Incidental Mutation 'R7376:Adgrl3'
ID |
572378 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Adgrl3
|
Ensembl Gene |
ENSMUSG00000037605 |
Gene Name |
adhesion G protein-coupled receptor L3 |
Synonyms |
lectomedin 3, D130075K09Rik, 5430402I23Rik, Lphn3, LEC3 |
MMRRC Submission |
045459-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R7376 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
81167985-81972980 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 81942597 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Histidine to Arginine
at position 1477
(H1477R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000113482
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036068]
[ENSMUST00000072521]
[ENSMUST00000117253]
[ENSMUST00000117407]
[ENSMUST00000117985]
[ENSMUST00000118034]
[ENSMUST00000120673]
[ENSMUST00000118078]
[ENSMUST00000118442]
[ENSMUST00000119385]
[ENSMUST00000119788]
[ENSMUST00000120128]
[ENSMUST00000120144]
[ENSMUST00000120292]
[ENSMUST00000120445]
[ENSMUST00000121641]
[ENSMUST00000121707]
[ENSMUST00000122037]
[ENSMUST00000122356]
[ENSMUST00000132375]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000036068
AA Change: H1440R
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000045342 Gene: ENSMUSG00000037605 AA Change: H1440R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
6.6e-27 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
1.1e-7 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
2.2e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
4.4e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1276 |
2.4e-30 |
PFAM |
Pfam:Latrophilin
|
1272 |
1543 |
3.2e-113 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072521
AA Change: H1440R
PolyPhen 2
Score 0.747 (Sensitivity: 0.85; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000072336 Gene: ENSMUSG00000037605 AA Change: H1440R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
5.9e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.3e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
1.2e-58 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
2.5e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1274 |
4e-34 |
PFAM |
Pfam:Latrophilin
|
1272 |
1543 |
5e-89 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000117253
|
SMART Domains |
Protein: ENSMUSP00000112470 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
5e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1265 |
7.5e-55 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000117407
|
SMART Domains |
Protein: ENSMUSP00000112388 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.4e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
2.6e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
7.7e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1321 |
1.8e-61 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117985
AA Change: H1409R
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000113950 Gene: ENSMUSG00000037605 AA Change: H1409R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.3e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.7e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1512 |
6.8e-178 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000118034
AA Change: H1400R
PolyPhen 2
Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000113534 Gene: ENSMUSG00000037605 AA Change: H1400R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
6.6e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1503 |
6.7e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120673
AA Change: H1477R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113482 Gene: ENSMUSG00000037605 AA Change: H1477R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.7e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
