Incidental Mutation 'R9632:Ttc6'
| ID |
725603 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc6
|
| Ensembl Gene |
ENSMUSG00000046782 |
| Gene Name |
tetratricopeptide repeat domain 6 |
| Synonyms |
LOC217602, Gm9813, EG639426, 4921506M07Rik, AU024163 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.119)
|
| Stock # |
R9632 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
57610899-57784714 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 57664299 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 351
(M351V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000098946
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000101398]
[ENSMUST00000172939]
|
| AlphaFold |
G3UYY4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000101398
AA Change: M351V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000098946
Gene: ENSMUSG00000046782
AA Change: M351V
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
18 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
146 |
162 |
N/A |
INTRINSIC |
|
low complexity region
|
188 |
212 |
N/A |
INTRINSIC |
|
low complexity region
|
227 |
238 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172939
AA Change: M351V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000134273
Gene: ENSMUSG00000046782
AA Change: M351V
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
18 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
146 |
162 |
N/A |
INTRINSIC |
|
low complexity region
|
188 |
212 |
N/A |
INTRINSIC |
|
low complexity region
|
227 |
238 |
N/A |
INTRINSIC |
|
low complexity region
|
486 |
495 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
733 |
740 |
N/A |
INTRINSIC |
|
TPR
|
889 |
922 |
2e-4 |
SMART |
|
TPR
|
957 |
989 |
2.36e1 |
SMART |
|
TPR
|
990 |
1022 |
2.63e1 |
SMART |
|
TPR
|
1023 |
1056 |
9.39e-1 |
SMART |
|
TPR
|
1057 |
1090 |
3.78e-5 |
SMART |
|
Blast:TPR
|
1126 |
1157 |
1e-11 |
BLAST |
|
SEL1
|
1160 |
1192 |
3.39e1 |
SMART |
|
TPR
|
1160 |
1194 |
4.44e1 |
SMART |
|
TPR
|
1195 |
1228 |
7.87e0 |
SMART |
|
Blast:TPR
|
1229 |
1262 |
1e-11 |
BLAST |
|
TPR
|
1297 |
1330 |
1.24e0 |
SMART |
|
SEL1
|
1341 |
1372 |
9.26e-1 |
SMART |
|
TPR
|
1341 |
1374 |
3.45e-8 |
SMART |
|
TPR
|
1375 |
1407 |
8.76e-1 |
SMART |
|
TPR
|
1408 |
1441 |
1.45e-1 |
SMART |
|
TPR
|
1442 |
1475 |
1.36e1 |
SMART |
|
TPR
|
1476 |
1509 |
7.34e-3 |
SMART |
|
TPR
|
1513 |
1546 |
1.01e0 |
SMART |
|
TPR
|
1547 |
1580 |
2.55e-2 |
SMART |
|
TPR
|
1581 |
1617 |
2.43e1 |
SMART |
|
Blast:TPR
|
1618 |
1651 |
4e-12 |
BLAST |
|
TPR
|
1652 |
1685 |
7.87e0 |
SMART |
|
TPR
|
1686 |
1718 |
2.35e-1 |
SMART |
|
SEL1
|
1719 |
1750 |
1.21e2 |
SMART |
|
TPR
|
1719 |
1752 |
1.65e-5 |
SMART |
|
TPR
|
1753 |
1786 |
1.66e-1 |
SMART |
|
TPR
|
1787 |
1820 |
1.45e-1 |
SMART |
|
TPR
|
1821 |
1854 |
3.27e0 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acly |
A |
G |
11: 100,389,072 (GRCm39) |
I570T |
probably damaging |
Het |
| Adamtsl4 |
G |
A |
3: 95,589,090 (GRCm39) |
T447I |
probably damaging |
Het |
| Ahcyl1 |
T |
A |
3: 107,578,494 (GRCm39) |
I248F |
possibly damaging |
Het |
| Arhgef2 |
T |
C |
3: 88,528,576 (GRCm39) |
I4T |
probably benign |
Het |
| Bin2 |
T |
C |
15: 100,549,915 (GRCm39) |
D176G |
possibly damaging |
Het |
| Bptf |
T |
A |
11: 106,952,545 (GRCm39) |
T2166S |
probably damaging |
Het |
| Cachd1 |
T |
A |
4: 100,832,092 (GRCm39) |
N751K |
probably benign |
Het |
| Castor1 |
