Incidental Mutation 'R8964:Arhgef1'
| ID |
682603 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef1
|
| Ensembl Gene |
ENSMUSG00000040940 |
| Gene Name |
Rho guanine nucleotide exchange factor 1 |
| Synonyms |
Lbcl2, Lsc |
| MMRRC Submission |
068798-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.389)
|
| Stock # |
R8964 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
24602337-24626019 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 24622462 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 647
(E647G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000096280
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047873]
[ENSMUST00000098683]
[ENSMUST00000117419]
[ENSMUST00000117796]
[ENSMUST00000132751]
[ENSMUST00000205295]
[ENSMUST00000206508]
[ENSMUST00000206705]
|
| AlphaFold |
Q61210 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047873
AA Change: E588G
PolyPhen 2
Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000046469
Gene: ENSMUSG00000040940
AA Change: E588G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
13 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
40 |
230 |
1.3e-72 |
PFAM |
|
low complexity region
|
380 |
400 |
N/A |
INTRINSIC |
|
RhoGEF
|
419 |
603 |
1.87e-63 |
SMART |
|
PH
|
647 |
761 |
4.68e-5 |
SMART |
|
low complexity region
|
845 |
864 |
N/A |
INTRINSIC |
|
coiled coil region
|
867 |
890 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098683
AA Change: E647G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000096280
Gene: ENSMUSG00000040940
AA Change: E647G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
13 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
40 |
230 |
2.2e-78 |
PFAM |
|
PDB:3ODW|B
|
238 |
384 |
2e-57 |
PDB |
|
low complexity region
|
396 |
412 |
N/A |
INTRINSIC |
|
low complexity region
|
439 |
459 |
N/A |
INTRINSIC |
|
RhoGEF
|
478 |
662 |
1.87e-63 |
SMART |
|
PH
|
706 |
820 |
4.68e-5 |
SMART |
|
low complexity region
|
904 |
923 |
N/A |
INTRINSIC |
|
coiled coil region
|
926 |
949 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117419
AA Change: E588G
PolyPhen 2
Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000113366
Gene: ENSMUSG00000040940
AA Change: E588G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
13 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
40 |
230 |
1.3e-72 |
PFAM |
|
low complexity region
|
380 |
400 |
N/A |
INTRINSIC |
|
RhoGEF
|
419 |
603 |
1.87e-63 |
SMART |
|
PH
|
647 |
761 |
4.68e-5 |
SMART |
|
low complexity region
|
845 |
864 |
N/A |
INTRINSIC |
|
coiled coil region
|
867 |
890 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117796
AA Change: E644G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000113771
Gene: ENSMUSG00000040940
AA Change: E644G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
13 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
40 |
230 |
7.3e-73 |
PFAM |
|
low complexity region
|
393 |
409 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
RhoGEF
|
475 |
659 |
1.87e-63 |
SMART |
|
PH
|
703 |
817 |
4.68e-5 |
SMART |
|
low complexity region
|
901 |
920 |
N/A |
INTRINSIC |
|
coiled coil region
|
923 |
946 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132751
AA Change: E348G
PolyPhen 2
Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000117008
Gene: ENSMUSG00000040940
AA Change: E348G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
70 |
89 |
N/A |
INTRINSIC |
|
low complexity region
|
97 |
113 |
N/A |
INTRINSIC |
|
low complexity region
|
140 |
160 |
N/A |
INTRINSIC |
|
RhoGEF
|
179 |
363 |
1.87e-63 |
SMART |
|
PH
|
407 |
521 |
4.68e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205295
AA Change: E216G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206508
AA Change: E587G
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206705
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.2%
|
| Validation Efficiency |
