Incidental Mutation 'R9190:Vmn2r60'
| ID |
697679 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r60
|
| Ensembl Gene |
ENSMUSG00000090619 |
| Gene Name |
vomeronasal 2, receptor 60 |
| Synonyms |
Casr-rs3, EG637898, Gprc2a-rs3 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.100)
|
| Stock # |
R9190 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41765895-41845200 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 41844935 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 766
(M766K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128493
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166447]
|
| AlphaFold |
A0A3B2WBC8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166447
AA Change: M766K
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000128493
Gene: ENSMUSG00000090619
AA Change: M766K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
471 |
1.2e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
1.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (52/52) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
C |
T |
7: 40,642,880 (GRCm39) |
T183I |
possibly damaging |
Het |
| Abca13 |
T |
A |
11: 9,241,886 (GRCm39) |
S1250T |
probably damaging |
Het |
| Adamts12 |
T |
A |
15: 11,336,446 (GRCm39) |
S1510R |
probably benign |
Het |
| Adcy5 |
T |
A |
16: 35,089,364 (GRCm39) |
C520* |
probably null |
Het |
| Arhgap21 |
A |
T |
2: 20,858,983 (GRCm39) |
M1237K |
probably null |
Het |
| Atp8b4 |
T |
A |
2: 126,225,607 (GRCm39) |
N541I |
probably damaging |
Het |
| Bbs12 |
G |
T |
3: 37,375,223 (GRCm39) |
R557L |
probably damaging |
Het |
| Bcl7c |
T |
C |
7: 127,266,200 (GRCm39) |
T183A |
probably benign |
Het |
| Brd7 |
A |
G |
8: 89,081,274 (GRCm39) |
S192P |
probably damaging |
Het |
| Calhm3 |
G |
A |
19: 47,146,121 (GRCm39) |
A28V |
probably benign |
Het |
| Ccdc113 |
A |
G |
8: 96,263,101 (GRCm39) |
N37S |
probably damaging |
Het |
| Cdh5 |
T |
G |
8: 104,867,337 (GRCm39) |
V538G |
probably damaging |
Het |
| Cfap43 |
T |
C |
19: 47,726,293 (GRCm39) |
E1639G |
possibly damaging |
Het |
| Clca3a2 |
C |
T |
3: 144,796,599 (GRCm39) |
V203I |
probably benign |
Het |
| Clstn2 |
A |
G |
9: 97,414,815 (GRCm39) |
F360L |
probably damaging |
Het |
| Cnst |
GTGACACGCTTG |
GTG |
1: 179,407,039 (GRCm39) |
|
probably benign |
Het |
| Cog2 |
T |
C |
8: 125,260,058 (GRCm39) |
Y234H |
probably damaging |
Het |
| Ddhd2 |
T |
C |
8: 26,244,495 (GRCm39) |
S44G |
probably benign |
Het |
| Dync2i2 |
G |
T |
2: 29,922,211 (GRCm39) |
H417N |
probably benign |
Het |
| Farp1 |
A |
G |
14: 121,492,988 (GRCm39) |
E530G |
probably damaging |
Het |
| Fhad1 |
C |
T |
4: 141,646,058 (GRCm39) |
|
probably null |
Het |
| Foxj3 |
T |
A |
4: 119,477,538 (GRCm39) |
C449* |
probably null |
Het |
| Fsbp |
G |
C |
4: 11,584,005 (GRCm39) |
V235L |
probably benign |
Het |
| Fuom |
T |
C |
7: 139,681,252 (GRCm39) |
E73G |
probably benign |
Het |
| Gm5134 |
A |
G |
10: 75,844,645 (GRCm39) |
H667R |
probably damaging |
Het |
| Igsf21 |
A |
G |
4: 139,756,028 (GRCm39) |
I361T |
probably damaging |
Het |
| Iws1 |
G |
A |
18: 32,213,213 (GRCm39) |
E214K |
possibly damaging |
Het |
| Kmt2d |
A |
T |
15: 98,749,896 (GRCm39) |
V2599E |
unknown |
Het |
| Lama1 |
T |
A |
17: 68,111,514 (GRCm39) |
M2255K |
|
Het |
| Litafd |
C |
A |
16: 8,501,647 (GRCm39) |
P50T |
|
Het |
| Lrrc32 |
A |
G |
7: 98,148,234 (GRCm39) |
H338R |
probably benign |
Het |
| Map1b |
C |
A |
13: 99,571,914 (GRCm39) |
R269L |
probably damaging |
Het |
| Ms4a5 |
T |
A |
19: 11,256,733 (GRCm39) |
I55F |
probably damaging |
Het |
| Muc5b |
G |
C |
7: 141,411,939 (GRCm39) |
L1628F |
unknown |
Het |
| Myo6 |
A |
G |
9: 80,195,384 (GRCm39) |
Q918R |
unknown |
Het |
| Or1e25 |
T |
A |
11: 73,493,877 (GRCm39) |
M157K |
probably benign |
Het |
| Or2t48 |
A |
G |
11: 58,420,161 (GRCm39) |
V217A |
possibly damaging |
Het |
| Or5m11b |
T |
A |
2: 85,805,884 (GRCm39) |
I99N |
possibly damaging |
Het |
| Or9i1b |
T |
G |
