Incidental Mutation 'R8051:Adgrl3'
ID |
619046 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Adgrl3
|
Ensembl Gene |
ENSMUSG00000037605 |
Gene Name |
adhesion G protein-coupled receptor L3 |
Synonyms |
lectomedin 3, D130075K09Rik, 5430402I23Rik, Lphn3, LEC3 |
MMRRC Submission |
067488-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R8051 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
81167985-81972980 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 81613113 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Cysteine
at position 114
(Y114C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000112470
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036068]
[ENSMUST00000072521]
[ENSMUST00000117253]
[ENSMUST00000117407]
[ENSMUST00000117985]
[ENSMUST00000118034]
[ENSMUST00000118078]
[ENSMUST00000118442]
[ENSMUST00000119385]
[ENSMUST00000119788]
[ENSMUST00000120128]
[ENSMUST00000120144]
[ENSMUST00000120292]
[ENSMUST00000120445]
[ENSMUST00000120673]
[ENSMUST00000121641]
[ENSMUST00000121707]
[ENSMUST00000122037]
[ENSMUST00000122356]
[ENSMUST00000132375]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000036068
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000045342 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
6.6e-27 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
1.1e-7 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
2.2e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
4.4e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1276 |
2.4e-30 |
PFAM |
Pfam:Latrophilin
|
1272 |
1543 |
3.2e-113 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000072521
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000072336 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
5.9e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.3e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
1.2e-58 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
2.5e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1274 |
4e-34 |
PFAM |
Pfam:Latrophilin
|
1272 |
1543 |
5e-89 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117253
AA Change: Y114C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000112470 Gene: ENSMUSG00000037605 AA Change: Y114C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
5e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1265 |
7.5e-55 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117407
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000112388 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.4e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
2.6e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
7.7e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1321 |
1.8e-61 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117985
AA Change: Y114C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113950 Gene: ENSMUSG00000037605 AA Change: Y114C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.3e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.7e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1512 |
6.8e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000118034
AA Change: Y114C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113534 Gene: ENSMUSG00000037605 AA Change: Y114C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
6.6e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1503 |
6.7e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000118078
AA Change: Y114C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000112731 Gene: ENSMUSG00000037605 AA Change: Y114C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
9.7e-27 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.3e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
4.8e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1201 |
2.6e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000118442
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113836 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.4e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1278 |
2.8e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000119385
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113243 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
