Incidental Mutation 'IGL01601:Dock2'
ID 91789
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dock2
Ensembl Gene ENSMUSG00000020143
Gene Name dedicator of cyto-kinesis 2
Synonyms CED-5, Hch, MBC
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01601
Quality Score
Status
Chromosome 11
Chromosomal Location 34176815-34674719 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to A at 34189528 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000090884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093193]
AlphaFold Q8C3J5
Predicted Effect probably null
Transcript: ENSMUST00000093193
SMART Domains Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143

DomainStartEndE-ValueType
SH3 11 68 1.22e-11 SMART
Pfam:DOCK_N 71 414 2e-113 PFAM
Pfam:DOCK-C2 419 616 1e-60 PFAM
Pfam:DHR-2 1114 1614 6.3e-96 PFAM
low complexity region 1691 1706 N/A INTRINSIC
low complexity region 1793 1800 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf2 T C 17: 43,020,940 (GRCm39) D628G probably benign Het
Aldh1l1 T A 6: 90,568,823 (GRCm39) I708N probably damaging Het
Ank3 T A 10: 69,840,555 (GRCm39) F985I possibly damaging Het
Arap2 A G 5: 62,798,685 (GRCm39) W1315R probably damaging Het
Arhgef33 C A 17: 80,655,112 (GRCm39) Q106K probably damaging Het
Atad5 G A 11: 79,986,343 (GRCm39) G477S probably benign Het
Chgb T A 2: 132,635,411 (GRCm39) I451K probably benign Het
Cln6 T A 9: 62,754,252 (GRCm39) I98N probably damaging Het
Commd1 T C 11: 22,849,981 (GRCm39) E234G probably damaging Het
Flrt2 T C 12: 95,746,369 (GRCm39) S236P probably damaging Het
Garnl3 G A 2: 32,887,701 (GRCm39) Q770* probably null Het
Gpr22 C T 12: 31,760,044 (GRCm39) probably benign Het
Hmcn1 A T 1: 150,503,164 (GRCm39) D3880E probably benign Het
Lgals8 T C 13: 12,471,219 (GRCm39) probably benign Het
Mccc1 A G 3: 36,044,101 (GRCm39) V214A probably benign Het
Nat8l T C 5: 34,155,809 (GRCm39) L155P probably damaging Het
Nckipsd A G 9: 108,691,154 (GRCm39) S359G probably benign Het
Pex6 A C 17: 47,034,650 (GRCm39) N785T probably damaging Het
Potefam1 A T 2: 111,023,823 (GRCm39) C104S unknown Het
Ptprz1 T A 6: 23,000,437 (GRCm39) H842Q probably damaging Het
Rhno1 A T 6: 128,335,021 (GRCm39) S101T probably damaging Het
Rnf103 T G 6: 71,486,167 (GRCm39) V266G probably damaging Het
Slc25a39 T C 11: 102,296,544 (GRCm39) D100G probably damaging Het
Sspo T C 6: 48,463,313 (GRCm39) L3746P probably benign Het
Svep1 C T 4: 58,084,872 (GRCm39) G1822E probably damaging Het
Tbl3 T A 17: 24,921,291 (GRCm39) D500V probably damaging Het
Tmc5 T C 7: 118,223,047 (GRCm39) probably benign Het
Usp20 C T 2: 30,901,806 (GRCm39) R524W probably benign Het
Wnk2 G T 13: 49,230,038 (GRCm39) P829T probably damaging Het
Zmiz1 A G 14: 25,582,068 (GRCm39) N84S possibly damaging Het
Other mutations in Dock2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:Dock2 APN 11 34,595,488 (GRCm39) missense probably damaging 1.00
IGL00469:Dock2 APN 11 34,179,603 (GRCm39) splice site probably benign
IGL01061:Dock2 APN 11 34,596,653 (GRCm39) missense probably damaging 1.00
IGL01319:Dock2 APN 11 34,589,617 (GRCm39) missense possibly damaging 0.61
IGL01451:Dock2 APN 11 34,260,390 (GRCm39) missense probably damaging 1.00
IGL01490:Dock2 APN 11 34,596,608 (GRCm39) missense probably damaging 0.97
IGL01800:Dock2 APN 11 34,647,100 (GRCm39) missense probably damaging 1.00
IGL01804:Dock2 APN 11 34,212,433 (GRCm39) missense probably benign 0.01
IGL01823:Dock2 APN 11 34,212,391 (GRCm39) missense probably damaging 1.00
IGL01829:Dock2 APN 11 34,596,668 (GRCm39) missense probably damaging 0.98
IGL01830:Dock2 APN 11 34,582,744 (GRCm39) nonsense probably null
IGL01835:Dock2 APN 11 34,260,435 (GRCm39) missense possibly damaging 0.51
IGL01845:Dock2 APN 11 34,599,692 (GRCm39) missense probably benign 0.02
IGL01953:Dock2 APN 11 34,623,183 (GRCm39) missense probably benign 0.28
IGL01989:Dock2 APN 11 34,218,053 (GRCm39) missense probably benign
IGL02081:Dock2 APN 11 34,204,355 (GRCm39) missense probably benign
IGL02105:Dock2 APN 11 34,605,352 (GRCm39) missense probably damaging 1.00
IGL02153:Dock2 APN 11 34,180,670 (GRCm39) missense probably benign 0.01
IGL02170:Dock2 APN 11 34,217,949 (GRCm39) missense probably damaging 1.00
IGL02344:Dock2 APN 11 34,622,337 (GRCm39) missense probably damaging 0.98
IGL02389:Dock2 APN 11 34,589,567 (GRCm39) splice site probably benign
IGL02409:Dock2 APN 11 34,451,204 (GRCm39) missense probably benign 0.00
IGL02472:Dock2 APN 11 34,199,801 (GRCm39) missense probably benign 0.00
IGL02625:Dock2 APN 11 34,451,168 (GRCm39) critical splice donor site probably null
IGL02929:Dock2 APN 11 34,218,048 (GRCm39) missense probably damaging 1.00
IGL02951:Dock2 APN 11 34,260,448 (GRCm39) unclassified probably benign
IGL02999:Dock2 APN 11 34,583,086 (GRCm39) missense probably damaging 0.99
IGL03165:Dock2 APN 11 34,578,360 (GRCm39) missense probably damaging 0.99
Arches UTSW 11 34,580,587 (GRCm39) missense probably damaging 1.00
capitol_reef UTSW 11 34,244,170 (GRCm39) critical splice acceptor site probably null
Croesus UTSW 11 34,611,854 (GRCm39) missense probably damaging 1.00
denali UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
dew UTSW 11 34,198,636 (GRCm39) nonsense probably null
Dinghy UTSW 11 34,212,460 (GRCm39) missense possibly damaging 0.70
Dry UTSW 11 34,181,652 (GRCm39) missense possibly damaging 0.79
frazz UTSW 11 34,198,572 (GRCm39) critical splice donor site probably benign
frizz UTSW 11 34,208,184 (GRCm39) splice site probably benign
gildenstern UTSW 11 34,623,166 (GRCm39) critical splice donor site probably null
godsgrace UTSW 11 34,586,280 (GRCm39) missense probably damaging 1.00
Harborside UTSW 11 34,212,445 (GRCm39) missense probably benign
Landing UTSW 11 34,605,328 (GRCm39) missense possibly damaging 0.83
latest UTSW 11 34,647,049 (GRCm39) missense probably damaging 1.00
Launch UTSW 11 34,206,562 (GRCm39) missense probably damaging 1.00
liaoning UTSW 11 34,599,620 (GRCm39) missense probably damaging 1.00
lucre UTSW 11 34,595,436 (GRCm39) frame shift probably null
midas UTSW 11 34,244,323 (GRCm39) missense probably damaging 0.99
muelle UTSW 11 34,578,365 (GRCm39) missense probably damaging 1.00
narrowest UTSW 11 34,232,652 (GRCm39) missense probably damaging 0.98
pier UTSW 11 34,580,593 (GRCm39) missense probably damaging 1.00
Plank UTSW 11 34,674,622 (GRCm39) missense possibly damaging 0.51
resplendent UTSW 11 34,618,287 (GRCm39) nonsense probably null
riches UTSW 11 34,579,279 (GRCm39) critical splice donor site probably null
skiff UTSW 11 34,212,388 (GRCm39) missense probably null 0.80
Slip UTSW 11 34,244,286 (GRCm39) missense probably benign 0.25
toothskin UTSW 11 34,414,922 (GRCm39) missense probably damaging 1.00
Touch UTSW 11 34,223,750 (GRCm39) missense possibly damaging 0.95
