Incidental Mutation 'R9516:Myh4'
| ID |
718592 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh4
|
| Ensembl Gene |
ENSMUSG00000057003 |
| Gene Name |
myosin, heavy polypeptide 4, skeletal muscle |
| Synonyms |
MYH-2B, MM, MHC2B, MyHC-IIb, Myhsf, Minimsc, Minmus |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.410)
|
| Stock # |
R9516 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
67128855-67151272 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 67139290 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 536
(I536F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127514
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018632]
[ENSMUST00000170942]
|
| AlphaFold |
Q5SX39 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000018632
AA Change: I536F
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000018632
Gene: ENSMUSG00000057003
AA Change: I536F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
74 |
4.7e-14 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
847 |
1928 |
2.5e-168 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170942
AA Change: I536F
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000127514
Gene: ENSMUSG00000057003
AA Change: I536F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
76 |
1.1e-15 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
low complexity region
|
928 |
942 |
N/A |
INTRINSIC |
|
Pfam:Myosin_tail_1
|
1072 |
1930 |
N/A |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit decreased growth and muscle defects including reduced muscle mass, muscle fiber loss, compensatory fiber hypertrophy, and impaired strength. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(3) : Targeted, knock-out(1) Targeted, other(2) |
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3300002I08Rik |
T |
C |
2: 150,153,122 (GRCm39) |
N88D |
possibly damaging |
Het |
| 4933430I17Rik |
A |
G |
4: 62,460,916 (GRCm39) |
I264V |
probably benign |
Het |
| Abcc8 |
A |
G |
7: 45,787,429 (GRCm39) |
F591L |
probably benign |
Het |
| Abr |
G |
T |
11: 76,310,658 (GRCm39) |
T810K |
probably damaging |
Het |
| Abracl |
T |
C |
10: 17,894,631 (GRCm39) |
E6G |
unknown |
Het |
| Adamts3 |
A |
T |
5: 89,834,750 (GRCm39) |
Y871N |
probably damaging |
Het |
| Akap13 |
T |
C |
7: 75,354,275 (GRCm39) |
Y80H |
probably benign |
Het |
| Alas1 |
A |
G |
9: 106,115,840 (GRCm39) |
|
probably null |
Het |
| Anapc1 |
A |
C |
2: 128,517,633 (GRCm39) |
L337R |
possibly damaging |
Het |
| Apaf1 |
T |
C |
10: 90,915,816 (GRCm39) |
Y24C |
probably damaging |
Het |
| Arhgef16 |
A |
G |
4: 154,365,432 (GRCm39) |
V561A |
possibly damaging |
Het |
| Atp10b |
T |
A |
11: 43,121,224 (GRCm39) |
H962Q |
probably benign |
Het |
| Brsk2 |
A |
G |
7: 141,546,852 (GRCm39) |
T432A |
probably benign |
Het |
| C1rl |
T |
A |
6: 124,485,802 (GRCm39) |
V391E |
probably damaging |
Het |
| Caps2 |
A |
T |
10: 112,036,637 (GRCm39) |
H399L |
probably benign |
Het |
| Ccdc43 |
C |
A |
11: 102,577,207 (GRCm39) |
K199N |
probably benign |
Het |
| Ccdc7a |
G |
T |
8: 129,555,774 (GRCm39) |
P1198T |
unknown |
Het |
| Cct7 |
A |
G |
6: 85,444,625 (GRCm39) |
Y423C |
possibly damaging |
Het |
| Cep112 |
A |
G |
11: 108,648,514 (GRCm39) |
T783A |
probably damaging |
Het |
| Cep250 |
A |
G |
2: 155,833,459 (GRCm39) |
T1795A |
probably benign |
Het |
| Clasp1 |
T |
G |
1: 118,431,560 (GRCm39) |
S397A |
possibly damaging |
Het |
| Clock |
A |
C |
5: 76,377,227 (GRCm39) |
F691V |
possibly damaging |
Het |
| Cmklr1 |
A |
G |
5: 113,752,341 (GRCm39) |
V220A |
probably benign |
Het |
| Coro2b |
A |
T |
9: 62,335,291 (GRCm39) |
Y298* |
probably null |
Het |
| Cspg4b |
A |
T |
13: 113,455,649 (GRCm39) |
N565I |
|
Het |
| Cyp2t4 |
G |
A |
7: 26,854,717 (GRCm39) |
V66M |
possibly damaging |
Het |
| Dlk2 |
G |
A |
17: 46,613,432 (GRCm39) |
G186D |
probably damaging |
Het |
| Dok1 |
T |
C |
6: 83,009,972 (GRCm39) |
K46E |
probably damaging |
Het |
| Dok3 |
A |
G |
13: 55,672,186 (GRCm39) |
I164T |
probably benign |