5.2e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1269 |
2.7e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000119788
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000114067 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.8e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1279 |
3.6e-31 |
PFAM |
Pfam:Latrophilin
|
1273 |
1550 |
4.5e-113 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120128
AA Change: Y114C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113208 Gene: ENSMUSG00000037605 AA Change: Y114C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
9.8e-27 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.4e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1210 |
2.6e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120144
AA Change: Y114C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113619 Gene: ENSMUSG00000037605 AA Change: Y114C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
5.1e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1253 |
8.4e-62 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120292
AA Change: Y114C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000112548 Gene: ENSMUSG00000037605 AA Change: Y114C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1262 |
8.5e-62 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120445
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113249 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.2e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
2.8e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
5.1e-59 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.4e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1328 |
8e-64 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120673
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113482 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.7e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
3.3e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
6.4e-59 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.8e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1580 |
1.4e-158 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000121641
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113694 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.8e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
7e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1571 |
7.3e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000121707
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000112823 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
6.8e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1267 |
6.4e-30 |
PFAM |
Pfam:Latrophilin
|
1263 |
1534 |
8.7e-113 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000122037
AA Change: Y114C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113374 Gene: ENSMUSG00000037605 AA Change: Y114C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.3e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.5e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
6.3e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1199 |
4.4e-30 |
PFAM |
Pfam:Latrophilin
|
1194 |
1460 |
1.3e-112 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000122356
AA Change: Y182C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113600 Gene: ENSMUSG00000037605 AA Change: Y182C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.8e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
3.1e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
9.3e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1267 |
9e-30 |
PFAM |
Pfam:Latrophilin
|
1262 |
1528 |
2.8e-112 |
PFAM |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000132375
AA Change: I43V
|
SMART Domains |
Protein: ENSMUSP00000117211 Gene: ENSMUSG00000037605 AA Change: I43V
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.3045 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
Validation Efficiency |
100% (49/49) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 49 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acan |
T |
A |
7: 78,750,527 (GRCm39) |
L1766Q |
probably damaging |
Het |
Ano9 |
T |
A |
7: 140,684,445 (GRCm39) |
I472F |
