Incidental Mutation 'R8695:Zfp616'
ID |
668637 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp616
|
Ensembl Gene |
ENSMUSG00000069476 |
Gene Name |
zinc finger protein 616 |
Synonyms |
Gm12330 |
MMRRC Submission |
068549-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R8695 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
73960781-73978118 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 73975710 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Tryptophan
at position 660
(R660W)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000136549
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074813]
[ENSMUST00000108463]
[ENSMUST00000116546]
[ENSMUST00000178159]
|
AlphaFold |
J3QN14 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000074813
|
SMART Domains |
Protein: ENSMUSP00000074365 Gene: ENSMUSG00000069476
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
1.79e-34 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000108463
|
SMART Domains |
Protein: ENSMUSP00000104103 Gene: ENSMUSG00000069476
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
1.79e-34 |
SMART |
low complexity region
|
249 |
258 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000116546
|
SMART Domains |
Protein: ENSMUSP00000112245 Gene: ENSMUSG00000069476
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
1.79e-34 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000178159
AA Change: R660W
PolyPhen 2
Score 0.451 (Sensitivity: 0.89; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000136549 Gene: ENSMUSG00000069476 AA Change: R660W
Domain | Start | End | E-Value | Type |
internal_repeat_1
|
125 |
447 |
7.61e-6 |
PROSPERO |
ZnF_C2H2
|
452 |
474 |
3.11e-2 |
SMART |
ZnF_C2H2
|
509 |
531 |
2.61e-4 |
SMART |
ZnF_C2H2
|
537 |
559 |
1.47e-3 |
SMART |
ZnF_C2H2
|
565 |
587 |
5.21e-4 |
SMART |
ZnF_C2H2
|
593 |
615 |
1.22e-4 |
SMART |
ZnF_C2H2
|
621 |
643 |
2.57e-3 |
SMART |
ZnF_C2H2
|
649 |
671 |
9.22e-5 |
SMART |
ZnF_C2H2
|
677 |
699 |
5.9e-3 |
SMART |
ZnF_C2H2
|
705 |
727 |
4.94e-5 |
SMART |
ZnF_C2H2
|
733 |
755 |
8.34e-3 |
SMART |
ZnF_C2H2
|
761 |
783 |
1.6e-4 |
SMART |
ZnF_C2H2
|
789 |
811 |
6.88e-4 |
SMART |
ZnF_C2H2
|
817 |
839 |
1.6e-4 |
SMART |
ZnF_C2H2
|
845 |
867 |
1.3e-4 |
SMART |
ZnF_C2H2
|
873 |
895 |
7.37e-4 |
SMART |
ZnF_C2H2
|
901 |
923 |
1.6e-4 |
SMART |
ZnF_C2H2
|
929 |
951 |
1.3e-4 |
SMART |
ZnF_C2H2
|
957 |
979 |
3.95e-4 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.5%
|
Validation Efficiency |
100% (78/78) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 78 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4921524J17Rik |
A |
G |
8: 86,138,870 (GRCm39) |
I73T |
probably benign |
Het |
4930556J24Rik |
A |
G |
11: 3,926,192 (GRCm39) |
|
probably benign |
Het |
Ace |
A |
G |
11: 105,875,971 (GRCm39) |
T1010A |
probably benign |
Het |
Adam20 |
A |
T |
8: 41,248,865 (GRCm39) |
Y325F |
probably benign |
Het |
Aff4 |
A |
C |
11: 53,259,509 (GRCm39) |
N7H |
probably damaging |
Het |
Apob |
A |
T |
12: 8,057,830 (GRCm39) |
D2104V |
probably damaging |
Het |
Asap3 |
T |
C |
4: 135,965,722 (GRCm39) |
S411P |
probably benign |
Het |
Atxn1l |
C |
T |
8: 110,458,462 (GRCm39) |