Het |
| Ercc5 |
T |
A |
1: 44,207,041 (GRCm39) |
D651E |
probably damaging |
Het |
| Erp27 |
T |
C |
6: 136,885,066 (GRCm39) |
K244R |
probably benign |
Het |
| Fhip1a |
G |
A |
3: 85,580,559 (GRCm39) |
Q549* |
probably null |
Het |
| Flvcr2 |
T |
C |
12: 85,793,954 (GRCm39) |
V110A |
possibly damaging |
Het |
| Gsta3 |
T |
C |
1: 21,320,060 (GRCm39) |
L22P |
probably damaging |
Het |
| Hdac5 |
T |
C |
11: 102,093,522 (GRCm39) |
T493A |
probably benign |
Het |
| Hivep2 |
T |
A |
10: 14,005,523 (GRCm39) |
I707N |
probably benign |
Het |
| Hmox1 |
A |
G |
8: 75,823,544 (GRCm39) |
N71D |
probably benign |
Het |
| Hnrnpr |
G |
T |
4: 136,063,615 (GRCm39) |
V342F |
probably damaging |
Het |
| Ifi44 |
T |
C |
3: 151,438,108 (GRCm39) |
D393G |
probably damaging |
Het |
| Ighv1-82 |
A |
T |
12: 115,916,566 (GRCm39) |
F9I |
probably damaging |
Het |
| Kalrn |
A |
G |
16: 33,854,864 (GRCm39) |
S1999P |
probably damaging |
Het |
| Kcnq2 |
A |
G |
2: 180,776,753 (GRCm39) |
S45P |
probably benign |
Het |
| Krt77 |
A |
T |
15: 101,769,779 (GRCm39) |
Y364N |
probably damaging |
Het |
| Kti12 |
T |
C |
4: 108,705,476 (GRCm39) |
V130A |
probably benign |
Het |
| Lama2 |
T |
C |
10: 27,100,015 (GRCm39) |
E830G |
probably benign |
Het |
| Lrrn1 |
T |
A |
6: 107,545,505 (GRCm39) |
H434Q |
probably benign |
Het |
| Med13 |
A |
T |
11: 86,179,801 (GRCm39) |
N1382K |
probably benign |
Het |
| Mrpl42 |
A |
G |
10: 95,332,684 (GRCm39) |
|
probably null |
Het |
| Mtor |
A |
G |
4: 148,569,103 (GRCm39) |
D1140G |
probably benign |
Het |
| Mtrr |
A |
G |
13: 68,720,755 (GRCm39) |
I280T |
probably benign |
Het |
| Nat10 |
A |
C |
2: 103,563,364 (GRCm39) |
L545R |
probably damaging |
Het |
| Nav3 |
T |
A |
10: 109,520,015 (GRCm39) |
D2356V |
probably damaging |
Het |
| Nbea |
A |
T |
3: 55,937,366 (GRCm39) |
S748R |
probably damaging |
Het |
| Nlrp1a |
T |
C |
11: 70,998,488 (GRCm39) |
T904A |
probably benign |
Het |
| Nod2 |
A |
T |
8: 89,397,050 (GRCm39) |
N820I |
probably damaging |
Het |
| Nptx1 |
A |
G |
11: 119,433,381 (GRCm39) |
V406A |
probably damaging |
Het |
| Nrdc |
T |
A |
4: 108,901,863 (GRCm39) |
I644K |
probably benign |
Het |
| Or4e1 |
T |
C |
14: 52,700,873 (GRCm39) |
I198V |
probably benign |
Het |
| Ostf1 |
T |
A |
19: 18,573,735 (GRCm39) |
I38F |
probably benign |
Het |
| Pacc1 |
G |
A |
1: 191,082,004 (GRCm39) |
R337Q |
probably damaging |
Het |
| Pde4b |
G |
T |
4: 102,462,183 (GRCm39) |
D605Y |
probably damaging |
Het |
| Pde4d |
A |
G |
13: 109,397,196 (GRCm39) |
T3A |
|
Het |
| Pknox1 |
A |
G |
17: 31,822,183 (GRCm39) |
I317V |
probably damaging |
Het |
| Plekhh2 |
A |
G |
17: 84,918,240 (GRCm39) |
N1283S |
probably benign |
Het |
| Ppp3cb |
G |
A |
14: 20,573,868 (GRCm39) |
A289V |
probably damaging |
Het |
| Prag1 |
A |
G |
8: 36,607,208 (GRCm39) |
D983G |
probably damaging |
Het |
| Psmd13 |
C |
T |
7: 140,478,455 (GRCm39) |
T62M |
|
Het |
| Rab42 |
C |
T |
4: 132,029,890 (GRCm39) |
V111I |
|
Het |
| Rabl2 |
T |
A |
15: 89,474,631 (GRCm39) |
|
probably null |
Het |
| Rapgef6 |
T |
A |
11: 54,582,169 (GRCm39) |
S1365R |
probably damaging |
Het |
| Rassf4 |
G |
T |
6: 116,617,265 (GRCm39) |
H247N |
possibly damaging |
Het |
| Rbfox1 |
A |
G |
16: 7,227,573 (GRCm39) |
T363A |
probably benign |
Het |
| Rbmyf9 |
T |
A |
Y: 3,774,888 (GRCm39) |
F28L |
probably damaging |
Het |
| Sbf1 |
T |
C |
15: 89,184,742 (GRCm39) |
D1091G |
probably damaging |
Het |
| Scaper |
A |
G |
9: 55,593,275 (GRCm39) |
V454A |
probably benign |
Het |
| Selenbp2 |
G |
A |
3: 94,607,352 (GRCm39) |
D258N |
probably benign |
Het |
| Sirpa |
A |
T |
2: 129,457,555 (GRCm39) |
I210F |
probably damaging |
Het |
| Skint4 |
T |
C |
4: 112,015,236 (GRCm39) |
S434P |
probably benign |
Het |
| Slc26a5 |
G |
A |
5: 22,016,337 (GRCm39) |
Q682* |
probably null |
Het |
| Slco4a1 |
C |
T |
2: 180,115,943 (GRCm39) |
S693F |
possibly damaging |
Het |
| Smpd3 |
A |
G |
8: 106,992,119 (GRCm39) |
F145L |
probably benign |
Het |
| Son |
CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC |
CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC |
16: 91,453,579 (GRCm39) |
|
probably benign |
Het |
| Spata31d1c |
A |
T |
13: 65,184,040 (GRCm39) |
L527F |
probably damaging |
Het |
| Srd5a3 |
A |
G |
5: 76,297,794 (GRCm39) |
N199D |
probably benign |
Het |
| Stard9 |
C |
G |
2: 120,534,564 (GRCm39) |
P3607R |
probably damaging |
Het |
| Sytl1 |
A |
G |
4: 132,986,291 (GRCm39) |
|
probably null |
Het |
| Tas2r126 |
A |
G |
6: 42,412,307 (GRCm39) |
H280R |
probably null |
Het |
| Tcf4 |
C |
T |
18: 69,652,944 (GRCm39) |
|
probably benign |
Het |
| Tlcd2 |
A |
G |
11: 75,359,112 (GRCm39) |
T28A |
probably damaging |
Het |
| Tm7sf3 |
C |
T |
6: 146,525,179 (GRCm39) |
D89N |
possibly damaging |
Het |
| Tmem119 |
A |
G |
5: 113,933,267 (GRCm39) |
L178P |
probably damaging |
Het |
| Tmprss7 |
T |
C |
16: 45,484,564 (GRCm39) |
D532G |
probably benign |
Het |
| Tnfaip8l3 |
A |
G |
9: 53,934,777 (GRCm39) |
I66T |
probably benign |
Het |
| Tor1b |
A |
G |
2: 30,843,185 (GRCm39) |
Y50C |
probably damaging |
Het |
| Tpp2 |
T |
A |
1: 44,017,648 (GRCm39) |
S751T |
probably benign |
Het |
| Tpra1 |
T |
C |
6: 88,887,221 (GRCm39) |
V193A |
probably benign |
Het |
| Trip12 |
A |
T |
1: 84,735,215 (GRCm39) |
V932E |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,777,104 (GRCm39) |
T1479S |
unknown |
Het |
| Unc13c |
A |
T |
9: 73,392,220 (GRCm39) |
V2044D |
probably damaging |
Het |
| Usp25 |
T |
G |
16: 76,852,076 (GRCm39) |
V197G |
probably damaging |
Het |
| Vmn2r34 |
A |
G |
7: 7,675,366 (GRCm39) |
V674A |
probably benign |
Het |
| Zfp7 |
T |
C |
15: 76,775,484 (GRCm39) |
S509P |
probably damaging |
Het |
| Zfp821 |
A |
G |
8: 110,447,856 (GRCm39) |
T66A |
probably damaging |
Het |
| Zfp97 |
T |
A |
17: 17,365,930 (GRCm39) |
N476K |
possibly damaging |
Het |
|
| Other mutations in Myh4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01471:Myh4
|
APN |
11 |
67,146,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01600:Myh4
|
APN |
11 |
67,151,015 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL01737:Myh4
|
APN |
11 |
67,134,245 (GRCm39) |
splice site |
probably benign |
|
|
IGL02208:Myh4
|
APN |
11 |
67,142,760 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02334:Myh4
|
APN |
11 |
67,136,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02376:Myh4
|
APN |
11 |
67,136,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02429:Myh4
|
APN |
11 |
67,149,808 (GRCm39) |
nonsense |
probably null |
|
|
IGL02450:Myh4
|
APN |
11 |
67,142,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02524:Myh4
|
APN |
11 |
67,140,066 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02612:Myh4
|
APN |
11 |
67,147,305 (GRCm39) |
missense |
probably benign |
|
|
IGL03024:Myh4
|
APN |
11 |
67,139,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Myh4
|
APN |
11 |
67,149,982 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03084:Myh4
|
APN |
11 |
67,142,777 (GRCm39) |
splice site |
probably null |
|
|
IGL03188:Myh4
|
APN |
11 |
67,137,369 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03204:Myh4
|
APN |
11 |
67,141,122 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL03252:Myh4
|
APN |
11 |
67,143,042 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03345:Myh4
|
APN |
11 |
67,146,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mr_chicken
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
Mrs_muir
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Willies
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
F6893:Myh4
|
UTSW |
11 |
67,146,283 (GRCm39) |
missense |
probably null |
0.12 |
|
PIT1430001:Myh4
|
UTSW |
11 |
67,149,658 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4458001:Myh4
|
UTSW |
11 |
67,131,821 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0099:Myh4
|
UTSW |
11 |
67,150,173 (GRCm39) |
missense |
probably benign |
|
|
R0194:Myh4
|
UTSW |
11 |
67,143,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0346:Myh4