19: 13,896,967 (GRCm39) |
N194K |
probably benign |
Het |
| Pals2 |
A |
G |
6: 50,157,219 (GRCm39) |
R296G |
probably damaging |
Het |
| Plin5 |
A |
G |
17: 56,419,462 (GRCm39) |
V320A |
probably damaging |
Het |
| Ptx4 |
A |
T |
17: 25,342,257 (GRCm39) |
Q244L |
possibly damaging |
Het |
| Rab3gap1 |
A |
G |
1: 127,858,495 (GRCm39) |
T535A |
probably benign |
Het |
| Ranbp2 |
T |
C |
10: 58,313,117 (GRCm39) |
F1279S |
probably damaging |
Het |
| Rgl1 |
T |
C |
1: 152,428,362 (GRCm39) |
H254R |
probably damaging |
Het |
| Rida |
C |
T |
15: 34,487,909 (GRCm39) |
A69T |
probably damaging |
Het |
| Scn2a |
T |
C |
2: 65,511,346 (GRCm39) |
F131L |
probably benign |
Het |
| Septin1 |
T |
C |
7: 126,816,092 (GRCm39) |
I141V |
probably benign |
Het |
| Slc10a6 |
A |
G |
5: 103,765,571 (GRCm39) |
S171P |
probably damaging |
Het |
| Slc18a1 |
A |
G |
8: 69,519,790 (GRCm39) |
|
probably null |
Het |
| Slc38a6 |
T |
C |
12: 73,388,526 (GRCm39) |
S247P |
possibly damaging |
Het |
| Tet2 |
A |
T |
3: 133,187,147 (GRCm39) |
I1094K |
possibly damaging |
Het |
| Tmem234 |
C |
T |
4: 129,501,333 (GRCm39) |
S138L |
probably benign |
Het |
| Trpv1 |
T |
A |
11: 73,145,148 (GRCm39) |
|
probably null |
Het |
| Vmn2r84 |
T |
C |
10: 130,226,843 (GRCm39) |
N332D |
probably benign |
Het |
| Zfp292 |
A |
T |
4: 34,819,563 (GRCm39) |
I258N |
probably damaging |
Het |
| Zxdc |
A |
G |
6: 90,375,773 (GRCm39) |
K750E |
probably damaging |
Het |
|
| Other mutations in Vmn2r60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01622:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL01623:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02363:Vmn2r60
|
APN |
7 |
41,844,578 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02485:Vmn2r60
|
APN |
7 |
41,844,890 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02651:Vmn2r60
|
APN |
7 |
41,845,010 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02660:Vmn2r60
|
APN |
7 |
41,791,720 (GRCm39) |
nonsense |
probably null |
|
|
IGL03135:Vmn2r60
|
APN |
7 |
41,786,018 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03307:Vmn2r60
|
APN |
7 |
41,765,971 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0310:Vmn2r60
|
UTSW |
7 |
41,844,564 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R0314:Vmn2r60
|
UTSW |
7 |
41,784,985 (GRCm39) |
splice site |
probably benign |
|
|
R0328:Vmn2r60
|
UTSW |
7 |
41,791,744 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Vmn2r60
|
UTSW |
7 |
41,785,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0755:Vmn2r60
|
UTSW |
7 |
41,844,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1119:Vmn2r60
|
UTSW |
7 |
41,844,365 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1162:Vmn2r60
|
UTSW |
7 |
41,845,195 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1241:Vmn2r60
|
UTSW |
7 |
41,786,476 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1488:Vmn2r60
|
UTSW |
7 |
41,786,137 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1623:Vmn2r60
|
UTSW |
7 |
41,785,279 (GRCm39) |
nonsense |
probably null |
|
|
R1628:Vmn2r60
|
UTSW |
7 |
41,785,830 (GRCm39) |
nonsense |
probably null |
|
|
R1883:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1884:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2182:Vmn2r60
|
UTSW |
7 |
41,844,931 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2275:Vmn2r60
|
UTSW |
7 |
41,786,251 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Vmn2r60
|
UTSW |
7 |
41,785,857 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2885:Vmn2r60
|
UTSW |
7 |
41,790,403 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2894:Vmn2r60
|
UTSW |
7 |
41,785,220 (GRCm39) |
missense |
probably benign |
|
|
R2921:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2922:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3772:Vmn2r60
|
UTSW |
7 |
41,765,980 (GRCm39) |
missense |
probably benign |
0.35 |
|
R3820:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3822:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3872:Vmn2r60
|
UTSW |
7 |
41,785,878 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4222:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4223:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4224:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4526:Vmn2r60
|
UTSW |
7 |
41,844,667 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4547:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R4840:Vmn2r60
|
UTSW |
7 |
41,785,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5173:Vmn2r60
|
UTSW |
7 |
41,844,935 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5231:Vmn2r60
|
UTSW |
7 |
41,786,448 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5480:Vmn2r60
|
UTSW |
7 |
41,785,154 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5521:Vmn2r60
|
UTSW |
7 |
41,845,049 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5834:Vmn2r60
|
UTSW |
7 |
41,765,932 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6112:Vmn2r60
|
UTSW |
7 |
41,844,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6149:Vmn2r60
|
UTSW |
7 |
41,786,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6170:Vmn2r60
|
UTSW |
7 |
41,785,045 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6383:Vmn2r60
|
UTSW |
7 |
41,765,895 (GRCm39) |
start codon destroyed |
probably null |
0.04 |
|
R6811:Vmn2r60
|
UTSW |
7 |
41,844,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6876:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R6997:Vmn2r60
|
UTSW |
7 |
41,791,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7040:Vmn2r60
|
UTSW |
7 |
41,791,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7116:Vmn2r60
|
UTSW |
7 |
41,786,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7128:Vmn2r60
|
UTSW |
7 |
41,844,536 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7232:Vmn2r60
|
UTSW |
7 |
41,786,166 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7296:Vmn2r60
|
UTSW |
7 |
41,785,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7376:Vmn2r60
|
UTSW |
7 |
41,844,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7526:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7527:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7528:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7764:Vmn2r60
|
UTSW |
7 |
41,844,535 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7843:Vmn2r60
|
UTSW |
7 |
41,844,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8080:Vmn2r60
|
UTSW |
7 |
41,790,521 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8290:Vmn2r60
|
UTSW |
7 |
41,791,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8342:Vmn2r60
|
UTSW |
7 |
41,790,494 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8362:Vmn2r60
|
UTSW |
7 |
41,844,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8418:Vmn2r60
|
UTSW |
7 |
41,844,850 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8848:Vmn2r60
|
UTSW |
7 |
41,786,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Vmn2r60
|
UTSW |
7 |
41,791,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8882:Vmn2r60
|
UTSW |
7 |
41,790,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8913:Vmn2r60
|
UTSW |
7 |
41,785,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9229:Vmn2r60
|
UTSW |
7 |
41,791,723 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9295:Vmn2r60
|
UTSW |
7 |
41,785,955 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9335:Vmn2r60
|
UTSW |
7 |
41,844,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9796:Vmn2r60
|
UTSW |
7 |
41,785,172 (GRCm39) |
missense |
probably benign |
|
|
RF024:Vmn2r60
|
UTSW |
7 |
41,790,363 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Vmn2r60
|
UTSW |
7 |
41,790,538 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTTAATGGTATCAAGAGCCCC -3'
(R):5'- TCCAAGGAGTGCTATATTGGAAG -3'
Sequencing Primer
(F):5'- GGTATCAAGAGCCCCTAATTTCATC -3'
(R):5'- TTGGAAGCCAAGATACAAAACACTTC -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation