Incidental Mutation 'R8695:Zfp616'
ID 668637
Institutional Source Beutler Lab
Gene Symbol Zfp616
Ensembl Gene ENSMUSG00000069476
Gene Name zinc finger protein 616
Synonyms Gm12330
MMRRC Submission 068549-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8695 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 73960781-73978118 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 73975710 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 660 (R660W)
Ref Sequence ENSEMBL: ENSMUSP00000136549 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074813] [ENSMUST00000108463] [ENSMUST00000116546] [ENSMUST00000178159]
AlphaFold J3QN14
Predicted Effect probably benign
Transcript: ENSMUST00000074813
SMART Domains Protein: ENSMUSP00000074365
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108463
SMART Domains Protein: ENSMUSP00000104103
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
low complexity region 249 258 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116546
SMART Domains Protein: ENSMUSP00000112245
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000178159
AA Change: R660W

PolyPhen 2 Score 0.451 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000136549
Gene: ENSMUSG00000069476
AA Change: R660W

DomainStartEndE-ValueType
internal_repeat_1 125 447 7.61e-6 PROSPERO
ZnF_C2H2 452 474 3.11e-2 SMART
ZnF_C2H2 509 531 2.61e-4 SMART
ZnF_C2H2 537 559 1.47e-3 SMART
ZnF_C2H2 565 587 5.21e-4 SMART
ZnF_C2H2 593 615 1.22e-4 SMART
ZnF_C2H2 621 643 2.57e-3 SMART
ZnF_C2H2 649 671 9.22e-5 SMART
ZnF_C2H2 677 699 5.9e-3 SMART
ZnF_C2H2 705 727 4.94e-5 SMART
ZnF_C2H2 733 755 8.34e-3 SMART
ZnF_C2H2 761 783 1.6e-4 SMART
ZnF_C2H2 789 811 6.88e-4 SMART
ZnF_C2H2 817 839 1.6e-4 SMART
ZnF_C2H2 845 867 1.3e-4 SMART
ZnF_C2H2 873 895 7.37e-4 SMART
ZnF_C2H2 901 923 1.6e-4 SMART
ZnF_C2H2 929 951 1.3e-4 SMART
ZnF_C2H2 957 979 3.95e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 100% (78/78)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524J17Rik A G 8: 86,138,870 (GRCm39) I73T probably benign Het
4930556J24Rik A G 11: 3,926,192 (GRCm39) probably benign Het
Ace A G 11: 105,875,971 (GRCm39) T1010A probably benign Het
Adam20 A T 8: 41,248,865 (GRCm39) Y325F probably benign Het
Aff4 A C 11: 53,259,509 (GRCm39) N7H probably damaging Het
Apob A T 12: 8,057,830 (GRCm39) D2104V probably damaging Het
Asap3 T C 4: 135,965,722 (GRCm39) S411P probably benign Het
Atxn1l C T 8: 110,458,462 (GRCm39) G600D probably damaging Het
Brd3 A T 2: 27,352,558 (GRCm39) M124K probably benign Het
Bsx A G 9: 40,785,484 (GRCm39) N4S probably damaging Het
Ccdc125 T C 13: 100,814,552 (GRCm39) I44T probably benign Het
Ccdc141 G A 2: 76,879,963 (GRCm39) T620I probably benign Het
Ccdc178 T A 18: 22,157,809 (GRCm39) I550F probably benign Het
Ccdc77 G T 6: 120,318,962 (GRCm39) T163N probably damaging Het
Cd55 A T 1: 130,380,273 (GRCm39) I235K probably benign Het
Cdc123 A T 2: 5,826,174 (GRCm39) M118K possibly damaging Het
Cep192 A T 18: 67,951,958 (GRCm39) K378* probably null Het
Chd7 C T 4: 8,850,812 (GRCm39) R1733C probably damaging Het
Crybg2 A T 4: 133,792,766 (GRCm39) S134C possibly damaging Het
Cyp2d26 A G 15: 82,676,907 (GRCm39) probably benign Het
