Incidental Mutation 'PIT4378001:Vmn2r84'
| ID |
555009 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r84
|
| Ensembl Gene |
ENSMUSG00000070601 |
| Gene Name |
vomeronasal 2, receptor 84 |
| Synonyms |
EG625068 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
PIT4378001 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130221669-130230110 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 130221784 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 812
(I812N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092079
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094502]
|
| AlphaFold |
D3YWE3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000094502
AA Change: I812N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000092079
Gene: ENSMUSG00000070601
AA Change: I812N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
448 |
1.3e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
561 |
6.9e-21 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
4.6e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 93.1%
- 3x: 90.8%
- 10x: 85.0%
- 20x: 72.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310033P09Rik |
T |
C |
11: 59,099,802 (GRCm39) |
V100A |
probably benign |
Het |
| Adamtsl1 |
T |
C |
4: 86,117,601 (GRCm39) |
V188A |
possibly damaging |
Het |
| Aldh6a1 |
T |
C |
12: 84,488,646 (GRCm39) |
D80G |
probably benign |
Het |
| Ankrd50 |
T |
C |
3: 38,509,412 (GRCm39) |
Q62R |
possibly damaging |
Het |
| Aopep |
T |
C |
13: 63,163,021 (GRCm39) |
L14P |
probably damaging |
Het |
| Arrdc1 |
T |
A |
2: 24,816,645 (GRCm39) |
Y177F |
probably damaging |
Het |
| Asap1 |
C |
T |
15: 64,007,697 (GRCm39) |
R384Q |
probably damaging |
Het |
| Atxn2l |
A |
T |
7: 126,096,443 (GRCm39) |
V433D |
probably benign |
Het |
| Bbs1 |
G |
A |
19: 4,941,703 (GRCm39) |
A529V |
probably benign |
Het |
| Bbx |
G |
A |
16: 50,100,836 (GRCm39) |
R20* |
probably null |
Het |
| Bend5 |
T |
C |
4: 111,288,304 (GRCm39) |
V106A |
probably benign |
Het |
| C1galt1 |
A |
G |
6: 7,863,944 (GRCm39) |
N8S |
probably benign |
Het |
| Cdc42ep1 |
G |
A |
15: 78,733,880 (GRCm39) |
D327N |
possibly damaging |
Het |
| Cep162 |
A |
G |
9: 87,099,198 (GRCm39) |
S767P |
probably benign |
Het |
| Cep43 |
T |
C |
17: 8,401,105 (GRCm39) |
S209P |
probably damaging |
Het |
| Csmd1 |
T |
C |
8: 15,945,728 (GRCm39) |
T3562A |
probably damaging |
Het |
| Dnah7a |
A |
G |
1: 53,570,362 (GRCm39) |
S1815P |
probably damaging |
Het |
| Ei24 |
A |
T |
9: 36,697,320 (GRCm39) |
L136Q |
probably damaging |
Het |
| Extl2 |
T |
G |
3: 115,804,339 (GRCm39) |
M1R |
probably null |
Het |
| Fat3 |
T |
C |
9: 16,288,104 (GRCm39) |
E473G |
probably benign |
Het |
| Fcgbpl1 |
G |
A |
7: 27,853,889 (GRCm39) |
D1618N |
possibly damaging |
Het |
| Fhip1a |
A |
G |
3: 85,637,858 (GRCm39) |
L147P |
probably damaging |
Het |
| G6pc3 |
T |
A |
11: 102,080,827 (GRCm39) |
W26R |
probably damaging |
Het |
| Hc |
T |
A |
2: 34,921,876 (GRCm39) |
Y610F |
probably benign |
Het |
| Hecw1 |
T |
C |
13: 14,552,368 (GRCm39) |
D77G |
probably damaging |
Het |
| Hgf |
T |
C |
5: 16,816,860 (GRCm39) |
V497A |
probably damaging |
Het |
| Hjurp |
CTCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCT |
C |
1: 88,193,999 (GRCm39) |
|
probably benign |
Het |
| Hyou1 |
A |
C |
9: 44,302,148 (GRCm39) |
D968A |
probably benign |
Het |
| Jmjd1c |
T |
A |
10: 67,065,692 (GRCm39) |
S1525T |
probably damaging |
Het |
| Kcnc4 |
G |
A |
3: 107,354,879 (GRCm39) |
T523I |
probably benign |
Het |
| Kcng1 |