G600D |
probably damaging |
Het |
Brd3 |
A |
T |
2: 27,352,558 (GRCm39) |
M124K |
probably benign |
Het |
Bsx |
A |
G |
9: 40,785,484 (GRCm39) |
N4S |
probably damaging |
Het |
Ccdc125 |
T |
C |
13: 100,814,552 (GRCm39) |
I44T |
probably benign |
Het |
Ccdc141 |
G |
A |
2: 76,879,963 (GRCm39) |
T620I |
probably benign |
Het |
Ccdc178 |
T |
A |
18: 22,157,809 (GRCm39) |
I550F |
probably benign |
Het |
Ccdc77 |
G |
T |
6: 120,318,962 (GRCm39) |
T163N |
probably damaging |
Het |
Cd55 |
A |
T |
1: 130,380,273 (GRCm39) |
I235K |
probably benign |
Het |
Cdc123 |
A |
T |
2: 5,826,174 (GRCm39) |
M118K |
possibly damaging |
Het |
Cep192 |
A |
T |
18: 67,951,958 (GRCm39) |
K378* |
probably null |
Het |
Chd7 |
C |
T |
4: 8,850,812 (GRCm39) |
R1733C |
probably damaging |
Het |
Crybg2 |
A |
T |
4: 133,792,766 (GRCm39) |
S134C |
possibly damaging |
Het |
Cyp2d26 |
A |
G |
15: 82,676,907 (GRCm39) |
|
probably benign |
Het |
D430041D05Rik |
A |
G |
2: 104,085,299 (GRCm39) |
|
probably null |
Het |
Dyrk2 |
A |
T |
10: 118,696,922 (GRCm39) |
V112E |
probably benign |
Het |
Eppk1 |
A |
G |
15: 75,994,598 (GRCm39) |
L761P |
probably benign |
Het |
Evpl |
T |
C |
11: 116,114,489 (GRCm39) |
K1067R |
probably benign |
Het |
Fancm |
C |
A |
12: 65,171,947 (GRCm39) |
D1862E |
probably damaging |
Het |
Fhl2 |
A |
G |
1: 43,167,571 (GRCm39) |
V174A |
probably damaging |
Het |
Gemin4 |
A |
T |
11: 76,102,656 (GRCm39) |
C702S |
probably damaging |
Het |
Ggnbp2 |
T |
A |
11: 84,760,767 (GRCm39) |
D10V |
possibly damaging |
Het |
Glul |
T |
C |
1: 153,778,769 (GRCm39) |
V26A |
probably benign |
Het |
Gml2 |
A |
G |
15: 74,696,089 (GRCm39) |
N161S |
probably benign |
Het |
Gnao1 |
C |
A |
8: 94,682,795 (GRCm39) |
T327K |
probably damaging |
Het |
Gpr179 |
A |
G |
11: 97,227,124 (GRCm39) |
V1677A |
possibly damaging |
Het |
Greb1l |
A |
T |
18: 10,544,450 (GRCm39) |
H1348L |
probably benign |
Het |
Grm8 |
T |
C |
6: 28,126,030 (GRCm39) |
H32R |
probably benign |
Het |
Hk2 |
T |
A |
6: 82,716,627 (GRCm39) |
M302L |
probably benign |
Het |
Hnrnpm |
C |
A |
17: 33,877,884 (GRCm39) |
M333I |
probably benign |
Het |
Hsd3b1 |
A |
G |
3: 98,760,223 (GRCm39) |
I256T |
probably damaging |
Het |
Irx5 |
G |
A |
8: 93,087,327 (GRCm39) |
G420R |
probably damaging |
Het |
Krt87 |
A |
G |
15: 101,331,901 (GRCm39) |
V279A |
probably benign |
Het |
Lamb2 |
G |
A |
9: 108,363,365 (GRCm39) |
S848N |
probably benign |
Het |
Lypd10 |
A |
T |
7: 24,413,203 (GRCm39) |
H174L |
probably benign |
Het |
Mc1r |
A |
T |
8: 124,135,116 (GRCm39) |
T290S |
probably benign |
Het |
Or10d4 |
A |
T |
9: 39,580,376 (GRCm39) |
T8S |
probably benign |
Het |
Or52n2c |
A |
T |
7: 104,574,146 (GRCm39) |
V275D |
probably benign |
Het |
Or52z1 |
A |
T |
7: 103,436,729 (GRCm39) |
C252S |
possibly damaging |
Het |
Or6c202 |
T |
A |
10: 128,996,233 (GRCm39) |
T207S |
probably damaging |
Het |
Pex6 |
T |
C |
17: 47,022,975 (GRCm39) |
S184P |
probably damaging |
Het |
Pglyrp3 |
A |
T |
3: 91,933,762 (GRCm39) |
S136C |
probably null |
Het |
Pik3r1 |
A |
G |
13: 101,894,062 (GRCm39) |
S36P |
probably benign |
Het |
Pomt2 |
G |
T |
12: 87,156,790 (GRCm39) |
T782K |
probably benign |
Het |
Ppfibp2 |
A |
G |
7: 107,285,063 (GRCm39) |
|
probably benign |
Het |
Prdm9 |
T |
C |
17: 15,765,019 (GRCm39) |
H587R |
probably damaging |
Het |
Prp2 |
A |
G |
6: 132,576,932 (GRCm39) |
Q73R |
unknown |
Het |
Psmb4 |
T |
C |
3: 94,793,435 (GRCm39) |
N149D |
probably benign |
Het |
Ptprj |
A |
T |
2: 90,301,481 (GRCm39) |
I217N |
possibly damaging |
Het |
Rasal3 |
A |
G |
17: 32,611,736 (GRCm39) |
F797S |
possibly damaging |
Het |
Rsrp1 |
T |
A |
4: 134,652,610 (GRCm39) |
M188K |
probably damaging |
Het |
Senp8 |
A |
G |
9: 59,644,499 (GRCm39) |
I219T |
probably damaging |
Het |
Serpinb10 |
A |
T |
1: 107,468,630 (GRCm39) |
N91I |
probably damaging |
Het |
Skint4 |
C |
T |
4: 111,975,264 (GRCm39) |
R75C |
probably damaging |
Het |
Slc25a48 |
C |
A |
13: 56,612,825 (GRCm39) |
A241E |
probably damaging |
Het |
Slc39a6 |
C |
A |
18: 24,736,811 (GRCm39) |
|
probably benign |
Het |
Smarcc1 |
G |
A |
9: 110,002,972 (GRCm39) |
R354H |
probably damaging |
Het |
Spata21 |
G |
C |
4: 140,838,755 (GRCm39) |
|
probably null |
Het |
Sptbn2 |
A |
G |
19: 4,796,724 (GRCm39) |
E1774G |
possibly damaging |
Het |
Tep1 |
A |
T |
14: 51,082,894 (GRCm39) |
F1038Y |
possibly damaging |
Het |
Thbs2 |
T |
A |
17: 14,899,963 (GRCm39) |
D638V |
probably benign |
Het |
Tmem161a |
G |
T |
8: 70,627,047 (GRCm39) |
C33F |
probably damaging |
Het |
Trim47 |
T |
C |
11: 116,000,926 (GRCm39) |
S41G |
probably benign |
Het |
Trim56 |
T |
A |
5: 137,143,429 (GRCm39) |
H29L |
probably benign |
Het |
Ugt2b35 |
T |
A |
5: 87,156,064 (GRCm39) |
H385Q |
probably damaging |
Het |
Ugt2b37 |
T |
A |
5: 87,390,243 (GRCm39) |
H401L |
probably benign |
Het |
Usp44 |
A |
C |
10: 93,682,365 (GRCm39) |
T272P |
probably damaging |
Het |
Usp46 |
C |
T |
5: 74,189,897 (GRCm39) |
E156K |
probably benign |
Het |
Vmn1r232 |
T |
C |
17: 21,134,109 (GRCm39) |
K164E |
probably benign |
Het |
Zan |
T |
A |
5: 137,385,217 (GRCm39) |
N5072I |
unknown |
Het |
Zfp318 |
T |
C |
17: 46,723,576 (GRCm39) |
S1860P |
probably benign |
Het |
Zfp870 |
C |
T |
17: 33,102,679 (GRCm39) |
V217I |
possibly damaging |
Het |
|
Other mutations in Zfp616 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00530:Zfp616
|
APN |
11 |
73,974,439 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL00570:Zfp616
|
APN |
11 |
73,976,631 (GRCm39) |
missense |
probably benign |
0.03 |
IGL00594:Zfp616
|
APN |
11 |
73,973,789 (GRCm39) |
missense |
possibly damaging |
0.72 |
IGL01861:Zfp616
|
APN |
11 |
73,973,742 (GRCm39) |
missense |
possibly damaging |
0.53 |
IGL03022:Zfp616
|
APN |
11 |
73,973,800 (GRCm39) |
missense |
possibly damaging |
0.85 |
R0197:Zfp616
|
UTSW |
11 |
73,976,500 (GRCm39) |
missense |
probably damaging |
1.00 |
R0442:Zfp616
|
UTSW |
11 |
73,975,321 (GRCm39) |
missense |
possibly damaging |
0.92 |
R0497:Zfp616
|
UTSW |
11 |
73,974,306 (GRCm39) |
missense |
probably benign |
0.00 |
R0651:Zfp616
|
UTSW |
11 |
73,974,555 (GRCm39) |
nonsense |
probably null |
|
R0730:Zfp616
|
UTSW |
11 |
73,975,648 (GRCm39) |
missense |
probably damaging |
1.00 |
R0883:Zfp616
|
UTSW |
11 |
73,976,500 (GRCm39) |
missense |
probably damaging |
1.00 |
R0926:Zfp616
|
UTSW |
11 |
73,976,644 (GRCm39) |
missense |
probably benign |
0.04 |
R0940:Zfp616
|
UTSW |
11 |
73,975,850 (GRCm39) |
missense |
probably damaging |
1.00 |
R1068:Zfp616
|
UTSW |
11 |
73,973,767 (GRCm39) |
makesense |
probably null |
|
R1272:Zfp616
|
UTSW |
11 |
73,976,062 (GRCm39) |
missense |
probably benign |
0.08 |
R1446:Zfp616
|
UTSW |
11 |
73,974,064 (GRCm39) |
splice site |
probably null |
|
R1482:Zfp616
|
UTSW |
11 |
73,974,803 (GRCm39) |
missense |
possibly damaging |
0.72 |
R1553:Zfp616
|
UTSW |
11 |
73,974,744 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1564:Zfp616
|
UTSW |
11 |
73,975,548 (GRCm39) |
missense |
probably damaging |
1.00 |
R1728:Zfp616
|
UTSW |
11 |
73,976,597 (GRCm39) |
missense |
probably damaging |
0.99 |
R1796:Zfp616
|
UTSW |
11 |
73,976,671 (GRCm39) |
missense |
probably damaging |
0.98 |
R1797:Zfp616
|
UTSW |
11 |
73,976,105 (GRCm39) |
nonsense |
probably null |
|
R1993:Zfp616
|
UTSW |
11 |
73,975,795 (GRCm39) |
missense |
probably benign |
0.08 |
R2026:Zfp616
|
UTSW |
11 |
73,974,413 (GRCm39) |
missense |
possibly damaging |
0.86 |
R2124:Zfp616
|
UTSW |
11 |
73,973,869 (GRCm39) |
splice site |
probably null |
|
R2126:Zfp616
|
UTSW |
11 |
73,976,229 (GRCm39) |
missense |
probably benign |
0.08 |
R2199:Zfp616
|
UTSW |
11 |
73,975,456 (GRCm39) |
missense |
possibly damaging |
0.58 |
R2265:Zfp616
|
UTSW |
11 |
73,976,289 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2404:Zfp616
|
UTSW |
11 |
73,975,682 (GRCm39) |
missense |
probably damaging |
1.00 |
R2508:Zfp616
|
UTSW |
11 |
73,974,121 (GRCm39) |
missense |
probably benign |
0.01 |
R2519:Zfp616
|
UTSW |
11 |
73,975,094 (GRCm39) |
nonsense |
probably null |
|
R3103:Zfp616
|
UTSW |
11 |
73,962,561 (GRCm39) |
missense |
probably benign |
0.01 |
R3611:Zfp616
|
UTSW |
11 |
73,974,268 (GRCm39) |
missense |
possibly damaging |
0.53 |
R3703:Zfp616
|
UTSW |
11 |
73,974,145 (GRCm39) |
nonsense |
probably null |
|
R3744:Zfp616
|
UTSW |
11 |
73,974,813 (GRCm39) |
missense |
probably benign |
0.01 |
R4043:Zfp616
|
UTSW |
11 |
73,976,108 (GRCm39) |
missense |
possibly damaging |
0.50 |
R4273:Zfp616
|
UTSW |
11 |
73,974,526 (GRCm39) |
missense |
probably benign |
0.00 |
R4384:Zfp616
|
UTSW |
11 |
73,974,005 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4469:Zfp616
|
UTSW |
11 |
73,961,950 (GRCm39) |
missense |
probably damaging |
0.98 |
R4560:Zfp616
|
UTSW |
11 |
73,973,860 (GRCm39) |
missense |
probably benign |
0.00 |
R4821:Zfp616
|
UTSW |
11 |
73,975,033 (GRCm39) |
missense |
probably benign |
0.41 |
R4844:Zfp616
|
UTSW |
11 |
73,975,225 (GRCm39) |
missense |
probably benign |
0.10 |
R4948:Zfp616
|
UTSW |
11 |
73,974,830 (GRCm39) |
missense |
possibly damaging |
0.72 |
R5007:Zfp616
|
UTSW |
11 |
73,974,643 (GRCm39) |
missense |
possibly damaging |
0.96 |
R5198:Zfp616
|
UTSW |
11 |
73,974,336 (GRCm39) |
missense |
probably benign |
0.33 |
R5344:Zfp616
|
UTSW |
11 |
73,975,321 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5918:Zfp616
|
UTSW |
11 |
73,974,086 (GRCm39) |
missense |
possibly damaging |
0.70 |
R5933:Zfp616
|
UTSW |
11 |
73,973,952 (GRCm39) |
missense |
probably damaging |
0.96 |
R6084:Zfp616
|
UTSW |
11 |
73,974,672 (GRCm39) |
nonsense |
probably null |
|
R6421:Zfp616
|
UTSW |
11 |
73,974,696 (GRCm39) |
missense |
possibly damaging |
0.53 |
R6494:Zfp616
|
UTSW |
11 |
73,976,018 (GRCm39) |
missense |
probably damaging |
1.00 |
R6523:Zfp616
|
UTSW |
11 |
73,973,968 (GRCm39) |
missense |
possibly damaging |
0.79 |
R6849:Zfp616
|
UTSW |
11 |
73,976,276 (GRCm39) |
missense |
possibly damaging |
0.70 |
R6910:Zfp616
|
UTSW |
11 |
73,975,828 (GRCm39) |
missense |
probably damaging |
1.00 |
R7146:Zfp616
|
UTSW |
11 |
73,976,087 (GRCm39) |
missense |
possibly damaging |
0.61 |
R7213:Zfp616
|
UTSW |
11 |
73,976,689 (GRCm39) |
missense |
probably benign |
0.05 |
R7302:Zfp616
|
UTSW |
11 |
73,976,205 (GRCm39) |
missense |
probably benign |
0.08 |
R7391:Zfp616
|
UTSW |
11 |
73,976,155 (GRCm39) |
missense |
probably benign |
0.08 |
R7654:Zfp616
|
UTSW |
11 |
73,974,013 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7877:Zfp616
|
UTSW |
11 |
73,975,188 (GRCm39) |
missense |
probably damaging |
1.00 |
R7889:Zfp616
|
UTSW |
11 |
73,976,271 (GRCm39) |
missense |
probably damaging |
1.00 |
R8022:Zfp616
|
UTSW |
11 |
73,974,894 (GRCm39) |
missense |
probably benign |
|
R8061:Zfp616
|
UTSW |
11 |
73,974,340 (GRCm39) |
missense |
possibly damaging |
0.96 |
R8212:Zfp616
|
UTSW |
11 |
73,976,569 (GRCm39) |
missense |
probably damaging |
0.96 |
R8335:Zfp616
|
UTSW |
11 |
73,974,726 (GRCm39) |
nonsense |
probably null |
|
R8361:Zfp616
|
UTSW |
11 |
73,975,476 (GRCm39) |
missense |
probably damaging |
0.98 |
R8486:Zfp616
|
UTSW |
11 |
73,974,909 (GRCm39) |
missense |
probably benign |
0.18 |
R8808:Zfp616
|
UTSW |
11 |
73,976,523 (GRCm39) |
missense |
probably damaging |
1.00 |
R9022:Zfp616
|
UTSW |
11 |
73,976,539 (GRCm39) |
missense |
probably damaging |
1.00 |
R9126:Zfp616
|
UTSW |
11 |
73,976,280 (GRCm39) |
missense |
probably damaging |
1.00 |
R9164:Zfp616
|
UTSW |
11 |
73,975,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R9293:Zfp616
|
UTSW |
11 |
73,974,744 (GRCm39) |
missense |
possibly damaging |
0.53 |
R9421:Zfp616
|
UTSW |
11 |
73,974,331 (GRCm39) |
missense |
possibly damaging |
0.72 |
R9512:Zfp616
|
UTSW |
11 |
73,975,936 (GRCm39) |
missense |
probably damaging |
1.00 |
R9529:Zfp616
|
UTSW |
11 |
73,976,596 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9529:Zfp616
|
UTSW |
11 |
73,975,660 (GRCm39) |
missense |
probably damaging |
1.00 |
R9606:Zfp616
|
UTSW |
11 |
73,976,220 (GRCm39) |
missense |
probably damaging |
1.00 |
R9708:Zfp616
|
UTSW |
11 |
73,976,283 (GRCm39) |
missense |
probably damaging |
1.00 |
R9788:Zfp616
|
UTSW |
11 |
73,975,276 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1176:Zfp616
|
UTSW |
11 |
73,976,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
Z1176:Zfp616
|
UTSW |
11 |
73,974,045 (GRCm39) |
missense |
possibly damaging |
0.72 |
Z1176:Zfp616
|
UTSW |
11 |
73,973,859 (GRCm39) |
missense |
probably benign |
|
Z1177:Zfp616
|
UTSW |
11 |
73,975,878 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Predicted Primers |
PCR Primer
(F):5'- TCAGGTCTTAAAAGGCACTACAGA -3'
(R):5'- TTGAAGATTTGAAGACTGGGCA -3'
Sequencing Primer
(F):5'- GTCTTAAAAGGCACTACAGAATCCAC -3'
(R):5'- CCTTTTAAGACTTGAGGAACAGGC -3'
|
Posted On |
2021-04-30 |