Incidental Mutation 'R4997:Llgl1'
| ID |
385362 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Llgl1
|
| Ensembl Gene |
ENSMUSG00000020536 |
| Gene Name |
LLGL1 scribble cell polarity complex component |
| Synonyms |
Lgl1 |
| MMRRC Submission |
042591-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4997 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
60590549-60605012 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 60600394 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Leucine
at position 581
(P581L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104359
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000002889]
[ENSMUST00000052346]
[ENSMUST00000108719]
|
| AlphaFold |
Q80Y17 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000002889
|
| SMART Domains |
Protein: ENSMUSP00000002889
Gene: ENSMUSG00000002812
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
55 |
78 |
1.08e-1 |
SMART |
|
LRR
|
103 |
126 |
4.08e0 |
SMART |
|
LRR
|
127 |
149 |
2.27e1 |
SMART |
|
LRR
|
150 |
173 |
1.25e-1 |
SMART |
|
LRR
|
222 |
244 |
6.78e1 |
SMART |
|
LRR
|
245 |
268 |
2.86e-1 |
SMART |
|
LRR
|
269 |
291 |
3.78e-1 |
SMART |
|
LRR
|
316 |
339 |
2.82e0 |
SMART |
|
LRR
|
340 |
362 |
2.27e2 |
SMART |
|
low complexity region
|
403 |
420 |
N/A |
INTRINSIC |
|
GEL
|
499 |
597 |
4.17e-25 |
SMART |
|
GEL
|
617 |
709 |
1.72e-26 |
SMART |
|
low complexity region
|
727 |
740 |
N/A |
INTRINSIC |
|
GEL
|
745 |
838 |
2.24e-25 |
SMART |
|
GEL
|
905 |
1039 |
1.13e-3 |
SMART |
|
GEL
|
1056 |
1152 |
7.28e-16 |
SMART |
|
GEL
|
1167 |
1263 |
5.51e-25 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000052346
AA Change: P581L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000060749
Gene: ENSMUSG00000020536
AA Change: P581L
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
22 |
62 |
4.42e1 |
SMART |
|
WD40
|
64 |
103 |
1.65e1 |
SMART |
|
WD40
|
187 |
223 |
2.74e2 |
SMART |
|
WD40
|
226 |
264 |
2.06e0 |
SMART |
|
Pfam:LLGL
|
278 |
379 |
1.2e-43 |
PFAM |
|
WD40
|
424 |
460 |
3.2e0 |
SMART |
|
Blast:WD40
|
498 |
541 |
2e-13 |
BLAST |
|
Blast:WD40
|
585 |
624 |
4e-9 |
BLAST |
|
Pfam:Lgl_C
|
732 |
978 |
1.2e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108719
AA Change: P581L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000104359
Gene: ENSMUSG00000020536
AA Change: P581L
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
22 |
62 |
4.42e1 |
SMART |
|
WD40
|
64 |
103 |
1.65e1 |
SMART |
|
WD40
|
187 |
223 |
2.74e2 |
SMART |
|
WD40
|
226 |
264 |
2.06e0 |
SMART |
|
Pfam:LLGL
|
275 |
379 |
2e-48 |
PFAM |
|
WD40
|
424 |
460 |
3.2e0 |
SMART |
|
Blast:WD40
|
498 |
540 |
2e-13 |
BLAST |
|
Blast:WD40
|
585 |
624 |
4e-9 |
BLAST |
|
Pfam:Lgl_C
|
804 |
976 |
1.3e-8 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128749
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154141
|
| Meta Mutation Damage Score |
0.0616 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutant mice die neonatally exhibiting hydroencephaly. Neural progenitor cell physiology is abnormal, resulting in a loss of cell polarity and the development of neuroepithelial rosette-like structures throughout the brain. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A630023A22Rik |
A |
T |
14: 33,775,623 (GRCm39) |
M1L |
probably benign |
Het |
| Abca7 |
C |
A |
10: 79,843,154 (GRCm39) |
Q1210K |
possibly damaging |
Het |
