609 (GRCm38)	S1043P	probably damaging	Het
Ackr2	A	G	9: 121,909,183 (GRCm38)	Y208C	probably damaging	Het
Adam1a	T	A	5: 121,519,434 (GRCm38)	T599S	probably benign	Het
Adamts12	A	T	15: 11,270,662 (GRCm38)	S668C	probably damaging	Het
Adcy8	A	G	15: 64,754,862 (GRCm38)	V709A	possibly damaging	Het
Adgrf2	A	C	17: 42,710,754 (GRCm38)	I393S	probably damaging	Het
Ahnak	G	T	19: 9,007,301 (GRCm38)	G1983V	probably damaging	Het
Aim2	T	A	1: 173,463,876 (GRCm38)	D282E	possibly damaging	Het
Ak8	A	G	2: 28,760,071 (GRCm38)	Y370C	probably damaging	Het
Akap9	A	G	5: 4,013,901 (GRCm38)	D1750G	probably damaging	Het
Als2cl	T	A	9: 110,889,136 (GRCm38)	V315E	probably damaging	Het
Ankrd28	A	C	14: 31,755,741 (GRCm38)	C115G	probably benign	Het
Ap3b2	C	T	7: 81,471,932 (GRCm38)	A519T	probably damaging	Het
Apool	C	T	X: 112,372,200 (GRCm38)	T166I	probably damaging	Het
Arhgef2	A	T	3: 88,631,940 (GRCm38)	K65*	probably null	Het
Arhgef38	G	T	3: 133,132,269 (GRCm38)	Y633*	probably null	Het
Asah2	T	C	19: 31,995,358 (GRCm38)	N659S	probably benign	Het
Atf7ip2	A	G	16: 10,241,886 (GRCm38)	D430G	possibly damaging	Het
Atp8a1	G	A	5: 67,813,120 (GRCm38)	S92L	probably benign	Het
Bag4	C	T	8: 25,769,488 (GRCm38)	A228T	probably benign	Het
BC024978	T	A	7: 27,201,043 (GRCm38)	M149K	probably damaging	Het
C130073F10Rik	C	A	4: 101,890,710 (GRCm38)	S89I	probably benign	Het
Cacna1g	T	C	11: 94,443,215 (GRCm38)	T867A	probably damaging	Het
Ccdc88a	T	G	11: 29,485,906 (GRCm38)	N1276K	probably benign	Het
Cdc42bpg	T	A	19: 6,311,191 (GRCm38)	V282E	probably damaging	Het
Cdipt	T	A	7: 126,978,358 (GRCm38)	L92H	probably damaging	Het
Celsr2	T	A	3: 108,398,952 (GRCm38)	D2012V	probably damaging	Het
Cenpt	A	G	8: 105,847,136 (GRCm38)	V254A	probably benign	Het
Cep104	T	A	4: 153,988,426 (GRCm38)	D380E	probably damaging	Het
Cers5	C	T	15: 99,741,637 (GRCm38)	R123Q	probably benign	Het
Ces2h	A	G	8: 105,014,604 (GRCm38)	E76G	probably damaging	Het
Cfap77	T	A	2: 28,984,388 (GRCm38)	E143D	probably benign	Het
Chmp7	C	A	14: 69,732,296 (GRCm38)	R65L	probably damaging	Het
Cldnd2	T	A	7: 43,442,189 (GRCm38)	C65S	possibly damaging	Het
Clec2g	C	A	6: 128,981,879 (GRCm38)	Y142*	probably null	Het
Coch	A	T	12: 51,605,019 (GRCm38)	E549V	probably benign	Het
Cog7	T	C	7: 121,964,244 (GRCm38)	D215G	probably benign	Het
Col4a2	A	G	8: 11,446,197 (GRCm38)	H1606R	probably benign	Het
Col4a2	T	C	8: 11,414,779 (GRCm38)	V348A	probably benign	Het
Cpd	T	C	11: 76,811,794 (GRCm38)	N583D	probably damaging	Het
Cyp2d11	T	A	15: 82,389,227 (GRCm38)	Y481F	probably benign	Het
D130043K22Rik	T	C	13: 24,899,665 (GRCm38)	S1038P	probably damaging	Het
Deptor	C	A	15: 55,181,010 (GRCm38)	H191N	probably benign	Het
Dgkz	A	T	2: 91,938,339 (GRCm38)	I699N	probably damaging	Het
Dnah12	C	T	14: 26,781,784 (GRCm38)	T1653I	probably damaging	Het
Dnah7c	T	A	1: 46,770,173 (GRCm38)	N3550K	probably damaging	Het
Dnah8	A	G	17: 30,775,061 (GRCm38)	K3384R	probably null	Het
Dnhd1	C	A	7: 105,673,849 (GRCm38)	N521K	probably benign	Het
Drg2	T	C	11: 60,461,396 (GRCm38)		probably null	Het
Dync1h1	C	T	12: 110,649,507 (GRCm38)	Q3030*	probably null	Het
Efhb	G	A	17: 53,426,244 (GRCm38)	T533I	probably damaging	Het
Eif2d	T	C	1: 131,164,727 (GRCm38)	V374A	probably damaging	Het
Etfb	T	C	7: 43,444,200 (GRCm38)	V17A	probably damaging	Het
F5	C	T	1: 164,181,657 (GRCm38)	T332M	probably damaging	Het
Fcho1	T	C	8: 71,716,795 (GRCm38)	T156A	probably benign	Het
Fn1	A	T	1: 71,602,512 (GRCm38)		probably null	Het
Fnip2	A	T	3: 79,481,652 (GRCm38)	S561T	probably damaging	Het
Frs2	T	A	10: 117,074,093 (GRCm38)	T455S	probably benign	Het
Fry	G	A	5: 150,386,007 (GRCm38)	E639K		Het
Fto	T	A	8: 91,409,714 (GRCm38)	D205E	probably damaging	Het
Galntl6	G	A	8: 58,427,813 (GRCm38)	P147L	probably damaging	Het
Gigyf1	T	A	5: 137,524,770 (GRCm38)	D844E	probably benign	Het
Gle1	T	C	2: 29,940,232 (GRCm38)	S267P	probably damaging	Het
Glg1	G	A	8: 111,187,755 (GRCm38)	R466W	probably damaging	Het
Gm10277	T	C	11: 77,786,097 (GRCm38)		probably benign	Het
Gm5724	A	T	6: 141,723,179 (GRCm38)	M509K	probably benign	Het
Gm6871	T	C	7: 41,546,749 (GRCm38)	I39V	probably benign	Het
Gpr35	T	G	1: 92,983,385 (GRCm38)	I57S	probably damaging	Het
Gprin1	C	T	13: 54,739,957 (GRCm38)	G168E	possibly damaging	Het
Gtf3c2	G	T	5: 31,160,057 (GRCm38)	P586T	probably damaging	Het
Gucy1a2	A	T	9: 3,759,424 (GRCm38)	H410L	probably benign	Het
Gucy2c	A	G	6: 136,767,152 (GRCm38)	S150P	probably damaging	Het
Ifi214	T	C	1: 173,526,591 (GRCm38)	Q171R	probably benign	Het
Igkv4-50	T	C	6: 69,701,000 (GRCm38)	K40R	probably benign	Het
Igkv8-18	T	A	6: 70,356,296 (GRCm38)	I74N	probably damaging	Het
Il2ra	T	A	2: 11,676,920 (GRCm38)	M112K	probably benign	Het
Itpr2	A	G	6: 146,373,173 (GRCm38)	F837S	probably damaging	Het
Kbtbd7	T	C	14: 79,428,800 (GRCm38)	*691Q	probably null	Het
Kcnn2	T	A	18: 45,560,349 (GRCm38)	S331T	possibly damaging	Het
Khnyn	T	A	14: 55,886,489 (GRCm38)		probably null	Het
Kif26a	G	A	12: 112,175,573 (GRCm38)	A754T	probably benign	Het
Klra3	T	A	6: 130,327,132 (GRCm38)	Y199F	possibly damaging	Het
Lhx2	A	G	2: 38,359,991 (GRCm38)	K274R	probably damaging	Het
Lrp2	T	C	2: 69,533,555 (GRCm38)	I313V	probably benign	Het
Lrrfip1	A	T	1: 91,115,647 (GRCm38)	E591D	probably benign	Het
Lrrk2	A	C	15: 91,688,849 (GRCm38)	E200A	probably damaging	Het
Lrrk2	G	A	15: 91,765,747 (GRCm38)	E1696K	probably damaging	Het
