Incidental Mutation 'R9190:Vmn2r84'
| ID |
697695 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r84
|
| Ensembl Gene |
ENSMUSG00000070601 |
| Gene Name |
vomeronasal 2, receptor 84 |
| Synonyms |
EG625068 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
R9190 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130221669-130230110 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 130226843 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Aspartic acid
at position 332
(N332D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092079
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094502]
|
| AlphaFold |
D3YWE3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094502
AA Change: N332D
PolyPhen 2
Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000092079
Gene: ENSMUSG00000070601
AA Change: N332D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
448 |
1.3e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
561 |
6.9e-21 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
4.6e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (52/52) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
C |
T |
7: 40,642,880 (GRCm39) |
T183I |
possibly damaging |
Het |
| Abca13 |
T |
A |
11: 9,241,886 (GRCm39) |
S1250T |
probably damaging |
Het |
| Adamts12 |
T |
A |
15: 11,336,446 (GRCm39) |
S1510R |
probably benign |
Het |
| Adcy5 |
T |
A |
16: 35,089,364 (GRCm39) |
C520* |
probably null |
Het |
| Arhgap21 |
A |
T |
2: 20,858,983 (GRCm39) |
M1237K |
probably null |
Het |
| Atp8b4 |
T |
A |
2: 126,225,607 (GRCm39) |
N541I |
probably damaging |
Het |
| Bbs12 |
G |
T |
3: 37,375,223 (GRCm39) |
R557L |
probably damaging |
Het |
| Bcl7c |
T |
C |
7: 127,266,200 (GRCm39) |
T183A |
probably benign |
Het |
| Brd7 |
A |
G |
8: 89,081,274 (GRCm39) |
S192P |
probably damaging |
Het |
| Calhm3 |
G |
A |
19: 47,146,121 (GRCm39) |
A28V |
probably benign |
Het |
| Ccdc113 |
A |
G |
8: 96,263,101 (GRCm39) |
N37S |
probably damaging |
Het |
| Cdh5 |
T |
G |
8: 104,867,337 (GRCm39) |
V538G |
probably damaging |
Het |
| Cfap43 |
T |
C |
19: 47,726,293 (GRCm39) |
E1639G |
possibly damaging |
Het |
| Clca3a2 |
C |
T |
3: 144,796,599 (GRCm39) |
V203I |
probably benign |
Het |
| Clstn2 |
A |
G |
9: 97,414,815 (GRCm39) |
F360L |
probably damaging |
Het |
| Cnst |
GTGACACGCTTG |
GTG |
1: 179,407,039 (GRCm39) |
|
probably benign |
Het |
| Cog2 |
T |
C |
8: 125,260,058 (GRCm39) |
Y234H |
probably damaging |
Het |
| Ddhd2 |
T |
C |
8: 26,244,495 (GRCm39) |
S44G |
probably benign |
Het |
| Dync2i2 |
G |
T |
2: 29,922,211 (GRCm39) |
H417N |
probably benign |
Het |
| Farp1 |
A |
G |
14: 121,492,988 (GRCm39) |
E530G |
probably damaging |
Het |
| Fhad1 |
C |
T |
4: 141,646,058 (GRCm39) |
|
probably null |
Het |
| Foxj3 |
T |
A |
4: 119,477,538 (GRCm39) |
C449* |
probably null |
Het |
| Fsbp |
G |
C |
4: 11,584,005 (GRCm39) |
V235L |
probably benign |
Het |
| Fuom |
T |
C |
7: 139,681,252 (GRCm39) |
E73G |
probably benign |
Het |
| Gm5134 |
A |
G |
10: 75,844,645 (GRCm39) |
H667R |
probably damaging |
Het |
| Igsf21 |
A |
G |
4: 139,756,028 (GRCm39) |
I361T |
probably damaging |
Het |
| Iws1 |
G |
A |
18: 32,213,213 (GRCm39) |
E214K |
possibly damaging |
Het |
| Kmt2d |
A |
T |
15: 98,749,896 (GRCm39) |
V2599E |
unknown |
Het |
| Lama1 |
T |
A |
17: 68,111,514 (GRCm39) |
M2255K |
|
Het |
| Litafd |
C |
A |
16: 8,501,647 (GRCm39) |
P50T |
|
Het |
| Lrrc32 |
A |
G |
7: 98,148,234 (GRCm39) |
H338R |
probably benign |
Het |
| Map1b |
C |
A |
13: 99,571,914 (GRCm39) |
R269L |
probably damaging |
Het |
| Ms4a5 |
T |
A |
19: 11,256,733 (GRCm39) |
I55F |
probably damaging |
Het |
| Muc5b |
G |
C |
7: 141,411,939 (GRCm39) |
L1628F |
unknown |
Het |
| Myo6 |
A |
G |
9: 80,195,384 (GRCm39) |
Q918R |
unknown |
Het |
| Or1e25 |
T |
A |
11: 73,493,877 (GRCm39) |
M157K |
probably benign |
Het |
| Or2t48 |
A |
G |
11: 58,420,161 (GRCm39) |
V217A |
possibly damaging |
Het |
| Or5m11b |
T |
A |
2: 85,805,884 (GRCm39) |
I99N |
possibly damaging |
Het |
| Or9i1b |
T |
G |
19: 13,896,967 (GRCm39) |
N194K |
probably benign |
Het |
| Pals2 |
