Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03216:Vmn2r17'

413464

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r17

Ensembl Gene

ENSMUSG00000091879

Gene Name

vomeronasal 2, receptor 17

Synonyms

EG384221

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

IGL03216

Quality Score

Status

Chromosome

Chromosomal Location

109567879-109601253 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109600756 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Tryptophan at position 685 (R685W)

Ref Sequence

ENSEMBL: ENSMUSP00000131450 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171841]

AlphaFold

E9PYF5

Predicted Effect

probably damaging
Transcript: ENSMUST00000171841
AA Change: R685W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: R685W

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	465	7e-26	PFAM
Pfam:NCD3G	508	562	3.5e-18	PFAM
Pfam:7tm_3	593	830	4.8e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ano10	A	T	9: 122,086,127 (GRCm39)	Y491N	probably damaging	Het
Cacna2d1	T	C	5: 16,558,840 (GRCm39)	F709L	probably damaging	Het
Cadps	A	G	14: 12,439,944 (GRCm38)	I1196T	probably damaging	Het
Cage1	T	C	13: 38,190,153 (GRCm39)		probably benign	Het
Cep350	A	T	1: 155,736,373 (GRCm39)	C2888S	probably benign	Het
Cfap52	T	C	11: 67,844,932 (GRCm39)	T46A	possibly damaging	Het
Cyp2d26	T	C	15: 82,677,462 (GRCm39)	M76V	probably benign	Het
Fermt3	A	T	19: 6,976,748 (GRCm39)	D653E	probably benign	Het
Foxj3	A	G	4: 119,467,180 (GRCm39)		probably benign	Het
Gm21985	T	A	2: 112,097,281 (GRCm39)	S39T	probably damaging	Het
Herc1	A	T	9: 66,386,228 (GRCm39)	D3727V	probably benign	Het
Ifi208	A	T	1: 173,506,507 (GRCm39)	T97S	possibly damaging	Het
Iqgap1	T	C	7: 80,392,836 (GRCm39)	E709G	probably benign	Het
Itgb5	T	A	16: 33,723,208 (GRCm39)	H361Q	probably benign	Het
Mr1	T	A	1: 155,005,035 (GRCm39)	N335I	possibly damaging	Het
Nadsyn1	A	T	7: 143,351,582 (GRCm39)	F684I	probably damaging	Het
Nf1	A	T	11: 79,455,721 (GRCm39)	I2544F	probably benign	Het
Or6c1b	A	G	10: 129,272,806 (GRCm39)	T42A	probably damaging	Het
Pnp2	T	G	14: 51,200,654 (GRCm39)	S107A	probably benign	Het
Pomt1	A	G	2: 32,132,955 (GRCm39)	I184V	probably damaging	Het
Slc6a19	T	G	13: 73,834,300 (GRCm39)	M301L	probably benign	Het
Smarca5	T	C	8: 81,446,287 (GRCm39)	Y471C	probably damaging	Het
Syne2	A	T	12: 75,989,735 (GRCm39)		probably benign	Het
Tasor2	C	T	13: 3,624,553 (GRCm39)	C1799Y	probably damaging	Het
Tex55	T	C	16: 38,649,052 (GRCm39)	D19G	possibly damaging	Het
Trmt6	T	C	2: 132,650,618 (GRCm39)	N330S	probably null	Het
Tsc22d1	T	C	14: 76,656,077 (GRCm39)	V770A	probably benign	Het
Ttll6	A	G	11: 96,042,840 (GRCm39)	D462G	probably benign	Het
Ttn	T	C	2: 76,775,393 (GRCm39)	H1883R	probably damaging	Het
Ubxn10	C	T	4: 138,448,050 (GRCm39)	V209M	probably damaging	Het
Urb1	T	C	16: 90,585,002 (GRCm39)	T540A	probably benign	Het
Vps4a	C	T	8: 107,763,335 (GRCm39)	R30C	probably damaging	Het
Xpo6	A	G	7: 125,703,985 (GRCm39)	V1055A	probably damaging	Het
Zfp445	C	T	9: 122,681,043 (GRCm39)	C966Y	probably damaging	Het

