Incidental Mutation 'R8719:Or14j8'
ID 670044
Institutional Source Beutler Lab
Gene Symbol Or14j8
Ensembl Gene ENSMUSG00000109376
Gene Name olfactory receptor family 14 subfamily J member 8
Synonyms Olfr1552-ps1, MOR218-6P, GA_x6K02T2PSCP-2403971-2403000, Olfr761, MOR218-12, MOR218-5P, MOR218-6P
MMRRC Submission 068614-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.784) question?
Stock # R8719 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38262942-38263913 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38263895 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 7 (T7A)
Ref Sequence ENSEMBL: ENSMUSP00000092917 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049620]
AlphaFold Q7TRJ0
Predicted Effect probably damaging
Transcript: ENSMUST00000049620
AA Change: T7A

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000092917
Gene: ENSMUSG00000109376
AA Change: T7A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.8e-45 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.1e-6 PFAM
Pfam:7tm_1 41 290 3.7e-22 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl1 T C 8: 46,966,700 (GRCm39) I224T probably benign Het
Adamts20 C G 15: 94,241,903 (GRCm39) A702P probably damaging Het
Ahdc1 T A 4: 132,791,533 (GRCm39) Y925N possibly damaging Het
Anapc1 T C 2: 128,483,369 (GRCm39) E1242G probably damaging Het
Angptl2 A G 2: 33,133,914 (GRCm39) N412S possibly damaging Het
Aox3 T C 1: 58,158,696 (GRCm39) V89A probably damaging Het
Atxn1l A T 8: 110,459,861 (GRCm39) S134T possibly damaging Het
Brf1 C A 12: 112,943,304 (GRCm39) probably benign Het
Cab39l A T 14: 59,734,314 (GRCm39) H11L probably benign Het
Cabcoco1 A G 10: 68,272,671 (GRCm39) probably benign Het
Ccdc150 C A 1: 54,302,668 (GRCm39) P96Q probably benign Het
Chek2 T C 5: 111,014,908 (GRCm39) V459A probably damaging Het
Cntnap2 A T 6: 45,978,161 (GRCm39) D272V probably damaging Het
Cspp1 T C 1: 10,160,516 (GRCm39) S572P possibly damaging Het
Cysltr2 T C 14: 73,267,111 (GRCm39) T200A possibly damaging Het
Dglucy T C 12: 100,804,821 (GRCm39) L104P probably damaging Het
Dnah8 T A 17: 30,960,289 (GRCm39) M2222K probably damaging Het
Dync2h1 C A 9: 7,041,641 (GRCm39) V3334F probably benign Het
Ear2 A T 14: 44,340,734 (GRCm39) T131S possibly damaging Het
Eef1akmt2 A T 7: 132,452,340 (GRCm39) V92D probably damaging Het
Fam83c T A 2: 155,671,128 (GRCm39) Q769L probably benign Het
Fanca A T 8: 124,014,867 (GRCm39) C812S probably benign Het
Gm21663 T G 5: 26,146,162 (GRCm39) R50S probably damaging Het
Gm5591 T G 7: 38,221,614 (GRCm39) S152R probably benign Het
Gm6370 T G 5: 146,430,626 (GRCm39) D270E probably damaging Het
H2-T22 T C 17: 36,352,835 (GRCm39) I91V probably benign Het
Hdac5 T C 11: 102,097,963 (GRCm39) M61V probably benign Het
Hsd17b6 A G 10: 127,829,492 (GRCm39) S237P possibly damaging Het
Khk T A 5: 31,088,374 (GRCm39) F294I possibly damaging Het
Klc1 G A 12: 111,772,509 (GRCm39) probably benign Het
Lamb3 T C 1: 193,006,099 (GRCm39) W143R probably damaging Het
Lmo2 T C 2: 103,811,264 (GRCm39) I171T probably damaging Het
Meis1 A G 11: 18,835,587 (GRCm39) S344P probably benign Het
Nf1 C A 11: 79,281,119 (GRCm39) R125S possibly damaging Het
Nrcam A G 12: 44,586,325 (GRCm39) E105G probably benign Het
Nudt22 T C 19: 6,972,638 (GRCm39) D150G possibly damaging Het
Or5an1 A G 19: 12,260,792 (GRCm39) I127V probably benign Het
Or5b109 A G 19: 13,211,836 (GRCm39) Y74C probably damaging Het
Pclo A T 5: 14,763,778 (GRCm39) R799* probably null Het
Pelp1 T C 11: 70,292,789 (GRCm39) N175S probably damaging Het
Perm1 TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT TGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCTGAGCCTGACACGGCTTTGTCTACACCCGCCTCT 4: 156,302,525 (GRCm39) probably benign Het
Pik3r4 C A 9: 105,559,394 (GRCm39) S1162R probably benign Het
Pkd1l3 A T 8: 110,341,255 (GRCm39) N36I unknown Het