Mast4	A	T	13: 102,772,572 (GRCm38)	M465K	probably damaging	Het
Moxd2	T	G	6: 40,878,859 (GRCm38)	I599L	probably benign	Het
Mug2	T	C	6: 122,071,872 (GRCm38)	S866P	probably damaging	Het
Ncam2	A	G	16: 81,434,884 (GRCm38)	T79A	possibly damaging	Het
Ncoa6	C	A	2: 155,421,301 (GRCm38)	Q404H	probably damaging	Het
Neb	A	G	2: 52,279,079 (GRCm38)	Y1815H	probably damaging	Het
Nell1	A	G	7: 50,856,217 (GRCm38)	D724G	probably damaging	Het
Nkx3-2	A	G	5: 41,762,144 (GRCm38)	V167A	probably benign	Het
Nsun3	C	A	16: 62,735,119 (GRCm38)	C348F	possibly damaging	Het
Obox6	A	T	7: 15,834,772 (GRCm38)	S60T	possibly damaging	Het
Olfr1	T	C	11: 73,395,695 (GRCm38)	D109G	probably benign	Het
Olfr1378	G	A	11: 50,969,266 (GRCm38)	V83M	possibly damaging	Het
Olfr138	T	A	17: 38,275,547 (GRCm38)	Y259N	probably damaging	Het
Olfr466	T	C	13: 65,152,653 (GRCm38)	V143A	possibly damaging	Het
Olfr744	T	A	14: 50,618,569 (GRCm38)	C116S	probably benign	Het
Olfr94	T	C	17: 37,197,024 (GRCm38)	T315A	probably damaging	Het
Olfr980	A	T	9: 40,006,268 (GRCm38)	I227N	probably damaging	Het
Pabpc1	A	T	15: 36,599,284 (GRCm38)	V389E	probably benign	Het
Pank4	A	T	4: 154,971,390 (GRCm38)	M291L	probably benign	Het
Pcf11	T	C	7: 92,658,833 (GRCm38)	D709G	probably benign	Het
Pcgf1	T	A	6: 83,079,957 (GRCm38)		probably benign	Het
Pcnx	A	G	12: 81,995,751 (GRCm38)	I2256V	probably benign	Het
Pex6	A	G	17: 46,722,288 (GRCm38)	D579G	probably benign	Het
Pex6	A	G	17: 46,724,707 (GRCm38)		probably null	Het
Piezo2	C	T	18: 63,030,401 (GRCm38)	A2149T	probably damaging	Het
Pik3c2g	A	G	6: 139,935,985 (GRCm38)	E781G	probably benign	Het
Pik3r4	G	A	9: 105,678,176 (GRCm38)	V1111I	possibly damaging	Het
Plekhg1	T	A	10: 3,957,506 (GRCm38)	S808T	probably benign	Het
Polr3c	A	T	3: 96,723,661 (GRCm38)	F148I	probably damaging	Het
Ppard	A	T	17: 28,286,443 (GRCm38)	T35S	probably benign	Het
Ptov1	T	C	7: 44,867,109 (GRCm38)	D134G	probably benign	Het
Ptprz1	T	A	6: 23,002,610 (GRCm38)	S1566R	probably benign	Het
Pum1	T	C	4: 130,718,193 (GRCm38)	S158P	probably benign	Het
Qk	T	C	17: 10,216,288 (GRCm38)	H269R	probably damaging	Het
Qrsl1	T	C	10: 43,876,663 (GRCm38)	Y388C	probably damaging	Het
Rapgef1	T	G	2: 29,689,160 (GRCm38)	I182S	probably damaging	Het
Ret	T	C	6: 118,163,193 (GRCm38)	S1013G	possibly damaging	Het
Rimbp3	A	G	16: 17,210,601 (GRCm38)	R630G	possibly damaging	Het
Ryr2	A	T	13: 11,577,909 (GRCm38)	M4653K	possibly damaging	Het
Sacm1l	G	A	9: 123,590,830 (GRCm38)	V553I	probably benign	Het
Sec31b	A	T	19: 44,532,677 (GRCm38)	S110T	probably damaging	Het
Serpina3k	G	A	12: 104,340,860 (GRCm38)	G117D	probably damaging	Het
Sesn2	T	C	4: 132,494,591 (GRCm38)	Y410C	probably damaging	Het
Slc24a1	G	A	9: 64,949,554 (GRCm38)	R24C	probably benign	Het