probably damaging |
Het |
Arhgap10 |
A |
G |
8: 78,244,309 (GRCm39) |
F35S |
probably damaging |
Het |
Bltp2 |
G |
A |
11: 78,164,238 (GRCm39) |
|
probably benign |
Het |
Btnl2 |
T |
A |
17: 34,582,473 (GRCm39) |
D346E |
probably damaging |
Het |
C4bp |
A |
T |
1: 130,583,705 (GRCm39) |
C88S |
probably damaging |
Het |
Cavin2 |
A |
T |
1: 51,340,283 (GRCm39) |
Q320L |
probably benign |
Het |
Chtf18 |
C |
A |
17: 25,942,453 (GRCm39) |
V462L |
probably benign |
Het |
Crisp3 |
A |
T |
17: 40,543,451 (GRCm39) |
S134R |
probably benign |
Het |
Dlg4 |
C |
A |
11: 69,922,468 (GRCm39) |
|
probably benign |
Het |
Dsc3 |
A |
T |
18: 20,114,270 (GRCm39) |
M328K |
probably damaging |
Het |
Efemp2 |
T |
A |
19: 5,526,095 (GRCm39) |
D73E |
probably damaging |
Het |
Fbn1 |
C |
T |
2: 125,148,383 (GRCm39) |
A2622T |
possibly damaging |
Het |
Flt1 |
T |
C |
5: 147,519,501 (GRCm39) |
H938R |
probably benign |
Het |
Flt3 |
T |
G |
5: 147,295,765 (GRCm39) |
|
probably benign |
Het |
Fnbp4 |
T |
C |
2: 90,608,083 (GRCm39) |
V935A |
possibly damaging |
Het |
Frem2 |
T |
C |
3: 53,442,776 (GRCm39) |
N2587S |
probably benign |
Het |
Gabbr2 |
C |
T |
4: 46,736,349 (GRCm39) |
|
probably null |
Het |
Gm36864 |
A |
T |
7: 43,891,976 (GRCm39) |
I385F |
probably benign |
Het |
Il17re |
G |
T |
6: 113,436,328 (GRCm39) |
R47L |
probably benign |
Het |
Il27ra |
A |
G |
8: 84,760,578 (GRCm39) |
|
probably null |
Het |
Irf4 |
A |
G |
13: 30,945,456 (GRCm39) |
I401V |
probably damaging |
Het |
Kat6a |
T |
C |
8: 23,400,265 (GRCm39) |
L342S |
probably damaging |
Het |
Klc1 |
T |
A |
12: 111,748,384 (GRCm39) |
C390S |
possibly damaging |
Het |
Klhl22 |
A |
T |
16: 17,610,443 (GRCm39) |
I565F |
probably damaging |
Het |
Krt26 |
A |
T |
11: 99,228,672 (GRCm39) |
L20Q |
probably damaging |
Het |
Lamb3 |
T |
C |
1: 193,012,375 (GRCm39) |
V384A |
possibly damaging |
Het |
Lmo2 |
T |
A |
2: 103,801,045 (GRCm39) |
L80Q |
possibly damaging |
Het |
Lrrc37a |
T |
G |
11: 103,393,952 (GRCm39) |
E491A |
possibly damaging |
Het |
Ninj1 |
T |
A |
13: 49,347,288 (GRCm39) |
M51K |
probably damaging |
Het |
Or11g26 |
C |
A |
14: 50,753,100 (GRCm39) |
N146K |
probably benign |
Het |
Or12d17 |
G |
A |
17: 37,777,213 (GRCm39) |
G39R |
probably damaging |
Het |
Plppr3 |
T |
A |
10: 79,702,838 (GRCm39) |
T142S |
probably damaging |
Het |
Rab2b |
T |
C |
14: 52,506,153 (GRCm39) |
D103G |
probably damaging |
Het |
Rap1gap2 |
G |
T |
11: 74,286,651 (GRCm39) |
R550S |
probably damaging |
Het |
Rbm33 |
A |
G |
5: 28,557,623 (GRCm39) |
N279D |
probably damaging |
Het |
Rhox9 |
C |
T |
X: 36,990,253 (GRCm39) |
G40R |
probably benign |
Het |
Selplg |
G |
A |
5: 113,957,502 (GRCm39) |
T268I |
probably damaging |
Het |
Slc20a1 |
T |
C |
2: 129,050,120 (GRCm39) |
M426T |
possibly damaging |
Het |
Spata18 |
A |
T |
5: 73,827,063 (GRCm39) |
Y220F |
|
Het |
Spns1 |
T |
C |
7: 125,971,708 (GRCm39) |
T281A |
probably benign |
Het |
Sptan1 |
C |
T |
2: 29,920,171 (GRCm39) |
R2288C |
probably damaging |
Het |
Tacstd2 |
T |
C |
6: 67,512,383 (GRCm39) |
D103G |
probably damaging |
Het |
Tmem121 |
C |
T |
12: 113,152,487 (GRCm39) |
A235V |
probably benign |
Het |
Try4 |
A |
G |
6: 41,281,996 (GRCm39) |
D194G |
probably damaging |
Het |
Tyrp1 |
C |
A |
4: 80,755,897 (GRCm39) |
T222K |
probably damaging |
Het |
Zfp57 |
T |
A |
17: 37,320,785 (GRCm39) |
V213D |
probably damaging |
Het |
Zfy2 |
A |
T |
Y: 2,117,380 (GRCm39) |
|
probably benign |
Het |
Zkscan4 |
G |
A |
13: 21,668,823 (GRCm39) |
G454R |
not run |
Het |
|
Other mutations in Adgrl3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00391:Adgrl3
|
APN |
5 |
81,872,071 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL00596:Adgrl3
|
APN |
5 |
81,794,314 (GRCm39) |
missense |
probably benign |
0.01 |
IGL00766:Adgrl3
|
APN |
5 |
81,942,415 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00787:Adgrl3
|
APN |
5 |
81,841,401 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00917:Adgrl3
|
APN |
5 |
81,841,421 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01155:Adgrl3
|
APN |
5 |
81,708,740 (GRCm39) |
missense |
probably benign |
0.39 |
IGL01348:Adgrl3
|
APN |
5 |
81,874,570 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01401:Adgrl3
|
APN |
5 |
