Mutagenetix > Incidental Mutations

Incidental Mutation 'R6146:Olfr1006'

488862

Institutional Source

Beutler Lab

Gene Symbol

Olfr1006

Ensembl Gene

ENSMUSG00000075211

Gene Name

olfactory receptor 1006

Synonyms

MOR213-4, GA_x6K02T2Q125-47154544-47153606

MMRRC Submission

044293-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6146 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

85673657-85678767 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 85674594 bp

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 186 (K186*)

Ref Sequence

ENSEMBL: ENSMUSP00000149868 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099917] [ENSMUST00000216084]

Predicted Effect

probably null
Transcript: ENSMUST00000099917
AA Change: K186*

SMART Domains

Protein: ENSMUSP00000097501
Gene: ENSMUSG00000075211
AA Change: K186*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	39	315	1.3e-51	PFAM
Pfam:7tm_1	49	298	3.6e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000099919
AA Change: K186*

SMART Domains

Protein: ENSMUSP00000097503
Gene: ENSMUSG00000075211
AA Change: K186*

Domain	Start	End	E-Value	Type
Pfam:7tm_1	41	290	3.7e-30	PFAM
Pfam:7tm_4	139	283	3.3e-51	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000216084
AA Change: K186*

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216207

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb4	A	G	5: 8,896,587	E29G	probably benign	Het
Abi3bp	T	C	16: 56,671,265	S552P	probably damaging	Het
Adgrg7	A	G	16: 56,773,466	I129T	probably benign	Het
Adhfe1	A	G	1: 9,553,718	N148S	probably damaging	Het
AI182371	A	G	2: 35,097,971	Y77H	probably damaging	Het
Aldh5a1	C	T	13: 24,919,678		probably null	Het
Ankrd2	A	G	19: 42,040,105	T67A	possibly damaging	Het
Anln	A	T	9: 22,376,308	C232*	probably null	Het
C330027C09Rik	A	T	16: 48,994,329	K18*	probably null	Het
Cchcr1	A	G	17: 35,528,578	D587G	possibly damaging	Het
Cgn	G	T	3: 94,767,125	Q901K	possibly damaging	Het
Cluh	G	T	11: 74,667,228		probably null	Het
Crebbp	G	A	16: 4,084,623	Q2213*	probably null	Het
Cyp2d22	T	A	15: 82,373,835		probably null	Het
Dcdc2a	T	C	13: 25,205,457	V456A	probably benign	Het
Depdc5	A	G	5: 32,968,731	E569G	probably benign	Het
Dnah5	T	C	15: 28,459,185	F4517L	probably benign	Het
Doc2b	T	C	11: 75,773,595	K317E	probably damaging	Het
Dysf	T	A	6: 84,203,199	D1951E	probably damaging	Het
Epha6	C	A	16: 60,424,835	A334S	possibly damaging	Het
F2rl2	A	C	13: 95,700,641	I65L	probably benign	Het
Fbxw17	A	G	13: 50,432,512	K417E	probably benign	Het
Fkbpl	G	A	17: 34,645,329	A24T	probably benign	Het
Fxr2	A	G	11: 69,641,339	M96V	possibly damaging	Het
Kcnj10	C	A	1: 172,369,325	Y135*	probably null	Het
Kidins220	G	A	12: 25,052,813	R1238Q	probably damaging	Het
Krt31	T	C	11: 100,048,230	N255S	probably benign	Het
Lrp2	T	C	2: 69,511,001	D945G	probably benign	Het
Lrrc66	T	C	5: 73,608,089	D537G	probably benign	Het
Ltbp4	T	A	7: 27,319,724	I992F	probably damaging	Het
Lzts1	A	G	8: 69,140,872	S28P	probably benign	Het
Mrc2	C	A	11: 105,325,644	N86K	probably damaging	Het
Mroh6	C	A	15: 75,886,637	A302S	possibly damaging	Het
Muc16	T	A	9: 18,497,797	N198Y	probably damaging	Het
Myo9a	T	C	9: 59,871,229	S1423P	probably benign	Het
Olfr1124	A	T	2: 87,435,318	D277V	possibly damaging	Het
Olfr1141	A	C	2: 87,753,258	L245R	probably damaging	Het
Olfr1367	A	T	13: 21,346,994	Y22F	possibly damaging	Het
Olfr190	A	G	16: 59,074,714	V122A	probably benign	Het
Olfr477	G	T	7: 107,990,413	G16V	probably damaging	Het
Otogl	G	A	10: 107,777,117		silent	Het
Polg	T	C	7: 79,450,512	M1184V	probably benign	Het
Prl8a8	T	C	13: 27,510,480	Y108C	probably damaging	Het
Proser1	T	A	3: 53,478,119	I474N	probably damaging	Het
Rab44	A	G	17: 29,135,417		probably benign	Het
Rbp1	C	A	9: 98,425,616	D79E	possibly damaging	Het
Rnf213	T	C	11: 119,435,999	V1605A	probably benign	Het
Rps24	A	T	14: 24,490,735		probably null	Het
Setd5	T	C	6: 113,121,812		probably null	Het
Slc38a3	T	C	9: 107,655,029	I435V	probably benign	Het
Slco1a5	T	A	6: 142,234,808	M623L	probably benign	Het
Spaca9	G	A	2: 28,693,781	R64W	probably damaging	Het
Spn	A	G	7: 127,136,307	S343P	possibly damaging	Het
Sptan1	A	G	2: 30,004,523	T1168A	probably benign	Het
Sptbn4	A	T	7: 27,364,587	L2138*	probably null	Het
Tg	T	A	15: 66,673,367		probably null	Het
Tigd5	T	A	15: 75,910,245	L152Q	probably damaging	Het
Tmem163	C	T	1: 127,519,389	V170I	probably benign	Het
Tpr	T	C	1: 150,423,162	C1068R	possibly damaging	Het
Ttc37	A	G	13: 76,185,240	E1536G	probably damaging	Het
Ubr1	A	T	2: 120,893,209	Y1290N	probably damaging	Het
Vmn1r184	T	A	7: 26,267,392	F188I	probably benign	Het
Vmn2r100	G	A	17: 19,522,260	V299I	probably benign	Het
Vmn2r91	T	G	17: 18,136,256	H728Q	probably benign	Het
Vta1	T	C	10: 14,705,352	Y37C	probably damaging	Het
Wbp2	C	A	11: 116,083,902	M35I	probably benign	Het
Zcchc9	G	A	13: 91,805,867	Q90*	probably null	Het

Other mutations in Olfr1006

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01139:Olfr1006	APN	2	85674497	missense	probably damaging	1.00
IGL01520:Olfr1006	APN	2	85674357	missense	probably benign	0.00
IGL01939:Olfr1006	APN	2	85674941	missense	probably damaging	1.00
IGL02060:Olfr1006	APN	2	85674834	missense	probably benign	0.34
IGL02171:Olfr1006	APN	2	85674941	missense	probably damaging	1.00
IGL03058:Olfr1006	APN	2	85674681	missense	probably benign	0.00
IGL03210:Olfr1006	APN	2	85674353	missense	probably damaging	1.00
R0294:Olfr1006	UTSW	2	85674716	missense	probably damaging	0.99
R1304:Olfr1006	UTSW	2	85674338	missense	probably damaging	1.00
R1476:Olfr1006	UTSW	2	85674918	missense	possibly damaging	0.92
R4757:Olfr1006	UTSW	2	85674320	missense	probably damaging	1.00
R4793:Olfr1006	UTSW	2	85674498	missense	probably damaging	1.00
R5804:Olfr1006	UTSW	2	85674338	missense	probably damaging	1.00
R6511:Olfr1006	UTSW	2	85674840	missense	possibly damaging	0.61
R6896:Olfr1006	UTSW	2	85674933	missense	probably damaging	0.97
R7075:Olfr1006	UTSW	2	85674824	missense
R7344:Olfr1006	UTSW	2	85674931	nonsense	probably null
R7350:Olfr1006	UTSW	2	85674845	missense

Predicted Primers

PCR Primer
(F):5'- AGAAGAGGGCAGCCACTTTG -3'
(R):5'- GGCTTATGACCGACATTCTGC -3'

Sequencing Primer
(F):5'- GGTTGAACTAGGCCTTGAATACATG -3'
(R):5'- GACCGACATTCTGCAATTTGTAGTC -3'

Posted On

2017-10-10