100% (80/80) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in impaired humeral immunity, reduced numbers of marginal zone B (MZB) cells, decreased basal T cell proliferation, and reduced basal motility of lymphocytes but enhanced migration of MZB cells after serum activation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933402N03Rik |
C |
T |
7: 130,740,716 (GRCm39) |
V167M |
probably benign |
Het |
| Abca6 |
G |
A |
11: 110,139,363 (GRCm39) |
P37L |
probably benign |
Het |
| Abca9 |
A |
T |
11: 110,038,075 (GRCm39) |
Y490* |
probably null |
Het |
| Abcb11 |
A |
G |
2: 69,117,061 (GRCm39) |
V529A |
possibly damaging |
Het |
| Acox2 |
G |
T |
14: 8,243,768 (GRCm38) |
Y529* |
probably null |
Het |
| Acte1 |
A |
G |
7: 143,423,030 (GRCm39) |
T39A |
probably benign |
Het |
| Adck2 |
G |
T |
6: 39,551,083 (GRCm39) |
|
probably benign |
Het |
| Agxt |
T |
A |
1: 93,072,869 (GRCm39) |
C409S |
possibly damaging |
Het |
| Ahsa1 |
T |
A |
12: 87,318,131 (GRCm39) |
I164N |
probably damaging |
Het |
| Axin1 |
T |
G |
17: 26,361,718 (GRCm39) |
F21V |
probably damaging |
Het |
| B3galnt1 |
A |
G |
3: 69,482,589 (GRCm39) |
I224T |
probably damaging |
Het |
| Bche |
T |
C |
3: 73,608,406 (GRCm39) |
K340R |
probably benign |
Het |
| Bpifb5 |
T |
A |
2: 154,072,198 (GRCm39) |
W302R |
possibly damaging |
Het |
| Cd72 |
G |
A |
4: 43,450,218 (GRCm39) |
T230I |
probably damaging |
Het |
| Cdc42ep4 |
T |
A |
11: 113,620,278 (GRCm39) |
M38L |
probably damaging |
Het |
| Cdcp1 |
G |
A |
9: 123,012,561 (GRCm39) |
Q329* |
probably null |
Het |
| Clps |
C |
A |
17: 28,777,730 (GRCm39) |
|
probably benign |
Het |
| Cluap1 |
A |
G |
16: 3,729,334 (GRCm39) |
|
probably benign |
Het |
| CN725425 |
C |
T |
15: 91,119,972 (GRCm39) |
S31L |
possibly damaging |
Het |
| Cnbp |
T |
C |
6: 87,821,086 (GRCm39) |
N158D |
probably benign |
Het |
| Crebbp |
A |
G |
16: 3,909,753 (GRCm39) |
F1545S |
probably damaging |
Het |
| Cyp39a1 |
A |
T |
17: 44,002,558 (GRCm39) |
T258S |
probably benign |
Het |
| Dclk2 |
T |
C |
3: 86,743,698 (GRCm39) |
D257G |
probably damaging |
Het |
| Dock7 |
A |
T |
4: 98,949,476 (GRCm39) |
D455E |
|
Het |
| Ehbp1 |
G |
A |
11: 22,101,154 (GRCm39) |
Q259* |
probably null |
Het |
| Eif3a |
A |
T |
19: 60,751,630 (GRCm39) |
D1228E |
unknown |
Het |
| Has2 |
A |
T |
15: 56,531,061 (GRCm39) |
D551E |
probably damaging |
Het |
| Herc1 |
T |
A |
9: 66,352,872 (GRCm39) |
N2119K |
probably damaging |
Het |
| Hsdl1 |
C |
T |
8: 120,292,899 (GRCm39) |
A179T |
probably benign |
Het |
| Htt |
T |
A |
5: 35,062,720 (GRCm39) |
M2818K |
probably benign |
Het |
| Il18bp |
A |
G |
7: 101,665,591 (GRCm39) |
S80P |
possibly damaging |
Het |
| Ints10 |
A |
G |
8: 69,264,631 (GRCm39) |
M455V |
probably benign |
Het |
| Ipcef1 |
T |
C |
10: 6,869,789 (GRCm39) |
T255A |
possibly damaging |
Het |
| Krt1 |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
15: 101,758,813 (GRCm39) |
|
probably benign |
Het |
| Lrba |
T |
A |
3: 86,258,552 (GRCm39) |
D1346E |
probably benign |
Het |
| Mdm1 |
T |
A |
10: 118,002,585 (GRCm39) |
D635E |
probably damaging |
Het |
| Met |
C |
T |
6: 17,527,144 (GRCm39) |
P532S |
probably damaging |
Het |
| Nlrc5 |
T |
A |
8: 95,232,116 (GRCm39) |
M1314K |
possibly damaging |
Het |
| Notch1 |
A |
T |
2: 26,371,062 (GRCm39) |
S341R |
possibly damaging |
Het |
| Nr3c2 |
T |
G |
8: 77,881,941 (GRCm39) |
L670V |
probably damaging |
Het |
| Nuak1 |
C |
T |
10: 84,210,734 (GRCm39) |
M451I |
probably benign |
Het |
| Nubp1 |
G |
A |
16: 10,238,894 (GRCm39) |
V170I |
probably benign |
Het |
| Or5v1 |
G |
A |
17: 37,809,664 (GRCm39) |
G41S |
probably damaging |
Het |
| Or9g8 |
T |
A |
2: 85,606,964 (GRCm39) |
I12N |
probably damaging |
Het |
| Pamr1 |
T |
C |
2: 102,464,811 (GRCm39) |
V320A |
possibly damaging |
Het |
| Pcdhb11 |
T |
A |
18: 37,556,660 (GRCm39) |
N663K |
probably benign |
Het |
| Pcnx1 |
G |
A |
12: 82,039,812 (GRCm39) |
G1400D |
|
Het |
| Pdxk |
A |
T |