Slc35g2	A	C	9: 100,552,502 (GRCm38)	V372G	probably benign	Het
Slc7a7	T	C	14: 54,408,733 (GRCm38)	Y91C	probably damaging	Het
Slc7a9	T	A	7: 35,453,563 (GRCm38)	Y135*	probably null	Het
Slco4a1	A	G	2: 180,473,615 (GRCm38)	N662D	probably damaging	Het
Slfn4	T	A	11: 83,189,282 (GRCm38)		probably benign	Het
Slmap	T	C	14: 26,468,535 (GRCm38)	N156S	probably damaging	Het
Snx18	A	G	13: 113,617,774 (GRCm38)	S208P	probably benign	Het
Sorbs1	T	A	19: 40,314,689 (GRCm38)	R485S	probably benign	Het
Spib	A	G	7: 44,528,885 (GRCm38)	S154P	probably damaging	Het
Spty2d1	T	C	7: 46,996,110 (GRCm38)	D595G	probably damaging	Het
St7	T	A	6: 17,906,516 (GRCm38)		probably null	Het
Susd1	T	C	4: 59,428,029 (GRCm38)	T52A	possibly damaging	Het
Svs2	T	A	2: 164,237,123 (GRCm38)	D288V	possibly damaging	Het
Syt7	T	A	19: 10,442,924 (GRCm38)	I355N	probably damaging	Het
Tarm1	G	A	7: 3,496,900 (GRCm38)	Q145*	probably null	Het
Teddm2	T	A	1: 153,850,741 (GRCm38)	E76V	probably damaging	Het
Thsd7b	T	C	1: 129,613,186 (GRCm38)	S343P	probably damaging	Het
Tigd2	T	A	6: 59,211,415 (GRCm38)	H422Q	probably benign	Het
Tle1	T	C	4: 72,125,019 (GRCm38)	N538D	possibly damaging	Het
Tmc2	A	G	2: 130,261,397 (GRCm38)		probably null	Het
Tmtc1	A	C	6: 148,284,980 (GRCm38)		probably null	Het
Tns3	C	T	11: 8,450,986 (GRCm38)	R1104H	probably benign	Het
Trim6	T	C	7: 104,232,648 (GRCm38)	Y369H	probably damaging	Het
Triobp	G	A	15: 78,967,113 (GRCm38)	R489K	probably damaging	Het
Trpv4	T	C	5: 114,622,753 (GRCm38)	D732G	possibly damaging	Het
Trrap	G	A	5: 144,816,570 (GRCm38)	V1883I	probably damaging	Het
Tsc2	C	A	17: 24,603,275 (GRCm38)	V1141F	possibly damaging	Het
Ttn	A	G	2: 76,899,827 (GRCm38)		probably benign	Het
Ttn	A	T	2: 76,943,011 (GRCm38)	M2395K	unknown	Het
Tyrp1	A	T	4: 80,844,935 (GRCm38)	D353V	possibly damaging	Het
Ubd	A	C	17: 37,195,702 (GRCm38)	T160P	probably benign	Het
Ugt2b36	G	T	5: 87,081,538 (GRCm38)	Y156*	probably null	Het
Ulk4	G	A	9: 121,263,638 (GRCm38)	R178*	probably null	Het
Unc13d	A	G	11: 116,073,582 (GRCm38)	V312A	possibly damaging	Het
Urb2	G	T	8: 124,028,897 (GRCm38)	A448S	probably damaging	Het
Urod	G	A	4: 116,991,673 (GRCm38)	A92V	possibly damaging	Het
Vmn1r33	T	A	6: 66,611,819 (GRCm38)	R250S	probably benign	Het
Vmn1r87	A	T	7: 13,132,327 (GRCm38)	M11K	possibly damaging	Het
Vmn2r77	C	T	7: 86,800,987 (GRCm38)	T147I	probably benign	Het
Vstm4	A	G	14: 32,917,902 (GRCm38)	K96E	possibly damaging	Het
Washc4	A	T	10: 83,574,479 (GRCm38)	M644L	probably benign	Het
Wwp1	T	C	4: 19,661,990 (GRCm38)	D172G	probably benign	Het
Zbtb38	A	T	9: 96,687,684 (GRCm38)	V449E	probably damaging	Het
Zfp229	C	T	17: 21,745,286 (GRCm38)	H166Y	possibly damaging	Het