Other mutations in Vmn2r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00325:Vmn2r17	APN	5	109,575,858 (GRCm39)	missense	probably benign	0.15
IGL01457:Vmn2r17	APN	5	109,600,898 (GRCm39)	missense	probably benign	0.00
IGL01527:Vmn2r17	APN	5	109,601,006 (GRCm39)	missense	probably damaging	1.00
IGL01693:Vmn2r17	APN	5	109,600,384 (GRCm39)	missense	probably damaging	1.00
IGL01738:Vmn2r17	APN	5	109,577,364 (GRCm39)	missense	probably damaging	1.00
IGL01767:Vmn2r17	APN	5	109,567,903 (GRCm39)	missense	probably benign	0.01
IGL01932:Vmn2r17	APN	5	109,574,916 (GRCm39)	missense	probably benign	0.00
IGL01970:Vmn2r17	APN	5	109,575,813 (GRCm39)	missense	probably damaging	0.97
IGL02009:Vmn2r17	APN	5	109,600,714 (GRCm39)	missense	possibly damaging	0.67
IGL02365:Vmn2r17	APN	5	109,601,175 (GRCm39)	missense	probably damaging	1.00
IGL02385:Vmn2r17	APN	5	109,582,247 (GRCm39)	missense	probably damaging	1.00
IGL02457:Vmn2r17	APN	5	109,601,012 (GRCm39)	missense	probably damaging	1.00
IGL02646:Vmn2r17	APN	5	109,600,946 (GRCm39)	missense	probably damaging	1.00
IGL02741:Vmn2r17	APN	5	109,568,077 (GRCm39)	missense	probably benign
IGL03213:Vmn2r17	APN	5	109,582,256 (GRCm39)	critical splice donor site	probably null
IGL03342:Vmn2r17	APN	5	109,575,782 (GRCm39)	missense	probably damaging	1.00
IGL03408:Vmn2r17	APN	5	109,577,238 (GRCm39)	splice site	probably benign
R0349:Vmn2r17	UTSW	5	109,576,202 (GRCm39)	missense	probably damaging	1.00
R0418:Vmn2r17	UTSW	5	109,600,747 (GRCm39)	missense	probably damaging	1.00
R0800:Vmn2r17	UTSW	5	109,575,192 (GRCm39)	splice site	probably benign
R0836:Vmn2r17	UTSW	5	109,575,822 (GRCm39)	missense	possibly damaging	0.89
R1715:Vmn2r17	UTSW	5	109,576,110 (GRCm39)	missense	probably benign	0.00
R1738:Vmn2r17	UTSW	5	109,576,377 (GRCm39)	missense	probably benign	0.10
R1801:Vmn2r17	UTSW	5	109,576,344 (GRCm39)	missense	probably damaging	1.00
R2054:Vmn2r17	UTSW	5	109,600,352 (GRCm39)	missense	probably damaging	0.98
R2060:Vmn2r17	UTSW	5	109,575,075 (GRCm39)	missense	probably benign	0.00
R2192:Vmn2r17	UTSW	5	109,582,144 (GRCm39)	missense	possibly damaging	0.81
R2315:Vmn2r17	UTSW	5	109,575,897 (GRCm39)	missense	probably damaging	1.00
R2374:Vmn2r17	UTSW	5	109,575,104 (GRCm39)	missense	probably benign
R3612:Vmn2r17	UTSW	5	109,577,463 (GRCm39)	missense	probably benign	0.00
R3832:Vmn2r17	UTSW	5	109,576,262 (GRCm39)	missense	probably damaging	1.00
R4273:Vmn2r17	UTSW	5	109,600,832 (GRCm39)	missense	probably benign	0.44
R4494:Vmn2r17	UTSW	5	109,576,335 (GRCm39)	missense	probably damaging	1.00
R4597:Vmn2r17	UTSW	5	109,577,428 (GRCm39)	missense	probably benign	0.01
R4675:Vmn2r17	UTSW	5	109,575,049 (GRCm39)	missense	probably benign	0.00
R4701:Vmn2r17	UTSW	5	109,575,849 (GRCm39)	missense	probably damaging	0.99
R4754:Vmn2r17	UTSW	5	109,600,715 (GRCm39)	missense	probably damaging	0.99