10: 78,283,771 (GRCm39) |
V141E |
probably benign |
Het |
| Pex5 |
A |
T |
6: 124,375,740 (GRCm39) |
N520K |
probably benign |
Het |
| Pklr |
T |
C |
3: 89,050,036 (GRCm39) |
V337A |
probably benign |
Het |
| Polb |
T |
C |
8: 23,143,341 (GRCm39) |
D17G |
probably damaging |
Het |
| Ppp1r9b |
T |
C |
11: 94,882,705 (GRCm39) |
L111P |
probably damaging |
Het |
| Prl3d1 |
A |
G |
13: 27,283,926 (GRCm39) |
E165G |
possibly damaging |
Het |
| Prpf40a |
A |
G |
2: 53,035,906 (GRCm39) |
F657S |
probably damaging |
Het |
| Ptgs2 |
C |
T |
1: 149,980,798 (GRCm39) |
R455C |
probably damaging |
Het |
| Pzp |
T |
A |
6: 128,464,462 (GRCm39) |
D1355V |
probably benign |
Het |
| Rasl12 |
T |
A |
9: 65,314,913 (GRCm39) |
V72D |
probably damaging |
Het |
| Rfx2 |
C |
A |
17: 57,093,696 (GRCm39) |
R266L |
probably damaging |
Het |
| Rnaseh2a |
T |
C |
8: 85,686,434 (GRCm39) |
D204G |
probably benign |
Het |
| S1pr3 |
A |
C |
13: 51,573,248 (GRCm39) |
K143T |
probably damaging |
Het |
| Sdr39u1 |
C |
A |
14: 56,135,170 (GRCm39) |
A258S |
possibly damaging |
Het |
| Sntb2 |
T |
A |
8: 107,707,808 (GRCm39) |
S191T |
possibly damaging |
Het |
| Sod3 |
T |
A |
5: 52,525,696 (GRCm39) |
F132I |
probably damaging |
Het |
| Sorcs2 |
C |
T |
5: 36,386,511 (GRCm39) |
V176I |
possibly damaging |
Het |
| Syne1 |
T |
C |
10: 5,060,872 (GRCm39) |
I7256V |
|
Het |
| Tbc1d22b |
A |
G |
17: 29,819,202 (GRCm39) |
E459G |
probably damaging |
Het |
| Tbkbp1 |
A |
G |
11: 97,037,169 (GRCm39) |
S278P |
probably damaging |
Het |
| Thoc5 |
A |
T |
11: 4,860,647 (GRCm39) |
E245D |
possibly damaging |
Het |
| Tmc7 |
G |
A |
7: 118,160,228 (GRCm39) |
P203L |
probably benign |
Het |
| Tns2 |
T |
C |
15: 102,011,553 (GRCm39) |
L11P |
possibly damaging |
Het |
| Trip11 |
A |
G |
12: 101,811,315 (GRCm39) |
|
probably null |
Het |
| Ttn |
T |
G |
2: 76,551,309 (GRCm39) |
Y31361S |
probably damaging |
Het |
| Vars2 |
T |
C |
17: 35,970,699 (GRCm39) |
E678G |
possibly damaging |
Het |
| Vav1 |
C |
A |
17: 57,606,122 (GRCm39) |
H249N |
probably benign |
Het |
| Vmn2r9 |
T |
A |
5: 108,996,031 (GRCm39) |
I206L |
probably benign |
Het |
| Vps4a |
T |
C |
8: 107,771,686 (GRCm39) |
S410P |
probably damaging |
Het |
| Wdr82 |
T |
C |
9: 106,053,861 (GRCm39) |
Y71H |
possibly damaging |
Het |
| Zfand1 |
A |
G |
3: 10,413,631 (GRCm39) |
Y19H |
probably benign |
Het |
| Zfp365 |
A |
T |
10: 67,745,088 (GRCm39) |
I230N |
probably damaging |
Het |
| Zfp763 |
T |
C |
17: 33,240,710 (GRCm39) |
T40A |
probably benign |
Het |
| Zfp788 |
A |
T |
7: 41,297,003 (GRCm39) |
D51V |
probably damaging |
Het |
|
| Other mutations in Arhgef1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00421:Arhgef1
|
APN |
7 |
24,607,784 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00901:Arhgef1
|
APN |
7 |
24,612,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01139:Arhgef1
|
APN |
7 |
24,625,376 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01479:Arhgef1
|
APN |
7 |
24,612,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01935:Arhgef1
|
APN |
7 |
24,621,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01944:Arhgef1
|
APN |
7 |
24,625,208 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02032:Arhgef1
|
APN |
7 |
24,622,796 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL02059:Arhgef1
|
APN |
7 |
24,611,977 (GRCm39) |
splice site |
probably benign |
|
|
IGL02202:Arhgef1
|
APN |
7 |
24,612,854 (GRCm39) |
nonsense |
probably null |
|
|
IGL02324:Arhgef1
|
APN |
7 |
24,623,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02328:Arhgef1
|
APN |
7 |
24,623,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03027:Arhgef1
|
APN |
7 |
24,623,157 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03227:Arhgef1
|
APN |
7 |
24,622,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03404:Arhgef1
|
APN |
7 |
24,616,268 (GRCm39) |
missense |
probably benign |
0.07 |
|
BB009:Arhgef1
|
UTSW |
7 |
