Incidental Mutation 'R2124:Vmn2r84'
ID 229680
Institutional Source Beutler Lab
Gene Symbol Vmn2r84
Ensembl Gene ENSMUSG00000070601
Gene Name vomeronasal 2, receptor 84
Synonyms EG625068
MMRRC Submission 040127-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R2124 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 130221669-130230110 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 130227100 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 246 (M246R)
Ref Sequence ENSEMBL: ENSMUSP00000092079 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094502]
AlphaFold D3YWE3
Predicted Effect probably damaging
Transcript: ENSMUST00000094502
AA Change: M246R

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000092079
Gene: ENSMUSG00000070601
AA Change: M246R

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 77 448 1.3e-27 PFAM
Pfam:NCD3G 508 561 6.9e-21 PFAM
Pfam:7tm_3 594 830 4.6e-55 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 98% (80/82)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik T A 4: 62,457,109 (GRCm39) L143M possibly damaging Het
Abca13 T C 11: 9,259,013 (GRCm39) probably benign Het
Abcg5 T A 17: 84,978,575 (GRCm39) E294D probably benign Het
Adgrg6 T C 10: 14,342,930 (GRCm39) D339G probably damaging Het
Ahctf1 C A 1: 179,597,017 (GRCm39) R43L probably damaging Het
Ambn T A 5: 88,608,617 (GRCm39) probably benign Het
Arap3 A C 18: 38,106,403 (GRCm39) L1480R probably damaging Het
Arhgef10 A G 8: 14,984,820 (GRCm39) D200G probably damaging Het
Aspg G A 12: 112,087,608 (GRCm39) V8I probably benign Het
Aven T A 2: 112,455,541 (GRCm39) W26R probably damaging Het
Car4 T A 11: 84,854,911 (GRCm39) probably benign Het
Cd163 C T 6: 124,295,815 (GRCm39) R720C probably damaging Het
Cdh1 A G 8: 107,390,842 (GRCm39) I653V probably benign Het
Cdh3 A T 8: 107,279,520 (GRCm39) H712L probably damaging Het
Cdr2 T C 7: 120,581,250 (GRCm39) E9G probably damaging Het
Cfap47 T C X: 78,553,927 (GRCm39) I267V probably benign Het
Chrnb2 T C 3: 89,676,648 (GRCm39) probably benign Het
Col4a2 C A 8: 11,466,070 (GRCm39) P443Q probably damaging Het
Cyp2a12 A G 7: 26,736,071 (GRCm39) *493W probably null Het
Ddias T C 7: 92,507,464 (GRCm39) Q817R probably benign Het
Ddx6 C T 9: 44,535,816 (GRCm39) Q182* probably null Het
Dhrs7 A G 12: 72,699,951 (GRCm39) I227T probably damaging Het
Dhx8 A T 11: 101,653,071 (GRCm39) M970L probably damaging Het
Dnah7a A T 1: 53,536,101 (GRCm39) D2647E possibly damaging Het
Dstyk G A 1: 132,380,857 (GRCm39) G451R possibly damaging Het
Ednrb T A 14: 104,059,204 (GRCm39) D274V probably benign Het
Efl1 C T 7: 82,342,121 (GRCm39) R510C probably damaging Het
Eif4g3 A G 4: 137,912,053 (GRCm39) E1409G probably damaging Het
Fam78b G A 1: 166,906,278 (GRCm39) V146M probably damaging Het
Fcgbp T C 7: 27,791,444 (GRCm39) Y902H probably benign Het
Fgf18 A C 11: 33,068,003 (GRCm39) F129C probably damaging Het
Gbp9 T A 5: 105,242,409 (GRCm39) D110V probably damaging Het
