Incidental Mutation 'R4428:Vmn2r22'
ID 328273
Institutional Source Beutler Lab
Gene Symbol Vmn2r22
Ensembl Gene ENSMUSG00000095486
Gene Name vomeronasal 2, receptor 22
Synonyms EG546913
MMRRC Submission 041698-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R4428 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 123586717-123627594 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 123614817 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 258 (T258A)
Ref Sequence ENSEMBL: ENSMUSP00000132043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170808]
AlphaFold E9Q7S8
Predicted Effect possibly damaging
Transcript: ENSMUST00000170808
AA Change: T258A

PolyPhen 2 Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000132043
Gene: ENSMUSG00000095486
AA Change: T258A

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 473 1.4e-32 PFAM
Pfam:NCD3G 517 570 2.2e-23 PFAM
Pfam:7tm_3 601 838 1.2e-54 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
Abcc1 T A 16: 14,263,164 (GRCm39) V708E probably damaging Het
Bag4 C T 8: 26,259,516 (GRCm39) A228T probably benign Het
Ccdc18 A G 5: 108,283,943 (GRCm39) Y82C probably benign Het
Cd82 T C 2: 93,250,214 (GRCm39) Y266C probably damaging Het
Chrna4 A G 2: 180,670,413 (GRCm39) S448P probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Cmpk1 T C 4: 114,820,559 (GRCm39) E180G probably benign Het
Dock8 T C 19: 25,177,863 (GRCm39) I2066T probably damaging Het
Dock8 T C 19: 25,042,754 (GRCm39) V112A probably benign Het
Fgf3 T C 7: 144,394,444 (GRCm39) V86A probably damaging Het
Frem2 A G 3: 53,561,759 (GRCm39) I916T probably benign Het
Gsk3b T A 16: 38,014,298 (GRCm39) L252Q probably damaging Het
Kif18a A G 2: 109,118,466 (GRCm39) T94A probably damaging Het
Klhdc1 T A 12: 69,315,000 (GRCm39) probably benign Het
Klhl25 T A 7: 75,515,162 (GRCm39) F23I probably damaging Het
Mapk7 T C 11: 61,380,055 (GRCm39) D701G possibly damaging Het
Mbd5 A T 2: 49,169,776 (GRCm39) Q47L possibly damaging Het
Nrcam A G 12: 44,623,558 (GRCm39) D1049G possibly damaging Het
Olfml2a G T 2: 38,831,755 (GRCm39) M111I probably damaging Het
Or3a1c T C 11: 74,046,025 (GRCm39) F15S probably damaging Het
Pld2 A T 11: 70,432,160 (GRCm39) H93L probably damaging Het
Pomgnt2 T C 9: 121,811,320 (GRCm39) E487G possibly damaging Het
Psg17 G T 7: 18,550,717 (GRCm39) N379K probably benign Het
Rfk T A 19: 17,375,959 (GRCm39) H84Q possibly damaging Het
Scn8a A G 15: 100,881,784 (GRCm39) Y617C probably damaging Het
Sema3d T C 5: 12,498,087 (GRCm39) F31S probably benign Het
Shq1 T C 6: 100,647,889 (GRCm39) Y45C probably damaging Het
Siglecg C T 7: 43,067,350 (GRCm39) P639L possibly damaging Het
Skp2 A T 15: 9,117,034 (GRCm39) N325K probably benign Het
Sost G A 11: 101,857,670 (GRCm39) P44S probably damaging Het
Sp8 T A 12: 118,812,938 (GRCm39) S264R possibly damaging Het
Sun1 T C 5: 139,220,230 (GRCm39) probably benign Het
Tardbp A G 4: 148,709,659 (GRCm39) V54A possibly damaging Het
Tert T A 13: 73,775,594 (GRCm39) F115Y probably damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Tmem68 A T 4: 3,569,534 (GRCm39) I52K probably benign Het
Trhde A T 10: 114,339,028 (GRCm39) L594Q probably damaging Het