Pomk T A 8: 26,473,503 (GRCm39) Y150F possibly damaging Het
Rdh11 T A 12: 79,229,574 (GRCm39) H233L probably benign Het
Rln1 A T 19: 29,309,281 (GRCm39) M166K probably benign Het
Rnf40 T A 7: 127,191,834 (GRCm39) L356Q probably damaging Het
Sin3b G T 8: 73,450,139 (GRCm39) G19W unknown Het
Slc6a15 A G 10: 103,240,176 (GRCm39) R300G probably damaging Het
Sncaip A T 18: 53,027,910 (GRCm39) K433M probably damaging Het
Tead2 A T 7: 44,882,316 (GRCm39) probably benign Het
Tespa1 A G 10: 130,184,108 (GRCm39) D63G probably benign Het
Tmem117 T C 15: 94,992,248 (GRCm39) F303L probably damaging Het
Tmem270 T G 5: 134,930,650 (GRCm39) T204P probably damaging Het
Trip12 A G 1: 84,722,790 (GRCm39) V1320A probably damaging Het
Ttc7b A G 12: 100,267,812 (GRCm39) L843P probably damaging Het
Ttn T C 2: 76,543,041 (GRCm39) Y33315C probably damaging Het
Ttn A G 2: 76,607,146 (GRCm39) V17959A possibly damaging Het
Vmn2r73 A G 7: 85,521,095 (GRCm39) V291A probably damaging Het
Ywhag T A 5: 135,939,998 (GRCm39) T199S probably benign Het
Zfp810 T C 9: 22,190,571 (GRCm39) T77A probably benign Het
Other mutations in Or14j8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01557:Or14j8 APN 17 38,263,742 (GRCm39) missense probably damaging 1.00
IGL02104:Or14j8 APN 17 38,263,182 (GRCm39) missense probably damaging 1.00
IGL02431:Or14j8 APN 17 38,263,413 (GRCm39) missense probably benign 0.06
IGL02649:Or14j8 APN 17 38,263,864 (GRCm39) missense probably damaging 1.00
IGL03109:Or14j8 APN 17 38,263,378 (GRCm39) missense probably damaging 1.00
IGL03261:Or14j8 APN 17 38,263,697 (GRCm39) missense possibly damaging 0.76
R0898:Or14j8 UTSW 17 38,263,127 (GRCm39) missense probably benign 0.17
R1373:Or14j8 UTSW 17 38,263,251 (GRCm39) missense probably damaging 1.00
R1527:Or14j8 UTSW 17 38,263,720 (GRCm39) missense possibly damaging 0.88
R1664:Or14j8 UTSW 17 38,263,784 (GRCm39) missense probably benign 0.44
R1835:Or14j8 UTSW 17 38,263,276 (GRCm39) missense possibly damaging 0.79
R4124:Or14j8 UTSW 17 38,263,681 (GRCm39) missense probably benign 0.16
R4125:Or14j8 UTSW 17 38,263,681 (GRCm39) missense probably benign 0.16
R4128:Or14j8 UTSW 17 38,263,681 (GRCm39) missense probably benign 0.16
R4534:Or14j8 UTSW 17 38,263,613 (GRCm39) missense probably benign
R4557:Or14j8 UTSW 17 38,263,142 (GRCm39) missense probably benign 0.10
R4790:Or14j8 UTSW 17 38,263,633 (GRCm39) missense probably damaging 0.99
R4856:Or14j8 UTSW 17 38,262,962 (GRCm39) missense probably benign 0.15
R4886:Or14j8 UTSW 17 38,262,962 (GRCm39) missense probably benign 0.15
R4955:Or14j8 UTSW 17 38,263,789 (GRCm39) missense probably damaging 1.00
R5162:Or14j8 UTSW 17 38,263,255 (GRCm39) missense probably benign 0.00
R6016:Or14j8 UTSW 17 38,262,967 (GRCm39) missense probably benign 0.13
R6282:Or14j8 UTSW 17 38,263,315 (GRCm39) missense possibly damaging 0.80
R7018:Or14j8 UTSW 17 38,263,393 (GRCm39) missense probably damaging 1.00
R7199:Or14j8 UTSW 17 38,263,048 (GRCm39) missense probably damaging 1.00
R7340:Or14j8 UTSW 17 38,263,413 (GRCm39) missense probably benign 0.06
R7360:Or14j8 UTSW 17 38,263,900 (GRCm39) missense probably damaging 1.00
R7464:Or14j8 UTSW 17 38,263,171 (GRCm39) missense probably damaging 1.00
R7974:Or14j8 UTSW 17 38,263,672 (GRCm39) missense probably damaging 1.00
R8738:Or14j8 UTSW 17 38,263,673 (GRCm39) missense possibly damaging 0.79
R8817:Or14j8 UTSW 17 38,263,273 (GRCm39) missense probably damaging 0.99
R8856:Or14j8 UTSW 17 38,263,091 (GRCm39) missense possibly damaging 0.87
R9006:Or14j8 UTSW 17 38,263,545 (GRCm39) nonsense probably null
R9432:Or14j8 UTSW 17 38,263,559 (GRCm39) missense probably damaging 1.00
X0064:Or14j8 UTSW 17 38,263,705 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAGAATGGAAAGGTGCTTCAG -3'
(R):5'- TAGCTTGATGAACTGCAATTCC -3'

Sequencing Primer
(F):5'- GGTGCTTCAGAAAGTAATACATTGG -3'
(R):5'- GCTTGATGAACTGCAATTCCTTAAAC -3'
Posted On 2021-04-30