3.3e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
6.4e-59 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.8e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1580 |
1.4e-158 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000118078
|
SMART Domains |
Protein: ENSMUSP00000112731 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
9.7e-27 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.3e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
4.8e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1201 |
2.6e-30 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000118442
|
SMART Domains |
Protein: ENSMUSP00000113836 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.4e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1278 |
2.8e-30 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000119385
|
SMART Domains |
Protein: ENSMUSP00000113243 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
5.2e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1269 |
2.7e-30 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000119788
AA Change: H1447R
PolyPhen 2
Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000114067 Gene: ENSMUSG00000037605 AA Change: H1447R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.8e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1279 |
3.6e-31 |
PFAM |
Pfam:Latrophilin
|
1273 |
1550 |
4.5e-113 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000120128
|
SMART Domains |
Protein: ENSMUSP00000113208 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
9.8e-27 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.4e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1210 |
2.6e-30 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000120144
|
SMART Domains |
Protein: ENSMUSP00000113619 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
5.1e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1253 |
8.4e-62 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000120292
|
SMART Domains |
Protein: ENSMUSP00000112548 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1262 |
8.5e-62 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000120445
|
SMART Domains |
Protein: ENSMUSP00000113249 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.2e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
2.8e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
5.1e-59 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.4e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1328 |
8e-64 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000121641
AA Change: H1468R
PolyPhen 2
Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
|
SMART Domains |
Protein: ENSMUSP00000113694 Gene: ENSMUSG00000037605 AA Change: H1468R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.8e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
7e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1571 |
7.3e-178 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000121707
AA Change: H1431R
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000112823 Gene: ENSMUSG00000037605 AA Change: H1431R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
6.8e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1267 |
6.4e-30 |
PFAM |
Pfam:Latrophilin
|
1263 |
1534 |
8.7e-113 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000122037
AA Change: H1357R
PolyPhen 2
Score 0.787 (Sensitivity: 0.85; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000113374 Gene: ENSMUSG00000037605 AA Change: H1357R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.3e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.5e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
6.3e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1199 |
4.4e-30 |
PFAM |
Pfam:Latrophilin
|
1194 |
1460 |
1.3e-112 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000122356
AA Change: H1425R
PolyPhen 2
Score 0.747 (Sensitivity: 0.85; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000113600 Gene: ENSMUSG00000037605 AA Change: H1425R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.8e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
3.1e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
9.3e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1267 |
9e-30 |
PFAM |
Pfam:Latrophilin
|
1262 |
1528 |
2.8e-112 |
PFAM |
|
Predicted Effect |
|
SMART Domains |
Protein: ENSMUSP00000118882 Gene: ENSMUSG00000037605 AA Change: H769R
Domain | Start | End | E-Value | Type |
Pfam:GAIN
|
2 |
201 |
1.8e-51 |
PFAM |
GPS
|
227 |
279 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
287 |
523 |
9.1e-75 |
PFAM |
Pfam:Latrophilin
|
543 |
610 |
7.2e-35 |
PFAM |
Pfam:Latrophilin
|
607 |
873 |
1.8e-89 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000132375
|
SMART Domains |
Protein: ENSMUSP00000117211 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
98% (60/61) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 58 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca13 |
A |
G |
11: 9,241,118 (GRCm39) |
I994V |
probably benign |
Het |
Acan |
T |
G |
7: 78,738,055 (GRCm39) |
|
probably null |
Het |
Adamts12 |
G |
A |
15: 11,277,425 (GRCm39) |
V680I |
possibly damaging |
Het |
Adgrg7 |
T |
C |
16: 56,545,342 (GRCm39) |
I712V |
probably damaging |
Het |
Adgrv1 |
T |
A |
13: 81,666,245 (GRCm39) |
D1937V |
probably damaging |
Het |
Alms1 |
T |
C |
6: 85,599,088 (GRCm39) |
S1305P |
probably benign |
Het |
Banp |
T |
A |
8: 122,701,236 (GRCm39) |
M39K |
probably damaging |
Het |
Bbs10 |
A |
G |
10: 111,135,111 (GRCm39) |
T75A |
probably benign |
Het |
BC028528 |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
3: 95,795,448 (GRCm39) |
|
probably benign |
Het |
Bltp3b |
G |
A |
10: 89,645,518 (GRCm39) |
G1197D |
probably damaging |
Het |
Brinp2 |
C |
T |
1: 158,078,938 (GRCm39) |
C295Y |
probably damaging |
Het |
Card11 |
C |
T |
5: 140,883,993 (GRCm39) |
V429I |
probably benign |
Het |
Cdca3 |
G |
A |
6: 124,809,538 (GRCm39) |
R184H |
probably benign |
Het |
Cep104 |
A |
G |
4: 154,067,509 (GRCm39) |
|
probably null |
Het |
Clspn |
A |
G |
4: 126,484,430 (GRCm39) |
K1196R |
possibly damaging |
Het |
Cntnap5b |
A |
G |
1: 99,894,994 (GRCm39) |
T89A |
possibly damaging |
Het |
Cpne9 |
A |
T |
6: 113,266,974 (GRCm39) |
I136L |
probably damaging |
Het |
Crat |
T |
A |
2: 30,296,477 (GRCm39) |
I330F |
probably damaging |
Het |
Ctbp2 |
G |
T |
7: 132,615,697 (GRCm39) |
Q413K |
possibly damaging |
Het |
D630045J12Rik |
T |
C |
6: 38,151,238 (GRCm39) |
E1220G |
probably damaging |
Het |
Dap |
A |
G |
15: 31,235,985 (GRCm39) |
D41G |
probably damaging |
Het |
Dnah14 |
A |
G |
1: 181,590,967 (GRCm39) |
I3287V |
probably benign |
Het |
Dsp |
A |
G |
13: 38,356,819 (GRCm39) |
H233R |
probably damaging |
Het |
Dst |
T |
C |
1: 34,231,770 (GRCm39) |
I3121T |
probably benign |
Het |
Espnl |
T |
G |
1: 91,250,036 (GRCm39) |
L61R |
probably damaging |
Het |
Evc2 |
T |
C |
5: 37,527,983 (GRCm39) |
S331P |
possibly damaging |
Het |
Gars1 |
A |
G |
6: 55,050,344 (GRCm39) |
E535G |
probably benign |
Het |
Hfm1 |
A |
G |
5: 107,043,084 (GRCm39) |
I650T |
possibly damaging |
Het |
Iyd |
T |
A |
10: 3,495,690 (GRCm39) |
I116N |
probably damaging |
Het |
Kif16b |
A |
G |
2: 142,553,792 (GRCm39) |
L1002S |
probably damaging |
Het |
Kifbp |
C |
T |
10: 62,394,843 (GRCm39) |
V600I |
possibly damaging |
Het |
Lgi1 |
G |
A |
19: 38,272,468 (GRCm39) |
