Incidental Mutation 'R2136:Adgrl3'
ID | 235801 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Adgrl3
|
Ensembl Gene |
ENSMUSG00000037605 |
Gene Name | adhesion G protein-coupled receptor L3 |
Synonyms | LEC3, 5430402I23Rik, lectomedin 3, Lphn3, D130075K09Rik |
MMRRC Submission |
040139-MU
|
Accession Numbers | |
Is this an essential gene? |
Non essential (E-score: 0.000)
|
Stock # | R2136 (G1)
|
Quality Score | 225 |
Status |
Not validated
|
Chromosome | 5 |
Chromosomal Location | 81020138-81825133 bp(+) (GRCm38) |
Type of Mutation | missense |
DNA Base Change (assembly) |
A to G
at 81512254 bp
|
Zygosity | Heterozygous |
Amino Acid Change |
Lysine to Arginine
at position 290
(K290R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000113249
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036068]
[ENSMUST00000072521]
[ENSMUST00000117253]
[ENSMUST00000117407]
[ENSMUST00000117985]
[ENSMUST00000118034]
[ENSMUST00000118078]
[ENSMUST00000118442]
[ENSMUST00000119385]
[ENSMUST00000119788]
[ENSMUST00000120128]
[ENSMUST00000120144]
[ENSMUST00000120292]
[ENSMUST00000120445]
[ENSMUST00000120673]
[ENSMUST00000121641]
[ENSMUST00000121707]
[ENSMUST00000122037]
[ENSMUST00000122356]
[ENSMUST00000132375]
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000036068
AA Change: K290R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000045342 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
6.6e-27 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
1.1e-7 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
2.2e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
4.4e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1276 |
2.4e-30 |
PFAM |
Pfam:Latrophilin
|
1272 |
1543 |
3.2e-113 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000072521
AA Change: K290R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000072336 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
5.9e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.3e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
1.2e-58 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
2.5e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1274 |
4e-34 |
PFAM |
Pfam:Latrophilin
|
1272 |
1543 |
5e-89 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117253
AA Change: K222R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000112470 Gene: ENSMUSG00000037605 AA Change: K222R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
5e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1265 |
7.5e-55 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117407
AA Change: K290R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000112388 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.4e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
2.6e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
7.7e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1321 |
1.8e-61 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117985
AA Change: K222R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000113950 Gene: ENSMUSG00000037605 AA Change: K222R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.3e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.7e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1512 |
6.8e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000118034
AA Change: K222R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000113534 Gene: ENSMUSG00000037605 AA Change: K222R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
6.6e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1503 |
6.7e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000118078
AA Change: K222R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000112731 Gene: ENSMUSG00000037605 AA Change: K222R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
9.7e-27 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.3e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
4.8e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1201 |
2.6e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000118442
AA Change: K290R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000113836 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.4e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1278 |
2.8e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000119385
AA Change: K290R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000113243 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
5.2e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1269 |
2.7e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000119788
AA Change: K290R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000114067 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.8e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1279 |