Gm10477 A G X: 55,570,192 (GRCm39) K31E probably damaging Het
Gm10542 T A 18: 44,334,355 (GRCm39) W9R probably null Het
Gpaa1 A G 15: 76,217,552 (GRCm39) Y330C probably damaging Het
Hectd4 T C 5: 121,456,702 (GRCm39) L689P probably damaging Het
Hoxd3 C A 2: 74,574,578 (GRCm39) P75T possibly damaging Het
Ikbkb A G 8: 23,156,036 (GRCm39) L570P probably damaging Het
Ikbkb T C 8: 23,157,233 (GRCm39) probably benign Het
Il1rap A T 16: 26,529,315 (GRCm39) H379L probably damaging Het
Ints6l T A X: 55,550,228 (GRCm39) S718T probably benign Het
Jaml T A 9: 45,012,362 (GRCm39) I283N probably damaging Het
Kidins220 G A 12: 25,091,302 (GRCm39) probably null Het
Kif1b T C 4: 149,306,753 (GRCm39) D869G probably benign Het
Loxl2 T C 14: 69,929,859 (GRCm39) Y746H probably benign Het
Ltbr A G 6: 125,286,440 (GRCm39) S249P probably benign Het
Mageb5 A G X: 90,823,701 (GRCm39) I226T probably damaging Het
Msantd2 C T 9: 37,434,227 (GRCm39) R357W probably damaging Het
Mtcl2 T C 2: 156,875,245 (GRCm39) E835G probably damaging Het
Neb A G 2: 52,154,076 (GRCm39) F2345S probably damaging Het
Or7e173 T G 9: 19,938,797 (GRCm39) I146L probably benign Het
Pabpc4l T C 3: 46,401,276 (GRCm39) T123A probably benign Het
Plekhg4 TAGTCGATGCCCGAGTC TAGTC 8: 106,103,084 (GRCm39) probably benign Het
Prkdc T C 16: 15,537,297 (GRCm39) V1716A probably benign Het
Prss37 G A 6: 40,492,294 (GRCm39) R186* probably null Het
Psg20 T A 7: 18,414,947 (GRCm39) Y316F probably benign Het
Rasgrp2 T A 19: 6,454,425 (GRCm39) M156K probably benign Het
Rims1 T A 1: 22,474,732 (GRCm39) R200* probably null Het
Rnf168 T G 16: 32,097,036 (GRCm39) L37R probably damaging Het
Sall3 C T 18: 81,015,012 (GRCm39) G972D probably benign Het
Sap18 T A 14: 58,036,011 (GRCm39) S66T probably damaging Het
Scamp5 C A 9: 57,354,508 (GRCm39) V49F possibly damaging Het
Sdk1 C A 5: 142,170,943 (GRCm39) D1935E possibly damaging Het
Setd2 A G 9: 110,378,932 (GRCm39) S632G probably benign Het
Syt16 T A 12: 74,285,009 (GRCm39) S401T probably damaging Het
Tas2r106 A T 6: 131,655,317 (GRCm39) L178H probably damaging Het
Tbcd A G 11: 121,494,146 (GRCm39) Y983C probably damaging Het
Tenm3 A G 8: 48,870,041 (GRCm39) probably null Het
Tll1 T C 8: 64,538,591 (GRCm39) E351G probably benign Het
Tmem44 T A 16: 30,366,262 (GRCm39) K55* probably null Het
Top2a T C 11: 98,895,054 (GRCm39) I849V probably benign Het
Ttn A G 2: 76,624,792 (GRCm39) V13516A probably damaging Het
Uxs1 A G 1: 43,814,006 (GRCm39) L77P probably damaging Het
Vmn2r121 A T X: 123,043,439 (GRCm39) probably null Het
Vps13b T A 15: 35,646,226 (GRCm39) N1443K probably benign Het
Wfdc6b C T 2: 164,459,363 (GRCm39) R142C probably benign Het
Zfp616 A G 11: 73,973,869 (GRCm39) probably null Het
Zmym1 T C 4: 126,943,363 (GRCm39) T244A probably benign Het
Other mutations in Vmn2r84
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01461:Vmn2r84 APN 10 130,227,094 (GRCm39) missense possibly damaging 0.65
IGL01590:Vmn2r84 APN 10 130,221,964 (GRCm39) missense probably damaging 1.00
IGL01639:Vmn2r84 APN 10 130,225,141 (GRCm39) nonsense probably null
IGL01843:Vmn2r84 APN 10 130,222,148 (GRCm39) missense probably benign
IGL01911:Vmn2r84 APN 10 130,222,277 (GRCm39) missense probably damaging 0.99
IGL01937:Vmn2r84 APN 10 130,221,755 (GRCm39) missense probably damaging 1.00
IGL01977:Vmn2r84 APN 10 130,229,935 (GRCm39) missense probably benign 0.11
IGL02177:Vmn2r84 APN 10 130,227,881 (GRCm39) missense probably benign 0.00
IGL02291:Vmn2r84 APN 10 130,226,617 (GRCm39) missense probably damaging 1.00
IGL02590:Vmn2r84 APN 10 130,227,356 (GRCm39) splice site probably benign
IGL02727:Vmn2r84 APN 10 130,229,995 (GRCm39) missense possibly damaging 0.95
IGL02900:Vmn2r84 APN 10 130,223,861 (GRCm39) splice site probably benign
IGL03383:Vmn2r84 APN 10 130,222,556 (GRCm39) missense probably damaging 1.00
PIT4378001:Vmn2r84 UTSW 10 130,221,784 (GRCm39) missense probably damaging 1.00
R0076:Vmn2r84 UTSW 10 130,230,062 (GRCm39) missense probably damaging 1.00
R0089:Vmn2r84 UTSW 10 130,222,588 (GRCm39) splice site probably benign
R0153:Vmn2r84 UTSW 10 130,227,877 (GRCm39) missense probably benign 0.06
R0611:Vmn2r84 UTSW 10 130,221,991 (GRCm39) missense probably damaging 1.00
R0883:Vmn2r84 UTSW 10 130,226,984 (GRCm39) missense probably damaging 0.99
R1237:Vmn2r84 UTSW 10 130,223,725 (GRCm39) splice site probably null
R1295:Vmn2r84 UTSW 10 130,225,008 (GRCm39) missense probably benign 0.12
R1401:Vmn2r84 UTSW 10 130,227,859 (GRCm39) missense possibly damaging 0.89
R1521:Vmn2r84 UTSW 10 130,225,137 (GRCm39) missense probably benign 0.10
R1590:Vmn2r84 UTSW 10 130,227,349 (GRCm39) critical splice acceptor site probably null
R1710:Vmn2r84 UTSW 10 130,226,968 (GRCm39) missense probably benign 0.02
R1891:Vmn2r84 UTSW 10 130,221,938 (GRCm39) missense possibly damaging 0.78
R1956:Vmn2r84 UTSW 10 130,226,677 (GRCm39) missense probably benign 0.01
R1957:Vmn2r84 UTSW 10 130,226,677 (GRCm39) missense probably benign 0.01
R1962:Vmn2r84 UTSW 10 130,226,591 (GRCm39) missense probably damaging 0.99
R1994:Vmn2r84 UTSW 10 130,221,878 (GRCm39) missense probably damaging 1.00
R2409:Vmn2r84 UTSW 10 130,227,940 (GRCm39) missense probably damaging 0.99
R2474:Vmn2r84 UTSW 10 130,222,392 (GRCm39) missense possibly damaging 0.50
R2851:Vmn2r84 UTSW 10 130,230,036 (GRCm39) missense probably benign 0.05
R3508:Vmn2r84 UTSW 10 130,226,777 (GRCm39) missense probably damaging 1.00
R3792:Vmn2r84 UTSW 10 130,221,669 (GRCm39) makesense probably null
R4051:Vmn2r84 UTSW 10 130,226,767 (GRCm39) missense probably damaging 1.00
R4061:Vmn2r84 UTSW 10 130,221,898 (GRCm39) missense probably damaging 1.00
R4091:Vmn2r84 UTSW 10 130,227,238 (GRCm39) missense probably damaging 1.00
R4190:Vmn2r84 UTSW 10 130,227,163 (GRCm39) nonsense probably null
R4520:Vmn2r84 UTSW 10 130,222,391 (GRCm39) missense probably damaging 1.00
R4584:Vmn2r84 UTSW 10 130,226,582 (GRCm39) missense probably benign 0.00