| Abcc4 |
C |
T |
14: 118,753,915 (GRCm39) |
W1024* |
probably null |
Het |
| Accs |
A |
T |
2: 93,672,228 (GRCm39) |
Y213* |
probably null |
Het |
| Adam6a |
G |
T |
12: 113,508,991 (GRCm39) |
G455C |
probably damaging |
Het |
| Adcy1 |
A |
C |
11: 7,111,298 (GRCm39) |
Y863S |
probably benign |
Het |
| Adgrg1 |
A |
G |
8: 95,736,148 (GRCm39) |
D434G |
probably damaging |
Het |
| Afap1l1 |
C |
T |
18: 61,884,879 (GRCm39) |
R202Q |
probably benign |
Het |
| Aldh3a1 |
T |
C |
11: 61,103,137 (GRCm39) |
V27A |
probably benign |
Het |
| Antxr2 |
A |
G |
5: 98,125,553 (GRCm39) |
F235L |
probably benign |
Het |
| Arhgap23 |
T |
A |
11: 97,342,846 (GRCm39) |
V376E |
probably damaging |
Het |
| Brca1 |
A |
C |
11: 101,415,159 (GRCm39) |
S992A |
probably damaging |
Het |
| Brcc3dc |
A |
G |
10: 108,535,649 (GRCm39) |
I102T |
probably benign |
Het |
| Calcrl |
A |
T |
2: 84,181,592 (GRCm39) |
C185* |
probably null |
Het |
| Cep152 |
T |
C |
2: 125,428,271 (GRCm39) |
T787A |
probably benign |
Het |
| Coch |
T |
A |
12: 51,649,964 (GRCm39) |
|
probably null |
Het |
| Col5a1 |
T |
A |
2: 27,922,794 (GRCm39) |
Y287* |
probably null |
Het |
| Dis3l |
A |
G |
9: 64,219,224 (GRCm39) |
S569P |
possibly damaging |
Het |
| Dnai1 |
A |
G |
4: 41,597,919 (GRCm39) |
I74V |
possibly damaging |
Het |
| Dpy19l4 |
A |
G |
4: 11,287,493 (GRCm39) |
V394A |
probably benign |
Het |
| Egfem1 |
A |
G |
3: 29,207,739 (GRCm39) |
H122R |
probably benign |
Het |
| Endou |
A |
G |
15: 97,617,458 (GRCm39) |
L164P |
probably damaging |
Het |
| Epgn |
A |
G |
5: 91,180,098 (GRCm39) |
E80G |
possibly damaging |
Het |
| Fcgbpl1 |
T |
G |
7: 27,843,349 (GRCm39) |
S746A |
possibly damaging |
Het |
| Fitm1 |
T |
C |
14: 55,814,364 (GRCm39) |
S287P |
probably benign |
Het |
| Foxm1 |
A |
G |
6: 128,342,731 (GRCm39) |
N22D |
probably benign |
Het |
| Gsdmc |
A |
T |
15: 63,648,629 (GRCm39) |
M426K |
probably damaging |
Het |
| Hmcn2 |
T |
A |
2: 31,291,720 (GRCm39) |
V2418D |
probably damaging |
Het |
| Hs3st2 |
T |
A |
7: 121,099,679 (GRCm39) |
L175Q |
possibly damaging |
Het |
| Il1r2 |
T |
C |
1: 40,160,206 (GRCm39) |
|
probably null |
Het |
| Il27ra |
A |
T |
8: 84,766,156 (GRCm39) |
Y209* |
probably null |
Het |
| Inpp5a |
A |
T |
7: 138,980,654 (GRCm39) |
S31C |
probably benign |
Het |
| Invs |
A |
G |
4: 48,396,332 (GRCm39) |
D335G |
probably damaging |
Het |
| Isg15 |
C |
T |
4: 156,284,154 (GRCm39) |
E125K |
possibly damaging |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Lama4 |
C |
A |
10: 38,968,262 (GRCm39) |
T1468K |
probably damaging |
Het |
| Lce1a2 |
A |
G |
3: 92,576,395 (GRCm39) |
S56P |
unknown |
Het |
| Lmf1 |
G |
A |
17: 25,807,650 (GRCm39) |
W164* |
probably null |
Het |
| Mad2l1bp |
G |
T |
17: 46,463,804 (GRCm39) |
C73* |
probably null |
Het |
| Mpzl1 |
A |
C |
1: 165,429,350 (GRCm39) |
V230G |
probably damaging |
Het |
| Myo3b |
A |
G |
2: 70,088,427 (GRCm39) |
T869A |
possibly damaging |
Het |
| Ncor2 |
T |
C |
5: 125,111,074 (GRCm39) |
H1316R |
probably damaging |
Het |
| Nlrp1b |
T |
A |
11: 71,109,160 (GRCm39) |
I114F |
probably damaging |
Het |
| Nsun7 |
A |
G |
5: 66,453,182 (GRCm39) |
I632M |
probably benign |
Het |
| Nubp1 |
T |
C |
16: 10,239,185 (GRCm39) |
I234T |
probably benign |
Het |
| Olfml1 |
A |
G |
7: 107,170,413 (GRCm39) |
D100G |
probably damaging |
Het |
| Or1e1b-ps1 |
T |
A |
11: 73,845,612 (GRCm39) |
