Incidental Mutation 'R4353:Vmn1r6'
ID 327407
Institutional Source Beutler Lab
Gene Symbol Vmn1r6
Ensembl Gene ENSMUSG00000115701
Gene Name vomeronasal 1 receptor 6
Synonyms V1rc20
MMRRC Submission 040866-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R4353 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 56979340-56980251 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 56979677 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 113 (A113V)
Ref Sequence ENSEMBL: ENSMUSP00000153988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079669] [ENSMUST00000226689] [ENSMUST00000227131] [ENSMUST00000227188] [ENSMUST00000227631] [ENSMUST00000227847] [ENSMUST00000228285]
AlphaFold Q8R2D4
Predicted Effect possibly damaging
Transcript: ENSMUST00000079669
AA Change: A113V

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000078611
Gene: ENSMUSG00000115701
AA Change: A113V

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.9e-54 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226689
AA Change: A113V

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227131
AA Change: A113V

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227188
AA Change: A91V

PolyPhen 2 Score 0.544 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227631
AA Change: A91V

PolyPhen 2 Score 0.544 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227847
AA Change: A113V

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228285
AA Change: A113V

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,557,349 (GRCm39) A115T probably benign Het
Alpk2 C T 18: 65,424,523 (GRCm39) R1888H possibly damaging Het
Arhgap33 C A 7: 30,223,561 (GRCm39) V823L possibly damaging Het
Atp2b2 T C 6: 113,742,745 (GRCm39) I736V probably benign Het
Atp8a1 T C 5: 67,926,451 (GRCm39) T260A probably damaging Het
B4galnt3 T C 6: 120,192,437 (GRCm39) E433G possibly damaging Het
Bzw2 A T 12: 36,173,978 (GRCm39) F99I probably damaging Het
Cdh20 A G 1: 104,906,814 (GRCm39) D547G probably damaging Het
Col27a1 G T 4: 63,143,868 (GRCm39) A519S probably benign Het
Coq6 G A 12: 84,414,923 (GRCm39) G110D probably damaging Het
Cpb1 T C 3: 20,316,708 (GRCm39) T281A probably benign Het
Cttnbp2 T C 6: 18,514,703 (GRCm39) D11G probably benign Het
Cyp2c37 A G 19: 39,988,989 (GRCm39) Y316C possibly damaging Het
Dcdc2a T A 13: 25,240,474 (GRCm39) I74N probably damaging Het
Dhx9 A G 1: 153,347,535 (GRCm39) L391P probably damaging Het
Dsc2 G T 18: 20,183,125 (GRCm39) L98I probably damaging Het
Dthd1 T A 5: 63,000,210 (GRCm39) S511T probably benign Het
Dusp2 A G 2: 127,179,256 (GRCm39) T204A probably damaging Het
Elovl5 T C 9: 77,868,199 (GRCm39) V37A probably benign Het
Etv1 A G 12: 38,907,105 (GRCm39) E369G probably damaging Het
Gem G A 4: 11,705,939 (GRCm39) R9H probably damaging Het
Heg1 A G 16: 33,530,847 (GRCm39) T108A probably benign Het
Inava C T 1: 136,153,946 (GRCm39) V180I probably damaging Het
Iqgap2 C T 13: 95,807,904 (GRCm39) V788M probably damaging Het
Kyat3 T C 3: 142,437,054 (GRCm39) probably null Het
Llgl1 C T 11: 60,600,394 (GRCm39) P581L probably benign Het
Mecom C A 3: 30,020,887 (GRCm39) V452L possibly damaging Het
Meis2 A G 2: 115,890,044 (GRCm39) M146T probably damaging Het