A |
G |
11: 4,169,015 (GRCm39) |
K61E |
probably benign |
Het |
| CN725425 |
A |
T |
15: 91,126,851 (GRCm39) |
T214S |
possibly damaging |
Het |
| Crtam |
A |
T |
9: 40,895,671 (GRCm39) |
D218E |
probably benign |
Het |
| Ctsj |
C |
T |
13: 61,151,828 (GRCm39) |
M76I |
probably benign |
Het |
| Cuedc1 |
C |
A |
11: 88,060,955 (GRCm39) |
S99R |
possibly damaging |
Het |
| Cyp4a14 |
T |
A |
4: 115,349,347 (GRCm39) |
I238F |
probably benign |
Het |
| Dnajb11 |
A |
T |
16: 22,681,344 (GRCm39) |
I41F |
probably damaging |
Het |
| Drd3 |
A |
G |
16: 43,643,135 (GRCm39) |
N425S |
probably damaging |
Het |
| Eci1 |
G |
C |
17: 24,645,859 (GRCm39) |
G25R |
probably damaging |
Het |
| Etl4 |
A |
T |
2: 20,666,749 (GRCm39) |
N52I |
probably benign |
Het |
| Fbxo34 |
T |
C |
14: 47,768,724 (GRCm39) |
Y746H |
probably damaging |
Het |
| Fcgbpl1 |
A |
G |
7: 27,841,726 (GRCm39) |
I554V |
probably benign |
Het |
| Fndc1 |
T |
C |
17: 7,991,622 (GRCm39) |
I691M |
unknown |
Het |
| Fut8 |
A |
G |
12: 77,440,507 (GRCm39) |
T165A |
probably benign |
Het |
| Galr1 |
A |
T |
18: 82,424,103 (GRCm39) |
L58Q |
probably damaging |
Het |
| Glt28d2 |
T |
C |
3: 85,779,059 (GRCm39) |
D138G |
probably benign |
Het |
| Gm11595 |
A |
T |
11: 99,663,097 (GRCm39) |
C194* |
probably null |
Het |
| Gm14403 |
T |
A |
2: 177,201,421 (GRCm39) |
N213K |
probably benign |
Het |
| Gmpr |
T |
C |
13: 45,699,519 (GRCm39) |
V343A |
probably benign |
Het |
| Hacd1 |
T |
C |
2: 14,040,678 (GRCm39) |
N152D |
possibly damaging |
Het |
| Hcn1 |
A |
G |
13: 118,010,522 (GRCm39) |
S367G |
probably benign |
Het |
| Impg1 |
A |
G |
9: 80,287,276 (GRCm39) |
V390A |
probably benign |
Het |
| Itpr1 |
T |
C |
6: 108,382,481 (GRCm39) |
C1458R |
possibly damaging |
Het |
| Kif16b |
A |
T |
2: 142,553,960 (GRCm39) |
V946E |
probably benign |
Het |
| Krt71 |
T |
C |
15: 101,644,988 (GRCm39) |
E441G |
probably damaging |
Het |
| Lhcgr |
A |
G |
17: 89,049,532 (GRCm39) |
F665L |
probably benign |
Het |
| Lrrc37 |
T |
A |
11: 103,433,252 (GRCm39) |
S3306C |
unknown |
Het |
| Lzic |
T |
A |
4: 149,573,141 (GRCm39) |
F98I |
probably damaging |
Het |
| Map3k8 |
A |
T |
18: 4,339,546 (GRCm39) |
V275D |
probably damaging |
Het |
| Marchf8 |
C |
T |
6: 116,378,405 (GRCm39) |
T113I |
possibly damaging |
Het |
| Mmp15 |
A |
G |
8: 96,098,731 (GRCm39) |
|
probably null |
Het |
| Mpst |
A |
G |
15: 78,294,469 (GRCm39) |
D67G |
probably damaging |
Het |
| Nanog |
T |
C |
6: 122,684,799 (GRCm39) |
S20P |
probably benign |
Het |
| Ndufc2 |
T |
C |
7: 97,056,102 (GRCm39) |
S67P |
probably damaging |
Het |
| Nrg1 |
T |
C |
8: 32,407,621 (GRCm39) |
K204R |
possibly damaging |
Het |
| Nsf |
T |
A |
11: 103,714,594 (GRCm39) |
K728N |
probably damaging |
Het |
| Nutm2 |
C |
A |
13: 50,628,901 (GRCm39) |
P655H |
probably benign |
Het |
| Obscn |
G |
A |
11: 58,943,397 (GRCm39) |
R4251C |
probably benign |
Het |
| Or10g9 |
A |
T |
9: 39,912,172 (GRCm39) |
M117K |
probably damaging |
Het |
| Or11h4 |
C |
T |
14: 50,974,199 (GRCm39) |
C140Y |
probably benign |
Het |
| Or4a15 |
T |
C |
2: 89,193,065 (GRCm39) |
Y236C |
probably damaging |
Het |
| Or4c102 |
A |
T |
2: 88,423,057 (GRCm39) |
Q303L |
probably benign |
Het |
| Or4c120 |
T |
C |
2: 89,001,752 (GRCm39) |
|
probably benign |
Het |
| Or56a5 |
T |
A |
7: 104,793,165 (GRCm39) |
T112S |
probably benign |
Het |
| Otog |
A |
T |
7: 45,915,143 (GRCm39) |
Q836L |