D430041D05Rik A G 2: 104,085,299 (GRCm39) probably null Het
Dyrk2 A T 10: 118,696,922 (GRCm39) V112E probably benign Het
Eppk1 A G 15: 75,994,598 (GRCm39) L761P probably benign Het
Evpl T C 11: 116,114,489 (GRCm39) K1067R probably benign Het
Fancm C A 12: 65,171,947 (GRCm39) D1862E probably damaging Het
Fhl2 A G 1: 43,167,571 (GRCm39) V174A probably damaging Het
Gemin4 A T 11: 76,102,656 (GRCm39) C702S probably damaging Het
Ggnbp2 T A 11: 84,760,767 (GRCm39) D10V possibly damaging Het
Glul T C 1: 153,778,769 (GRCm39) V26A probably benign Het
Gml2 A G 15: 74,696,089 (GRCm39) N161S probably benign Het
Gnao1 C A 8: 94,682,795 (GRCm39) T327K probably damaging Het
Gpr179 A G 11: 97,227,124 (GRCm39) V1677A possibly damaging Het
Greb1l A T 18: 10,544,450 (GRCm39) H1348L probably benign Het
Grm8 T C 6: 28,126,030 (GRCm39) H32R probably benign Het
Hk2 T A 6: 82,716,627 (GRCm39) M302L probably benign Het
Hnrnpm C A 17: 33,877,884 (GRCm39) M333I probably benign Het
Hsd3b1 A G 3: 98,760,223 (GRCm39) I256T probably damaging Het
Irx5 G A 8: 93,087,327 (GRCm39) G420R probably damaging Het
Krt87 A G 15: 101,331,901 (GRCm39) V279A probably benign Het
Lamb2 G A 9: 108,363,365 (GRCm39) S848N probably benign Het
Lypd10 A T 7: 24,413,203 (GRCm39) H174L probably benign Het
Mc1r A T 8: 124,135,116 (GRCm39) T290S probably benign Het
Or10d4 A T 9: 39,580,376 (GRCm39) T8S probably benign Het
Or52n2c A T 7: 104,574,146 (GRCm39) V275D probably benign Het
Or52z1 A T 7: 103,436,729 (GRCm39) C252S possibly damaging Het
Or6c202 T A 10: 128,996,233 (GRCm39) T207S probably damaging Het
Pex6 T C 17: 47,022,975 (GRCm39) S184P probably damaging Het
Pglyrp3 A T 3: 91,933,762 (GRCm39) S136C probably null Het
Pik3r1 A G 13: 101,894,062 (GRCm39) S36P probably benign Het
Pomt2 G T 12: 87,156,790 (GRCm39) T782K probably benign Het
Ppfibp2 A G 7: 107,285,063 (GRCm39) probably benign Het
Prdm9 T C 17: 15,765,019 (GRCm39) H587R probably damaging Het
Prp2 A G 6: 132,576,932 (GRCm39) Q73R unknown Het
Psmb4 T C 3: 94,793,435 (GRCm39) N149D probably benign Het
Ptprj A T 2: 90,301,481 (GRCm39) I217N possibly damaging Het
Rasal3 A G 17: 32,611,736 (GRCm39) F797S possibly damaging Het
Rsrp1 T A 4: 134,652,610 (GRCm39) M188K probably damaging Het
Senp8 A G 9: 59,644,499 (GRCm39) I219T probably damaging Het
Serpinb10 A T 1: 107,468,630 (GRCm39) N91I probably damaging Het
Skint4 C T 4: 111,975,264 (GRCm39) R75C probably damaging Het
Slc25a48 C A 13: 56,612,825 (GRCm39) A241E probably damaging Het
Slc39a6 C A 18: 24,736,811 (GRCm39) probably benign Het
Smarcc1 G A 9: 110,002,972 (GRCm39) R354H probably damaging Het
Spata21 G C 4: 140,838,755 (GRCm39) probably null Het
Sptbn2 A G 19: 4,796,724 (GRCm39) E1774G possibly damaging Het
Tep1 A T 14: 51,082,894 (GRCm39) F1038Y possibly damaging Het
Thbs2 T A 17: 14,899,963 (GRCm39) D638V probably benign Het
Tmem161a G T 8: 70,627,047 (GRCm39) C33F probably damaging Het
Trim47 T C 11: 116,000,926 (GRCm39) S41G probably benign Het
Trim56 T A 5: 137,143,429 (GRCm39) H29L probably benign Het
Ugt2b35 T A 5: 87,156,064 (GRCm39) H385Q probably damaging Het
Ugt2b37 T A 5: 87,390,243 (GRCm39) H401L probably benign Het
Usp44 A C 10: 93,682,365 (GRCm39) T272P probably damaging Het
Usp46 C T 5: 74,189,897 (GRCm39) E156K probably benign Het
Vmn1r232 T C 17: 21,134,109 (GRCm39) K164E probably benign Het
Zan T A 5: 137,385,217 (GRCm39) N5072I unknown Het
Zfp318 T C 17: 46,723,576 (GRCm39) S1860P probably benign Het
Zfp870 C T 17: 33,102,679 (GRCm39) V217I possibly damaging Het
Other mutations in Zfp616
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00530:Zfp616 APN 11 73,974,439 (GRCm39) missense probably damaging 0.98
IGL00570:Zfp616 APN 11 73,976,631 (GRCm39) missense probably benign 0.03
IGL00594:Zfp616 APN 11 73,973,789 (GRCm39) missense possibly damaging 0.72
IGL01861:Zfp616 APN 11 73,973,742 (GRCm39) missense possibly damaging 0.53
IGL03022:Zfp616 APN 11 73,973,800 (GRCm39) missense possibly damaging 0.85
R0197:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0442:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R0497:Zfp616 UTSW 11 73,974,306 (GRCm39) missense probably benign 0.00
R0651:Zfp616 UTSW 11 73,974,555 (GRCm39) nonsense probably null
R0730:Zfp616 UTSW 11 73,975,648 (GRCm39) missense probably damaging 1.00
R0883:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0926:Zfp616 UTSW 11 73,976,644 (GRCm39) missense probably benign 0.04
R0940:Zfp616 UTSW 11 73,975,850 (GRCm39) missense probably damaging 1.00
R1068:Zfp616 UTSW 11 73,973,767 (GRCm39) makesense probably null
R1272:Zfp616 UTSW 11 73,976,062 (GRCm39) missense probably benign 0.08
R1446:Zfp616 UTSW 11 73,974,064 (GRCm39) splice site probably null
R1482:Zfp616 UTSW 11 73,974,803 (GRCm39) missense possibly damaging 0.72
R1553:Zfp616 UTSW 11 73,974,744 (GRCm39) missense possibly damaging 0.53
R1564:Zfp616 UTSW 11 73,975,548 (GRCm39) missense probably damaging 1.00
R1728:Zfp616 UTSW 11 73,976,597 (GRCm39) missense probably damaging 0.99
R1796:Zfp616 UTSW 11 73,976,671 (GRCm39) missense probably damaging 0.98
R1797:Zfp616 UTSW 11 73,976,105 (GRCm39) nonsense probably null
R1993:Zfp616 UTSW 11 73,975,795 (GRCm39) missense probably benign 0.08
R2026:Zfp616 UTSW 11 73,974,413 (GRCm39) missense possibly damaging 0.86
R2124:Zfp616 UTSW 11 73,973,869 (GRCm39) splice site probably null
R2126:Zfp616 UTSW 11 73,976,229 (GRCm39) missense probably benign 0.08
R2199:Zfp616 UTSW 11 73,975,456 (GRCm39) missense possibly damaging 0.58
R2265:Zfp616 UTSW 11 73,976,289 (GRCm39) missense possibly damaging 0.89
R2404:Zfp616 UTSW 11 73,975,682 (GRCm39) missense probably damaging 1.00
R2508:Zfp616 UTSW 11 73,974,121 (GRCm39) missense probably benign 0.01
R2519:Zfp616 UTSW 11 73,975,094 (GRCm39) nonsense probably null
R3103:Zfp616 UTSW 11 73,962,561 (GRCm39) missense probably benign 0.01
R3611:Zfp616 UTSW 11 73,974,268 (GRCm39) missense possibly damaging 0.53
R3703:Zfp616 UTSW 11 73,974,145 (GRCm39) nonsense probably null
R3744:Zfp616 UTSW 11 73,974,813 (GRCm39) missense probably benign 0.01
R4043:Zfp616 UTSW 11 73,976,108 (GRCm39) missense possibly damaging 0.50
R4273:Zfp616 UTSW 11 73,974,526 (GRCm39) missense probably benign 0.00
R4384:Zfp616 UTSW 11 73,974,005 (GRCm39) missense possibly damaging 0.94
R4469:Zfp616 UTSW 11 73,961,950 (GRCm39) missense probably damaging 0.98
R4560:Zfp616 UTSW 11 73,973,860 (GRCm39) missense probably benign 0.00
R4821:Zfp616 UTSW 11 73,975,033 (GRCm39) missense probably benign 0.41
