Incidental Mutation 'R4673:Kynu'
ID 348594
Institutional Source Beutler Lab
Gene Symbol Kynu
Ensembl Gene ENSMUSG00000026866
Gene Name kynureninase
Synonyms L-kynurenine hydrolase, 4432411A05Rik
MMRRC Submission 041928-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4673 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 43445341-43572734 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43569815 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 366 (T366A)
Ref Sequence ENSEMBL: ENSMUSP00000108445 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028223] [ENSMUST00000112826]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000028223
AA Change: T366A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028223
Gene: ENSMUSG00000026866
AA Change: T366A

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 400 3.8e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000112826
AA Change: T366A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108445
Gene: ENSMUSG00000026866
AA Change: T366A

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 405 8.4e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148855
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 T C 8: 25,374,471 (GRCm39) E507G probably damaging Het
Adam39 C T 8: 41,277,768 (GRCm39) T53I probably benign Het
Adam4 A T 12: 81,468,535 (GRCm39) S29T possibly damaging Het
Adamdec1 C A 14: 68,815,353 (GRCm39) E104* probably null Het
Alas1 G T 9: 106,113,676 (GRCm39) P523Q probably damaging Het
Aldh3a1 A G 11: 61,104,320 (GRCm39) D69G probably benign Het
Arhgap29 T A 3: 121,808,620 (GRCm39) V1266E probably damaging Het
Bcdin3d T C 15: 99,368,719 (GRCm39) D160G probably damaging Het
Btaf1 T A 19: 36,955,772 (GRCm39) F569I probably benign Het
Cacna1b A G 2: 24,521,956 (GRCm39) L1718S probably damaging Het
Casd1 A G 6: 4,629,975 (GRCm39) Y457C probably damaging Het
Creb3 T C 4: 43,563,192 (GRCm39) V97A probably benign Het
Cux2 G T 5: 122,025,539 (GRCm39) S43* probably null Het
Fhip1a A T 3: 85,638,020 (GRCm39) V93D probably damaging Het
Fsbp T G 4: 11,579,841 (GRCm39) N36K probably benign Het
Gm11565 A G 11: 99,806,040 (GRCm39) D144G probably benign Het
Gpn3 A G 5: 122,511,981 (GRCm39) Y19C probably damaging Het
Gstz1 A T 12: 87,208,837 (GRCm39) T148S probably benign Het
Gtf3c5 A G 2: 28,462,236 (GRCm39) I282T probably benign Het
Hspa2 T A 12: 76,452,514 (GRCm39) S403T possibly damaging Het
Il27 G A 7: 126,190,251 (GRCm39) T121I possibly damaging Het
Itpr2 A G 6: 146,274,671 (GRCm39) F837S probably damaging Het
Kctd1 T A 18: 15,196,284 (GRCm39) probably benign Het
Lama5 G A 2: 179,841,059 (GRCm39) T507I probably damaging Het
Myh11 C T 16: 14,087,105 (GRCm39) V124M probably damaging Het
Myh14 T A 7: 44,273,754 (GRCm39) H1331L probably damaging Het
Myh2 T A 11: 67,079,303 (GRCm39) L957Q probably damaging Het
Myh4 T C 11: 67,137,227 (GRCm39) F483L probably benign Het
Nbeal1 A C 1: 60,368,549 (GRCm39) K2631N probably damaging Het
Ofcc1 G A 13: 40,168,864 (GRCm39) T841I probably damaging Het
Ogg1 T C 6: 113,304,268 (GRCm39) C28R probably damaging Het
Or13c7c T C 4: 43,836,430 (GRCm39) H20R probably benign Het
Or5b24 G A 19: 12,912,461 (GRCm39) A120T probably damaging Het
Or5k17 C T 16: 58,746,053 (GRCm39) V294I possibly damaging Het
Or6e1 C T 14: 54,519,789 (GRCm39) A188T possibly damaging Het
Or7g35 A G 9: 19,496,726 (GRCm39) K298E possibly damaging Het
Parp6 G C 9: 59,547,393 (GRCm39) R460P probably damaging Het
Phf14 A G 6: 11,992,056 (GRCm39) H744R probably damaging Het
Pibf1 A G 14: 99,370,787 (GRCm39) N263S possibly damaging Het
Plcb4 A G 2: 135,774,191 (GRCm39) T158A possibly damaging Het