Zfp512b	A	G	2: 181,588,739 (GRCm38)	S453P	probably benign	Het
Zp2	C	A	7: 120,138,120 (GRCm38)	V282L	probably damaging	Het

Other mutations in Pkd1l2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01338:Pkd1l2	APN	8	117,059,520 (GRCm38)	nonsense	probably null
IGL01353:Pkd1l2	APN	8	117,057,443 (GRCm38)	missense	probably benign	0.24
IGL01362:Pkd1l2	APN	8	117,021,856 (GRCm38)	missense	probably damaging	1.00
IGL01486:Pkd1l2	APN	8	117,059,592 (GRCm38)	missense	probably benign
IGL01672:Pkd1l2	APN	8	117,080,732 (GRCm38)	missense	possibly damaging	0.94
IGL01696:Pkd1l2	APN	8	117,056,387 (GRCm38)	missense	probably benign	0.12
IGL01819:Pkd1l2	APN	8	116,998,174 (GRCm38)	missense	probably damaging	1.00
IGL01833:Pkd1l2	APN	8	117,060,525 (GRCm38)	missense	probably benign	0.00
IGL01981:Pkd1l2	APN	8	117,016,916 (GRCm38)	missense	probably benign	0.04
IGL02066:Pkd1l2	APN	8	117,009,564 (GRCm38)	splice site	probably benign
IGL02381:Pkd1l2	APN	8	117,035,800 (GRCm38)	splice site	probably benign
IGL02416:Pkd1l2	APN	8	117,040,835 (GRCm38)	missense	possibly damaging	0.82
IGL02736:Pkd1l2	APN	8	117,040,666 (GRCm38)	missense	probably benign	0.00
IGL02828:Pkd1l2	APN	8	117,029,559 (GRCm38)	missense	probably benign
IGL02861:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02862:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02883:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02884:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02894:Pkd1l2	APN	8	117,013,891 (GRCm38)	missense	probably damaging	0.97
IGL02900:Pkd1l2	APN	8	117,024,091 (GRCm38)	missense	probably benign	0.03
IGL02901:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02929:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02941:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02957:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02969:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03028:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03059:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03065:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03066:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03083:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03084:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03124:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03162:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03165:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03335:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03357:Pkd1l2	APN	8	116,995,809 (GRCm38)	missense	probably damaging	1.00
IGL02835:Pkd1l2	UTSW	8	117,065,745 (GRCm38)	missense	probably benign	0.07