probably benign |
Het |
| Pcdhb11 |
T |
C |
18: 37,556,019 (GRCm39) |
F450L |
probably damaging |
Het |
| Pelp1 |
T |
C |
11: 70,284,835 (GRCm39) |
E1011G |
unknown |
Het |
| Pfkfb3 |
T |
G |
2: 11,486,109 (GRCm39) |
R459S |
probably benign |
Het |
| Pgm1 |
T |
C |
4: 99,843,918 (GRCm39) |
L567P |
probably damaging |
Het |
| Phf2 |
T |
A |
13: 48,971,292 (GRCm39) |
D460V |
unknown |
Het |
| Polr1f |
G |
A |
12: 33,479,723 (GRCm39) |
G24R |
possibly damaging |
Het |
| Pou5f1 |
G |
A |
17: 35,819,731 (GRCm39) |
|
probably benign |
Het |
| Pou6f2 |
T |
C |
13: 18,299,848 (GRCm39) |
R604G |
|
Het |
| Pramel5 |
T |
A |
4: 143,999,545 (GRCm39) |
I181F |
probably benign |
Het |
| Ptprc |
T |
C |
1: 138,008,627 (GRCm39) |
R687G |
probably damaging |
Het |
| Ptprz1 |
T |
A |
6: 23,007,292 (GRCm39) |
H1618Q |
probably damaging |
Het |
| Qars1 |
G |
A |
9: 108,391,582 (GRCm39) |
D618N |
probably damaging |
Het |
| Ripply3 |
A |
G |
16: 94,134,139 (GRCm39) |
T68A |
probably benign |
Het |
| Rrad |
A |
G |
8: 105,356,320 (GRCm39) |
M160T |
probably benign |
Het |
| Rtn1 |
A |
G |
12: 72,350,961 (GRCm39) |
V416A |
probably damaging |
Het |
| Rttn |
A |
G |
18: 89,035,334 (GRCm39) |
N736S |
possibly damaging |
Het |
| Sash1 |
A |
T |
10: 8,615,969 (GRCm39) |
V631E |
probably damaging |
Het |
| Selenof |
T |
A |
3: 144,283,370 (GRCm39) |
F33L |
probably benign |
Het |
| Serpinb6b |
A |
T |
13: 33,155,532 (GRCm39) |
N82Y |
possibly damaging |
Het |
| Sez6 |
G |
A |
11: 77,865,121 (GRCm39) |
E623K |
possibly damaging |
Het |
| Shpk |
G |
T |
11: 73,104,238 (GRCm39) |
R129L |
probably damaging |
Het |
| Slc2a10 |
A |
C |
2: 165,358,176 (GRCm39) |
I434L |
probably damaging |
Het |
| Slc30a6 |
G |
T |
17: 74,730,059 (GRCm39) |
M316I |
probably benign |
Het |
| Slx4 |
A |
T |
16: 3,803,969 (GRCm39) |
H948Q |
probably benign |
Het |
| Sncaip |
A |
G |
18: 53,039,726 (GRCm39) |
E640G |
probably damaging |
Het |
| Sox7 |
G |
A |
14: 64,185,509 (GRCm39) |
A182T |
probably benign |
Het |
| Spata31e5 |
T |
A |
1: 28,817,120 (GRCm39) |
Y304F |
probably benign |
Het |
| Srcin1 |
A |
G |
11: 97,442,648 (GRCm39) |
I60T |
probably benign |
Het |
| Srm |
C |
T |
4: 148,676,039 (GRCm39) |
|
probably benign |
Het |
| Srrt |
A |
T |
5: 137,296,689 (GRCm39) |
M447K |
possibly damaging |
Het |
| Stam |
A |
T |
2: 14,122,204 (GRCm39) |
H101L |
probably damaging |
Het |
| Suz12 |
C |
T |
11: 79,915,748 (GRCm39) |
T407M |
possibly damaging |
Het |
| Tbc1d10b |
A |
G |
7: 126,807,036 (GRCm39) |
V167A |
probably benign |
Het |
| Trav16 |
T |
A |
14: 53,980,910 (GRCm39) |
V33E |
possibly damaging |
Het |
| Tshr |
C |
T |
12: 91,504,409 (GRCm39) |
P449L |
probably damaging |
Het |
| Ttc17 |
A |
G |
2: 94,209,097 (GRCm39) |
V119A |
probably damaging |
Het |
| Ttc19 |
A |
G |
11: 62,203,997 (GRCm39) |
I319M |
probably benign |
Het |
| Ttn |
G |
A |
2: 76,714,897 (GRCm39) |
R8026* |
probably null |
Het |
| Ttn |
A |
T |
2: 76,750,210 (GRCm39) |
V3613E |
probably benign |
Het |
| Txndc16 |
T |
C |
14: 45,400,467 (GRCm39) |
I345V |
probably benign |
Het |
| Ube3b |
T |
C |
5: 114,553,370 (GRCm39) |
I914T |
probably benign |
Het |
| Vmn1r73 |
T |
C |
7: 11,490,407 (GRCm39) |
F75S |
possibly damaging |
Het |
| Vmn2r54 |
A |
T |
7: 12,363,753 (GRCm39) |
M380K |
possibly damaging |
Het |
| Zfp820 |
T |
C |
17: 22,038,107 (GRCm39) |
Y407C |
probably damaging |
Het |
| Zic5 |
C |
T |