wassup UTSW 11 34,453,413 (GRCm39) missense probably damaging 1.00
Wharf UTSW 11 34,623,198 (GRCm39) missense possibly damaging 0.81
BB009:Dock2 UTSW 11 34,217,998 (GRCm39) missense probably benign 0.00
BB019:Dock2 UTSW 11 34,217,998 (GRCm39) missense probably benign 0.00
IGL03052:Dock2 UTSW 11 34,182,853 (GRCm39) missense probably benign 0.01
PIT4377001:Dock2 UTSW 11 34,611,835 (GRCm39) missense probably benign 0.02
R0006:Dock2 UTSW 11 34,262,453 (GRCm39) unclassified probably benign
R0012:Dock2 UTSW 11 34,674,622 (GRCm39) missense possibly damaging 0.51
R0063:Dock2 UTSW 11 34,647,111 (GRCm39) critical splice acceptor site probably null
R0063:Dock2 UTSW 11 34,647,111 (GRCm39) critical splice acceptor site probably null
R0116:Dock2 UTSW 11 34,579,392 (GRCm39) intron probably benign
R0149:Dock2 UTSW 11 34,388,327 (GRCm39) missense probably damaging 1.00
R0361:Dock2 UTSW 11 34,388,327 (GRCm39) missense probably damaging 1.00
R0462:Dock2 UTSW 11 34,218,052 (GRCm39) missense possibly damaging 0.74
R0471:Dock2 UTSW 11 34,579,380 (GRCm39) missense probably benign 0.30
R0538:Dock2 UTSW 11 34,595,545 (GRCm39) splice site probably benign
R0543:Dock2 UTSW 11 34,244,325 (GRCm39) missense probably damaging 1.00
R0660:Dock2 UTSW 11 34,198,621 (GRCm39) missense probably damaging 1.00
R0676:Dock2 UTSW 11 34,586,063 (GRCm39) missense probably damaging 0.99
R0722:Dock2 UTSW 11 34,414,970 (GRCm39) splice site probably benign
R0801:Dock2 UTSW 11 34,599,620 (GRCm39) missense probably damaging 1.00
R1110:Dock2 UTSW 11 34,206,535 (GRCm39) missense possibly damaging 0.78
R1171:Dock2 UTSW 11 34,586,068 (GRCm39) missense probably damaging 1.00
R1387:Dock2 UTSW 11 34,223,309 (GRCm39) splice site probably benign
R1445:Dock2 UTSW 11 34,189,705 (GRCm39) missense probably benign
R1494:Dock2 UTSW 11 34,232,761 (GRCm39) nonsense probably null
R1589:Dock2 UTSW 11 34,597,288 (GRCm39) missense probably damaging 0.99
R1597:Dock2 UTSW 11 34,595,474 (GRCm39) missense probably benign 0.00
R1629:Dock2 UTSW 11 34,212,480 (GRCm39) splice site probably null
R1749:Dock2 UTSW 11 34,182,767 (GRCm39) critical splice donor site probably null
R1888:Dock2 UTSW 11 34,598,169 (GRCm39) missense probably damaging 1.00
R1888:Dock2 UTSW 11 34,598,169 (GRCm39) missense probably damaging 1.00
R1899:Dock2 UTSW 11 34,244,286 (GRCm39) missense probably benign 0.25
R1924:Dock2 UTSW 11 34,414,934 (GRCm39) missense possibly damaging 0.69
R2031:Dock2 UTSW 11 34,618,297 (GRCm39) splice site probably benign
R2045:Dock2 UTSW 11 34,244,106 (GRCm39) splice site probably null
R2098:Dock2 UTSW 11 34,609,832 (GRCm39) missense probably damaging 0.99
R2098:Dock2 UTSW 11 34,216,279 (GRCm39) missense probably benign 0.16
R2129:Dock2 UTSW 11 34,618,242 (GRCm39) missense probably damaging 1.00
R2147:Dock2 UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
R2149:Dock2 UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
R2150:Dock2 UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
R2176:Dock2 UTSW 11 34,586,044 (GRCm39) missense probably benign 0.00
R2230:Dock2 UTSW 11 34,244,323 (GRCm39) missense probably damaging 0.99
R2508:Dock2 UTSW 11 34,262,485 (GRCm39) missense probably benign 0.04
R2875:Dock2 UTSW 11 34,609,712 (GRCm39) missense probably damaging 1.00
R2885:Dock2 UTSW 11 34,580,593 (GRCm39) missense probably damaging 1.00
R2910:Dock2 UTSW 11 34,182,910 (GRCm39) splice site probably benign
R3081:Dock2 UTSW 11 34,181,610 (GRCm39) missense probably benign
R3418:Dock2 UTSW 11 34,580,587 (GRCm39) missense probably damaging 1.00
R3552:Dock2 UTSW 11 34,611,787 (GRCm39) missense probably benign 0.22
R3731:Dock2 UTSW 11 34,599,722 (GRCm39) missense probably damaging 1.00
R3846:Dock2 UTSW 11 34,623,198 (GRCm39) missense possibly damaging 0.81
R4135:Dock2 UTSW 11 34,605,328 (GRCm39) missense possibly damaging 0.83
R4598:Dock2 UTSW 11 34,189,536 (GRCm39) missense probably damaging 1.00
R4599:Dock2 UTSW 11 34,189,536 (GRCm39) missense probably damaging 1.00
R4715:Dock2 UTSW 11 34,244,118 (GRCm39) missense probably damaging 1.00
R4722:Dock2 UTSW 11 34,586,298 (GRCm39) missense probably damaging 1.00
R4742:Dock2 UTSW 11 34,244,170 (GRCm39) critical splice acceptor site probably null
R4830:Dock2 UTSW 11 34,223,767 (GRCm39) splice site probably null
R4884:Dock2 UTSW 11 34,216,248 (GRCm39) missense probably damaging 1.00
R4990:Dock2 UTSW 11 34,586,078 (GRCm39) missense probably damaging 1.00
R5334:Dock2 UTSW 11 34,178,643 (GRCm39) missense probably benign 0.00
R5570:Dock2 UTSW 11 34,618,233 (GRCm39) missense probably damaging 1.00
R5602:Dock2 UTSW 11 34,204,391 (GRCm39) missense probably benign 0.16
R5681:Dock2 UTSW 11 34,199,836 (GRCm39) missense probably benign 0.06
R5809:Dock2 UTSW 11 34,212,445 (GRCm39) missense probably benign
R5860:Dock2 UTSW 11 34,206,562 (GRCm39) missense probably damaging 1.00
R6111:Dock2 UTSW 11 34,599,614 (GRCm39) missense probably damaging 0.99
R6155:Dock2 UTSW 11 34,244,123 (GRCm39) missense probably benign 0.06
R6156:Dock2 UTSW 11 34,197,789 (GRCm39) missense possibly damaging 0.51
R6173:Dock2 UTSW 11 34,212,388 (GRCm39) missense probably null 0.80
R6182:Dock2 UTSW 11 34,179,476 (GRCm39) missense probably damaging 0.97
R6188:Dock2 UTSW 11 34,453,396 (GRCm39) missense probably damaging 0.98
R6191:Dock2 UTSW 11 34,181,652 (GRCm39) missense possibly damaging 0.79
R6283:Dock2 UTSW 11 34,598,152 (GRCm39) missense probably damaging 0.99
R6395:Dock2 UTSW 11 34,182,874 (GRCm39) missense probably damaging 1.00
R6465:Dock2 UTSW 11 34,453,413 (GRCm39) missense probably damaging 1.00
R6500:Dock2 UTSW 11 34,312,822 (GRCm39) missense possibly damaging 0.76
R6561:Dock2 UTSW 11 34,578,365 (GRCm39) missense probably damaging 1.00
R6745:Dock2 UTSW 11 34,596,670 (GRCm39) missense probably damaging 1.00
R6745:Dock2 UTSW 11 34,596,669 (GRCm39) missense probably damaging 1.00
R6880:Dock2 UTSW 11 34,579,279 (GRCm39) critical splice donor site probably null
R6913:Dock2 UTSW 11 34,647,049 (GRCm39) missense probably damaging 1.00
R6997:Dock2 UTSW 11 34,414,922 (GRCm39) missense probably damaging 1.00
R7057:Dock2 UTSW 11 34,586,044 (GRCm39) missense probably benign 0.00
R7057:Dock2 UTSW 11 34,177,684 (GRCm39) missense probably benign 0.10
R7134:Dock2 UTSW 11 34,260,363 (GRCm39) missense probably benign 0.03
R7188:Dock2 UTSW 11 34,189,675 (GRCm39) missense possibly damaging 0.87
R7239:Dock2 UTSW 11 34,181,677 (GRCm39) missense probably benign 0.00
R7247:Dock2 UTSW 11 34,605,340 (GRCm39) nonsense probably null
R7250:Dock2 UTSW 11 34,586,120 (GRCm39) missense probably damaging 1.00
R7250:Dock2 UTSW 11 34,586,032 (GRCm39) missense probably benign 0.01
R7271:Dock2 UTSW 11 34,223,750 (GRCm39) missense possibly damaging 0.95
R7284:Dock2 UTSW 11 34,180,672 (GRCm39) missense probably benign 0.01