L32Q |
probably damaging |
Het |
| Or5p73 |
C |
A |
7: 108,064,701 (GRCm39) |
Q57K |
probably benign |
Het |
| Or7g23 |
A |
T |
9: 19,086,627 (GRCm39) |
L115Q |
probably damaging |
Het |
| Osmr |
G |
T |
15: 6,845,120 (GRCm39) |
P882Q |
probably benign |
Het |
| Peg10 |
TCAGGATCC |
TCAGGATCCCCAGCAGGATCC |
6: 4,756,457 (GRCm39) |
|
probably benign |
Het |
| Per2 |
T |
A |
1: 91,378,505 (GRCm39) |
T15S |
probably benign |
Het |
| Piezo2 |
A |
G |
18: 63,216,184 (GRCm39) |
Y1184H |
probably damaging |
Het |
| Pik3c2b |
C |
T |
1: 133,032,819 (GRCm39) |
A1560V |
probably damaging |
Het |
| Pik3cd |
A |
C |
4: 149,743,441 (GRCm39) |
L256R |
probably damaging |
Het |
| Ppl |
C |
A |
16: 4,907,235 (GRCm39) |
R1020L |
probably damaging |
Het |
| Ppp1r10 |
A |
G |
17: 36,234,976 (GRCm39) |
N60S |
probably damaging |
Het |
| Prkcg |
T |
C |
7: 3,371,097 (GRCm39) |
|
probably null |
Het |
| Prkci |
T |
C |
3: 31,085,375 (GRCm39) |
|
probably null |
Het |
| Prrc2b |
A |
G |
2: 32,112,323 (GRCm39) |
Y1929C |
probably damaging |
Het |
| Prss12 |
T |
C |
3: 123,240,857 (GRCm39) |
V17A |
probably benign |
Het |
| Qtrt1 |
A |
G |
9: 21,328,654 (GRCm39) |
N206S |
probably benign |
Het |
| Rad54l2 |
A |
C |
9: 106,600,108 (GRCm39) |
S50A |
possibly damaging |
Het |
| Rhov |
C |
T |
2: 119,100,949 (GRCm39) |
R96H |
probably damaging |
Het |
| Rph3a |
A |
T |
5: 121,101,906 (GRCm39) |
V110E |
probably damaging |
Het |
| Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
| Ryr2 |
A |
T |
13: 11,610,192 (GRCm39) |
N646K |
probably benign |
Het |
| Scn8a |
A |
G |
15: 100,854,935 (GRCm39) |
T141A |
probably damaging |
Het |
| Serping1 |
T |
C |
2: 84,600,629 (GRCm39) |
R238G |
possibly damaging |
Het |
| Shank3 |
T |
A |
15: 89,433,901 (GRCm39) |
W1474R |
probably damaging |
Het |
| Slc16a12 |
T |
A |
19: 34,652,358 (GRCm39) |
M263L |
probably benign |
Het |
| Spata13 |
T |
C |
14: 60,946,908 (GRCm39) |
V652A |
probably damaging |
Het |
| Spata31 |
G |
A |
13: 65,067,537 (GRCm39) |
M66I |
probably benign |
Het |
| Spem2 |
T |
C |
11: 69,708,558 (GRCm39) |
I136V |
probably benign |
Het |
| Supt5 |
T |
C |
7: 28,015,462 (GRCm39) |
H925R |
probably benign |
Het |
| Syk |
A |
T |
13: 52,766,484 (GRCm39) |
K190* |
probably null |
Het |
| Thsd1 |
T |
A |
8: 22,733,340 (GRCm39) |
V129D |
probably damaging |
Het |
| Tiprl |
A |
G |
1: 165,047,759 (GRCm39) |
V174A |
possibly damaging |
Het |
| Tmed4 |
T |
A |
11: 6,224,500 (GRCm39) |
|
probably null |
Het |
| Tnfrsf19 |
T |
C |
14: 61,208,658 (GRCm39) |
T288A |
probably benign |
Het |
| Tnfrsf25 |
T |
C |
4: 152,202,153 (GRCm39) |
|
probably null |
Het |
| Tpd52 |
A |
G |
3: 9,000,056 (GRCm39) |
L121S |
probably damaging |
Het |
| Trim30a |
T |
A |
7: 104,060,827 (GRCm39) |
K316N |
probably benign |
Het |
| Ttc3 |
T |
G |
16: 94,253,841 (GRCm39) |
D1221E |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,714,403 (GRCm39) |
|
probably benign |
Het |
| Ttn |
T |
C |
2: 76,776,615 (GRCm39) |
I1514V |
probably benign |
Het |
| Ulk2 |
T |
C |
11: 61,689,982 (GRCm39) |
T671A |
probably benign |
Het |
| Wasf1 |
C |
T |
10: 40,810,600 (GRCm39) |
P281S |
probably damaging |
Het |
| Wnt10b |
C |
A |
15: 98,672,084 (GRCm39) |
R211L |
probably damaging |
Het |
| Xpnpep3 |
T |
A |
15: 81,332,577 (GRCm39) |
C371* |
probably null |
Het |
| Zfp41 |
C |
T |
15: 75,490,617 (GRCm39) |
|
probably benign |
Het |