C |
T |
2: 168,104,604 (GRCm39) |
C414Y |
probably damaging |
Het |
| Klhdc10 |
T |
C |
6: 30,447,411 (GRCm39) |
I204T |
probably damaging |
Het |
| Krt18 |
A |
T |
15: 101,938,358 (GRCm39) |
T194S |
probably benign |
Het |
| Krt76 |
A |
C |
15: 101,800,842 (GRCm39) |
N151K |
probably damaging |
Het |
| Krtap31-2 |
A |
G |
11: 99,827,542 (GRCm39) |
T125A |
possibly damaging |
Het |
| Lama5 |
A |
G |
2: 179,831,238 (GRCm39) |
V1807A |
possibly damaging |
Het |
| Lats1 |
T |
G |
10: 7,581,369 (GRCm39) |
V718G |
probably damaging |
Het |
| Mef2b |
A |
G |
8: 70,616,910 (GRCm39) |
K4E |
probably damaging |
Het |
| Mertk |
T |
C |
2: 128,624,537 (GRCm39) |
|
probably null |
Het |
| Mroh8 |
A |
G |
2: 157,070,620 (GRCm39) |
V577A |
possibly damaging |
Het |
| Mtcl1 |
T |
G |
17: 66,745,274 (GRCm39) |
N381T |
probably damaging |
Het |
| Nfyc |
T |
A |
4: 120,647,688 (GRCm39) |
|
probably null |
Het |
| Nol4 |
C |
A |
18: 23,172,933 (GRCm39) |
W56L |
probably damaging |
Het |
| Notch2 |
A |
T |
3: 98,050,272 (GRCm39) |
D1849V |
probably damaging |
Het |
| Or10ad1 |
G |
A |
15: 98,105,452 (GRCm39) |
T271I |
probably damaging |
Het |
| Or10j7 |
T |
C |
1: 173,011,381 (GRCm39) |
T207A |
probably benign |
Het |
| Or14c45 |
A |
T |
7: 86,176,306 (GRCm39) |
T114S |
possibly damaging |
Het |
| Or4n4b |
T |
C |
14: 50,536,355 (GRCm39) |
N137S |
probably benign |
Het |
| Or5an10 |
A |
G |
19: 12,276,076 (GRCm39) |
M140T |
probably damaging |
Het |
| Or7g28 |
T |
A |
9: 19,272,471 (GRCm39) |
Y60F |
probably damaging |
Het |
| Or8s5 |
A |
G |
15: 98,238,153 (GRCm39) |
V239A |
possibly damaging |
Het |
| Oxr1 |
G |
A |
15: 41,664,978 (GRCm39) |
V138I |
probably benign |
Het |
| Pars2 |
A |
G |
4: 106,511,490 (GRCm39) |
E424G |
possibly damaging |
Het |
| Peli2 |
C |
A |
14: 48,405,726 (GRCm39) |
Y50* |
probably null |
Het |
| Plag1 |
T |
A |
4: 3,905,492 (GRCm39) |
H66L |
probably benign |
Het |
| Psme4 |
T |
C |
11: 30,771,079 (GRCm39) |
|
probably benign |
Het |
| Robo1 |
A |
T |
16: 72,801,423 (GRCm39) |
S1016C |
probably damaging |
Het |
| Rrbp1 |
A |
G |
2: 143,816,460 (GRCm39) |
V723A |
probably benign |
Het |
| Sgip1 |
C |
A |
4: 102,778,280 (GRCm39) |
D292E |
unknown |
Het |
| Skint4 |
T |
A |
4: 111,944,232 (GRCm39) |
C23S |
probably benign |
Het |
| Slc22a28 |
A |
C |
19: 8,049,279 (GRCm39) |
S323R |
probably damaging |
Het |
| Slc41a3 |
A |
G |
6: 90,617,891 (GRCm39) |
T306A |
probably benign |
Het |
| Spata13 |
A |
G |
14: 60,987,445 (GRCm39) |
M868V |
probably damaging |
Het |
| Spata6 |
T |
G |
4: 111,603,378 (GRCm39) |
I31S |
possibly damaging |
Het |
| Sycp3 |
A |
T |
10: 88,302,366 (GRCm39) |
K119* |
probably null |
Het |
| Tlk2 |
T |
A |
11: 105,172,046 (GRCm39) |
S739T |
unknown |
Het |
| Trim10 |
T |
C |
17: 37,188,020 (GRCm39) |
V412A |
probably damaging |
Het |
| Ttc3 |
T |
A |
16: 94,211,765 (GRCm39) |
F377I |
probably benign |
Het |
| Uck1 |
T |
A |
2: 32,146,046 (GRCm39) |
H283L |
probably damaging |
Het |
| Unc5a |
T |
C |
13: 55,143,681 (GRCm39) |
Y122H |
possibly damaging |
Het |
| Uncx |
C |
T |
5: 139,530,377 (GRCm39) |
R152* |
probably null |
Het |
| Usp44 |
A |
G |
10: 93,681,517 (GRCm39) |
|
probably benign |
Het |
| Vamp2 |
A |
C |
11: 68,980,564 (GRCm39) |
D44A |
probably benign |
Het |
| Vmn2r83 |
A |
G |
10: 79,304,849 (GRCm39) |
T20A |
probably benign |
Het |
| Vrtn |
T |
G |
12: 84,695,943 (GRCm39) |
L231R |
probably damaging |
Het |
| Wdr75 |
A |
G |
1: 45,859,333 (GRCm39) |
T677A |
probably damaging |
Het |
| Xylt1 |
C |
A |
7: 117,148,100 (GRCm39) |
S221R |
possibly damaging |
Het |
| Zscan22 |
A |
G |
7: 12,637,983 (GRCm39) |
E125G |
possibly damaging |
Het |
| Zxdc |
A |
T |
6: 90,350,698 (GRCm39) |
H383L |
probably damaging |
Het |
|
| Other mutations in Vmn2r84 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01461:Vmn2r84
|
APN |
10 |
130,227,094 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01590:Vmn2r84
|
APN |
10 |
130,221,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01639:Vmn2r84
|
APN |
10 |
130,225,141 (GRCm39) |
nonsense |
probably null |
|
|
IGL01843:Vmn2r84
|
APN |
10 |
130,222,148 (GRCm39) |
missense |
probably benign |
|
|
IGL01911:Vmn2r84
|
APN |
10 |
130,222,277 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01937:Vmn2r84
|
APN |
10 |
130,221,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01977:Vmn2r84
|
APN |
10 |
130,229,935 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02177:Vmn2r84
|
APN |
10 |
130,227,881 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02291:Vmn2r84
|
APN |
10 |
130,226,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02590:Vmn2r84
|
APN |
10 |
130,227,356 (GRCm39) |
splice site |
probably benign |
|
|
IGL02727:Vmn2r84
|
APN |
10 |
130,229,995 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02900:Vmn2r84
|
APN |
10 |
130,223,861 (GRCm39) |
splice site |
probably benign |
|
|
IGL03383:Vmn2r84
|
APN |
10 |
130,222,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0076:Vmn2r84
|
UTSW |
10 |
130,230,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0089:Vmn2r84
|
UTSW |
10 |
130,222,588 (GRCm39) |
splice site |
probably benign |
|
|
R0153:Vmn2r84
|
UTSW |
10 |
130,227,877 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0611:Vmn2r84
|
UTSW |
10 |
130,221,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0883:Vmn2r84
|
UTSW |
10 |
130,226,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1237:Vmn2r84
|
UTSW |
10 |
130,223,725 (GRCm39) |
splice site |
probably null |
|
|
R1295:Vmn2r84
|
UTSW |
10 |
130,225,008 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1401:Vmn2r84
|
UTSW |
10 |
130,227,859 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1521:Vmn2r84
|
UTSW |
10 |
130,225,137 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1590:Vmn2r84
|
UTSW |
10 |
130,227,349 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1710:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1891:Vmn2r84
|
UTSW |
10 |
130,221,938 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1956:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1957:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1962:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1994:Vmn2r84
|
UTSW |
10 |
130,221,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Vmn2r84
|
UTSW |
10 |
130,227,100 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2409:Vmn2r84
|
UTSW |
10 |
130,227,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2474:Vmn2r84
|
UTSW |
10 |
130,222,392 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2851:Vmn2r84
|
UTSW |
10 |
130,230,036 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3508:Vmn2r84
|
UTSW |
10 |
130,226,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3792:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
|
R4051:Vmn2r84
|
UTSW |
10 |
130,226,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4061:Vmn2r84
|
UTSW |
10 |
130,221,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4091:Vmn2r84
|
UTSW |
10 |