R4588:Vmn2r84 UTSW 10 130,221,809 (GRCm39) missense probably damaging 0.98
R4655:Vmn2r84 UTSW 10 130,229,973 (GRCm39) nonsense probably null
R4860:Vmn2r84 UTSW 10 130,221,712 (GRCm39) missense probably damaging 0.99
R4860:Vmn2r84 UTSW 10 130,221,712 (GRCm39) missense probably damaging 0.99
R5022:Vmn2r84 UTSW 10 130,222,417 (GRCm39) missense probably damaging 1.00
R5146:Vmn2r84 UTSW 10 130,221,971 (GRCm39) missense probably damaging 1.00
R5237:Vmn2r84 UTSW 10 130,221,863 (GRCm39) missense probably damaging 0.99
R5695:Vmn2r84 UTSW 10 130,225,064 (GRCm39) missense probably benign 0.12
R5793:Vmn2r84 UTSW 10 130,221,754 (GRCm39) missense probably damaging 0.99
R6210:Vmn2r84 UTSW 10 130,222,114 (GRCm39) missense probably damaging 1.00
R6286:Vmn2r84 UTSW 10 130,226,737 (GRCm39) missense possibly damaging 0.65
R6580:Vmn2r84 UTSW 10 130,225,110 (GRCm39) missense possibly damaging 0.93
R6607:Vmn2r84 UTSW 10 130,226,731 (GRCm39) missense possibly damaging 0.87
R6818:Vmn2r84 UTSW 10 130,222,147 (GRCm39) missense probably benign 0.09
R6956:Vmn2r84 UTSW 10 130,225,136 (GRCm39) missense probably damaging 0.98
R6994:Vmn2r84 UTSW 10 130,226,876 (GRCm39) missense possibly damaging 0.90
R7075:Vmn2r84 UTSW 10 130,226,941 (GRCm39) missense probably damaging 0.99
R7225:Vmn2r84 UTSW 10 130,222,552 (GRCm39) missense probably damaging 0.99
R7252:Vmn2r84 UTSW 10 130,222,279 (GRCm39) missense probably damaging 1.00
R7263:Vmn2r84 UTSW 10 130,225,077 (GRCm39) missense probably damaging 1.00
R7297:Vmn2r84 UTSW 10 130,227,119 (GRCm39) missense probably benign 0.19
R7439:Vmn2r84 UTSW 10 130,227,982 (GRCm39) missense possibly damaging 0.90
R7441:Vmn2r84 UTSW 10 130,227,982 (GRCm39) missense possibly damaging 0.90
R7857:Vmn2r84 UTSW 10 130,226,738 (GRCm39) missense probably benign 0.00
R8263:Vmn2r84 UTSW 10 130,227,037 (GRCm39) missense probably damaging 1.00
R8555:Vmn2r84 UTSW 10 130,230,100 (GRCm39) missense probably benign 0.28
R8766:Vmn2r84 UTSW 10 130,222,241 (GRCm39) missense probably damaging 0.98
R8821:Vmn2r84 UTSW 10 130,226,968 (GRCm39) missense probably benign 0.02
R8831:Vmn2r84 UTSW 10 130,226,968 (GRCm39) missense probably benign 0.02
R8970:Vmn2r84 UTSW 10 130,222,244 (GRCm39) missense probably damaging 0.98
R9164:Vmn2r84 UTSW 10 130,221,669 (GRCm39) makesense probably null
R9190:Vmn2r84 UTSW 10 130,226,843 (GRCm39) missense probably benign 0.03
R9261:Vmn2r84 UTSW 10 130,229,976 (GRCm39) missense probably benign 0.00
R9310:Vmn2r84 UTSW 10 130,227,993 (GRCm39) missense possibly damaging 0.81
R9434:Vmn2r84 UTSW 10 130,221,745 (GRCm39) missense possibly damaging 0.65
R9613:Vmn2r84 UTSW 10 130,226,591 (GRCm39) missense probably damaging 0.99
Z1177:Vmn2r84 UTSW 10 130,227,771 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGTGCAAAAGTGACAGTACC -3'
(R):5'- CACACATTTGTCCCATGGCATG -3'

Sequencing Primer
(F):5'- TACCATGGAAGAGATCAAGGCTG -3'
(R):5'- CCATGGCATGGTCTCCTTGATG -3'
Posted On 2014-09-17