81,836,516 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL01443:Adgrl3
|
APN |
5 |
81,613,134 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01532:Adgrl3
|
APN |
5 |
81,842,416 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01779:Adgrl3
|
APN |
5 |
81,535,717 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01920:Adgrl3
|
APN |
5 |
81,613,143 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02065:Adgrl3
|
APN |
5 |
81,660,064 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02365:Adgrl3
|
APN |
5 |
81,660,428 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02879:Adgrl3
|
APN |
5 |
81,659,966 (GRCm39) |
missense |
probably damaging |
1.00 |
R0010:Adgrl3
|
UTSW |
5 |
81,940,250 (GRCm39) |
missense |
possibly damaging |
0.58 |
R0077:Adgrl3
|
UTSW |
5 |
81,919,532 (GRCm39) |
splice site |
probably benign |
|
R0103:Adgrl3
|
UTSW |
5 |
81,940,194 (GRCm39) |
intron |
probably benign |
|
R0138:Adgrl3
|
UTSW |
5 |
81,841,454 (GRCm39) |
missense |
probably damaging |
1.00 |
R0149:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R0349:Adgrl3
|
UTSW |
5 |
81,919,491 (GRCm39) |
missense |
probably damaging |
1.00 |
R0361:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R0522:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0610:Adgrl3
|
UTSW |
5 |
81,841,563 (GRCm39) |
splice site |
probably benign |
|
R0658:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably benign |
0.18 |
R0671:Adgrl3
|
UTSW |
5 |
81,708,752 (GRCm39) |
missense |
probably benign |
0.45 |
R0679:Adgrl3
|
UTSW |
5 |
81,942,824 (GRCm39) |
missense |
probably damaging |
1.00 |
R1413:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
R1444:Adgrl3
|
UTSW |
5 |
81,660,200 (GRCm39) |
missense |
probably damaging |
1.00 |
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R1738:Adgrl3
|
UTSW |
5 |
81,535,826 (GRCm39) |
missense |
probably damaging |
0.99 |
R1744:Adgrl3
|
UTSW |
5 |
81,942,267 (GRCm39) |
missense |
probably damaging |
1.00 |
R1803:Adgrl3
|
UTSW |
5 |
81,919,464 (GRCm39) |
nonsense |
probably null |
|
R1891:Adgrl3
|
UTSW |
5 |
81,659,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R1988:Adgrl3
|
UTSW |
5 |
81,836,414 (GRCm39) |
missense |
probably damaging |
1.00 |
R2126:Adgrl3
|
UTSW |
5 |
81,660,383 (GRCm39) |
missense |
probably damaging |
1.00 |
R2136:Adgrl3
|
UTSW |
5 |
81,660,101 (GRCm39) |
missense |
probably damaging |
1.00 |
R2171:Adgrl3
|
UTSW |
5 |
81,660,362 (GRCm39) |
nonsense |
probably null |
|
R2891:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
R3508:Adgrl3
|
UTSW |
5 |
81,872,103 (GRCm39) |
missense |
probably damaging |
1.00 |
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
R3733:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
R3982:Adgrl3
|
UTSW |
5 |
81,842,373 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4085:Adgrl3
|
UTSW |
5 |
81,660,391 (GRCm39) |
missense |
probably benign |
0.02 |
R4462:Adgrl3
|
UTSW |
5 |
81,836,357 (GRCm39) |
missense |
probably damaging |
1.00 |
R4725:Adgrl3
|
UTSW |
5 |
81,914,052 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4726:Adgrl3
|
UTSW |
5 |
81,794,425 (GRCm39) |
missense |
possibly damaging |
0.61 |
R4781:Adgrl3
|
UTSW |
5 |
81,908,571 (GRCm39) |
missense |
probably damaging |
1.00 |
R4837:Adgrl3
|
UTSW |
5 |
81,914,081 (GRCm39) |
missense |
probably benign |
0.07 |
R4841:Adgrl3
|
UTSW |
5 |
81,942,118 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4883:Adgrl3
|
UTSW |
5 |
81,837,493 (GRCm39) |
missense |
probably damaging |
1.00 |
R4921:Adgrl3
|
UTSW |
5 |
81,659,957 (GRCm39) |
missense |
probably damaging |
1.00 |
R4945:Adgrl3
|
UTSW |
5 |
81,659,895 (GRCm39) |
missense |
probably damaging |
1.00 |
R5055:Adgrl3
|
UTSW |
5 |
81,794,398 (GRCm39) |
missense |
possibly damaging |
0.48 |
R5313:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R5385:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
probably damaging |
1.00 |
R5447:Adgrl3
|
UTSW |
5 |
81,613,188 (GRCm39) |
intron |
probably benign |
|
R5482:Adgrl3
|
UTSW |
5 |
81,942,360 (GRCm39) |
missense |
probably damaging |
1.00 |
R5586:Adgrl3
|
UTSW |
5 |
81,871,994 (GRCm39) |
missense |
probably damaging |
0.99 |
R5637:Adgrl3
|
UTSW |
5 |
81,841,391 (GRCm39) |
missense |
