Incidental Mutation 'R9022:Kif16b'
ID 686254
Institutional Source Beutler Lab
Gene Symbol Kif16b
Ensembl Gene ENSMUSG00000038844
Gene Name kinesin family member 16B
Synonyms N-3 kinesin, 8430434E15Rik
MMRRC Submission 068852-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9022 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 142460260-142743535 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 142554537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 754 (E754K)
Ref Sequence ENSEMBL: ENSMUSP00000042551 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043589] [ENSMUST00000211861] [ENSMUST00000230763]
AlphaFold B1AVY7
Predicted Effect possibly damaging
Transcript: ENSMUST00000043589
AA Change: E754K

PolyPhen 2 Score 0.460 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000042551
Gene: ENSMUSG00000038844
AA Change: E754K

DomainStartEndE-ValueType
KISc 1 366 4.87e-173 SMART
FHA 477 529 1.43e-1 SMART
coiled coil region 597 809 N/A INTRINSIC
coiled coil region 835 858 N/A INTRINSIC
coiled coil region 941 1022 N/A INTRINSIC
PX 1179 1281 1.58e-5 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000211861
AA Change: E754K

PolyPhen 2 Score 0.873 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000230763
AA Change: E765K

PolyPhen 2 Score 0.595 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 100% (84/84)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
PHENOTYPE: Chimera embryos containing a knock-out allele and derived from tetraploid rescue exhibit lethal growth arrest at the blastocyst stage with abnormal development of the primitive endoderm, epiblast epithelium, and basement membrane. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl6a G T 3: 32,769,649 (GRCm39) A155S probably benign Het
Adar A G 3: 89,643,045 (GRCm39) T309A probably benign Het
Adgrv1 A T 13: 81,303,312 (GRCm39) W6125R probably damaging Het
Adprhl1 A G 8: 13,274,352 (GRCm39) L802P probably benign Het
Ahcy A G 2: 154,910,779 (GRCm39) L63P probably damaging Het
Ang5 G A 14: 44,200,352 (GRCm39) D139N probably damaging Het
Ankrd31 A G 13: 96,962,655 (GRCm39) D482G probably benign Het
Arhgef7 A G 8: 11,850,469 (GRCm39) N257D probably benign Het
Art3 C A 5: 92,540,393 (GRCm39) S45R probably benign Het
Atxn1 T C 13: 45,720,891 (GRCm39) R335G probably damaging Het
Bag6 T A 17: 35,363,641 (GRCm39) L775H probably damaging Het
BC004004 T G 17: 29,501,130 (GRCm39) H26Q possibly damaging Het
Camsap3 T C 8: 3,656,575 (GRCm39) L986S probably benign Het
Cbx5 T C 15: 103,121,586 (GRCm39) E17G probably damaging Het
Cc2d1b T C 4: 108,484,617 (GRCm39) probably null Het
Ccdc59 T C 10: 105,683,007 (GRCm39) Y231H probably damaging Het
Cemip2 T C 19: 21,789,986 (GRCm39) probably null Het
Csnk1g1 T C 9: 65,917,854 (GRCm39) probably null Het
Cybrd1 A G 2: 70,967,904 (GRCm39) I158M possibly damaging Het
Disp2 T A 2: 118,621,179 (GRCm39) I637N probably benign Het
Dll4 TC T 2: 119,163,054 (GRCm39) probably null Het
Dnah7a T C 1: 53,512,116 (GRCm39) probably null Het
Duox2 C A 2: 122,110,919 (GRCm39) *1518L probably null Het
Dym A G 18: 75,258,507 (GRCm39) I422V probably benign Het
Entpd8 A C 2: 24,975,144 (GRCm39) I492L probably benign Het
Fabp12 A G 3: 10,317,333 (GRCm39) S13P probably damaging Het