G113D |
probably damaging |
Het |
Lgi2 |
G |
A |
5: 52,695,604 (GRCm39) |
R452C |
probably damaging |
Het |
Man2b2 |
T |
G |
5: 36,970,722 (GRCm39) |
N764T |
probably damaging |
Het |
Mrps18b |
A |
G |
17: 36,221,587 (GRCm39) |
I246T |
probably benign |
Het |
Muc5b |
A |
G |
7: 141,426,287 (GRCm39) |
T4795A |
possibly damaging |
Het |
Mybl2 |
G |
A |
2: 162,924,513 (GRCm39) |
G627D |
possibly damaging |
Het |
Ndufb8 |
C |
T |
19: 44,543,794 (GRCm39) |
R16K |
probably benign |
Het |
Or5k17 |
A |
T |
16: 58,746,121 (GRCm39) |
V271E |
possibly damaging |
Het |
P4htm |
C |
T |
9: 108,457,991 (GRCm39) |
V335M |
probably damaging |
Het |
Pbx3 |
A |
G |
2: 34,094,889 (GRCm39) |
I249T |
probably damaging |
Het |
Plod3 |
G |
T |
5: 137,019,335 (GRCm39) |
V360L |
probably benign |
Het |
Podxl2 |
C |
T |
6: 88,826,632 (GRCm39) |
D161N |
probably benign |
Het |
Polr1b |
G |
T |
2: 128,960,993 (GRCm39) |
V651L |
probably benign |
Het |
Prr14 |
T |
C |
7: 127,075,749 (GRCm39) |
S586P |
probably benign |
Het |
Pum3 |
C |
T |
19: 27,371,728 (GRCm39) |
G575D |
probably benign |
Het |
Rnf157 |
C |
A |
11: 116,251,192 (GRCm39) |
A111S |
probably benign |
Het |
Robo3 |
A |
G |
9: 37,344,212 (GRCm39) |
L29P |
probably damaging |
Het |
Smarca5 |
T |
C |
8: 81,452,680 (GRCm39) |
N342S |
probably damaging |
Het |
Specc1 |
T |
A |
11: 62,009,078 (GRCm39) |
I198K |
probably benign |
Het |
Tmem177 |
A |
T |
1: 119,837,744 (GRCm39) |
*312R |
probably null |
Het |
Tom1l2 |
A |
T |
11: 60,152,026 (GRCm39) |
M172K |
probably benign |
Het |
Tsc22d4 |
T |
C |
5: 137,756,414 (GRCm39) |
V3A |
unknown |
Het |
Vmn1r128 |
G |
T |
7: 21,083,668 (GRCm39) |
G124V |
probably damaging |
Het |
Vmn1r15 |
T |
C |
6: 57,235,342 (GRCm39) |
I70T |
probably benign |
Het |
Vmn2r60 |
A |
G |
7: 41,844,631 (GRCm39) |
T665A |
probably damaging |
Het |
Vmn2r83 |
T |
C |
10: 79,314,790 (GRCm39) |
F346S |
probably benign |
Het |
Wdr7 |
T |
A |
18: 63,910,691 (GRCm39) |
D694E |
probably damaging |
Het |
|
Other mutations in Adgrl3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00391:Adgrl3
|
APN |
5 |
81,872,071 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL00596:Adgrl3
|
APN |
5 |
81,794,314 (GRCm39) |
missense |
probably benign |
0.01 |
IGL00766:Adgrl3
|
APN |
5 |
81,942,415 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00787:Adgrl3
|
APN |
5 |
81,841,401 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00917:Adgrl3
|
APN |
5 |
81,841,421 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01155:Adgrl3
|
APN |
5 |
81,708,740 (GRCm39) |
missense |
probably benign |
0.39 |
IGL01348:Adgrl3
|
APN |
5 |
81,874,570 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01401:Adgrl3
|
APN |
5 |
81,836,516 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL01443:Adgrl3
|
APN |
5 |
81,613,134 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01532:Adgrl3
|
APN |
5 |
81,842,416 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01779:Adgrl3
|
APN |
5 |
81,535,717 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01920:Adgrl3
|
APN |
5 |
81,613,143 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02065:Adgrl3
|
APN |
5 |
81,660,064 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02365:Adgrl3
|
APN |
5 |
81,660,428 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02879:Adgrl3
|
APN |
5 |
81,659,966 (GRCm39) |
missense |
probably damaging |
1.00 |
R0010:Adgrl3
|
UTSW |
5 |
81,940,250 (GRCm39) |
missense |
possibly damaging |
0.58 |
R0077:Adgrl3
|
UTSW |
5 |
81,919,532 (GRCm39) |
splice site |
probably benign |
|
R0103:Adgrl3
|
UTSW |
5 |
81,940,194 (GRCm39) |
intron |
probably benign |
|
R0138:Adgrl3
|
UTSW |
5 |
81,841,454 (GRCm39) |
missense |
probably damaging |