24,619,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB019:Arhgef1
|
UTSW |
7 |
24,619,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0082:Arhgef1
|
UTSW |
7 |
24,612,030 (GRCm39) |
nonsense |
probably null |
|
|
R0277:Arhgef1
|
UTSW |
7 |
24,623,224 (GRCm39) |
unclassified |
probably benign |
|
|
R0336:Arhgef1
|
UTSW |
7 |
24,621,382 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0494:Arhgef1
|
UTSW |
7 |
24,618,785 (GRCm39) |
intron |
probably benign |
|
|
R0668:Arhgef1
|
UTSW |
7 |
24,607,345 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1520:Arhgef1
|
UTSW |
7 |
24,619,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1531:Arhgef1
|
UTSW |
7 |
24,624,423 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1656:Arhgef1
|
UTSW |
7 |
24,613,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2979:Arhgef1
|
UTSW |
7 |
24,607,176 (GRCm39) |
missense |
unknown |
|
|
R3855:Arhgef1
|
UTSW |
7 |
24,618,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3856:Arhgef1
|
UTSW |
7 |
24,618,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4080:Arhgef1
|
UTSW |
7 |
24,625,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4081:Arhgef1
|
UTSW |
7 |
24,625,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4583:Arhgef1
|
UTSW |
7 |
24,611,996 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4750:Arhgef1
|
UTSW |
7 |
24,618,001 (GRCm39) |
intron |
probably benign |
|
|
R4914:Arhgef1
|
UTSW |
7 |
24,623,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5255:Arhgef1
|
UTSW |
7 |
24,624,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5275:Arhgef1
|
UTSW |
7 |
24,618,777 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5295:Arhgef1
|
UTSW |
7 |
24,618,777 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5430:Arhgef1
|
UTSW |
7 |
24,611,732 (GRCm39) |
splice site |
probably null |
|
|
R5604:Arhgef1
|
UTSW |
7 |
24,612,210 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6150:Arhgef1
|
UTSW |
7 |
24,618,782 (GRCm39) |
splice site |
probably null |
|
|
R6151:Arhgef1
|
UTSW |
7 |
24,617,367 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6788:Arhgef1
|
UTSW |
7 |
24,619,205 (GRCm39) |
splice site |
probably null |
|
|
R6943:Arhgef1
|
UTSW |
7 |
24,623,156 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6988:Arhgef1
|
UTSW |
7 |
24,616,348 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7422:Arhgef1
|
UTSW |
7 |
24,615,461 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7701:Arhgef1
|
UTSW |
7 |
24,612,003 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7706:Arhgef1
|
UTSW |
7 |
24,616,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7707:Arhgef1
|
UTSW |
7 |
24,616,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7708:Arhgef1
|
UTSW |
7 |
24,616,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7932:Arhgef1
|
UTSW |
7 |
24,619,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Arhgef1
|
UTSW |
7 |
24,616,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7970:Arhgef1
|
UTSW |
7 |
24,616,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7995:Arhgef1
|
UTSW |
7 |
24,618,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8029:Arhgef1
|
UTSW |
7 |
24,619,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8132:Arhgef1
|
UTSW |
7 |
24,619,174 (GRCm39) |
nonsense |
probably null |
|
|
R8132:Arhgef1
|
UTSW |
7 |
24,607,087 (GRCm39) |
intron |
probably benign |
|
|
R8168:Arhgef1
|
UTSW |
7 |
24,624,831 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9114:Arhgef1
|
UTSW |
7 |
24,607,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9553:Arhgef1
|
UTSW |
7 |
24,619,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9676:Arhgef1
|
UTSW |
7 |
24,625,501 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAGCGACTGACCAAGTAC -3'
(R):5'- TGATATAAGGCCAACTGCAGG -3'
Sequencing Primer
(F):5'- GTACCCACTGCTGCTACAGAG -3'
(R):5'- TGAGGTCCAGATCTGACCTC -3'
|
| Posted On |
2021-10-11 |
Incidental Mutation