R4841:Vmn2r17	UTSW	5	109,582,246 (GRCm39)	missense	probably damaging	1.00
R4842:Vmn2r17	UTSW	5	109,582,246 (GRCm39)	missense	probably damaging	1.00
R4865:Vmn2r17	UTSW	5	109,574,985 (GRCm39)	missense	probably damaging	1.00
R4902:Vmn2r17	UTSW	5	109,601,220 (GRCm39)	missense	probably benign	0.14
R4989:Vmn2r17	UTSW	5	109,575,739 (GRCm39)	missense	probably benign	0.07
R5101:Vmn2r17	UTSW	5	109,576,217 (GRCm39)	missense	probably damaging	0.99
R5109:Vmn2r17	UTSW	5	109,577,342 (GRCm39)	missense	probably benign	0.06
R5123:Vmn2r17	UTSW	5	109,575,774 (GRCm39)	missense	possibly damaging	0.90
R5474:Vmn2r17	UTSW	5	109,582,150 (GRCm39)	missense	probably damaging	1.00
R5485:Vmn2r17	UTSW	5	109,567,972 (GRCm39)	missense	probably benign	0.06
R5611:Vmn2r17	UTSW	5	109,576,030 (GRCm39)	missense	probably damaging	0.97
R5652:Vmn2r17	UTSW	5	109,577,430 (GRCm39)	missense	probably benign	0.10
R5717:Vmn2r17	UTSW	5	109,575,140 (GRCm39)	missense	possibly damaging	0.94
R5735:Vmn2r17	UTSW	5	109,600,716 (GRCm39)	missense	possibly damaging	0.67
R5766:Vmn2r17	UTSW	5	109,575,139 (GRCm39)	missense	possibly damaging	0.46
R6645:Vmn2r17	UTSW	5	109,576,247 (GRCm39)	missense	probably damaging	1.00
R6786:Vmn2r17	UTSW	5	109,575,695 (GRCm39)	missense	probably benign	0.30
R6821:Vmn2r17	UTSW	5	109,577,331 (GRCm39)	missense	probably damaging	1.00
R6979:Vmn2r17	UTSW	5	109,576,265 (GRCm39)	missense	possibly damaging	0.46
R6984:Vmn2r17	UTSW	5	109,600,533 (GRCm39)	missense	probably benign	0.10
R7269:Vmn2r17	UTSW	5	109,576,337 (GRCm39)	missense	possibly damaging	0.88
R7509:Vmn2r17	UTSW	5	109,575,695 (GRCm39)	missense	probably benign	0.30
R7736:Vmn2r17	UTSW	5	109,600,757 (GRCm39)	missense	probably benign	0.05
R7789:Vmn2r17	UTSW	5	109,600,831 (GRCm39)	missense	possibly damaging	0.77
R7814:Vmn2r17	UTSW	5	109,575,739 (GRCm39)	missense	probably benign	0.07
R7847:Vmn2r17	UTSW	5	109,568,063 (GRCm39)	missense	probably damaging	1.00
R7863:Vmn2r17	UTSW	5	109,568,035 (GRCm39)	missense	probably benign
R7893:Vmn2r17	UTSW	5	109,575,944 (GRCm39)	missense	probably benign	0.05
R8234:Vmn2r17	UTSW	5	109,601,235 (GRCm39)	missense	probably benign	0.01
R8382:Vmn2r17	UTSW	5	109,576,387 (GRCm39)	missense	probably benign	0.01
R8435:Vmn2r17	UTSW	5	109,576,172 (GRCm39)	missense	probably benign	0.01
R8465:Vmn2r17	UTSW	5	109,600,691 (GRCm39)	missense	probably damaging	0.99
R8555:Vmn2r17	UTSW	5	109,600,810 (GRCm39)	missense	probably damaging	0.99
R8900:Vmn2r17	UTSW	5	109,575,863 (GRCm39)	missense	probably benign	0.25
R9293:Vmn2r17	UTSW	5	109,600,712 (GRCm39)	missense	probably damaging	1.00
R9308:Vmn2r17	UTSW	5	109,600,505 (GRCm39)	missense	probably damaging	0.98
R9378:Vmn2r17	UTSW	5	109,575,732 (GRCm39)	missense	possibly damaging	0.94
R9597:Vmn2r17	UTSW	5	109,575,669 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02