Incidental Mutation 'R9022:Zfp616'
ID 686301
Institutional Source Beutler Lab
Gene Symbol Zfp616
Ensembl Gene ENSMUSG00000069476
Gene Name zinc finger protein 616
Synonyms Gm12330
MMRRC Submission 068852-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9022 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 73960781-73978118 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73976539 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 936 (K936R)
Ref Sequence ENSEMBL: ENSMUSP00000136549 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074813] [ENSMUST00000108463] [ENSMUST00000116546] [ENSMUST00000178159]
AlphaFold J3QN14
Predicted Effect probably benign
Transcript: ENSMUST00000074813
SMART Domains Protein: ENSMUSP00000074365
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108463
SMART Domains Protein: ENSMUSP00000104103
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
low complexity region 249 258 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116546
SMART Domains Protein: ENSMUSP00000112245
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000178159
AA Change: K936R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000136549
Gene: ENSMUSG00000069476
AA Change: K936R

DomainStartEndE-ValueType
internal_repeat_1 125 447 7.61e-6 PROSPERO
ZnF_C2H2 452 474 3.11e-2 SMART
ZnF_C2H2 509 531 2.61e-4 SMART
ZnF_C2H2 537 559 1.47e-3 SMART
ZnF_C2H2 565 587 5.21e-4 SMART
ZnF_C2H2 593 615 1.22e-4 SMART
ZnF_C2H2 621 643 2.57e-3 SMART
ZnF_C2H2 649 671 9.22e-5 SMART
ZnF_C2H2 677 699 5.9e-3 SMART
ZnF_C2H2 705 727 4.94e-5 SMART
ZnF_C2H2 733 755 8.34e-3 SMART
ZnF_C2H2 761 783 1.6e-4 SMART
ZnF_C2H2 789 811 6.88e-4 SMART
ZnF_C2H2 817 839 1.6e-4 SMART
ZnF_C2H2 845 867 1.3e-4 SMART
ZnF_C2H2 873 895 7.37e-4 SMART
ZnF_C2H2 901 923 1.6e-4 SMART
ZnF_C2H2 929 951 1.3e-4 SMART
ZnF_C2H2 957 979 3.95e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 100% (84/84)
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl6a G T 3: 32,769,649 (GRCm39) A155S probably benign Het
Adar A G 3: 89,643,045 (GRCm39) T309A probably benign Het
Adgrv1 A T 13: 81,303,312 (GRCm39) W6125R probably damaging Het
Adprhl1 A G 8: 13,274,352 (GRCm39) L802P probably benign Het
Ahcy A G 2: 154,910,779 (GRCm39) L63P probably damaging Het
Ang5 G A 14: 44,200,352 (GRCm39) D139N probably damaging Het
Ankrd31 A G 13: 96,962,655 (GRCm39) D482G probably benign Het
Arhgef7 A G 8: 11,850,469 (GRCm39) N257D probably benign Het
Art3 C A 5: 92,540,393 (GRCm39) S45R probably benign Het
Atxn1 T C 13: 45,720,891 (GRCm39) R335G probably damaging Het
Bag6 T A 17: 35,363,641 (GRCm39) L775H probably damaging Het
BC004004 T G 17: 29,501,130 (GRCm39) H26Q possibly damaging Het
Camsap3 T C 8: 3,656,575 (GRCm39) L986S probably benign Het
Cbx5 T C 15: 103,121,586 (GRCm39) E17G probably damaging Het
Cc2d1b T C 4: 108,484,617 (GRCm39) probably null Het
Ccdc59 T C 10: 105,683,007 (GRCm39) Y231H probably damaging Het
Cemip2 T C 19: 21,789,986 (GRCm39) probably null Het
Csnk1g1 T C 9: 65,917,854 (GRCm39) probably null Het
Cybrd1 A G 2: 70,967,904 (GRCm39) I158M possibly damaging Het
Disp2 T A 2: 118,621,179 (GRCm39) I637N probably benign Het
Dll4 TC T 2: 119,163,054 (GRCm39) probably null Het
Dnah7a T C 1: 53,512,116 (GRCm39) probably null Het
Duox2 C A 2: 122,110,919 (GRCm39) *1518L probably null Het