130,227,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4190:Vmn2r84
|
UTSW |
10 |
130,227,163 (GRCm39) |
nonsense |
probably null |
|
|
R4520:Vmn2r84
|
UTSW |
10 |
130,222,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4584:Vmn2r84
|
UTSW |
10 |
130,226,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4588:Vmn2r84
|
UTSW |
10 |
130,221,809 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4655:Vmn2r84
|
UTSW |
10 |
130,229,973 (GRCm39) |
nonsense |
probably null |
|
|
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5022:Vmn2r84
|
UTSW |
10 |
130,222,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5146:Vmn2r84
|
UTSW |
10 |
130,221,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5237:Vmn2r84
|
UTSW |
10 |
130,221,863 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5695:Vmn2r84
|
UTSW |
10 |
130,225,064 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5793:Vmn2r84
|
UTSW |
10 |
130,221,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6210:Vmn2r84
|
UTSW |
10 |
130,222,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6286:Vmn2r84
|
UTSW |
10 |
130,226,737 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6580:Vmn2r84
|
UTSW |
10 |
130,225,110 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6607:Vmn2r84
|
UTSW |
10 |
130,226,731 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6818:Vmn2r84
|
UTSW |
10 |
130,222,147 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6956:Vmn2r84
|
UTSW |
10 |
130,225,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6994:Vmn2r84
|
UTSW |
10 |
130,226,876 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7075:Vmn2r84
|
UTSW |
10 |
130,226,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7225:Vmn2r84
|
UTSW |
10 |
130,222,552 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7252:Vmn2r84
|
UTSW |
10 |
130,222,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7263:Vmn2r84
|
UTSW |
10 |
130,225,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7297:Vmn2r84
|
UTSW |
10 |
130,227,119 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7439:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7441:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7857:Vmn2r84
|
UTSW |
10 |
130,226,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8263:Vmn2r84
|
UTSW |
10 |
130,227,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Vmn2r84
|
UTSW |
10 |
130,230,100 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8766:Vmn2r84
|
UTSW |
10 |
130,222,241 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8821:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8831:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8970:Vmn2r84
|
UTSW |
10 |
130,222,244 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9164:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
|
R9190:Vmn2r84
|
UTSW |
10 |
130,226,843 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9261:Vmn2r84
|
UTSW |
10 |
130,229,976 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9310:Vmn2r84
|
UTSW |
10 |
130,227,993 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9434:Vmn2r84
|
UTSW |
10 |
130,221,745 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9613:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r84
|
UTSW |
10 |
130,227,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGACAGTGCTATCCTGTTTG -3'
(R):5'- ATACTTGGGTTCCTTGGCTC -3'
Sequencing Primer
(F):5'- GACAGTGCTATCCTGTTTGTAAGTCC -3'
(R):5'- CTCTGGGGAGCTTCACTGTG -3'
|
| Posted On |
2019-06-07 |
Incidental Mutation