14: 122,701,787 (GRCm39) |
A315T |
unknown |
Het |
| Zmiz1 |
C |
A |
14: 25,663,411 (GRCm39) |
D1053E |
unknown |
Het |
|
| Other mutations in Ttc6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03278:Ttc6
|
APN |
12 |
57,668,812 (GRCm39) |
missense |
probably damaging |
0.99 |
|
polonius
|
UTSW |
12 |
57,704,928 (GRCm39) |
splice site |
probably null |
|
|
tybalt
|
UTSW |
12 |
57,720,542 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02802:Ttc6
|
UTSW |
12 |
57,622,654 (GRCm39) |
missense |
probably benign |
0.14 |
|
PIT4802001:Ttc6
|
UTSW |
12 |
57,772,462 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0698:Ttc6
|
UTSW |
12 |
57,720,002 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0988:Ttc6
|
UTSW |
12 |
57,735,435 (GRCm39) |
splice site |
probably benign |
|
|
R1290:Ttc6
|
UTSW |
12 |
57,707,199 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1338:Ttc6
|
UTSW |
12 |
57,663,155 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1468:Ttc6
|
UTSW |
12 |
57,721,463 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1468:Ttc6
|
UTSW |
12 |
57,721,463 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1481:Ttc6
|
UTSW |
12 |
57,783,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1488:Ttc6
|
UTSW |
12 |
57,696,301 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1558:Ttc6
|
UTSW |
12 |
57,733,132 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1570:Ttc6
|
UTSW |
12 |
57,721,549 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1619:Ttc6
|
UTSW |
12 |
57,784,454 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1819:Ttc6
|
UTSW |
12 |
57,741,286 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1826:Ttc6
|
UTSW |
12 |
57,707,033 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1863:Ttc6
|
UTSW |
12 |
57,760,881 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1872:Ttc6
|
UTSW |
12 |
57,751,338 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1887:Ttc6
|
UTSW |
12 |
57,720,044 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1937:Ttc6
|
UTSW |
12 |
57,663,109 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2014:Ttc6
|
UTSW |
12 |
57,623,003 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2056:Ttc6
|
UTSW |
12 |
57,784,479 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2058:Ttc6
|
UTSW |
12 |
57,784,479 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2059:Ttc6
|
UTSW |
12 |
57,784,479 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2152:Ttc6
|
UTSW |
12 |
57,752,338 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2179:Ttc6
|
UTSW |
12 |
57,719,904 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2275:Ttc6
|
UTSW |
12 |
57,749,084 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2432:Ttc6
|
UTSW |
12 |
57,668,821 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2474:Ttc6
|
UTSW |
12 |
57,622,713 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2853:Ttc6
|
UTSW |
12 |
57,622,967 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3848:Ttc6
|
UTSW |
12 |
57,723,932 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3853:Ttc6
|
UTSW |
12 |
57,775,335 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3950:Ttc6
|
UTSW |
12 |
57,696,292 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3953:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3954:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3955:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3957:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4135:Ttc6