1.00 |
R0149:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R0349:Adgrl3
|
UTSW |
5 |
81,919,491 (GRCm39) |
missense |
probably damaging |
1.00 |
R0361:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R0522:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0610:Adgrl3
|
UTSW |
5 |
81,841,563 (GRCm39) |
splice site |
probably benign |
|
R0658:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably benign |
0.18 |
R0671:Adgrl3
|
UTSW |
5 |
81,708,752 (GRCm39) |
missense |
probably benign |
0.45 |
R0679:Adgrl3
|
UTSW |
5 |
81,942,824 (GRCm39) |
missense |
probably damaging |
1.00 |
R1413:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
R1444:Adgrl3
|
UTSW |
5 |
81,660,200 (GRCm39) |
missense |
probably damaging |
1.00 |
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R1738:Adgrl3
|
UTSW |
5 |
81,535,826 (GRCm39) |
missense |
probably damaging |
0.99 |
R1744:Adgrl3
|
UTSW |
5 |
81,942,267 (GRCm39) |
missense |
probably damaging |
1.00 |
R1803:Adgrl3
|
UTSW |
5 |
81,919,464 (GRCm39) |
nonsense |
probably null |
|
R1891:Adgrl3
|
UTSW |
5 |
81,659,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R1988:Adgrl3
|
UTSW |
5 |
81,836,414 (GRCm39) |
missense |
probably damaging |
1.00 |
R2126:Adgrl3
|
UTSW |
5 |
81,660,383 (GRCm39) |
missense |
probably damaging |
1.00 |
R2136:Adgrl3
|
UTSW |
5 |
81,660,101 (GRCm39) |
missense |
probably damaging |
1.00 |
R2171:Adgrl3
|
UTSW |
5 |
81,660,362 (GRCm39) |
nonsense |
probably null |
|
R2891:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
R3508:Adgrl3
|
UTSW |
5 |
81,872,103 (GRCm39) |
missense |
probably damaging |
1.00 |
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
R3733:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
R3982:Adgrl3
|
UTSW |
5 |
81,842,373 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4085:Adgrl3
|
UTSW |
5 |
81,660,391 (GRCm39) |
missense |
probably benign |
0.02 |
R4462:Adgrl3
|
UTSW |
5 |
81,836,357 (GRCm39) |
missense |
probably damaging |
1.00 |
R4725:Adgrl3
|
UTSW |
5 |
81,914,052 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4726:Adgrl3
|
UTSW |
5 |
81,794,425 (GRCm39) |
missense |
possibly damaging |
0.61 |
R4781:Adgrl3
|
UTSW |
5 |
81,908,571 (GRCm39) |
missense |
probably damaging |
1.00 |
R4837:Adgrl3
|
UTSW |
5 |
81,914,081 (GRCm39) |
missense |
probably benign |
0.07 |
R4841:Adgrl3
|
UTSW |
5 |
81,942,118 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4883:Adgrl3
|
UTSW |
5 |
81,837,493 (GRCm39) |
missense |
probably damaging |
1.00 |
R4921:Adgrl3
|
UTSW |
5 |
81,659,957 (GRCm39) |
missense |
probably damaging |
1.00 |
R4945:Adgrl3
|
UTSW |
5 |
81,659,895 (GRCm39) |
missense |
probably damaging |
1.00 |
R5055:Adgrl3
|
UTSW |
5 |
81,794,398 (GRCm39) |
missense |
possibly damaging |
0.48 |
R5313:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R5385:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
probably damaging |
1.00 |
R5447:Adgrl3
|
UTSW |
5 |
81,613,188 (GRCm39) |
intron |
probably benign |
|
R5482:Adgrl3
|
UTSW |
5 |
81,942,360 (GRCm39) |
missense |
probably damaging |
1.00 |
R5586:Adgrl3
|
UTSW |
5 |
81,871,994 (GRCm39) |
missense |
probably damaging |
0.99 |
R5637:Adgrl3
|
UTSW |
5 |
81,841,391 (GRCm39) |
missense |
probably damaging |
1.00 |
R5919:Adgrl3
|
UTSW |
5 |
81,794,417 (GRCm39) |
missense |
probably benign |
0.00 |
R6090:Adgrl3
|
UTSW |
5 |
81,660,173 (GRCm39) |
missense |
probably damaging |
1.00 |
R6093:Adgrl3
|
UTSW |
5 |
81,794,369 (GRCm39) |
missense |
probably benign |
0.42 |
R6107:Adgrl3
|
UTSW |
5 |
81,836,410 (GRCm39) |
missense |
probably damaging |
0.97 |
R6245:Adgrl3
|
UTSW |
5 |
81,836,403 (GRCm39) |
missense |
probably benign |
0.01 |
R6426:Adgrl3
|
UTSW |
5 |
81,874,717 (GRCm39) |
missense |
probably damaging |
1.00 |
R6440:Adgrl3
|
UTSW |
5 |
81,942,341 (GRCm39) |
nonsense |
probably null |
|
R6516:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
R6527:Adgrl3
|
UTSW |
5 |
81,935,364 (GRCm39) |
missense |
probably damaging |
0.99 |
R6622:Adgrl3
|
UTSW |
5 |
81,942,606 (GRCm39) |
missense |
probably benign |
0.34 |
R6842:Adgrl3
|
UTSW |
5 |
81,888,927 (GRCm39) |
missense |
probably damaging |
1.00 |
R6902:Adgrl3
|
UTSW |
5 |
81,837,434 (GRCm39) |
missense |
probably damaging |
1.00 |
R6921:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably damaging |
0.99 |
R7201:Adgrl3
|
UTSW |
5 |
81,872,069 (GRCm39) |
missense |
probably damaging |
1.00 |
R7207:Adgrl3
|
UTSW |
5 |
81,457,874 (GRCm39) |
start codon destroyed |
probably null |
0.33 |
R7215:Adgrl3
|
UTSW |
5 |
81,841,397 (GRCm39) |
missense |
probably damaging |
1.00 |
R7441:Adgrl3
|
UTSW |
5 |
81,871,987 (GRCm39) |
missense |
possibly damaging |
0.70 |
R7582:Adgrl3
|
UTSW |
5 |
81,841,523 (GRCm39) |
missense |
probably damaging |
0.99 |
R7682:Adgrl3
|
UTSW |
5 |
81,942,407 (GRCm39) |
missense |
probably damaging |
0.97 |
R7863:Adgrl3
|
UTSW |
5 |
81,660,596 (GRCm39) |
missense |
probably damaging |
1.00 |
R7877:Adgrl3
|
UTSW |
5 |
81,842,467 (GRCm39) |
missense |
probably benign |
0.30 |
R8051:Adgrl3
|
UTSW |
5 |
81,613,113 (GRCm39) |
missense |
probably damaging |
1.00 |
R8237:Adgrl3
|
UTSW |
5 |
81,935,408 (GRCm39) |
frame shift |
probably null |
|
R8390:Adgrl3
|
UTSW |
5 |
81,914,057 (GRCm39) |
missense |
probably damaging |
1.00 |
R8392:Adgrl3
|
UTSW |
5 |
81,794,397 (GRCm39) |
missense |
probably benign |
0.01 |
R8475:Adgrl3
|
UTSW |
5 |
81,871,976 (GRCm39) |
missense |
probably benign |
0.31 |
R8478:Adgrl3
|
UTSW |
5 |
81,942,348 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8550:Adgrl3
|
UTSW |
5 |
81,942,599 (GRCm39) |
missense |
possibly damaging |
0.79 |
R8685:Adgrl3
|
UTSW |
5 |
81,874,708 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8792:Adgrl3
|
UTSW |
5 |
81,836,522 (GRCm39) |
missense |
probably damaging |
0.99 |
R8851:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
R8868:Adgrl3
|
UTSW |
5 |
81,794,451 (GRCm39) |
missense |
probably benign |
|
R8889:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R8892:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R8942:Adgrl3
|
UTSW |
5 |
81,796,568 (GRCm39) |
missense |
probably benign |
0.09 |
R9023:Adgrl3
|
UTSW |
5 |
81,613,065 (GRCm39) |
missense |
probably damaging |
0.99 |
R9089:Adgrl3
|
UTSW |
5 |
81,808,291 (GRCm39) |
missense |
possibly damaging |
0.77 |
R9100:Adgrl3
|
UTSW |
5 |
81,842,299 (GRCm39) |
missense |
possibly damaging |
0.85 |
R9104:Adgrl3
|
UTSW |
5 |
81,457,912 (GRCm39) |
missense |
probably benign |
0.00 |
R9172:Adgrl3
|
UTSW |
5 |
81,922,251 (GRCm39) |
missense |
probably benign |
0.01 |
R9284:Adgrl3
|
UTSW |
5 |
81,657,568 (GRCm39) |
splice site |
probably benign |
|
R9286:Adgrl3
|
UTSW |
5 |
81,794,413 (GRCm39) |
missense |
probably benign |
|
R9644:Adgrl3
|
UTSW |
5 |
81,872,036 (GRCm39) |
missense |
probably damaging |
0.99 |
R9689:Adgrl3
|
UTSW |
5 |
81,942,780 (GRCm39) |
missense |
probably damaging |
0.98 |
R9757:Adgrl3
|
UTSW |
5 |
81,613,086 (GRCm39) |
missense |
probably benign |
0.07 |
R9795:Adgrl3
|
UTSW |
5 |
81,837,421 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Adgrl3
|
UTSW |
5 |
81,660,005 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Adgrl3
|
UTSW |
5 |
81,477,729 (GRCm39) |
missense |
probably benign |
0.33 |
|
Predicted Primers |
PCR Primer
(F):5'- TTAACCACGAGGAGAGTCTGGG -3'
(R):5'- ACTATGAATCCGTCGCTGCTG -3'
Sequencing Primer
(F):5'- AGTCTGGGCCTGGAACTCATTC -3'
(R):5'- ACGTGGTTTCTGGAGCCC -3'
|
Posted On |
2019-09-13 |