R7397:Dock2 UTSW 11 34,609,816 (GRCm39) missense probably benign 0.00
R7464:Dock2 UTSW 11 34,586,105 (GRCm39) missense probably damaging 0.99
R7512:Dock2 UTSW 11 34,262,542 (GRCm39) missense possibly damaging 0.95
R7556:Dock2 UTSW 11 34,611,778 (GRCm39) missense probably benign 0.43
R7663:Dock2 UTSW 11 34,611,854 (GRCm39) missense probably damaging 1.00
R7779:Dock2 UTSW 11 34,605,282 (GRCm39) missense probably benign 0.38
R7797:Dock2 UTSW 11 34,232,652 (GRCm39) missense probably damaging 0.98
R7855:Dock2 UTSW 11 34,223,698 (GRCm39) missense probably damaging 1.00
R7922:Dock2 UTSW 11 34,598,154 (GRCm39) missense probably benign 0.29
R7932:Dock2 UTSW 11 34,217,998 (GRCm39) missense probably benign 0.00
R8013:Dock2 UTSW 11 34,596,677 (GRCm39) missense probably damaging 0.96
R8192:Dock2 UTSW 11 34,623,166 (GRCm39) critical splice donor site probably null
R8244:Dock2 UTSW 11 34,586,280 (GRCm39) missense probably damaging 1.00
R8307:Dock2 UTSW 11 34,260,362 (GRCm39) missense possibly damaging 0.95
R8418:Dock2 UTSW 11 34,609,795 (GRCm39) missense probably benign 0.01
R8460:Dock2 UTSW 11 34,180,825 (GRCm39) critical splice acceptor site probably null
R8495:Dock2 UTSW 11 34,181,622 (GRCm39) missense probably benign 0.14
R8556:Dock2 UTSW 11 34,212,457 (GRCm39) missense possibly damaging 0.84
R8690:Dock2 UTSW 11 34,618,287 (GRCm39) nonsense probably null
R8743:Dock2 UTSW 11 34,223,252 (GRCm39) nonsense probably null
R8757:Dock2 UTSW 11 34,586,067 (GRCm39) missense probably benign 0.13
R8759:Dock2 UTSW 11 34,586,067 (GRCm39) missense probably benign 0.13
R8793:Dock2 UTSW 11 34,451,215 (GRCm39) missense probably benign 0.00
R8882:Dock2 UTSW 11 34,595,436 (GRCm39) frame shift probably null
R8885:Dock2 UTSW 11 34,260,396 (GRCm39) missense probably benign 0.01
R8943:Dock2 UTSW 11 34,599,646 (GRCm39) missense possibly damaging 0.63
R9171:Dock2 UTSW 11 34,589,670 (GRCm39) missense probably benign 0.12
R9182:Dock2 UTSW 11 34,260,398 (GRCm39) missense possibly damaging 0.51
R9203:Dock2 UTSW 11 34,622,366 (GRCm39) missense possibly damaging 0.92
R9310:Dock2 UTSW 11 34,244,139 (GRCm39) missense possibly damaging 0.71
R9388:Dock2 UTSW 11 34,212,460 (GRCm39) missense possibly damaging 0.70
R9490:Dock2 UTSW 11 34,589,582 (GRCm39) missense possibly damaging 0.90
R9568:Dock2 UTSW 11 34,599,638 (GRCm39) missense possibly damaging 0.83
R9593:Dock2 UTSW 11 34,178,607 (GRCm39) missense probably benign 0.34
R9694:Dock2 UTSW 11 34,218,054 (GRCm39) missense probably benign
R9697:Dock2 UTSW 11 34,204,417 (GRCm39) missense probably benign
R9753:Dock2 UTSW 11 34,223,673 (GRCm39) missense possibly damaging 0.68
R9783:Dock2 UTSW 11 34,208,128 (GRCm39) missense possibly damaging 0.83
X0017:Dock2 UTSW 11 34,216,271 (GRCm39) missense probably benign 0.08
X0018:Dock2 UTSW 11 34,182,833 (GRCm39) missense possibly damaging 0.65
X0058:Dock2 UTSW 11 34,206,564 (GRCm39) missense probably damaging 1.00
X0066:Dock2 UTSW 11 34,260,357 (GRCm39) missense possibly damaging 0.95
Z1088:Dock2 UTSW 11 34,583,209 (GRCm39) missense probably damaging 1.00
Z1088:Dock2 UTSW 11 34,388,300 (GRCm39) missense probably benign 0.14
Z1088:Dock2 UTSW 11 34,586,039 (GRCm39) nonsense probably null
Z1176:Dock2 UTSW 11 34,609,751 (GRCm39) missense probably benign 0.04
Z1177:Dock2 UTSW 11 34,262,553 (GRCm39) missense possibly damaging 0.68
Posted On 2013-12-09