Plce1 T C 19: 38,737,840 (GRCm39) S1615P possibly damaging Het
Plxna3 T G X: 73,382,554 (GRCm39) probably null Het
Rad54b T A 4: 11,609,449 (GRCm39) H633Q probably benign Het
Rgs22 T A 15: 36,100,079 (GRCm39) Y212F probably benign Het
Rnd3 G A 2: 51,022,553 (GRCm39) A163V probably benign Het
Rnf10 A T 5: 115,389,148 (GRCm39) V315E probably damaging Het
Robo2 C T 16: 73,701,266 (GRCm39) probably null Het
Rp1l1 T G 14: 64,268,719 (GRCm39) V1435G probably damaging Het
Scaf8 T A 17: 3,248,260 (GRCm39) D1194E probably benign Het
Septin12 T C 16: 4,809,807 (GRCm39) T198A probably damaging Het
Shisa2 A G 14: 59,867,629 (GRCm39) T294A probably damaging Het
Spta1 A G 1: 174,018,628 (GRCm39) probably null Het
Strbp A T 2: 37,535,691 (GRCm39) S6T probably damaging Het
Syf2 A G 4: 134,661,804 (GRCm39) E56G probably damaging Het
Thap4 T C 1: 93,642,588 (GRCm39) probably benign Het
Tnfaip3 T C 10: 18,887,580 (GRCm39) probably benign Het
Tnxb A G 17: 34,891,514 (GRCm39) E619G probably damaging Het
Tpr G A 1: 150,299,318 (GRCm39) A1173T probably benign Het
Tspan3 G A 9: 56,043,980 (GRCm39) R240W probably damaging Het
Tut7 G T 13: 59,944,659 (GRCm39) T658K probably damaging Het
Ubr4 C T 4: 139,138,027 (GRCm39) S1128L probably damaging Het
Ucp1 T C 8: 84,021,876 (GRCm39) V236A probably damaging Het
Usp34 TCACCACCACCACCACCACCACCACCAC TCACCACCACCACCACCACCACCAC 11: 23,314,480 (GRCm39) probably benign Het
Zfp940 T C 7: 29,544,863 (GRCm39) D348G probably benign Het
Zpld2 G A 4: 133,927,658 (GRCm39) A365V probably benign Het
Other mutations in Kynu
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Kynu APN 2 43,561,394 (GRCm39) missense possibly damaging 0.91
IGL01974:Kynu APN 2 43,571,352 (GRCm39) unclassified probably benign
R0099:Kynu UTSW 2 43,519,065 (GRCm39) critical splice donor site probably null
R0304:Kynu UTSW 2 43,569,893 (GRCm39) missense probably damaging 0.99
R1681:Kynu UTSW 2 43,569,837 (GRCm39) missense probably damaging 1.00
R1799:Kynu UTSW 2 43,494,169 (GRCm39) missense possibly damaging 0.65
R2016:Kynu UTSW 2 43,494,289 (GRCm39) nonsense probably null
R2345:Kynu UTSW 2 43,471,397 (GRCm39) missense probably damaging 1.00
R3085:Kynu UTSW 2 43,492,312 (GRCm39) missense probably benign 0.00
R3825:Kynu UTSW 2 43,571,451 (GRCm39) missense probably benign
R4091:Kynu UTSW 2 43,569,884 (GRCm39) missense possibly damaging 0.94
R4241:Kynu UTSW 2 43,571,422 (GRCm39) missense probably benign 0.00
R4594:Kynu UTSW 2 43,569,902 (GRCm39) missense probably benign 0.00
R4871:Kynu UTSW 2 43,569,830 (GRCm39) missense possibly damaging 0.58
R5371:Kynu UTSW 2 43,479,406 (GRCm39) missense probably benign 0.00
R6272:Kynu UTSW 2 43,525,001 (GRCm39) missense probably benign 0.01
R6342:Kynu UTSW 2 43,571,463 (GRCm39) missense probably benign 0.09
R6866:Kynu UTSW 2 43,453,122 (GRCm39) nonsense probably null
R7203:Kynu UTSW 2 43,571,365 (GRCm39) missense probably damaging 1.00
R8163:Kynu UTSW 2 43,518,966 (GRCm39) missense probably damaging 1.00
R9024:Kynu UTSW 2 43,490,807 (GRCm39) missense possibly damaging 0.62
R9089:Kynu UTSW 2 43,489,620 (GRCm39) missense probably damaging 1.00
R9303:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9305:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9506:Kynu UTSW 2 43,571,414 (GRCm39) missense probably damaging 1.00
R9702:Kynu UTSW 2 43,479,469 (GRCm39) missense probably damaging 1.00
R9759:Kynu UTSW 2 43,569,881 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCTGTCATGGAAACTACCTTTG -3'
(R):5'- GGCTAACGCTGAGTGCTAAG -3'

Sequencing Primer
(F):5'- AGACAACATGCTTTACTGGAATAAG -3'
(R):5'- CTAACGCTGAGTGCTAAGTTGATGTC -3'
Posted On 2015-10-08