A |
G |
6: 50,157,219 (GRCm39) |
R296G |
probably damaging |
Het |
| Plin5 |
A |
G |
17: 56,419,462 (GRCm39) |
V320A |
probably damaging |
Het |
| Ptx4 |
A |
T |
17: 25,342,257 (GRCm39) |
Q244L |
possibly damaging |
Het |
| Rab3gap1 |
A |
G |
1: 127,858,495 (GRCm39) |
T535A |
probably benign |
Het |
| Ranbp2 |
T |
C |
10: 58,313,117 (GRCm39) |
F1279S |
probably damaging |
Het |
| Rgl1 |
T |
C |
1: 152,428,362 (GRCm39) |
H254R |
probably damaging |
Het |
| Rida |
C |
T |
15: 34,487,909 (GRCm39) |
A69T |
probably damaging |
Het |
| Scn2a |
T |
C |
2: 65,511,346 (GRCm39) |
F131L |
probably benign |
Het |
| Septin1 |
T |
C |
7: 126,816,092 (GRCm39) |
I141V |
probably benign |
Het |
| Slc10a6 |
A |
G |
5: 103,765,571 (GRCm39) |
S171P |
probably damaging |
Het |
| Slc18a1 |
A |
G |
8: 69,519,790 (GRCm39) |
|
probably null |
Het |
| Slc38a6 |
T |
C |
12: 73,388,526 (GRCm39) |
S247P |
possibly damaging |
Het |
| Tet2 |
A |
T |
3: 133,187,147 (GRCm39) |
I1094K |
possibly damaging |
Het |
| Tmem234 |
C |
T |
4: 129,501,333 (GRCm39) |
S138L |
probably benign |
Het |
| Trpv1 |
T |
A |
11: 73,145,148 (GRCm39) |
|
probably null |
Het |
| Vmn2r60 |
T |
A |
7: 41,844,935 (GRCm39) |
M766K |
probably damaging |
Het |
| Zfp292 |
A |
T |
4: 34,819,563 (GRCm39) |
I258N |
probably damaging |
Het |
| Zxdc |
A |
G |
6: 90,375,773 (GRCm39) |
K750E |
probably damaging |
Het |
|
| Other mutations in Vmn2r84 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01461:Vmn2r84
|
APN |
10 |
130,227,094 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01590:Vmn2r84
|
APN |
10 |
130,221,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01639:Vmn2r84
|
APN |
10 |
130,225,141 (GRCm39) |
nonsense |
probably null |
|
|
IGL01843:Vmn2r84
|
APN |
10 |
130,222,148 (GRCm39) |
missense |
probably benign |
|
|
IGL01911:Vmn2r84
|
APN |
10 |
130,222,277 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01937:Vmn2r84
|
APN |
10 |
130,221,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01977:Vmn2r84
|
APN |
10 |
130,229,935 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02177:Vmn2r84
|
APN |
10 |
130,227,881 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02291:Vmn2r84
|
APN |
10 |
130,226,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02590:Vmn2r84
|
APN |
10 |
130,227,356 (GRCm39) |
splice site |
probably benign |
|
|
IGL02727:Vmn2r84
|
APN |
10 |
130,229,995 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02900:Vmn2r84
|
APN |
10 |
130,223,861 (GRCm39) |
splice site |
probably benign |
|
|
IGL03383:Vmn2r84
|
APN |
10 |
130,222,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Vmn2r84
|
UTSW |
10 |
130,221,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0076:Vmn2r84
|
UTSW |
10 |
130,230,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0089:Vmn2r84
|
UTSW |
10 |
130,222,588 (GRCm39) |
splice site |
probably benign |
|
|
R0153:Vmn2r84
|
UTSW |
10 |
130,227,877 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0611:Vmn2r84
|
UTSW |
10 |
130,221,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0883:Vmn2r84
|
UTSW |
10 |
130,226,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1237:Vmn2r84
|
UTSW |
10 |
130,223,725 (GRCm39) |
splice site |
probably null |
|
|
R1295:Vmn2r84
|
UTSW |
10 |
130,225,008 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1401:Vmn2r84
|
UTSW |
10 |
130,227,859 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1521:Vmn2r84
|
UTSW |
10 |
130,225,137 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1590:Vmn2r84
|
UTSW |
10 |
130,227,349 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1710:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1891:Vmn2r84
|
UTSW |
10 |
130,221,938 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1956:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1957:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1962:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1994:Vmn2r84
|
UTSW |
10 |
130,221,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Vmn2r84
|
UTSW |
10 |
130,227,100 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2409:Vmn2r84