Dym A G 18: 75,258,507 (GRCm39) I422V probably benign Het
Entpd8 A C 2: 24,975,144 (GRCm39) I492L probably benign Het
Fabp12 A G 3: 10,317,333 (GRCm39) S13P probably damaging Het
Fam124b A G 1: 80,190,705 (GRCm39) I226T probably damaging Het
Fer1l6 T C 15: 58,455,329 (GRCm39) L763P probably damaging Het
Git2 A G 5: 114,907,676 (GRCm39) probably null Het
Gltpd2 A T 11: 70,410,153 (GRCm39) Y37F probably benign Het
Gm44511 T G 6: 128,797,271 (GRCm39) Q72H possibly damaging Het
Grid2ip A T 5: 143,366,204 (GRCm39) T565S probably benign Het
Grk6 T C 13: 55,606,877 (GRCm39) S532P possibly damaging Het
Haspin A T 11: 73,026,831 (GRCm39) F753I probably damaging Het
Herpud1 T A 8: 95,116,197 (GRCm39) S92T possibly damaging Het
Heyl C T 4: 123,139,768 (GRCm39) A109V probably damaging Het
Hivep3 T C 4: 119,955,304 (GRCm39) S1207P probably benign Het
Hk1 A G 10: 62,105,768 (GRCm39) S893P probably damaging Het
Itih1 C A 14: 30,652,327 (GRCm39) V789L probably benign Het
Kif12 T C 4: 63,090,121 (GRCm39) D10G possibly damaging Het
Kif16b C T 2: 142,554,537 (GRCm39) E754K possibly damaging Het
Kif20a A G 18: 34,760,898 (GRCm39) Q191R probably benign Het
Lap3 A G 5: 45,652,548 (GRCm39) D48G probably benign Het
Matn3 T A 12: 9,002,355 (GRCm39) V189E probably damaging Het
Mbp G A 18: 82,597,067 (GRCm39) E143K possibly damaging Het
Mrgprd A G 7: 144,875,555 (GRCm39) H142R probably benign Het
Nbea A T 3: 55,551,110 (GRCm39) C2685S possibly damaging Het
Nhsl1 A C 10: 18,403,409 (GRCm39) I1381L possibly damaging Het
Npc1 A G 18: 12,346,422 (GRCm39) M258T probably benign Het
Or2w3 T C 11: 58,556,550 (GRCm39) L55P probably damaging Het
Or7e178 T A 9: 20,225,268 (GRCm39) N316I probably damaging Het
Osbpl10 C T 9: 114,807,939 (GRCm39) A65V unknown Het
Pdia4 C G 6: 47,785,149 (GRCm39) A73P probably benign Het
Plxnb2 T C 15: 89,048,471 (GRCm39) Y646C possibly damaging Het
Pmm1 C T 15: 81,839,896 (GRCm39) R143H probably damaging Het
Pold2 T C 11: 5,824,121 (GRCm39) D228G probably benign Het
Popdc2 T G 16: 38,194,508 (GRCm39) C310G probably benign Het
Prdm10 A G 9: 31,268,424 (GRCm39) Y791C probably benign Het
Psg19 C T 7: 18,530,762 (GRCm39) V131I probably benign Het
Psg19 T A 7: 18,531,044 (GRCm39) T37S probably benign Het
Psme1 A G 14: 55,817,271 (GRCm39) E39G probably damaging Het
Rabep2 A G 7: 126,043,719 (GRCm39) E472G probably damaging Het
Rap1gap T C 4: 137,445,309 (GRCm39) F297S probably damaging Het
Reln A G 5: 22,181,613 (GRCm39) S1757P possibly damaging Het
Rybp G T 6: 100,210,074 (GRCm39) D95E possibly damaging Het
Slc12a8 T A 16: 33,466,934 (GRCm39) D480E probably benign Het
Slc25a1 A G 16: 17,745,294 (GRCm39) V80A probably benign Het
Slc25a24 A T 3: 109,070,757 (GRCm39) D372V probably benign Het
Slc49a4 T C 16: 35,570,912 (GRCm39) T131A probably benign Het
Stab1 T C 14: 30,882,226 (GRCm39) T490A probably benign Het
Stat5b A T 11: 100,681,634 (GRCm39) I540N probably benign Het
Tasor2 A G 13: 3,626,659 (GRCm39) V1097A probably benign Het
Thy1 T A 9: 43,957,947 (GRCm39) L25Q probably damaging Het
Trim30a A G 7: 104,084,956 (GRCm39) S85P probably benign Het
Use1 G A 8: 71,819,942 (GRCm39) V36I probably benign Het
Vmn1r228 T A 17: 20,996,778 (GRCm39) I247F probably damaging Het
Vmn2r13 T A 5: 109,304,242 (GRCm39) T730S possibly damaging Het