| Zfp553 |
T |
A |
7: 126,834,683 (GRCm39) |
N79K |
probably benign |
Het |
| Zmynd8 |
G |
T |
2: 165,634,736 (GRCm39) |
D1096E |
probably benign |
Het |
|
| Other mutations in Llgl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01137:Llgl1
|
APN |
11 |
60,600,825 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL01400:Llgl1
|
APN |
11 |
60,597,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03066:Llgl1
|
APN |
11 |
60,596,860 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03174:Llgl1
|
APN |
11 |
60,597,036 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03306:Llgl1
|
APN |
11 |
60,602,180 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0284:Llgl1
|
UTSW |
11 |
60,602,967 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1137:Llgl1
|
UTSW |
11 |
60,595,559 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1432:Llgl1
|
UTSW |
11 |
60,599,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1769:Llgl1
|
UTSW |
11 |
60,597,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1786:Llgl1
|
UTSW |
11 |
60,598,066 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1835:Llgl1
|
UTSW |
11 |
60,595,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1943:Llgl1
|
UTSW |
11 |
60,596,842 (GRCm39) |
missense |
probably benign |
|
|
R2197:Llgl1
|
UTSW |
11 |
60,600,865 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2510:Llgl1
|
UTSW |
11 |
60,600,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2568:Llgl1
|
UTSW |
11 |
60,599,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3690:Llgl1
|
UTSW |
11 |
60,597,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3853:Llgl1
|
UTSW |
11 |
60,598,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Llgl1
|
UTSW |
11 |
60,601,110 (GRCm39) |
splice site |
probably null |
|
|
R4259:Llgl1
|
UTSW |
11 |
60,600,394 (GRCm39) |
missense |
probably benign |
|
|
R4348:Llgl1
|
UTSW |
11 |
60,600,394 (GRCm39) |
missense |
probably benign |
|
|
R4349:Llgl1
|
UTSW |
11 |
60,600,394 (GRCm39) |
missense |
probably benign |
|
|
R4352:Llgl1
|
UTSW |
11 |
60,600,394 (GRCm39) |
missense |
probably benign |
|
|
R4353:Llgl1
|
UTSW |
11 |
60,600,394 (GRCm39) |
missense |
probably benign |
|
|
R4396:Llgl1
|
UTSW |
11 |
60,596,834 (GRCm39) |
missense |
probably benign |
|
|
R4584:Llgl1
|
UTSW |
11 |
60,602,908 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4594:Llgl1
|
UTSW |
11 |
60,597,147 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4628:Llgl1
|
UTSW |
11 |
60,600,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4651:Llgl1
|
UTSW |
11 |
60,599,477 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4653:Llgl1
|
UTSW |
11 |
60,599,477 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4731:Llgl1
|
UTSW |
11 |
60,597,051 (GRCm39) |
nonsense |
probably null |
|
|
R4869:Llgl1
|
UTSW |
11 |
60,598,036 (GRCm39) |
nonsense |
probably null |
|
|
R4898:Llgl1
|
UTSW |
11 |
60,600,394 (GRCm39) |
missense |
probably benign |
|
|
R4899:Llgl1
|
UTSW |
11 |
60,600,394 (GRCm39) |
missense |
probably benign |
|
|
R4939:Llgl1
|
UTSW |
11 |
60,600,805 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4941:Llgl1
|
UTSW |
11 |
60,600,394 (GRCm39) |
missense |
probably benign |
|
|
R4942:Llgl1
|
UTSW |
11 |
60,600,394 (GRCm39) |
missense |
probably benign |
|
|
R4958:Llgl1
|
UTSW |
11 |
60,602,261 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4995:Llgl1