PIT4453001:Pkd1l2	UTSW	8	117,022,022 (GRCm38)	missense	probably benign	0.00
R0127:Pkd1l2	UTSW	8	117,050,048 (GRCm38)	splice site	probably benign
R0309:Pkd1l2	UTSW	8	116,997,576 (GRCm38)	missense	probably damaging	0.99
R0365:Pkd1l2	UTSW	8	117,021,850 (GRCm38)	missense	probably benign	0.02
R0526:Pkd1l2	UTSW	8	117,082,260 (GRCm38)	missense	probably damaging	1.00
R0571:Pkd1l2	UTSW	8	117,082,218 (GRCm38)	missense	probably benign	0.01
R0716:Pkd1l2	UTSW	8	117,051,100 (GRCm38)	missense	probably damaging	1.00
R0787:Pkd1l2	UTSW	8	117,076,177 (GRCm38)	missense	possibly damaging	0.90
R0893:Pkd1l2	UTSW	8	117,044,492 (GRCm38)	missense	probably damaging	0.99
R1256:Pkd1l2	UTSW	8	117,019,543 (GRCm38)	critical splice acceptor site	probably null
R1391:Pkd1l2	UTSW	8	117,054,934 (GRCm38)	missense	possibly damaging	0.87
R1474:Pkd1l2	UTSW	8	117,065,497 (GRCm38)	splice site	probably benign
R1491:Pkd1l2	UTSW	8	117,028,408 (GRCm38)	missense	probably damaging	1.00
R1520:Pkd1l2	UTSW	8	117,046,159 (GRCm38)	missense	probably benign	0.00
R1521:Pkd1l2	UTSW	8	117,065,500 (GRCm38)	splice site	probably null
R1544:Pkd1l2	UTSW	8	117,038,235 (GRCm38)	frame shift	probably null
R1558:Pkd1l2	UTSW	8	117,082,252 (GRCm38)	missense	possibly damaging	0.94
R1673:Pkd1l2	UTSW	8	117,040,775 (GRCm38)	missense	probably benign	0.00
R1691:Pkd1l2	UTSW	8	117,056,419 (GRCm38)	missense	possibly damaging	0.60
R1754:Pkd1l2	UTSW	8	117,030,719 (GRCm38)	missense	possibly damaging	0.81
R1857:Pkd1l2	UTSW	8	117,040,669 (GRCm38)	missense	possibly damaging	0.70
R1939:Pkd1l2	UTSW	8	117,046,182 (GRCm38)	nonsense	probably null
R1955:Pkd1l2	UTSW	8	117,043,361 (GRCm38)	missense	probably benign
R1957:Pkd1l2	UTSW	8	117,030,682 (GRCm38)	missense	probably damaging	1.00
R1959:Pkd1l2	UTSW	8	117,043,231 (GRCm38)	critical splice donor site	probably null
R2024:Pkd1l2	UTSW	8	117,019,533 (GRCm38)	missense	probably benign
R2046:Pkd1l2	UTSW	8	116,999,955 (GRCm38)	missense	probably damaging	1.00
R2102:Pkd1l2	UTSW	8	117,081,469 (GRCm38)	missense	probably damaging	0.98
R2116:Pkd1l2	UTSW	8	117,030,722 (GRCm38)	missense	possibly damaging	0.93
R2148:Pkd1l2	UTSW	8	117,056,325 (GRCm38)	missense	probably damaging	0.98
R2251:Pkd1l2	UTSW	8	117,057,438 (GRCm38)	missense	probably damaging	1.00
R2252:Pkd1l2	UTSW	8	117,057,438 (GRCm38)	missense	probably damaging	1.00
R2366:Pkd1l2	UTSW	8	117,043,317 (GRCm38)	missense	probably benign	0.01
R2566:Pkd1l2	UTSW	8	117,019,494 (GRCm38)	missense	probably damaging	1.00
R2872:Pkd1l2	UTSW	8	117,038,164 (GRCm38)	missense	probably benign	0.10
R2872:Pkd1l2	UTSW	8	117,038,164 (GRCm38)	missense	probably benign	0.10
R2985:Pkd1l2	UTSW	8	117,065,551 (GRCm38)	missense	probably benign	0.00