Vmn2r9 T C 5: 108,992,923 (GRCm39) D529G possibly damaging Het
Washc5 A G 15: 59,217,233 (GRCm39) I778T possibly damaging Het
Washc5 A T 15: 59,233,069 (GRCm39) M294K probably damaging Het
Wnt8a A T 18: 34,680,298 (GRCm39) D221V probably damaging Het
Zfp618 G A 4: 63,012,687 (GRCm39) C133Y probably damaging Het
Zfp82 A G 7: 29,761,714 (GRCm39) S56P probably damaging Het
Zkscan16 T A 4: 58,957,021 (GRCm39) D434E probably benign Het
Other mutations in Zfp616
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00530:Zfp616 APN 11 73,974,439 (GRCm39) missense probably damaging 0.98
IGL00570:Zfp616 APN 11 73,976,631 (GRCm39) missense probably benign 0.03
IGL00594:Zfp616 APN 11 73,973,789 (GRCm39) missense possibly damaging 0.72
IGL01861:Zfp616 APN 11 73,973,742 (GRCm39) missense possibly damaging 0.53
IGL03022:Zfp616 APN 11 73,973,800 (GRCm39) missense possibly damaging 0.85
R0197:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0442:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R0497:Zfp616 UTSW 11 73,974,306 (GRCm39) missense probably benign 0.00
R0651:Zfp616 UTSW 11 73,974,555 (GRCm39) nonsense probably null
R0730:Zfp616 UTSW 11 73,975,648 (GRCm39) missense probably damaging 1.00
R0883:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0926:Zfp616 UTSW 11 73,976,644 (GRCm39) missense probably benign 0.04
R0940:Zfp616 UTSW 11 73,975,850 (GRCm39) missense probably damaging 1.00
R1068:Zfp616 UTSW 11 73,973,767 (GRCm39) makesense probably null
R1272:Zfp616 UTSW 11 73,976,062 (GRCm39) missense probably benign 0.08
R1446:Zfp616 UTSW 11 73,974,064 (GRCm39) splice site probably null
R1482:Zfp616 UTSW 11 73,974,803 (GRCm39) missense possibly damaging 0.72
R1553:Zfp616 UTSW 11 73,974,744 (GRCm39) missense possibly damaging 0.53
R1564:Zfp616 UTSW 11 73,975,548 (GRCm39) missense probably damaging 1.00
R1728:Zfp616 UTSW 11 73,976,597 (GRCm39) missense probably damaging 0.99
R1796:Zfp616 UTSW 11 73,976,671 (GRCm39) missense probably damaging 0.98
R1797:Zfp616 UTSW 11 73,976,105 (GRCm39) nonsense probably null
R1993:Zfp616 UTSW 11 73,975,795 (GRCm39) missense probably benign 0.08
R2026:Zfp616 UTSW 11 73,974,413 (GRCm39) missense possibly damaging 0.86
R2124:Zfp616 UTSW 11 73,973,869 (GRCm39) splice site probably null
R2126:Zfp616 UTSW 11 73,976,229 (GRCm39) missense probably benign 0.08
R2199:Zfp616 UTSW 11 73,975,456 (GRCm39) missense possibly damaging 0.58
R2265:Zfp616 UTSW 11 73,976,289 (GRCm39) missense possibly damaging 0.89
R2404:Zfp616 UTSW 11 73,975,682 (GRCm39) missense probably damaging 1.00
R2508:Zfp616 UTSW 11 73,974,121 (GRCm39) missense probably benign 0.01
R2519:Zfp616 UTSW 11 73,975,094 (GRCm39) nonsense probably null
R3103:Zfp616 UTSW 11 73,962,561 (GRCm39) missense probably benign 0.01
R3611:Zfp616 UTSW 11 73,974,268 (GRCm39) missense possibly damaging 0.53
R3703:Zfp616 UTSW 11 73,974,145 (GRCm39) nonsense probably null
R3744:Zfp616 UTSW 11 73,974,813 (GRCm39) missense probably benign 0.01
R4043:Zfp616 UTSW 11 73,976,108 (GRCm39) missense possibly damaging 0.50
R4273:Zfp616 UTSW 11 73,974,526 (GRCm39) missense probably benign 0.00
R4384:Zfp616 UTSW 11 73,974,005 (GRCm39) missense possibly damaging 0.94
R4469:Zfp616 UTSW 11 73,961,950 (GRCm39) missense probably damaging 0.98
R4560:Zfp616 UTSW 11 73,973,860 (GRCm39) missense probably benign 0.00