Fam124b A G 1: 80,190,705 (GRCm39) I226T probably damaging Het
Fer1l6 T C 15: 58,455,329 (GRCm39) L763P probably damaging Het
Git2 A G 5: 114,907,676 (GRCm39) probably null Het
Gltpd2 A T 11: 70,410,153 (GRCm39) Y37F probably benign Het
Gm44511 T G 6: 128,797,271 (GRCm39) Q72H possibly damaging Het
Grid2ip A T 5: 143,366,204 (GRCm39) T565S probably benign Het
Grk6 T C 13: 55,606,877 (GRCm39) S532P possibly damaging Het
Haspin A T 11: 73,026,831 (GRCm39) F753I probably damaging Het
Herpud1 T A 8: 95,116,197 (GRCm39) S92T possibly damaging Het
Heyl C T 4: 123,139,768 (GRCm39) A109V probably damaging Het
Hivep3 T C 4: 119,955,304 (GRCm39) S1207P probably benign Het
Hk1 A G 10: 62,105,768 (GRCm39) S893P probably damaging Het
Itih1 C A 14: 30,652,327 (GRCm39) V789L probably benign Het
Kif12 T C 4: 63,090,121 (GRCm39) D10G possibly damaging Het
Kif20a A G 18: 34,760,898 (GRCm39) Q191R probably benign Het
Lap3 A G 5: 45,652,548 (GRCm39) D48G probably benign Het
Matn3 T A 12: 9,002,355 (GRCm39) V189E probably damaging Het
Mbp G A 18: 82,597,067 (GRCm39) E143K possibly damaging Het
Mrgprd A G 7: 144,875,555 (GRCm39) H142R probably benign Het
Nbea A T 3: 55,551,110 (GRCm39) C2685S possibly damaging Het
Nhsl1 A C 10: 18,403,409 (GRCm39) I1381L possibly damaging Het
Npc1 A G 18: 12,346,422 (GRCm39) M258T probably benign Het
Or2w3 T C 11: 58,556,550 (GRCm39) L55P probably damaging Het
Or7e178 T A 9: 20,225,268 (GRCm39) N316I probably damaging Het
Osbpl10 C T 9: 114,807,939 (GRCm39) A65V unknown Het
Pdia4 C G 6: 47,785,149 (GRCm39) A73P probably benign Het
Plxnb2 T C 15: 89,048,471 (GRCm39) Y646C possibly damaging Het
Pmm1 C T 15: 81,839,896 (GRCm39) R143H probably damaging Het
Pold2 T C 11: 5,824,121 (GRCm39) D228G probably benign Het
Popdc2 T G 16: 38,194,508 (GRCm39) C310G probably benign Het
Prdm10 A G 9: 31,268,424 (GRCm39) Y791C probably benign Het
Psg19 C T 7: 18,530,762 (GRCm39) V131I probably benign Het
Psg19 T A 7: 18,531,044 (GRCm39) T37S probably benign Het
Psme1 A G 14: 55,817,271 (GRCm39) E39G probably damaging Het
Rabep2 A G 7: 126,043,719 (GRCm39) E472G probably damaging Het
Rap1gap T C 4: 137,445,309 (GRCm39) F297S probably damaging Het
Reln A G 5: 22,181,613 (GRCm39) S1757P possibly damaging Het
Rybp G T 6: 100,210,074 (GRCm39) D95E possibly damaging Het
Slc12a8 T A 16: 33,466,934 (GRCm39) D480E probably benign Het
Slc25a1 A G 16: 17,745,294 (GRCm39) V80A probably benign Het
Slc25a24 A T 3: 109,070,757 (GRCm39) D372V probably benign Het
Slc49a4 T C 16: 35,570,912 (GRCm39) T131A probably benign Het
Stab1 T C 14: 30,882,226 (GRCm39) T490A probably benign Het
Stat5b A T 11: 100,681,634 (GRCm39) I540N probably benign Het
Tasor2 A G 13: 3,626,659 (GRCm39) V1097A probably benign Het
Thy1 T A 9: 43,957,947 (GRCm39) L25Q probably damaging Het
Trim30a A G 7: 104,084,956 (GRCm39) S85P probably benign Het
Use1 G A 8: 71,819,942 (GRCm39) V36I probably benign Het
Vmn1r228 T A 17: 20,996,778 (GRCm39) I247F probably damaging Het
Vmn2r13 T A 5: 109,304,242 (GRCm39) T730S possibly damaging Het
Vmn2r9 T C 5: 108,992,923 (GRCm39) D529G possibly damaging Het
Washc5 A G 15: 59,217,233 (GRCm39) I778T possibly damaging Het
Washc5 A T 15: 59,233,069 (GRCm39) M294K probably damaging Het
Wnt8a A T 18: 34,680,298 (GRCm39) D221V probably damaging Het
Zfp616 A G 11: 73,976,539 (GRCm39) K936R probably damaging Het
Zfp618 G A 4: 63,012,687 (GRCm39) C133Y probably damaging Het
Zfp82 A G 7: 29,761,714 (GRCm39) S56P probably damaging Het
Zkscan16 T A 4: 58,957,021 (GRCm39) D434E probably benign Het
Other mutations in Kif16b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00466:Kif16b APN 2 142,689,955 (GRCm39) nonsense probably null
IGL00499:Kif16b APN 2 142,699,244 (GRCm39) missense probably damaging 1.00
IGL00913:Kif16b APN 2 142,545,927 (GRCm39) nonsense probably null
IGL00971:Kif16b APN 2 142,553,664 (GRCm39) missense probably benign 0.01
IGL01712:Kif16b APN 2 142,490,391 (GRCm39) missense probably damaging 1.00
IGL01965:Kif16b APN 2 142,690,325 (GRCm39) missense probably damaging 1.00
IGL02428:Kif16b APN 2 142,514,280 (GRCm39) missense possibly damaging 0.88
IGL02576:Kif16b APN 2 142,704,465 (GRCm39) splice site probably benign
IGL02884:Kif16b APN 2 142,544,534 (GRCm39) splice site probably benign
IGL03065:Kif16b APN 2 142,461,833 (GRCm39) missense probably damaging 1.00
IGL03103:Kif16b APN 2 142,704,408 (GRCm39) missense probably damaging 1.00
IGL03403:Kif16b APN 2 142,553,789 (GRCm39) missense probably damaging 1.00
IGL02835:Kif16b UTSW 2 142,554,133 (GRCm39) missense probably benign 0.00
R0058:Kif16b UTSW 2 142,699,225 (GRCm39) splice site probably null
R0058:Kif16b UTSW 2 142,699,225 (GRCm39) splice site probably null
R0081:Kif16b UTSW 2 142,549,346 (GRCm39) splice site probably benign
R0123:Kif16b UTSW 2 142,514,295 (GRCm39) missense probably benign
R0134:Kif16b UTSW 2 142,514,295 (GRCm39) missense probably benign
R0388:Kif16b UTSW 2 142,582,857 (GRCm39) missense probably damaging 1.00
R0396:Kif16b UTSW 2 142,695,579 (GRCm39) missense probably damaging 1.00
R0502:Kif16b UTSW 2 142,554,075 (GRCm39) missense probably benign 0.00
R1027:Kif16b UTSW 2 142,696,458 (GRCm39) splice site probably benign
R1674:Kif16b UTSW 2 142,554,873 (GRCm39) nonsense probably null
R1752:Kif16b UTSW 2 142,532,586 (GRCm39) missense probably benign 0.01
R2154:Kif16b UTSW 2 142,532,500 (GRCm39) missense probably damaging 1.00
R2262:Kif16b UTSW 2 142,582,837 (GRCm39) missense probably damaging 1.00
R2401:Kif16b UTSW 2 142,598,042 (GRCm39) missense probably benign 0.04
R3951:Kif16b UTSW 2 142,549,279 (GRCm39) missense probably benign 0.01
R4161:Kif16b UTSW 2 142,549,324 (GRCm39) missense probably benign 0.00
R4697:Kif16b UTSW 2 142,532,614 (GRCm39) missense probably benign 0.09
R4747:Kif16b UTSW 2 142,699,346 (GRCm39) missense probably damaging 1.00
R4808:Kif16b UTSW 2 142,699,278 (GRCm39) missense probably damaging 1.00
R4878:Kif16b UTSW 2 142,689,923 (GRCm39) missense probably damaging 1.00
R5068:Kif16b UTSW 2 142,553,627 (GRCm39) missense probably benign
R5120:Kif16b UTSW 2 142,690,259 (GRCm39) missense probably damaging 1.00
R5358:Kif16b UTSW 2 142,582,889 (GRCm39) missense probably damaging 1.00
R5821:Kif16b UTSW 2 142,544,586 (GRCm39) missense probably damaging 1.00
R5833:Kif16b UTSW 2 142,549,287 (GRCm39) missense probably benign
R5882:Kif16b UTSW 2 142,549,178 (GRCm39) critical splice donor site probably null
R5974:Kif16b UTSW 2 142,699,301 (GRCm39) missense probably damaging 1.00
R6043:Kif16b UTSW 2 142,553,820 (GRCm39) missense probably damaging 1.00
R6230:Kif16b UTSW 2 142,691,832 (GRCm39) missense probably damaging 1.00
R6373:Kif16b UTSW 2 142,541,618 (GRCm39) missense possibly damaging 0.91
R6472:Kif16b UTSW 2 142,541,868 (GRCm39) intron probably benign
R6622:Kif16b UTSW 2 142,554,362 (GRCm39) missense probably benign 0.01
R6654:Kif16b UTSW 2 142,543,197 (GRCm39) intron probably benign
R6912:Kif16b UTSW 2 142,542,019 (GRCm39) intron probably benign
R7003:Kif16b UTSW 2 142,600,749 (GRCm39) missense possibly damaging 0.95
R7265:Kif16b UTSW 2 142,556,650 (GRCm39) missense probably damaging 1.00
R7307:Kif16b UTSW 2 142,554,851 (GRCm39) missense probably benign 0.00
R7376:Kif16b UTSW 2 142,553,792 (GRCm39) missense probably damaging 0.99
R7381:Kif16b UTSW 2 142,699,343 (GRCm39) missense probably damaging 1.00
R7558:Kif16b UTSW 2 142,600,746 (GRCm39) missense probably damaging 1.00
R7681:Kif16b UTSW 2 142,598,046 (GRCm39) missense probably damaging 1.00
R7896:Kif16b UTSW 2 142,675,995 (GRCm39) critical splice donor site probably null
R7956:Kif16b UTSW 2 142,704,390 (GRCm39) missense probably benign 0.00
R8053:Kif16b UTSW 2 142,695,634 (GRCm39) missense probably damaging 1.00
R8056:Kif16b UTSW 2 142,554,762 (GRCm39) missense probably damaging 1.00
R8139:Kif16b UTSW 2 142,743,285 (GRCm39) missense probably benign 0.00
R8182:Kif16b UTSW 2 142,554,819 (GRCm39) missense possibly damaging 0.90
R8224:Kif16b UTSW 2 142,676,008 (GRCm39) missense probably benign 0.03
R8357:Kif16b UTSW 2 142,553,828 (GRCm39) missense probably damaging 1.00
R8359:Kif16b UTSW 2 142,553,777 (GRCm39) missense probably benign 0.05
R8360:Kif16b UTSW 2 142,553,777 (GRCm39) missense probably benign 0.05
R8369:Kif16b UTSW 2 142,553,777 (GRCm39) missense probably benign 0.05
R8385:Kif16b UTSW 2 142,554,258 (GRCm39) missense probably benign 0.09
R8457:Kif16b UTSW 2 142,553,828 (GRCm39) missense probably damaging 1.00
R8720:Kif16b UTSW 2 142,691,792 (GRCm39) missense probably damaging 1.00
R8898:Kif16b UTSW 2 142,554,899 (GRCm39) missense possibly damaging 0.81
R8987:Kif16b UTSW 2 142,743,278 (GRCm39) missense probably benign 0.00
R8987:Kif16b UTSW 2 142,691,783 (GRCm39) critical splice donor site probably null
R9040:Kif16b UTSW 2 142,691,798 (GRCm39) missense probably benign 0.02
R9044:Kif16b UTSW 2 142,541,577 (GRCm39) missense possibly damaging 0.91
R9138:Kif16b UTSW 2 142,542,476 (GRCm39) missense
R9167:Kif16b UTSW 2 142,542,840 (GRCm39) nonsense probably null
R9218:Kif16b UTSW 2 142,541,583 (GRCm39) missense possibly damaging 0.77
R9283:Kif16b UTSW 2 142,554,900 (GRCm39) missense probably benign 0.00
R9300:Kif16b UTSW 2 142,541,207 (GRCm39) missense probably benign
R9378:Kif16b UTSW 2 142,461,738 (GRCm39) nonsense probably null
R9522:Kif16b UTSW 2 142,691,827 (GRCm39) missense probably damaging 0.96
R9588:Kif16b UTSW 2 142,553,804 (GRCm39) missense possibly damaging 0.82
R9632:Kif16b UTSW 2 142,553,960 (GRCm39) missense probably benign 0.00
R9641:Kif16b UTSW 2 142,542,589 (GRCm39) missense probably benign 0.01
X0058:Kif16b UTSW 2 142,600,781 (GRCm39) missense probably damaging 1.00
Z1177:Kif16b UTSW 2 142,553,744 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CAAGCTGCCTTCTCTTGAAC -3'
(R):5'- GAGGAAGAGAGCTTATTCCGC -3'

Sequencing Primer
(F):5'- AAGAAGTACTGCTGAGCCCTTTC -3'
(R):5'- TATTCCGCATCAGAGAAGAGCTTCG -3'
Posted On 2021-10-11