|
UTSW |
12 |
57,679,581 (GRCm39) |
intron |
probably benign |
|
|
R4387:Ttc6
|
UTSW |
12 |
57,689,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4577:Ttc6
|
UTSW |
12 |
57,623,441 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4747:Ttc6
|
UTSW |
12 |
57,721,478 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4779:Ttc6
|
UTSW |
12 |
57,776,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4803:Ttc6
|
UTSW |
12 |
57,775,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4871:Ttc6
|
UTSW |
12 |
57,749,142 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4898:Ttc6
|
UTSW |
12 |
57,707,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4930:Ttc6
|
UTSW |
12 |
57,720,609 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4946:Ttc6
|
UTSW |
12 |
57,689,926 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5257:Ttc6
|
UTSW |
12 |
57,749,061 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5303:Ttc6
|
UTSW |
12 |
57,622,606 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5385:Ttc6
|
UTSW |
12 |
57,689,821 (GRCm39) |
splice site |
probably null |
|
|
R5402:Ttc6
|
UTSW |
12 |
57,783,817 (GRCm39) |
nonsense |
probably null |
|
|
R5428:Ttc6
|
UTSW |
12 |
57,736,620 (GRCm39) |
missense |
probably null |
0.98 |
|
R5436:Ttc6
|
UTSW |
12 |
57,721,380 (GRCm39) |
splice site |
probably null |
|
|
R5646:Ttc6
|
UTSW |
12 |
57,622,805 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5697:Ttc6
|
UTSW |
12 |
57,724,000 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5792:Ttc6
|
UTSW |
12 |
57,719,990 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5808:Ttc6
|
UTSW |
12 |
57,664,397 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5842:Ttc6
|
UTSW |
12 |
57,783,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5935:Ttc6
|
UTSW |
12 |
57,720,590 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6144:Ttc6
|
UTSW |
12 |
57,719,886 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6155:Ttc6
|
UTSW |
12 |
57,784,402 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6283:Ttc6
|
UTSW |
12 |
57,749,048 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6371:Ttc6
|
UTSW |
12 |
57,775,249 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6715:Ttc6
|
UTSW |
12 |
57,721,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6738:Ttc6
|
UTSW |
12 |
57,735,426 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6795:Ttc6
|
UTSW |
12 |
57,751,199 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6959:Ttc6
|
UTSW |
12 |
57,704,928 (GRCm39) |
splice site |
probably null |
|
|
R7053:Ttc6
|
UTSW |
12 |
57,707,318 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7125:Ttc6
|
UTSW |
12 |
57,623,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7259:Ttc6
|
UTSW |
12 |
57,622,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7304:Ttc6
|
UTSW |
12 |
57,622,837 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7369:Ttc6
|
UTSW |
12 |
57,719,717 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7409:Ttc6
|
UTSW |
12 |
57,743,772 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7429:Ttc6
|
UTSW |
12 |
57,704,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7430:Ttc6
|
UTSW |
12 |
57,704,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7492:Ttc6
|
UTSW |
12 |