R4821:Zfp616 UTSW 11 73,975,033 (GRCm39) missense probably benign 0.41
R4844:Zfp616 UTSW 11 73,975,225 (GRCm39) missense probably benign 0.10
R4948:Zfp616 UTSW 11 73,974,830 (GRCm39) missense possibly damaging 0.72
R5007:Zfp616 UTSW 11 73,974,643 (GRCm39) missense possibly damaging 0.96
R5198:Zfp616 UTSW 11 73,974,336 (GRCm39) missense probably benign 0.33
R5344:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R5918:Zfp616 UTSW 11 73,974,086 (GRCm39) missense possibly damaging 0.70
R5933:Zfp616 UTSW 11 73,973,952 (GRCm39) missense probably damaging 0.96
R6084:Zfp616 UTSW 11 73,974,672 (GRCm39) nonsense probably null
R6421:Zfp616 UTSW 11 73,974,696 (GRCm39) missense possibly damaging 0.53
R6494:Zfp616 UTSW 11 73,976,018 (GRCm39) missense probably damaging 1.00
R6523:Zfp616 UTSW 11 73,973,968 (GRCm39) missense possibly damaging 0.79
R6849:Zfp616 UTSW 11 73,976,276 (GRCm39) missense possibly damaging 0.70
R6910:Zfp616 UTSW 11 73,975,828 (GRCm39) missense probably damaging 1.00
R7146:Zfp616 UTSW 11 73,976,087 (GRCm39) missense possibly damaging 0.61
R7213:Zfp616 UTSW 11 73,976,689 (GRCm39) missense probably benign 0.05
R7302:Zfp616 UTSW 11 73,976,205 (GRCm39) missense probably benign 0.08
R7391:Zfp616 UTSW 11 73,976,155 (GRCm39) missense probably benign 0.08
R7654:Zfp616 UTSW 11 73,974,013 (GRCm39) missense possibly damaging 0.53
R7877:Zfp616 UTSW 11 73,975,188 (GRCm39) missense probably damaging 1.00
R7889:Zfp616 UTSW 11 73,976,271 (GRCm39) missense probably damaging 1.00
R8022:Zfp616 UTSW 11 73,974,894 (GRCm39) missense probably benign
R8061:Zfp616 UTSW 11 73,974,340 (GRCm39) missense possibly damaging 0.96
R8212:Zfp616 UTSW 11 73,976,569 (GRCm39) missense probably damaging 0.96
R8335:Zfp616 UTSW 11 73,974,726 (GRCm39) nonsense probably null
R8361:Zfp616 UTSW 11 73,975,476 (GRCm39) missense probably damaging 0.98
R8486:Zfp616 UTSW 11 73,974,909 (GRCm39) missense probably benign 0.18
R8695:Zfp616 UTSW 11 73,975,710 (GRCm39) missense probably benign 0.45
R8808:Zfp616 UTSW 11 73,976,523 (GRCm39) missense probably damaging 1.00
R9126:Zfp616 UTSW 11 73,976,280 (GRCm39) missense probably damaging 1.00
R9164:Zfp616 UTSW 11 73,975,825 (GRCm39) missense probably damaging 1.00
R9293:Zfp616 UTSW 11 73,974,744 (GRCm39) missense possibly damaging 0.53
R9421:Zfp616 UTSW 11 73,974,331 (GRCm39) missense possibly damaging 0.72
R9512:Zfp616 UTSW 11 73,975,936 (GRCm39) missense probably damaging 1.00
R9529:Zfp616 UTSW 11 73,976,596 (GRCm39) missense possibly damaging 0.90
R9529:Zfp616 UTSW 11 73,975,660 (GRCm39) missense probably damaging 1.00
R9606:Zfp616 UTSW 11 73,976,220 (GRCm39) missense probably damaging 1.00
R9708:Zfp616 UTSW 11 73,976,283 (GRCm39) missense probably damaging 1.00
R9788:Zfp616 UTSW 11 73,975,276 (GRCm39) missense probably damaging 0.99
Z1176:Zfp616 UTSW 11 73,976,467 (GRCm39) missense possibly damaging 0.90
Z1176:Zfp616 UTSW 11 73,974,045 (GRCm39) missense possibly damaging 0.72
Z1176:Zfp616 UTSW 11 73,973,859 (GRCm39) missense probably benign
Z1177:Zfp616 UTSW 11 73,975,878 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- GTGGTAAATATTTTGCCCGTTCCTC -3'
(R):5'- GATTACTGGGTAAATGATTTCCCAC -3'

Sequencing Primer
(F):5'- CGTTCCTCAAGTCTTAAAGATCAC -3'
(R):5'- GAGGACTGTGTAAATGATTTCCCAC -3'
Posted On 2021-10-11