R4844:Zfp616 UTSW 11 73,975,225 (GRCm39) missense probably benign 0.10
R4948:Zfp616 UTSW 11 73,974,830 (GRCm39) missense possibly damaging 0.72
R5007:Zfp616 UTSW 11 73,974,643 (GRCm39) missense possibly damaging 0.96
R5198:Zfp616 UTSW 11 73,974,336 (GRCm39) missense probably benign 0.33
R5344:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R5918:Zfp616 UTSW 11 73,974,086 (GRCm39) missense possibly damaging 0.70
R5933:Zfp616 UTSW 11 73,973,952 (GRCm39) missense probably damaging 0.96
R6084:Zfp616 UTSW 11 73,974,672 (GRCm39) nonsense probably null
R6421:Zfp616 UTSW 11 73,974,696 (GRCm39) missense possibly damaging 0.53
R6494:Zfp616 UTSW 11 73,976,018 (GRCm39) missense probably damaging 1.00
R6523:Zfp616 UTSW 11 73,973,968 (GRCm39) missense possibly damaging 0.79
R6849:Zfp616 UTSW 11 73,976,276 (GRCm39) missense possibly damaging 0.70
R6910:Zfp616 UTSW 11 73,975,828 (GRCm39) missense probably damaging 1.00
R7146:Zfp616 UTSW 11 73,976,087 (GRCm39) missense possibly damaging 0.61
R7213:Zfp616 UTSW 11 73,976,689 (GRCm39) missense probably benign 0.05
R7302:Zfp616 UTSW 11 73,976,205 (GRCm39) missense probably benign 0.08
R7391:Zfp616 UTSW 11 73,976,155 (GRCm39) missense probably benign 0.08
R7654:Zfp616 UTSW 11 73,974,013 (GRCm39) missense possibly damaging 0.53
R7877:Zfp616 UTSW 11 73,975,188 (GRCm39) missense probably damaging 1.00
R7889:Zfp616 UTSW 11 73,976,271 (GRCm39) missense probably damaging 1.00
R8022:Zfp616 UTSW 11 73,974,894 (GRCm39) missense probably benign
R8061:Zfp616 UTSW 11 73,974,340 (GRCm39) missense possibly damaging 0.96
R8212:Zfp616 UTSW 11 73,976,569 (GRCm39) missense probably damaging 0.96
R8335:Zfp616 UTSW 11 73,974,726 (GRCm39) nonsense probably null
R8361:Zfp616 UTSW 11 73,975,476 (GRCm39) missense probably damaging 0.98
R8486:Zfp616 UTSW 11 73,974,909 (GRCm39) missense probably benign 0.18
R8808:Zfp616 UTSW 11 73,976,523 (GRCm39) missense probably damaging 1.00
R9022:Zfp616 UTSW 11 73,976,539 (GRCm39) missense probably damaging 1.00
R9126:Zfp616 UTSW 11 73,976,280 (GRCm39) missense probably damaging 1.00
R9164:Zfp616 UTSW 11 73,975,825 (GRCm39) missense probably damaging 1.00
R9293:Zfp616 UTSW 11 73,974,744 (GRCm39) missense possibly damaging 0.53
R9421:Zfp616 UTSW 11 73,974,331 (GRCm39) missense possibly damaging 0.72
R9512:Zfp616 UTSW 11 73,975,936 (GRCm39) missense probably damaging 1.00
R9529:Zfp616 UTSW 11 73,976,596 (GRCm39) missense possibly damaging 0.90
R9529:Zfp616 UTSW 11 73,975,660 (GRCm39) missense probably damaging 1.00
R9606:Zfp616 UTSW 11 73,976,220 (GRCm39) missense probably damaging 1.00
R9708:Zfp616 UTSW 11 73,976,283 (GRCm39) missense probably damaging 1.00
R9788:Zfp616 UTSW 11 73,975,276 (GRCm39) missense probably damaging 0.99
Z1176:Zfp616 UTSW 11 73,976,467 (GRCm39) missense possibly damaging 0.90
Z1176:Zfp616 UTSW 11 73,974,045 (GRCm39) missense possibly damaging 0.72
Z1176:Zfp616 UTSW 11 73,973,859 (GRCm39) missense probably benign
Z1177:Zfp616 UTSW 11 73,975,878 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TCAGGTCTTAAAAGGCACTACAGA -3'
(R):5'- TTGAAGATTTGAAGACTGGGCA -3'

Sequencing Primer
(F):5'- GTCTTAAAAGGCACTACAGAATCCAC -3'
(R):5'- CCTTTTAAGACTTGAGGAACAGGC -3'
Posted On 2021-04-30