3.6e-31 |
PFAM |
Pfam:Latrophilin
|
1273 |
1550 |
4.5e-113 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120128
AA Change: K222R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113208 Gene: ENSMUSG00000037605 AA Change: K222R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
9.8e-27 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.4e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1210 |
2.6e-30 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000120144
AA Change: K222R
PolyPhen 2
Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000113619 Gene: ENSMUSG00000037605 AA Change: K222R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
5.1e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1253 |
8.4e-62 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120292
AA Change: K222R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000112548 Gene: ENSMUSG00000037605 AA Change: K222R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1262 |
8.5e-62 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120445
AA Change: K290R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000113249 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.2e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
2.8e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
5.1e-59 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.4e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1328 |
8e-64 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120673
AA Change: K290R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000113482 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.7e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
3.3e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
6.4e-59 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.8e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1580 |
1.4e-158 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000121641
AA Change: K290R
PolyPhen 2
Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000113694 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.8e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
7e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1571 |
7.3e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000121707
AA Change: K290R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000112823 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
6.8e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1267 |
6.4e-30 |
PFAM |
Pfam:Latrophilin
|
1263 |
1534 |
8.7e-113 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000122037
AA Change: K222R
PolyPhen 2
Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000113374 Gene: ENSMUSG00000037605 AA Change: K222R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.3e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.5e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
6.3e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1199 |
4.4e-30 |
PFAM |
Pfam:Latrophilin
|
1194 |
1460 |
1.3e-112 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000122356
AA Change: K290R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000113600 Gene: ENSMUSG00000037605 AA Change: K290R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.8e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
3.1e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
9.3e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1267 |
9e-30 |
PFAM |
Pfam:Latrophilin
|
1262 |
1528 |
2.8e-112 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127046
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000132375
|
SMART Domains |
Protein: ENSMUSP00000117211 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136104
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149280
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153264
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.6%
- 20x: 95.9%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine. [provided by MGI curators]
|
Allele List at MGI | |
Other mutations in this stock |
Total: 77 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2210010C04Rik |
A |
G |
6: 41,035,462 |
F6S |
probably benign |
Het |
2810474O19Rik |
T |
A |
6: 149,328,822 |
I1122K |
probably benign |
Het |
A930003A15Rik |
T |
G |
16: 19,883,780 |
|
noncoding transcript |
Het |
Abca5 |
T |
C |
11: 110,319,832 |
T174A |
probably benign |
Het |
Abcg3 |
G |
A |
5: 104,966,814 |
S279L |
probably benign |
Het |
Acap3 |
T |
C |
4: 155,896,912 |
L85P |
probably damaging |
Het |
Ankhd1 |
A |
G |
18: 36,647,621 |
T1909A |
probably benign |
Het |
Asap1 |
T |
C |
15: 64,110,959 |
D832G |
probably damaging |
Het |
Atp6v0a2 |
T |
A |
5: 124,718,488 |