|
UTSW |
11 |
60,600,550 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5177:Llgl1
|
UTSW |
11 |
60,602,833 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5257:Llgl1
|
UTSW |
11 |
60,602,389 (GRCm39) |
splice site |
probably null |
|
|
R5258:Llgl1
|
UTSW |
11 |
60,602,389 (GRCm39) |
splice site |
probably null |
|
|
R5401:Llgl1
|
UTSW |
11 |
60,597,297 (GRCm39) |
missense |
probably benign |
|
|
R5406:Llgl1
|
UTSW |
11 |
60,604,010 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5432:Llgl1
|
UTSW |
11 |
60,598,449 (GRCm39) |
missense |
probably benign |
|
|
R5587:Llgl1
|
UTSW |
11 |
60,601,168 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5732:Llgl1
|
UTSW |
11 |
60,600,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5758:Llgl1
|
UTSW |
11 |
60,599,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5879:Llgl1
|
UTSW |
11 |
60,603,806 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6268:Llgl1
|
UTSW |
11 |
60,602,989 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6286:Llgl1
|
UTSW |
11 |
60,600,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6455:Llgl1
|
UTSW |
11 |
60,600,486 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6805:Llgl1
|
UTSW |
11 |
60,593,691 (GRCm39) |
missense |
probably benign |
0.25 |
|
R6929:Llgl1
|
UTSW |
11 |
60,601,179 (GRCm39) |
nonsense |
probably null |
|
|
R7274:Llgl1
|
UTSW |
11 |
60,596,812 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7889:Llgl1
|
UTSW |
11 |
60,598,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7986:Llgl1
|
UTSW |
11 |
60,602,221 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8141:Llgl1
|
UTSW |
11 |
60,601,142 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8176:Llgl1
|
UTSW |
11 |
60,597,387 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8223:Llgl1
|
UTSW |
11 |
60,593,648 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8332:Llgl1
|
UTSW |
11 |
60,601,210 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8350:Llgl1
|
UTSW |
11 |
60,602,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8500:Llgl1
|
UTSW |
11 |
60,595,809 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8979:Llgl1
|
UTSW |
11 |
60,601,129 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9155:Llgl1
|
UTSW |
11 |
60,597,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9163:Llgl1
|
UTSW |
11 |
60,600,402 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9225:Llgl1
|
UTSW |
11 |
60,600,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9234:Llgl1
|
UTSW |
11 |
60,600,956 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1186:Llgl1
|
UTSW |
11 |
60,603,923 (GRCm39) |
frame shift |
probably null |
|
|
Z1187:Llgl1
|
UTSW |
11 |
60,603,923 (GRCm39) |
frame shift |
probably null |
|
|
Z1188:Llgl1
|
UTSW |
11 |
60,603,923 (GRCm39) |
frame shift |
probably null |
|
|
Z1189:Llgl1
|
UTSW |
11 |
60,603,923 (GRCm39) |
frame shift |
probably null |
|
|
Z1190:Llgl1
|
UTSW |
11 |
60,603,923 (GRCm39) |
frame shift |
probably null |
|
|
Z1191:Llgl1
|
UTSW |
11 |
60,603,923 (GRCm39) |
frame shift |
probably null |
|
|
Z1192:Llgl1
|
UTSW |
11 |
60,603,923 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAGTGAAGGCTTTGGTACATTG -3'
(R):5'- ACCTCGTGCCACATACCTAG -3'
Sequencing Primer
(F):5'- ACATTGTAGGTATTCAGGGGCC -3'
(R):5'- TACCTAGCCAGCACAGGG -3'
|
| Posted On |
2016-05-10 |
Incidental Mutation