57,719,922 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7535:Ttc6
|
UTSW |
12 |
57,623,305 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7866:Ttc6
|
UTSW |
12 |
57,721,435 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7901:Ttc6
|
UTSW |
12 |
57,735,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7944:Ttc6
|
UTSW |
12 |
57,707,229 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7945:Ttc6
|
UTSW |
12 |
57,707,229 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7965:Ttc6
|
UTSW |
12 |
57,720,542 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8062:Ttc6
|
UTSW |
12 |
57,783,764 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8119:Ttc6
|
UTSW |
12 |
57,752,429 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8142:Ttc6
|
UTSW |
12 |
57,744,258 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8154:Ttc6
|
UTSW |
12 |
57,776,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8171:Ttc6
|
UTSW |
12 |
57,720,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8335:Ttc6
|
UTSW |
12 |
57,707,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8343:Ttc6
|
UTSW |
12 |
57,707,282 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8696:Ttc6
|
UTSW |
12 |
57,784,492 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8875:Ttc6
|
UTSW |
12 |
57,776,194 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8875:Ttc6
|
UTSW |
12 |
57,751,199 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8876:Ttc6
|
UTSW |
12 |
57,784,489 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8924:Ttc6
|
UTSW |
12 |
57,697,790 (GRCm39) |
nonsense |
probably null |
|
|
R8944:Ttc6
|
UTSW |
12 |
57,689,826 (GRCm39) |
missense |
|
|
|
R8956:Ttc6
|
UTSW |
12 |
57,775,196 (GRCm39) |
nonsense |
probably null |
|
|
R9009:Ttc6
|
UTSW |
12 |
57,744,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9020:Ttc6
|
UTSW |
12 |
57,752,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9051:Ttc6
|
UTSW |
12 |
57,783,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9232:Ttc6
|
UTSW |
12 |
57,776,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9291:Ttc6
|
UTSW |
12 |
57,622,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9304:Ttc6
|
UTSW |
12 |
57,776,117 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9309:Ttc6
|
UTSW |
12 |
57,753,649 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9331:Ttc6
|
UTSW |
12 |
57,720,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9398:Ttc6
|
UTSW |
12 |
57,784,404 (GRCm39) |
nonsense |
probably null |
|
|
R9430:Ttc6
|
UTSW |
12 |
57,733,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9688:Ttc6
|
UTSW |
12 |
57,720,602 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9732:Ttc6
|
UTSW |
12 |
57,775,335 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9740:Ttc6
|
UTSW |
12 |
57,736,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9749:Ttc6
|
UTSW |
12 |
57,701,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0021:Ttc6
|
UTSW |
12 |
57,622,904 (GRCm39) |
missense |
probably damaging |
0.96 |
|
X0058:Ttc6
|
UTSW |
12 |
57,753,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Ttc6
|
UTSW |
12 |
57,744,161 (GRCm39) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCAGACCAAGCTGAGTTC -3'
(R):5'- ATCACCGGTTCTCACAGTTC -3'
Sequencing Primer
(F):5'- AAGCTGAGTTCCAGACTTGC -3'
(R):5'- TAAGTGTTTCCGACGCCAACAG -3'
|
| Posted On |
2022-09-12 |
Incidental Mutation