R3055:Pkd1l2	UTSW	8	117,068,315 (GRCm38)	critical splice acceptor site	probably null
R3436:Pkd1l2	UTSW	8	117,040,739 (GRCm38)	missense	probably benign	0.01
R4732:Pkd1l2	UTSW	8	116,995,842 (GRCm38)	critical splice acceptor site	probably null
R4763:Pkd1l2	UTSW	8	117,019,429 (GRCm38)	missense	probably damaging	0.96
R4789:Pkd1l2	UTSW	8	117,011,575 (GRCm38)	missense	probably damaging	0.99
R4921:Pkd1l2	UTSW	8	117,054,885 (GRCm38)	missense	probably benign	0.03
R4921:Pkd1l2	UTSW	8	117,072,549 (GRCm38)	missense	probably damaging	0.97
R4999:Pkd1l2	UTSW	8	117,047,374 (GRCm38)	splice site	probably null
R5057:Pkd1l2	UTSW	8	117,055,008 (GRCm38)	missense	probably benign	0.21
R5209:Pkd1l2	UTSW	8	117,056,442 (GRCm38)	missense	probably benign	0.23
R5241:Pkd1l2	UTSW	8	117,035,118 (GRCm38)	missense	probably damaging	1.00
R5480:Pkd1l2	UTSW	8	117,030,649 (GRCm38)	missense	probably damaging	0.99
R5501:Pkd1l2	UTSW	8	117,065,830 (GRCm38)	missense	probably damaging	0.98
R5533:Pkd1l2	UTSW	8	117,068,116 (GRCm38)	missense	probably benign	0.03
R5582:Pkd1l2	UTSW	8	117,040,783 (GRCm38)	nonsense	probably null
R5610:Pkd1l2	UTSW	8	117,042,320 (GRCm38)	missense	probably benign	0.04
R5770:Pkd1l2	UTSW	8	117,055,018 (GRCm38)	missense	probably damaging	1.00
R5854:Pkd1l2	UTSW	8	117,065,746 (GRCm38)	missense	possibly damaging	0.48
R5867:Pkd1l2	UTSW	8	117,055,011 (GRCm38)	missense	probably damaging	0.96
R5881:Pkd1l2	UTSW	8	116,997,582 (GRCm38)	missense	probably damaging	0.99
R5906:Pkd1l2	UTSW	8	117,029,648 (GRCm38)	missense	probably damaging	1.00
R5909:Pkd1l2	UTSW	8	117,024,056 (GRCm38)	missense	probably benign	0.00
R6030:Pkd1l2	UTSW	8	117,043,237 (GRCm38)	missense	probably damaging	1.00
R6030:Pkd1l2	UTSW	8	117,043,237 (GRCm38)	missense	probably damaging	1.00
R6084:Pkd1l2	UTSW	8	117,013,987 (GRCm38)	missense	probably damaging	1.00
R6122:Pkd1l2	UTSW	8	117,082,368 (GRCm38)	missense	probably benign	0.02
R6216:Pkd1l2	UTSW	8	117,081,470 (GRCm38)	missense	probably damaging	1.00
R6406:Pkd1l2	UTSW	8	117,035,847 (GRCm38)	missense	probably damaging	0.99
R6417:Pkd1l2	UTSW	8	117,013,899 (GRCm38)	missense	probably damaging	1.00
R6420:Pkd1l2	UTSW	8	117,013,899 (GRCm38)	missense	probably damaging	1.00
R6601:Pkd1l2	UTSW	8	117,040,666 (GRCm38)	missense	probably benign	0.00
R6743:Pkd1l2	UTSW	8	117,030,631 (GRCm38)	missense	probably damaging	1.00
R7053:Pkd1l2	UTSW	8	117,013,942 (GRCm38)	missense	probably damaging	1.00
R7144:Pkd1l2	UTSW	8	117,076,131 (GRCm38)	nonsense	probably null
R7148:Pkd1l2	UTSW	8	117,080,786 (GRCm38)	missense	probably benign	0.00
R7169:Pkd1l2	UTSW	8	117,040,835 (GRCm38)	missense	possibly damaging	0.82
R7217:Pkd1l2	UTSW	8	116,995,797 (GRCm38)	missense	probably benign	0.24
R7310:Pkd1l2	UTSW	8	117,024,034 (GRCm38)	missense	probably benign
R7382:Pkd1l2	UTSW	8	117,054,871 (GRCm38)	missense	possibly damaging	0.95
R7397:Pkd1l2	UTSW	8	117,035,902 (GRCm38)	missense	possibly damaging	0.94
R7408:Pkd1l2	UTSW	8	117,028,479 (GRCm38)	missense	possibly damaging	0.77
R7437:Pkd1l2	UTSW	8	117,030,682 (GRCm38)	missense	probably damaging	0.96
R7492:Pkd1l2	UTSW	8	117,068,110 (GRCm38)	missense	probably damaging	1.00
R7496:Pkd1l2	UTSW	8	117,060,594 (GRCm38)	missense	possibly damaging	0.89
R7519:Pkd1l2	UTSW	8	117,065,529 (GRCm38)	missense	probably benign
R7590:Pkd1l2	UTSW	8	117,080,786 (GRCm38)	missense	probably benign	0.00
R7623:Pkd1l2	UTSW	8	117,029,645 (GRCm38)	missense	probably damaging	1.00
R7768:Pkd1l2	UTSW	8	117,054,860 (GRCm38)	critical splice donor site	probably null
R7897:Pkd1l2	UTSW	8	116,998,088 (GRCm38)	missense	possibly damaging	0.69
R7982:Pkd1l2	UTSW	8	117,051,187 (GRCm38)	missense	possibly damaging	0.70
R8024:Pkd1l2	UTSW	8	117,076,182 (GRCm38)	missense	possibly damaging	0.85
R8140:Pkd1l2	UTSW	8	117,047,497 (GRCm38)	missense	probably benign
R8145:Pkd1l2	UTSW	8	117,055,003 (GRCm38)	missense	probably benign
R8228:Pkd1l2	UTSW	8	117,065,775 (GRCm38)	missense	probably damaging	0.97
R8252:Pkd1l2	UTSW	8	117,040,733 (GRCm38)	missense	probably benign	0.29
R8500:Pkd1l2	UTSW	8	117,047,563 (GRCm38)	critical splice acceptor site	probably null
R8732:Pkd1l2	UTSW	8	117,065,572 (GRCm38)	missense	probably benign	0.28
R8809:Pkd1l2	UTSW	8	116,999,921 (GRCm38)	missense	probably damaging	1.00
R8896:Pkd1l2	UTSW	8	117,013,876 (GRCm38)	missense	possibly damaging	0.91
R8961:Pkd1l2	UTSW	8	116,999,978 (GRCm38)	missense	possibly damaging	0.52
R8985:Pkd1l2	UTSW	8	117,038,110 (GRCm38)	missense	probably benign	0.01
R9008:Pkd1l2	UTSW	8	117,042,298 (GRCm38)	missense	probably benign	0.32
R9091:Pkd1l2	UTSW	8	117,032,694 (GRCm38)	missense	probably damaging	1.00
R9138:Pkd1l2	UTSW	8	117,055,009 (GRCm38)	missense	probably benign	0.43
R9160:Pkd1l2	UTSW	8	117,040,669 (GRCm38)	missense	possibly damaging	0.70
R9249:Pkd1l2	UTSW	8	117,019,420 (GRCm38)	missense	probably damaging	0.99
R9270:Pkd1l2	UTSW	8	117,032,694 (GRCm38)	missense	probably damaging	1.00
R9735:Pkd1l2	UTSW	8	117,046,081 (GRCm38)	missense	possibly damaging	0.94
Z1176:Pkd1l2	UTSW	8	117,054,914 (GRCm38)	missense	probably damaging	1.00
Z1177:Pkd1l2	UTSW	8	117,030,691 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACCTGTGGATAAACAGTTTAAACCC -3'
(R):5'- AGCCCCAGTAGAAGGACATC -3'

Sequencing Primer
(F):5'- TTTAAACCCGGGACAAAGCTTGTG -3'
(R):5'- ATCCCAAGCCTAGTGACTTTAGG -3'

Posted On

2015-11-11