Nrp2 A G 1: 62,777,576 (GRCm39) D127G probably damaging Het
Nt5el T C 13: 105,255,253 (GRCm39) Y445H probably benign Het
Nup214 T C 2: 31,867,929 (GRCm39) probably null Het
Or2h1b T A 17: 37,462,228 (GRCm39) I58F probably damaging Het
Pabpc4 C T 4: 123,184,060 (GRCm39) T191I probably damaging Het
Pcnx2 T C 8: 126,489,590 (GRCm39) H1668R probably damaging Het
Poln C T 5: 34,286,796 (GRCm39) C124Y probably benign Het
Ppp2r2a T A 14: 67,266,386 (GRCm39) I92L probably damaging Het
Prb1b T G 6: 132,290,624 (GRCm39) Y25S unknown Het
Ptch1 C T 13: 63,682,143 (GRCm39) R537H probably damaging Het
Rnf130 T C 11: 49,978,267 (GRCm39) V276A possibly damaging Het
Rnf31 AAC A 14: 55,838,555 (GRCm39) probably null Het
Rnf38 A T 4: 44,149,100 (GRCm39) N82K possibly damaging Het
Scn7a T A 2: 66,506,780 (GRCm39) M1370L probably benign Het
Sema4b C A 7: 79,865,399 (GRCm39) L125I probably damaging Het
Slc12a7 C T 13: 73,938,853 (GRCm39) T210I possibly damaging Het
Sox8 A C 17: 25,786,309 (GRCm39) *465G probably null Het
Spg11 G T 2: 121,943,675 (GRCm39) T159K possibly damaging Het
Stk36 A G 1: 74,671,966 (GRCm39) R889G possibly damaging Het
Tmbim7 A G 5: 3,711,796 (GRCm39) S14G probably benign Het
Usp16 A G 16: 87,267,242 (GRCm39) N211D probably damaging Het
Zc3h14 A G 12: 98,730,219 (GRCm39) N92D possibly damaging Het
Zfp638 T C 6: 83,961,041 (GRCm39) S1206P probably damaging Het
Other mutations in Vmn1r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00905:Vmn1r6 APN 6 56,979,789 (GRCm39) missense probably damaging 1.00
IGL01011:Vmn1r6 APN 6 56,979,529 (GRCm39) missense probably benign 0.00
IGL01147:Vmn1r6 APN 6 56,979,626 (GRCm39) missense probably damaging 1.00
IGL01475:Vmn1r6 APN 6 56,979,896 (GRCm39) missense probably damaging 1.00
IGL01638:Vmn1r6 APN 6 56,980,177 (GRCm39) nonsense probably null
IGL01860:Vmn1r6 APN 6 56,979,674 (GRCm39) nonsense probably null
IGL01876:Vmn1r6 APN 6 56,979,446 (GRCm39) missense probably benign 0.12
IGL01988:Vmn1r6 APN 6 56,979,650 (GRCm39) missense probably damaging 0.99
R0531:Vmn1r6 UTSW 6 56,979,583 (GRCm39) missense probably benign 0.00
R1495:Vmn1r6 UTSW 6 56,980,058 (GRCm39) missense possibly damaging 0.58
R1733:Vmn1r6 UTSW 6 56,979,607 (GRCm39) missense probably damaging 1.00
R2037:Vmn1r6 UTSW 6 56,980,109 (GRCm39) missense probably damaging 1.00
R3625:Vmn1r6 UTSW 6 56,979,920 (GRCm39) missense probably damaging 0.96
R4484:Vmn1r6 UTSW 6 56,980,174 (GRCm39) missense probably benign
R4854:Vmn1r6 UTSW 6 56,979,683 (GRCm39) missense probably benign 0.00
R5237:Vmn1r6 UTSW 6 56,980,179 (GRCm39) missense probably damaging 1.00
R5341:Vmn1r6 UTSW 6 56,979,789 (GRCm39) missense probably damaging 1.00
R5611:Vmn1r6 UTSW 6 56,979,362 (GRCm39) missense probably damaging 1.00
R6795:Vmn1r6 UTSW 6 56,979,422 (GRCm39) missense possibly damaging 0.85
R8423:Vmn1r6 UTSW 6 56,979,495 (GRCm39) missense probably benign 0.30
R9249:Vmn1r6 UTSW 6 56,979,760 (GRCm39) missense probably benign
R9582:Vmn1r6 UTSW 6 56,979,925 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGGGGATGTTTGGCTTACAGAC -3'
(R):5'- ACTTGTGGTTAGCATGGCTCC -3'

Sequencing Primer
(F):5'- GGCTTACAGACTTATTTGAGTCACTG -3'
(R):5'- GGTTAGCATGGCTCCTACAAG -3'
Posted On 2015-07-07