Incidental Mutation 'R6371:Or10al6'
ID 513545
Institutional Source Beutler Lab
Gene Symbol Or10al6
Ensembl Gene ENSMUSG00000083947
Gene Name olfactory receptor family 10 subfamily AL member 6
Synonyms GA_x6K02T2PSCP-2230932-2231897, MOR263-10, Olfr122
MMRRC Submission 044521-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R6371 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38079533-38083511 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38083326 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 261 (T261A)
Ref Sequence ENSEMBL: ENSMUSP00000149334 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119082] [ENSMUST00000172582] [ENSMUST00000217119]
AlphaFold W4VSP0
Predicted Effect probably benign
Transcript: ENSMUST00000119082
AA Change: T270A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000113170
Gene: ENSMUSG00000083947
AA Change: T270A

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 2.2e-58 PFAM
Pfam:7TM_GPCR_Srsx 50 320 2.7e-6 PFAM
Pfam:7tm_1 56 305 3.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172582
AA Change: T261A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000134283
Gene: ENSMUSG00000083947
AA Change: T261A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 41 311 9.5e-8 PFAM
Pfam:7tm_1 47 296 7.8e-36 PFAM
Pfam:7tm_4 145 289 1e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215449
Predicted Effect probably benign
Transcript: ENSMUST00000217119
AA Change: T261A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.7%
  • 10x: 98.2%
  • 20x: 94.1%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b C T 12: 113,453,894 (GRCm39) S237L probably damaging Het
Ank3 T G 10: 69,644,709 (GRCm39) L58V probably damaging Het
Arsb A T 13: 93,926,574 (GRCm39) I115F possibly damaging Het
Atad2b T C 12: 5,023,970 (GRCm39) Y32H probably damaging Het
Brd1 A C 15: 88,598,201 (GRCm39) M515R probably benign Het
Cbx7 A G 15: 79,803,023 (GRCm39) S30P possibly damaging Het
Cdk12 A G 11: 98,136,114 (GRCm39) T1123A unknown Het
Cep170b A G 12: 112,707,379 (GRCm39) D375G probably damaging Het
Clcn3 T C 8: 61,390,369 (GRCm39) K164E probably benign Het
Clip4 A C 17: 72,163,459 (GRCm39) K677T probably damaging Het
Clrn2 T C 5: 45,617,540 (GRCm39) I137T possibly damaging Het
Cntln T C 4: 84,802,816 (GRCm39) S39P probably damaging Het
Crocc2 T A 1: 93,143,353 (GRCm39) N1318K probably benign Het
Emc1 C T 4: 139,098,976 (GRCm39) Q820* probably null Het
Fbxl2 G A 9: 113,818,451 (GRCm39) T170I probably damaging Het
Fyb2 A G 4: 104,852,975 (GRCm39) T552A probably damaging Het
Garin5b A G 7: 4,762,358 (GRCm39) V257A probably benign Het
Gm2381 G A 7: 42,470,010 (GRCm39) A38V probably benign Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
Helz2 C T 2: 180,875,260 (GRCm39) E1745K probably damaging Het
Hspg2 T C 4: 137,269,006 (GRCm39) Y2213H probably damaging Het
Ifnar2 T C 16: 91,184,986 (GRCm39) Y24H possibly damaging Het
Inpp5d T A 1: 87,627,397 (GRCm39) L566Q probably damaging Het
Itgb2 C A 10: 77,384,431 (GRCm39) P184H probably damaging Het
Kcnb2 T A 1: 15,781,436 (GRCm39) D769E probably benign Het
Lrp1b A G 2: 40,741,666 (GRCm39) M3087T possibly damaging Het
Ltbp3 A G 19: 5,795,800 (GRCm39) probably null Het
Ms4a6b A G 19: 11,497,728 (GRCm39) E9G probably damaging Het
Nat3 G A 8: 67,976,831 (GRCm39) probably null Het
Ndufaf1 A T 2: 119,490,534 (GRCm39) D175E probably damaging Het
Nop58 T G 1: 59,750,471 (GRCm39) probably benign Het
Or8s16 A G 15: 98,211,219 (GRCm39) Y71H possibly damaging Het
P3h4 C T 11: 100,302,575 (GRCm39) E354K probably benign Het
Plekhm2 T G 4: 141,356,843 (GRCm39) T787P possibly damaging Het
Ppia C T 11: 6,368,230 (GRCm39) T37I probably benign Het
Reln T A 5: 22,200,511 (GRCm39) M1330L probably benign Het
Ric1 A G 19: 29,539,426 (GRCm39) E53G probably benign Het
Sgip1 T A 4: 102,823,482 (GRCm39) V721E probably damaging Het
Slc33a1 A T 3: 63,850,709 (GRCm39) D538E probably benign Het
Son T C 16: 91,471,629 (GRCm39) Het
Srebf1 A T 11: 60,094,341 (GRCm39) S591R probably damaging Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Taok2 G A 7: 126,469,319 (GRCm39) R1170W probably damaging Het
Tsc2 A T 17: 24,845,688 (GRCm39) V210E probably benign Het
Ttc6 T A 12: 57,775,249 (GRCm39) N1648K possibly damaging Het
Vgll3 C T 16: 65,636,131 (GRCm39) P94L probably damaging Het
Vmn2r54 A T 7: 12,349,362 (GRCm39) V740E probably damaging Het
Yeats2 A G 16: 20,040,460 (GRCm39) E1127G possibly damaging Het
Zfp709 T A 8: 72,643,329 (GRCm39) Y252N probably damaging Het
Other mutations in Or10al6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00954:Or10al6 APN 17 38,083,505 (GRCm39) missense probably benign 0.00
IGL01338:Or10al6 APN 17 38,082,730 (GRCm39) missense possibly damaging 0.90
IGL01447:Or10al6 APN 17 38,083,122 (GRCm39) missense probably damaging 1.00
PIT4514001:Or10al6 UTSW 17 38,082,758 (GRCm39) missense probably damaging 1.00
R0402:Or10al6 UTSW 17 38,083,284 (GRCm39) missense probably damaging 1.00
R0830:Or10al6 UTSW 17 38,082,804 (GRCm39) missense probably damaging 0.99
R2018:Or10al6 UTSW 17 38,083,467 (GRCm39) missense probably benign 0.00
R4258:Or10al6 UTSW 17 38,082,949 (GRCm39) missense probably damaging 1.00
R6481:Or10al6 UTSW 17 38,083,194 (GRCm39) missense probably damaging 1.00
R7468:Or10al6 UTSW 17 38,082,910 (GRCm39) missense probably damaging 1.00
R7492:Or10al6 UTSW 17 38,082,571 (GRCm39) missense possibly damaging 0.53
R8114:Or10al6 UTSW 17 38,082,880 (GRCm39) missense possibly damaging 0.67
R8172:Or10al6 UTSW 17 38,083,326 (GRCm39) missense probably benign
R8728:Or10al6 UTSW 17 38,082,642 (GRCm39) missense probably damaging 1.00
R8894:Or10al6 UTSW 17 38,082,940 (GRCm39) missense probably damaging 1.00
R9659:Or10al6 UTSW 17 38,082,880 (GRCm39) missense probably damaging 0.99
Z1177:Or10al6 UTSW 17 38,083,082 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- ACATCCCAAAATGAGGCTGC -3'
(R):5'- CTTTCAGGAGCACTTCAGGATC -3'

Sequencing Primer
(F):5'- CCAAAATGAGGCTGCAATTTTTGTGG -3'
(R):5'- GGAGCACTTCAGGATCCTCAGTTAC -3'
Posted On 2018-04-27