|
UTSW |
11 |
67,151,152 (GRCm39) |
missense |
probably benign |
|
|
R0427:Myh4
|
UTSW |
11 |
67,149,479 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0483:Myh4
|
UTSW |
11 |
67,143,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Myh4
|
UTSW |
11 |
67,141,157 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0854:Myh4
|
UTSW |
11 |
67,149,973 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0940:Myh4
|
UTSW |
11 |
67,133,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0946:Myh4
|
UTSW |
11 |
67,142,577 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1108:Myh4
|
UTSW |
11 |
67,146,532 (GRCm39) |
missense |
probably null |
0.01 |
|
R1162:Myh4
|
UTSW |
11 |
67,149,439 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1194:Myh4
|
UTSW |
11 |
67,146,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1347:Myh4
|
UTSW |
11 |
67,135,567 (GRCm39) |
splice site |
probably benign |
|
|
R1457:Myh4
|
UTSW |
11 |
67,139,287 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1531:Myh4
|
UTSW |
11 |
67,141,366 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1716:Myh4
|
UTSW |
11 |
67,141,135 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1766:Myh4
|
UTSW |
11 |
67,147,121 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1796:Myh4
|
UTSW |
11 |
67,151,150 (GRCm39) |
missense |
probably benign |
|
|
R1856:Myh4
|
UTSW |
11 |
67,146,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1873:Myh4
|
UTSW |
11 |
67,145,569 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2069:Myh4
|
UTSW |
11 |
67,137,192 (GRCm39) |
splice site |
probably benign |
|
|
R2370:Myh4
|
UTSW |
11 |
67,146,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2406:Myh4
|
UTSW |
11 |
67,150,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2414:Myh4
|
UTSW |
11 |
67,141,594 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2848:Myh4
|
UTSW |
11 |
67,139,459 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3111:Myh4
|
UTSW |
11 |
67,137,276 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3744:Myh4
|
UTSW |
11 |
67,146,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3845:Myh4
|
UTSW |
11 |
67,149,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3877:Myh4
|
UTSW |
11 |
67,148,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4498:Myh4
|
UTSW |
11 |
67,142,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4514:Myh4
|
UTSW |
11 |
67,146,395 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4601:Myh4
|
UTSW |
11 |
67,141,136 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4673:Myh4
|
UTSW |
11 |
67,137,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4684:Myh4
|
UTSW |
11 |
67,136,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4736:Myh4
|
UTSW |
11 |
67,131,746 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4837:Myh4
|
UTSW |
11 |
67,149,818 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4866:Myh4
|
UTSW |
11 |
67,139,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4869:Myh4
|
UTSW |
11 |
67,143,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4887:Myh4
|
UTSW |
11 |
67,131,880 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4921:Myh4
|
UTSW |
11 |
67,144,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5005:Myh4
|
UTSW |
11 |
67,144,241 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5008:Myh4
|
UTSW |
11 |
67,144,358 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5011:Myh4
|
UTSW |
11 |
67,147,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5087:Myh4
|
UTSW |
11 |
67,146,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Myh4
|
UTSW |
11 |
67,143,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Myh4
|
UTSW |
11 |
67,150,017 (GRCm39) |
splice site |
probably null |
|
|
R5354:Myh4
|
UTSW |
11 |
67,146,551 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5371:Myh4
|
UTSW |
11 |
67,150,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Myh4
|
UTSW |
11 |
67,142,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5774:Myh4
|
UTSW |
11 |
67,144,034 (GRCm39) |
nonsense |
probably null |
|
|
R5902:Myh4
|
UTSW |
11 |
67,141,733 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5941:Myh4
|
UTSW |
11 |
67,150,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6045:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6156:Myh4
|
UTSW |
11 |
67,141,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6301:Myh4
|
UTSW |
11 |
67,146,159 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6318:Myh4
|
UTSW |
11 |
67,134,268 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6352:Myh4
|
UTSW |
11 |
67,143,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6385:Myh4
|
UTSW |
11 |
67,146,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6493:Myh4
|
UTSW |
11 |
67,149,455 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6666:Myh4
|
UTSW |
11 |
67,142,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6826:Myh4
|
UTSW |
11 |
67,137,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Myh4
|
UTSW |
11 |
67,143,794 (GRCm39) |
splice site |
probably null |
|
|
R6857:Myh4
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7029:Myh4
|
UTSW |
11 |
67,137,251 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7076:Myh4
|
UTSW |
11 |
67,143,999 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7145:Myh4
|
UTSW |
11 |
67,151,054 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7179:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7365:Myh4
|
UTSW |
11 |
67,133,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7514:Myh4
|
UTSW |
11 |
67,134,148 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7553:Myh4
|
UTSW |
11 |
67,147,221 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Myh4
|
UTSW |
11 |
67,147,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7673:Myh4
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7685:Myh4
|
UTSW |
11 |
67,131,756 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8154:Myh4
|
UTSW |
11 |
67,144,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8343:Myh4
|
UTSW |
11 |
67,143,390 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R8446:Myh4
|
UTSW |
11 |
67,144,347 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8534:Myh4
|
UTSW |
11 |
67,134,335 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8710:Myh4
|
UTSW |
11 |
67,143,158 (GRCm39) |
missense |
probably benign |
|
|
R8775:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8775-TAIL:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8852:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Myh4
|
UTSW |
11 |
67,137,362 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8954:Myh4
|
UTSW |
11 |
67,143,806 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8957:Myh4
|
UTSW |
11 |
67,141,780 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9065:Myh4
|
UTSW |
11 |
67,139,573 (GRCm39) |
missense |
probably benign |
|
|
R9280:Myh4
|
UTSW |
11 |
67,146,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9296:Myh4
|
UTSW |
11 |
67,146,130 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9310:Myh4
|
UTSW |
11 |
67,145,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9314:Myh4
|
UTSW |
11 |
67,151,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Myh4
|
UTSW |
11 |
67,141,811 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9516:Myh4
|
UTSW |
11 |
67,141,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9773:Myh4
|
UTSW |
11 |
67,137,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Myh4
|
UTSW |
11 |
67,137,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,147,097 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1176:Myh4
|
UTSW |
11 |
67,144,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,139,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGCAAAGTATATGCGTTCCTATG -3'
(R):5'- ATGTTGTAGTCCACGGTGCC -3'
Sequencing Primer
(F):5'- CCTATGCATTCTTCAGATGATGATGG -3'
(R):5'- TGCCCGCATAGTGCACCAG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation