Incidental Mutation 'R7713:Armh1'
ID594724
Institutional Source Beutler Lab
Gene Symbol Armh1
Ensembl Gene ENSMUSG00000060268
Gene Namearmadillo-like helical domain containing 1
SynonymsLOC381543, LOC381544, Ncrna00082
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #R7713 (G1)
Quality Score225.009
Status Not validated
Chromosome4
Chromosomal Location117213333-117252125 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 117214228 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 355 (M355K)
Ref Sequence ENSEMBL: ENSMUSP00000128613 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077500] [ENSMUST00000165128]
Predicted Effect probably benign
Transcript: ENSMUST00000077500
SMART Domains Protein: ENSMUSP00000076706
Gene: ENSMUSG00000060268

DomainStartEndE-ValueType
SCOP:d1qbkb_ 156 272 3e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000165128
AA Change: M355K

PolyPhen 2 Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000128613
Gene: ENSMUSG00000060268
AA Change: M355K

DomainStartEndE-ValueType
low complexity region 162 176 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik T C 10: 87,230,311 S119P possibly damaging Het
Agtpbp1 T A 13: 59,514,152 I282F probably damaging Het
BC067074 T G 13: 113,346,541 V1559G Het
Cep128 A T 12: 91,019,322 D1013E probably benign Het
Clock A T 5: 76,245,420 probably null Het
D630003M21Rik G A 2: 158,216,778 Q401* probably null Het
Dnah17 C A 11: 118,025,171 V4302L probably benign Het
Drc3 A G 11: 60,370,560 Y179C probably benign Het
Erbb3 T C 10: 128,574,449 T647A probably benign Het
Esrp2 T C 8: 106,134,276 T205A probably benign Het
Fbxw7 T C 3: 84,967,565 probably null Het
Fmn1 C T 2: 113,525,814 P965S unknown Het
Fndc7 C T 3: 108,870,663 V412M possibly damaging Het
G2e3 C A 12: 51,369,056 A525E probably damaging Het
Gcfc2 C T 6: 81,941,390 R354C probably damaging Het
Ggt1 T A 10: 75,585,674 N510K probably damaging Het
Gnas C T 2: 174,299,027 T389I unknown Het
Hapln3 C T 7: 79,117,373 R306H probably benign Het
Hydin T C 8: 110,593,812 L4496P possibly damaging Het
Iqgap2 T A 13: 95,731,444 I219L probably benign Het
Kcnj2 T C 11: 111,072,483 S234P probably benign Het
Lipf T A 19: 33,973,065 S286T probably damaging Het
Lrrc32 G T 7: 98,499,338 G442W probably damaging Het
Megf10 GGCAGCAACAGCACCAGCAGCAACAGCACCAGCAGCA GGCAGCAACAGCACCAGCAGCA 18: 57,293,999 probably benign Het
Mtmr4 T C 11: 87,597,724 V68A probably damaging Het
Mug2 T C 6: 122,078,795 S1146P possibly damaging Het
Naa35 T C 13: 59,598,105 I75T probably benign Het
Nepn T A 10: 52,401,178 F337I probably benign Het
Nf1 A G 11: 79,425,606 M496V probably benign Het
Nthl1 A T 17: 24,638,657 I277F possibly damaging Het
Olfr1208 T C 2: 88,897,778 probably benign Het
Olfr518 A C 7: 108,880,682 I308S probably damaging Het
Osr1 A T 12: 9,579,253 Y42F probably damaging Het
Rad54l2 G A 9: 106,717,223 R369W probably damaging Het
Ryr3 T A 2: 112,635,346 T4828S probably benign Het
Slc25a54 T A 3: 109,102,817 C211S probably damaging Het
Ube4b C T 4: 149,398,781 R10Q possibly damaging Het
Usp9y G A Y: 1,304,411 Q2440* probably null Het
Yars G T 4: 129,210,498 V312L probably benign Het
Zfp26 G A 9: 20,441,334 T145I probably benign Het
Zic5 T C 14: 122,464,113 N402S unknown Het
Other mutations in Armh1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02049:Armh1 APN 4 117237663 missense probably benign 0.37
R0350:Armh1 UTSW 4 117215556 nonsense probably null
R0584:Armh1 UTSW 4 117229850 missense probably damaging 1.00
R1570:Armh1 UTSW 4 117229992 missense probably damaging 1.00
R4335:Armh1 UTSW 4 117214463 missense probably damaging 0.99
R4898:Armh1 UTSW 4 117237780 missense probably damaging 1.00
R5939:Armh1 UTSW 4 117229922 missense probably damaging 1.00
R6300:Armh1 UTSW 4 117231782 missense probably damaging 1.00
R6815:Armh1 UTSW 4 117229937 missense probably damaging 1.00
R7526:Armh1 UTSW 4 117213741 missense probably benign 0.02
R7529:Armh1 UTSW 4 117213741 missense probably benign 0.02
R7630:Armh1 UTSW 4 117213741 missense probably benign 0.02
R7632:Armh1 UTSW 4 117213741 missense probably benign 0.02
R7659:Armh1 UTSW 4 117213741 missense probably benign 0.02
R7660:Armh1 UTSW 4 117213741 missense probably benign 0.02
R7662:Armh1 UTSW 4 117213741 missense probably benign 0.02
R7663:Armh1 UTSW 4 117213741 missense probably benign 0.02
R7665:Armh1 UTSW 4 117213741 missense probably benign 0.02
R7666:Armh1 UTSW 4 117213741 missense probably benign 0.02
R8030:Armh1 UTSW 4 117229987 missense probably benign 0.31
R8433:Armh1 UTSW 4 117228338 missense probably benign 0.43
Z1088:Armh1 UTSW 4 117213795 missense probably benign
Predicted Primers PCR Primer
(F):5'- TAGGCAGAGAGATCCTGCTTCC -3'
(R):5'- ATGTCGGCCATGGGTAACAC -3'

Sequencing Primer
(F):5'- AGAGAGATCCTGCTTCCAGCTTAC -3'
(R):5'- GCCATGGGTAACACTGACC -3'
Posted On2019-11-12