Umps A C 16: 33,781,956 (GRCm39) V322G probably damaging Het
Vmn2r109 T C 17: 20,773,286 (GRCm39) D445G probably benign Het
Vmn2r4 C T 3: 64,322,590 (GRCm39) G43E probably damaging Het
Other mutations in Vmn2r22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01024:Vmn2r22 APN 6 123,615,012 (GRCm39) missense probably damaging 1.00
IGL01764:Vmn2r22 APN 6 123,627,379 (GRCm39) critical splice donor site probably null
IGL02037:Vmn2r22 APN 6 123,626,026 (GRCm39) missense probably damaging 1.00
IGL02183:Vmn2r22 APN 6 123,614,963 (GRCm39) missense probably damaging 1.00
IGL02335:Vmn2r22 APN 6 123,615,051 (GRCm39) missense probably damaging 0.99
IGL02440:Vmn2r22 APN 6 123,614,364 (GRCm39) missense probably benign 0.00
IGL02663:Vmn2r22 APN 6 123,626,117 (GRCm39) missense probably benign 0.11
IGL03101:Vmn2r22 APN 6 123,614,295 (GRCm39) missense probably benign 0.09
R0266:Vmn2r22 UTSW 6 123,614,363 (GRCm39) missense probably damaging 0.99
R0348:Vmn2r22 UTSW 6 123,614,684 (GRCm39) missense probably damaging 1.00
R0780:Vmn2r22 UTSW 6 123,614,933 (GRCm39) missense probably damaging 1.00
R0849:Vmn2r22 UTSW 6 123,614,363 (GRCm39) missense probably damaging 0.99
R1074:Vmn2r22 UTSW 6 123,626,217 (GRCm39) missense probably benign 0.02
R1456:Vmn2r22 UTSW 6 123,614,624 (GRCm39) missense possibly damaging 0.86
R1719:Vmn2r22 UTSW 6 123,614,802 (GRCm39) missense possibly damaging 0.68
R1989:Vmn2r22 UTSW 6 123,614,500 (GRCm39) missense probably damaging 1.00
R2928:Vmn2r22 UTSW 6 123,614,402 (GRCm39) missense probably damaging 0.96
R2939:Vmn2r22 UTSW 6 123,614,594 (GRCm39) missense probably damaging 0.99
R3727:Vmn2r22 UTSW 6 123,627,584 (GRCm39) missense possibly damaging 0.70
R3782:Vmn2r22 UTSW 6 123,627,591 (GRCm39) nonsense probably null
R3873:Vmn2r22 UTSW 6 123,614,339 (GRCm39) missense possibly damaging 0.68
R4344:Vmn2r22 UTSW 6 123,614,756 (GRCm39) missense probably damaging 1.00
R4407:Vmn2r22 UTSW 6 123,614,913 (GRCm39) missense probably damaging 1.00
R4430:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4431:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4701:Vmn2r22 UTSW 6 123,627,428 (GRCm39) missense probably benign 0.00
R5274:Vmn2r22 UTSW 6 123,627,593 (GRCm39) start codon destroyed probably null 0.93
R5668:Vmn2r22 UTSW 6 123,614,873 (GRCm39) missense probably benign 0.06
R5776:Vmn2r22 UTSW 6 123,614,673 (GRCm39) missense probably damaging 1.00
R6416:Vmn2r22 UTSW 6 123,614,697 (GRCm39) missense probably damaging 1.00
R7788:Vmn2r22 UTSW 6 123,614,559 (GRCm39) missense not run
R8208:Vmn2r22 UTSW 6 123,614,444 (GRCm39) missense probably damaging 1.00
R8267:Vmn2r22 UTSW 6 123,615,000 (GRCm39) missense possibly damaging 0.81
R8400:Vmn2r22 UTSW 6 123,614,486 (GRCm39) nonsense probably null
R8814:Vmn2r22 UTSW 6 123,614,789 (GRCm39) missense probably damaging 0.96
R8850:Vmn2r22 UTSW 6 123,614,454 (GRCm39) missense probably damaging 1.00
R9613:Vmn2r22 UTSW 6 123,615,075 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AATCCCAGAATTTGATCCATGC -3'
(R):5'- CAGGGAATTATTCAACTGCTGC -3'

Sequencing Primer
(F):5'- AGAAAATGATAATCCTCCACCAAAG -3'
(R):5'- AACTGCTGCTATACTTCACTTGGG -3'
Posted On 2015-07-07