L702Q |
possibly damaging |
Het |
Bsn |
A |
G |
9: 108,113,231 |
V1774A |
probably damaging |
Het |
Cd209e |
T |
C |
8: 3,853,248 |
E48G |
probably benign |
Het |
Cdadc1 |
T |
C |
14: 59,568,044 |
|
probably null |
Het |
Cfap65 |
C |
CA |
1: 74,917,273 |
|
probably null |
Het |
Cln3 |
A |
C |
7: 126,582,799 |
S30R |
probably benign |
Het |
Cluap1 |
C |
T |
16: 3,933,772 |
R332W |
probably damaging |
Het |
Crb1 |
A |
T |
1: 139,337,425 |
V85E |
probably benign |
Het |
Crocc |
G |
A |
4: 141,032,954 |
R789W |
probably damaging |
Het |
Cwh43 |
A |
G |
5: 73,415,054 |
I212V |
probably benign |
Het |
Cyp2t4 |
C |
A |
7: 27,158,160 |
F391L |
probably benign |
Het |
Dhx35 |
G |
T |
2: 158,831,861 |
R404L |
probably damaging |
Het |
Disp1 |
A |
G |
1: 183,088,378 |
L826S |
probably damaging |
Het |
Dync2h1 |
T |
A |
9: 7,122,772 |
E2061D |
probably damaging |
Het |
Ep300 |
T |
A |
15: 81,640,447 |
Y1393N |
unknown |
Het |
Fap |
C |
T |
2: 62,524,207 |
G446D |
possibly damaging |
Het |
Fat3 |
A |
G |
9: 16,377,051 |
I392T |
probably benign |
Het |
Fpr-rs4 |
CAGGAA |
CA |
17: 18,022,334 |
|
probably null |
Het |
Glipr1l1 |
T |
C |
10: 112,060,476 |
V56A |
probably damaging |
Het |
Grsf1 |
A |
G |
5: 88,672,658 |
V7A |
probably benign |
Het |
Hmcn1 |
G |
A |
1: 150,633,659 |
A3646V |
probably damaging |
Het |
Ipo9 |
A |
T |
1: 135,394,285 |
I569N |
probably damaging |
Het |
Irs1 |
G |
T |
1: 82,290,042 |
P151Q |
probably damaging |
Het |
Kalrn |
T |
C |
16: 34,307,724 |
D491G |
possibly damaging |
Het |
Kctd7 |
T |
C |
5: 130,152,366 |
L210P |
probably damaging |
Het |
Lifr |
C |
A |
15: 7,181,857 |
D625E |
possibly damaging |
Het |
Lrguk |
T |
C |
6: 34,043,519 |
V201A |
probably benign |
Het |
Mark1 |
A |
G |
1: 184,919,573 |
V135A |
probably damaging |
Het |
Mical2 |
T |
A |
7: 112,271,515 |
D70E |
possibly damaging |
Het |
Mrc1 |
T |
C |
2: 14,270,189 |
Y434H |
probably damaging |
Het |
Myh10 |
C |
A |
11: 68,804,714 |
Q1556K |
probably damaging |
Het |
Nav1 |
G |
A |
1: 135,454,436 |
T1400I |
probably null |
Het |
Olfr1173 |
T |
C |
2: 88,274,240 |
K270E |
probably damaging |
Het |
Olfr1178 |
T |
A |
2: 88,391,319 |
I24N |
probably benign |
Het |
Olfr1289 |
T |
C |
2: 111,483,616 |
V62A |
probably damaging |
Het |
Olfr13 |
A |
G |
6: 43,174,501 |
K172E |
probably benign |
Het |
Olfr142 |
A |
C |
2: 90,252,253 |
V245G |
probably damaging |
Het |
Olfr339 |
A |
G |
2: 36,421,938 |
D180G |
probably damaging |
Het |
Olfr513 |
G |
A |
7: 108,755,223 |
M122I |
possibly damaging |
Het |
Osmr |
T |
A |
15: 6,852,462 |
Q67L |
probably damaging |
Het |
Pan2 |
T |
G |
10: 128,313,637 |
V522G |
possibly damaging |
Het |
Pard3 |
T |
G |
8: 127,376,885 |
|
probably null |
Het |
Pcdhgc5 |
G |
T |
18: 37,820,113 |
A147S |
possibly damaging |
Het |
Pcsk9 |
T |
C |
4: 106,446,770 |
I506V |
probably benign |
Het |
Polr3d |
GCCCCC |
GCCCC |
14: 70,443,047 |
|
probably null |
Het |
Prdm4 |
G |
A |
10: 85,893,351 |
R731* |
probably null |
Het |
Prdx6b |
T |
A |
2: 80,293,163 |
D105E |
probably damaging |
Het |
Rab42 |
A |
G |
4: 132,302,479 |
L144P |
probably damaging |
Het |
Ralbp1 |
T |
A |
17: 65,864,666 |
K104M |
probably damaging |
Het |
Rrp12 |
A |
G |
19: 41,892,599 |
V131A |
probably damaging |
Het |
Sbno1 |
C |
T |
5: 124,387,534 |
|
probably null |
Het |
Sbno2 |
A |
T |
10: 80,062,693 |
I645N |
probably damaging |
Het |
Scfd2 |
T |
C |
5: 74,206,367 |
K624R |
probably benign |
Het |
Sgk2 |
C |
A |
2: 162,999,179 |
|
probably null |
Het |
Sirt4 |
A |
G |
5: 115,479,701 |
S299P |
probably benign |
Het |
Slit2 |
C |
T |
5: 48,304,225 |
A1521V |
probably benign |
Het |
Socs7 |
T |
G |
11: 97,373,107 |
V275G |
possibly damaging |
Het |
Spink11 |
G |
A |
18: 44,190,487 |
P102S |
probably benign |
Het |
Tacc3 |
A |
G |
5: 33,671,404 |
N534D |
probably damaging |
Het |
Tas2r115 |
T |
C |
6: 132,737,346 |
Y214C |
probably damaging |
Het |
Tcaf1 |
A |
T |
6: 42,673,520 |
M875K |
probably benign |
Het |
Ttc22 |
T |
A |
4: 106,622,672 |
L41Q |
possibly damaging |
Het |
Ttc37 |
T |
C |
13: 76,173,354 |
S1322P |
possibly damaging |
Het |
Vasn |
T |
A |
16: 4,649,795 |
C535* |
probably null |
Het |
Vcan |
T |
A |
13: 89,689,737 |
I2563F |
probably damaging |
Het |
Vmn2r63 |
T |
G |
7: 42,926,873 |
Q505H |
probably damaging |
Het |
Vmn2r65 |
T |
G |
7: 84,943,573 |
Q475H |
probably damaging |
Het |
Zbtb43 |
T |
C |
2: 33,454,520 |
Y231C |
probably damaging |
Het |
Zfp292 |
A |
G |
4: 34,810,266 |
V931A |
probably benign |
Het |
|
Other mutations in Adgrl3 |
|
Predicted Primers |
PCR Primer
(F):5'- AAGGACCCTCTACAGGCTTC -3'
(R):5'- TGTAAGGGTTCAACTGGCTAATG -3'
Sequencing Primer
(F):5'- CCTCTACAGGCTTCTGACAAG -3'
(R):5'- GGGTTCAACTGGCTAATGACAATC -3'
|
Posted On | 2014-10-01 |