probably damaging |
1.00 |
R5919:Adgrl3
|
UTSW |
5 |
81,794,417 (GRCm39) |
missense |
probably benign |
0.00 |
R6090:Adgrl3
|
UTSW |
5 |
81,660,173 (GRCm39) |
missense |
probably damaging |
1.00 |
R6093:Adgrl3
|
UTSW |
5 |
81,794,369 (GRCm39) |
missense |
probably benign |
0.42 |
R6107:Adgrl3
|
UTSW |
5 |
81,836,410 (GRCm39) |
missense |
probably damaging |
0.97 |
R6245:Adgrl3
|
UTSW |
5 |
81,836,403 (GRCm39) |
missense |
probably benign |
0.01 |
R6426:Adgrl3
|
UTSW |
5 |
81,874,717 (GRCm39) |
missense |
probably damaging |
1.00 |
R6440:Adgrl3
|
UTSW |
5 |
81,942,341 (GRCm39) |
nonsense |
probably null |
|
R6516:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
R6527:Adgrl3
|
UTSW |
5 |
81,935,364 (GRCm39) |
missense |
probably damaging |
0.99 |
R6622:Adgrl3
|
UTSW |
5 |
81,942,606 (GRCm39) |
missense |
probably benign |
0.34 |
R6842:Adgrl3
|
UTSW |
5 |
81,888,927 (GRCm39) |
missense |
probably damaging |
1.00 |
R6902:Adgrl3
|
UTSW |
5 |
81,837,434 (GRCm39) |
missense |
probably damaging |
1.00 |
R6921:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably damaging |
0.99 |
R7201:Adgrl3
|
UTSW |
5 |
81,872,069 (GRCm39) |
missense |
probably damaging |
1.00 |
R7207:Adgrl3
|
UTSW |
5 |
81,457,874 (GRCm39) |
start codon destroyed |
probably null |
0.33 |
R7215:Adgrl3
|
UTSW |
5 |
81,841,397 (GRCm39) |
missense |
probably damaging |
1.00 |
R7376:Adgrl3
|
UTSW |
5 |
81,942,597 (GRCm39) |
missense |
probably damaging |
1.00 |
R7441:Adgrl3
|
UTSW |
5 |
81,871,987 (GRCm39) |
missense |
possibly damaging |
0.70 |
R7582:Adgrl3
|
UTSW |
5 |
81,841,523 (GRCm39) |
missense |
probably damaging |
0.99 |
R7682:Adgrl3
|
UTSW |
5 |
81,942,407 (GRCm39) |
missense |
probably damaging |
0.97 |
R7863:Adgrl3
|
UTSW |
5 |
81,660,596 (GRCm39) |
missense |
probably damaging |
1.00 |
R7877:Adgrl3
|
UTSW |
5 |
81,842,467 (GRCm39) |
missense |
probably benign |
0.30 |
R8237:Adgrl3
|
UTSW |
5 |
81,935,408 (GRCm39) |
frame shift |
probably null |
|
R8390:Adgrl3
|
UTSW |
5 |
81,914,057 (GRCm39) |
missense |
probably damaging |
1.00 |
R8392:Adgrl3
|
UTSW |
5 |
81,794,397 (GRCm39) |
missense |
probably benign |
0.01 |
R8475:Adgrl3
|
UTSW |
5 |
81,871,976 (GRCm39) |
missense |
probably benign |
0.31 |
R8478:Adgrl3
|
UTSW |
5 |
81,942,348 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8550:Adgrl3
|
UTSW |
5 |
81,942,599 (GRCm39) |
missense |
possibly damaging |
0.79 |
R8685:Adgrl3
|
UTSW |
5 |
81,874,708 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8792:Adgrl3
|
UTSW |
5 |
81,836,522 (GRCm39) |
missense |
probably damaging |
0.99 |
R8851:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
R8868:Adgrl3
|
UTSW |
5 |
81,794,451 (GRCm39) |
missense |
probably benign |
|
R8889:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R8892:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R8942:Adgrl3
|
UTSW |
5 |
81,796,568 (GRCm39) |
missense |
probably benign |
0.09 |
R9023:Adgrl3
|
UTSW |
5 |
81,613,065 (GRCm39) |
missense |
probably damaging |
0.99 |
R9089:Adgrl3
|
UTSW |
5 |
81,808,291 (GRCm39) |
missense |
possibly damaging |
0.77 |
R9100:Adgrl3
|
UTSW |
5 |
81,842,299 (GRCm39) |
missense |
possibly damaging |
0.85 |
R9104:Adgrl3
|
UTSW |
5 |
81,457,912 (GRCm39) |
missense |
probably benign |
0.00 |
R9172:Adgrl3
|
UTSW |
5 |
81,922,251 (GRCm39) |
missense |
probably benign |
0.01 |
R9284:Adgrl3
|
UTSW |
5 |
81,657,568 (GRCm39) |
splice site |
probably benign |
|
R9286:Adgrl3
|
UTSW |
5 |
81,794,413 (GRCm39) |
missense |
probably benign |
|
R9644:Adgrl3
|
UTSW |
5 |
81,872,036 (GRCm39) |
missense |
probably damaging |
0.99 |
R9689:Adgrl3
|
UTSW |
5 |
81,942,780 (GRCm39) |
missense |
probably damaging |
0.98 |
R9757:Adgrl3
|
UTSW |
5 |
81,613,086 (GRCm39) |
missense |
probably benign |
0.07 |
R9795:Adgrl3
|
UTSW |
5 |
81,837,421 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Adgrl3
|
UTSW |
5 |
81,660,005 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Adgrl3
|
UTSW |
5 |
81,477,729 (GRCm39) |
missense |
probably benign |
0.33 |
|
Predicted Primers |
PCR Primer
(F):5'- AGTCTGAAGTCCTAAGGCAGC -3'
(R):5'- TTCGGTGTGCACATCCTACC -3'
Sequencing Primer
(F):5'- TGAAGTCCTAAGGCAGCAAACTTTC -3'
(R):5'- GCATTGTTACCACAGACATTCATG -3'
|
Posted On |
2020-01-23 |