Mutagenetix > Incidental Mutation

Incidental Mutation 'R6180:Vmn1r115'

487994

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r115

Ensembl Gene

ENSMUSG00000091435

Gene Name

vomeronasal 1 receptor 115

Synonyms

Gm8549

MMRRC Submission

044322-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R6180 (G1)

Quality Score

90.0077

Status

Not validated

Chromosome

Chromosomal Location

20844098-20844985 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 20844715 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Valine at position 91 (L91V)

Ref Sequence

ENSEMBL: ENSMUSP00000128692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169374]

AlphaFold

K7N6Y3

Predicted Effect

probably damaging
Transcript: ENSMUST00000169374
AA Change: L91V

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000128692
Gene: ENSMUSG00000091435
AA Change: L91V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	294	1.4e-15	PFAM
Pfam:7tm_1	31	292	3.5e-7	PFAM
Pfam:V1R	41	289	8e-15	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	A	G	11: 78,273,258	M1142V	possibly damaging	Het
Adam39	A	G	8: 40,826,573	N667S	probably benign	Het
Ap4e1	T	A	2: 127,066,588	C1085*	probably null	Het
BC035044	A	T	6: 128,885,034		probably benign	Het
Capn11	T	C	17: 45,630,766	D693G	probably damaging	Het
Cavin4	A	T	4: 48,663,917	H99L	possibly damaging	Het
Ccdc86	T	C	19: 10,948,581	K218R	possibly damaging	Het
Ccno	T	C	13: 112,989,845	S283P	probably damaging	Het
Ccser2	A	T	14: 36,940,319	S303T	probably benign	Het
Cd53	T	A	3: 106,767,364	N129I	probably damaging	Het
Cd63	G	A	10: 128,912,064		probably null	Het
Cyp2j6	G	C	4: 96,536,086	L145V	probably damaging	Het
Daam2	A	G	17: 49,469,666	M797T	probably damaging	Het
Dmgdh	G	A	13: 93,752,286	V811I	possibly damaging	Het
Dpysl4	A	T	7: 139,090,334	T123S	probably damaging	Het
Erap1	A	G	13: 74,666,226	E428G	possibly damaging	Het
Fam124b	T	A	1: 80,200,185	T366S	possibly damaging	Het
Fbxw22	T	C	9: 109,386,679	D167G	probably damaging	Het
Flrt2	C	T	12: 95,779,238	Q117*	probably null	Het
Ftsj3	A	T	11: 106,253,340		probably null	Het
Ggn	A	G	7: 29,173,049	Y618C	probably damaging	Het
Glis1	T	A	4: 107,627,513	S402T	probably benign	Het
Gm13762	T	G	2: 88,973,882	N3T	probably damaging	Het
Gm4781	T	A	10: 100,396,487		noncoding transcript	Het
Gm7168	T	A	17: 13,948,596	I75K	probably damaging	Het
Gm7298	C	T	6: 121,760,823	H348Y	probably benign	Het
Gria1	G	T	11: 57,242,792	R499L	probably damaging	Het
Gtf2ird2	C	T	5: 134,216,547	T549M	probably damaging	Het
H2-M10.6	T	A	17: 36,814,286	V323E	probably damaging	Het
Hoxb3	G	A	11: 96,346,103	V336I	probably benign	Het
Il12b	G	A	11: 44,412,626	A327T	probably benign	Het
Inpp4a	C	A	1: 37,380,102	P588T	probably benign	Het
Kctd12	C	A	14: 102,981,591	D284Y	probably damaging	Het
Kif28	C	A	1: 179,697,772		probably null	Het
Krt2	T	C	15: 101,815,044	N332S	probably benign	Het
Lama2	G	A	10: 26,981,499	T3118I	probably benign	Het
Lgi1	T	C	19: 38,264,956	L25P	probably damaging	Het
Lhx3	T	A	2: 26,201,491	M269L	probably benign	Het
Lmtk2	A	T	5: 144,175,342	E960V	probably damaging	Het
Loxl4	A	T	19: 42,608,352	D60E	probably damaging	Het
Lrp2	T	A	2: 69,503,524	N1458Y	possibly damaging	Het
Ltn1	A	T	16: 87,427,789	S16T	probably damaging	Het
Mllt6	G	A	11: 97,678,536	A875T	possibly damaging	Het
Mpp5	C	T	12: 78,817,310	H216Y	probably benign	Het
Mrgprb4	A	T	7: 48,198,826	I118N	probably damaging	Het
Mrps7	A	G	11: 115,604,881	T82A	possibly damaging	Het
Mug2	A	G	6: 122,079,606	E1170G	probably benign	Het
Nav2	A	G	7: 49,458,167	H647R	probably benign	Het
Nbeal2	T	C	9: 110,625,147	Y2710C	probably damaging	Het
Ndc1	A	T	4: 107,411,198	I644L	possibly damaging	Het
Olfr952	A	T	9: 39,426,712	Y120N	probably damaging	Het
Padi4	A	G	4: 140,756,473	M352T	possibly damaging	Het
Pcdhgc3	C	A	18: 37,806,937	D130E	probably damaging	Het
Pde6a	A	T	18: 61,284,092		probably null	Het
Pdpn	C	T	4: 143,299,222	G12R	probably damaging	Het
Pot1a	A	T	6: 25,771,621	D200E	probably benign	Het
Ppa1	A	T	10: 61,667,652	D236V	probably benign	Het
Ptprn2	T	A	12: 116,859,119	S273T	probably benign	Het
Rasgrf2	T	C	13: 92,029,101	E297G	probably damaging	Het
Rgl1	T	C	1: 152,519,172	N750S	probably damaging	Het
Rinl	A	G	7: 28,796,940	N449D	probably benign	Het
Samd8	T	A	14: 21,775,025	H79Q	probably benign	Het
Scn11a	T	C	9: 119,754,867	I1561V	probably benign	Het
Slc39a12	T	C	2: 14,396,127	L105P	probably benign	Het
Slc7a12	A	T	3: 14,481,140		probably null	Het
Slco1a4	A	G	6: 141,817,820	I390T	possibly damaging	Het
Snta1	T	C	2: 154,377,182	N411S	probably benign	Het
Srgap2	T	C	1: 131,349,541	T323A	probably benign	Het
Ssh2	G	T	11: 77,453,465	V759L	probably benign	Het
St5	A	C	7: 109,556,888	D218E	probably benign	Het
Swap70	G	T	7: 110,269,981	R327L	probably damaging	Het
Tbc1d4	C	A	14: 101,458,770	C914F	probably benign	Het
Tbx3	A	G	5: 119,674,067	D144G	probably damaging	Het
Tgfbr2	T	C	9: 116,110,144	K205R	possibly damaging	Het
Tmem94	A	T	11: 115,791,031		probably null	Het
Usf3	T	A	16: 44,221,105	F1983I	probably damaging	Het
Ush2a	T	A	1: 188,399,871	C763*	probably null	Het
Vmn1r201	A	T	13: 22,475,329	I238F	possibly damaging	Het
Vmn1r28	T	A	6: 58,265,491	S106R	probably damaging	Het
Vmn1r82	T	C	7: 12,305,085	V95A	probably damaging	Het
Vrk3	A	T	7: 44,769,611	N371I	possibly damaging	Het
Wnt8b	C	A	19: 44,511,643	A223E	probably benign	Het
Xirp2	T	C	2: 67,505,577		probably null	Het
Xpo7	T	C	14: 70,682,803	N642S	probably benign	Het
Ythdc1	G	A	5: 86,828,094	R520H	possibly damaging	Het
Zfp367	T	C	13: 64,135,390	E316G	probably damaging	Het
Zfp488	T	A	14: 33,970,794	R137S	possibly damaging	Het
Zfp532	G	T	18: 65,656,471	V994L	probably benign	Het

Other mutations in Vmn1r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02340:Vmn1r115	APN	7	20844528	missense	possibly damaging	0.70
R0243:Vmn1r115	UTSW	7	20844402	missense	probably benign	0.02
R1901:Vmn1r115	UTSW	7	20844273	missense	probably benign
R2020:Vmn1r115	UTSW	7	20844169	missense	probably null	0.38
R4411:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4412:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4413:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R5226:Vmn1r115	UTSW	7	20844244	missense	probably damaging	1.00
R5570:Vmn1r115	UTSW	7	20844630	missense	possibly damaging	0.87
R5986:Vmn1r115	UTSW	7	20844522	missense	probably benign	0.44
R8169:Vmn1r115	UTSW	7	20844219	missense	probably damaging	1.00
R8310:Vmn1r115	UTSW	7	20844894	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCAGTGACCTTAATTGGAATGTG -3'
(R):5'- GGACCTTGGCCAATGTCTTTC -3'

Sequencing Primer
(F):5'- GGAATGTGGATGTTACTTAAGACAC -3'
(R):5'- ACCTTGGCCAATGTCTTTCTGTTTG -3'

Posted On

2017-10-10