|
UTSW |
10 |
130,227,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2474:Vmn2r84
|
UTSW |
10 |
130,222,392 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2851:Vmn2r84
|
UTSW |
10 |
130,230,036 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3508:Vmn2r84
|
UTSW |
10 |
130,226,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3792:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
|
R4051:Vmn2r84
|
UTSW |
10 |
130,226,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4061:Vmn2r84
|
UTSW |
10 |
130,221,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4091:Vmn2r84
|
UTSW |
10 |
130,227,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4190:Vmn2r84
|
UTSW |
10 |
130,227,163 (GRCm39) |
nonsense |
probably null |
|
|
R4520:Vmn2r84
|
UTSW |
10 |
130,222,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4584:Vmn2r84
|
UTSW |
10 |
130,226,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4588:Vmn2r84
|
UTSW |
10 |
130,221,809 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4655:Vmn2r84
|
UTSW |
10 |
130,229,973 (GRCm39) |
nonsense |
probably null |
|
|
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5022:Vmn2r84
|
UTSW |
10 |
130,222,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5146:Vmn2r84
|
UTSW |
10 |
130,221,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5237:Vmn2r84
|
UTSW |
10 |
130,221,863 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5695:Vmn2r84
|
UTSW |
10 |
130,225,064 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5793:Vmn2r84
|
UTSW |
10 |
130,221,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6210:Vmn2r84
|
UTSW |
10 |
130,222,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6286:Vmn2r84
|
UTSW |
10 |
130,226,737 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6580:Vmn2r84
|
UTSW |
10 |
130,225,110 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6607:Vmn2r84
|
UTSW |
10 |
130,226,731 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6818:Vmn2r84
|
UTSW |
10 |
130,222,147 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6956:Vmn2r84
|
UTSW |
10 |
130,225,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6994:Vmn2r84
|
UTSW |
10 |
130,226,876 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7075:Vmn2r84
|
UTSW |
10 |
130,226,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7225:Vmn2r84
|
UTSW |
10 |
130,222,552 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7252:Vmn2r84
|
UTSW |
10 |
130,222,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7263:Vmn2r84
|
UTSW |
10 |
130,225,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7297:Vmn2r84
|
UTSW |
10 |
130,227,119 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7439:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7441:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7857:Vmn2r84
|
UTSW |
10 |
130,226,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8263:Vmn2r84
|
UTSW |
10 |
130,227,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Vmn2r84
|
UTSW |
10 |
130,230,100 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8766:Vmn2r84
|
UTSW |
10 |
130,222,241 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8821:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8831:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8970:Vmn2r84
|
UTSW |
10 |
130,222,244 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9164:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
|
R9261:Vmn2r84
|
UTSW |
10 |
130,229,976 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9310:Vmn2r84
|
UTSW |
10 |
130,227,993 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9434:Vmn2r84
|
UTSW |
10 |
130,221,745 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9613:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r84
|
UTSW |
10 |
130,227,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTATGGGCCACAGCATAAAC -3'
(R):5'- ATGACATCTTCAGCAAAGGTTG -3'
Sequencing Primer
(F):5'- AATTGTAACCTTCATCACTCAGGGC -3'
(R):5'- GACATCTTCAGCAAAGGTTGTTATC -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation