Incidental Mutation 'R4771:Dock3'
| ID |
367521 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock3
|
| Ensembl Gene |
ENSMUSG00000039716 |
| Gene Name |
dedicator of cyto-kinesis 3 |
| Synonyms |
Moca, PBP |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.549)
|
| Stock # |
R4771 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
106770024-107109108 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 106829557 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 1119
(H1119L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047652
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044532]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000044532
AA Change: H1119L
PolyPhen 2
Score 0.887 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000047652
Gene: ENSMUSG00000039716
AA Change: H1119L
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
9 |
66 |
3.85e-9 |
SMART |
|
Pfam:DOCK_N
|
69 |
412 |
1.4e-120 |
PFAM |
|
Pfam:DOCK-C2
|
417 |
608 |
7.7e-56 |
PFAM |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
916 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1121 |
1628 |
9e-133 |
PFAM |
|
low complexity region
|
1679 |
1690 |
N/A |
INTRINSIC |
|
low complexity region
|
1693 |
1704 |
N/A |
INTRINSIC |
|
low complexity region
|
1730 |
1754 |
N/A |
INTRINSIC |
|
low complexity region
|
1880 |
1902 |
N/A |
INTRINSIC |
|
low complexity region
|
1963 |
1977 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000165075
AA Change: H205L
|
| SMART Domains |
Protein: ENSMUSP00000130873
Gene: ENSMUSG00000039716
AA Change: H205L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168759
|
| SMART Domains |
Protein: ENSMUSP00000131410
Gene: ENSMUSG00000039716
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DHR-2
|
1 |
241 |
4e-48 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 111 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022B05Rik |
T |
C |
8: 125,366,300 (GRCm39) |
T148A |
probably benign |
Het |
| Abcc4 |
G |
T |
14: 118,721,796 (GRCm39) |
N1234K |
probably benign |
Het |
| Adamts20 |
C |
T |
15: 94,249,516 (GRCm39) |
|
probably null |
Het |
| Aqp9 |
C |
T |
9: 71,030,152 (GRCm39) |
G212S |
probably damaging |
Het |
| Asb15 |
A |
T |
6: 24,570,621 (GRCm39) |
N533I |
probably damaging |
Het |
| Brwd1 |
A |
G |
16: 95,804,518 (GRCm39) |
V1884A |
probably benign |
Het |
| Ccdc106 |
G |
A |
7: 5,060,521 (GRCm39) |
|
probably null |
Het |
| Cfap46 |
A |
T |
7: 139,210,524 (GRCm39) |
L1774Q |
probably null |
Het |
| Cfap95 |
A |
G |
19: 23,536,337 (GRCm39) |
L190P |
probably damaging |
Het |
| Cibar1 |
T |
A |
4: 12,155,689 (GRCm39) |
Q311L |
probably benign |
Het |
| Clec2h |
G |
A |
6: 128,651,118 (GRCm39) |
E133K |
probably damaging |
Het |
| Cntn1 |
T |
A |
15: 92,202,972 (GRCm39) |
F751L |
possibly damaging |
Het |
| Col20a1 |
A |
T |
2: 180,630,917 (GRCm39) |
M62L |
probably benign |
Het |
| Col7a1 |
T |
C |
9: 108,800,993 (GRCm39) |
V1899A |
probably damaging |
Het |
| Cpa5 |
T |
A |
6: 30,612,684 (GRCm39) |
L28* |
probably null |
Het |
| Crb1 |
T |
A |
1: 139,255,942 (GRCm39) |
E264D |
probably damaging |
Het |
| Creb3l2 |
A |
T |
6: 37,311,512 (GRCm39) |
S426T |
probably benign |
Het |
| Cspg5 |
T |
A |
9: 110,080,195 (GRCm39) |
N373K |
probably damaging |
Het |
| Ctso |
T |
C |
3: 81,840,047 (GRCm39) |
S26P |
probably benign |
Het |
| Depdc1b |
A |
C |
13: 108,519,434 (GRCm39) |
D348A |
probably benign |
Het |
| Diaph1 |
A |
T |
18: 37,986,604 (GRCm39) |
M1127K |
probably damaging |
Het |
| Dlgap1 |
A |
T |
17: 70,900,375 (GRCm39) |
K397* |
probably null |
Het |
| Dok4 |
G |
T |
8: 95,591,795 (GRCm39) |
|
probably null |
Het |
| Dram2 |
A |
G |
3: 106,480,361 (GRCm39) |
T225A |
probably damaging |
Het |
| Dst |
G |
A |
1: 34,288,565 (GRCm39) |
R5603H |
probably damaging |
Het |
| Ehbp1l1 |
A |
G |
19: 5,775,996 (GRCm39) |
F18S |
probably damaging |
Het |
| Epha5 |
A |
G |
5: 84,298,278 (GRCm39) |
V427A |
probably damaging |
Het |
| Exoc4 |
A |
T |
6: 33,418,884 (GRCm39) |
|
probably null |
Het |
| Exph5 |
C |
T |
9: 53,284,965 (GRCm39) |
T682I |
possibly damaging |
Het |
| Fnbp1l |
A |
T |
3: 122,351,752 (GRCm39) |
S264T |
possibly damaging |
Het |
| Ggnbp2 |
A |
T |
11: 84,725,314 (GRCm39) |
D580E |
probably benign |
Het |
| Gm10277 |
G |
A |
11: 77,676,534 (GRCm39) |
|
probably benign |
Het |
| Golm2 |
T |
A |
2: 121,756,126 (GRCm39) |
V352E |
probably damaging |
Het |
| Gtf2a1l |
C |
A |
17: 88,997,448 (GRCm39) |
P93Q |
probably benign |
Het |
| Hydin |
A |
T |
8: 111,259,515 (GRCm39) |
I2496F |
probably benign |
Het |
| Ighv7-2 |
A |
C |
12: 113,876,087 (GRCm39) |
I6S |
probably benign |
Het |
| Irs1 |
A |
G |
1: 82,265,696 (GRCm39) |
V840A |
probably benign |
Het |
| Itgal |
A |
G |
7: 126,927,405 (GRCm39) |
E965G |
probably damaging |
Het |
| Izumo1 |
T |
G |
7: 45,272,233 (GRCm39) |
F5V |
probably benign |
Het |
| Izumo1 |
T |
A |
7: 45,272,234 (GRCm39) |
F5Y |
probably damaging |
Het |
| Kif13a |
A |
G |
13: 46,978,687 (GRCm39) |
S175P |
probably damaging |
Het |
| Klf14 |
A |
G |
6: 30,934,960 (GRCm39) |
F225L |
probably damaging |
Het |
| Kpna1 |
T |
C |
16: 35,853,773 (GRCm39) |
Y468H |
probably damaging |
Het |
| Krt5 |
T |
A |
15: 101,617,494 (GRCm39) |
Q413L |
probably damaging |
Het |
| Lbr |
T |
C |
1: 181,665,986 (GRCm39) |
Y41C |
probably damaging |
Het |
| Lmcd1 |
A |
T |
6: 112,292,834 (GRCm39) |
N229Y |
probably damaging |
Het |
| Marchf3 |
T |
A |
18: 56,916,170 (GRCm39) |
H175L |
probably benign |
Het |
| Mcmbp |
A |
G |
7: 128,300,124 (GRCm39) |
|
probably null |
Het |
| Med27 |
T |
A |
2: 29,303,515 (GRCm39) |
L16Q |
probably damaging |
Het |
| Mex3b |
A |
T |
7: 82,518,273 (GRCm39) |
Q196L |
possibly damaging |
Het |
| Mga |
T |
C |
2: 119,794,775 (GRCm39) |
S2820P |
probably damaging |
Het |
| Mroh2a |
C |
T |
1: 88,179,087 (GRCm39) |
L1104F |
probably damaging |
Het |
| Mta3 |
A |
G |
17: 84,063,103 (GRCm39) |
E166G |
probably damaging |
Het |
| Mthfd2l |
A |
G |
5: 91,096,727 (GRCm39) |
E116G |
possibly damaging |
Het |
| Musk |
A |
G |
4: 58,301,706 (GRCm39) |
I155V |
probably benign |
Het |
| Myh7b |
G |
A |
2: 155,468,314 (GRCm39) |
W834* |
probably null |
Het |
| Myo18b |
T |
A |
5: 112,840,093 (GRCm39) |
R2567* |
probably null |
Het |
| Nars2 |
A |
T |
7: 96,684,452 (GRCm39) |
E325V |
probably damaging |
Het |
| Nploc4 |
A |
G |
11: 120,312,260 (GRCm39) |
V106A |
possibly damaging |
Het |
| Nudcd1 |
A |
T |
15: 44,268,878 (GRCm39) |
S167R |
probably damaging |
Het |
| Nup133 |
T |
A |
8: 124,656,137 (GRCm39) |
D448V |
probably damaging |
Het |
| Or5al1 |
G |
T |
2: 85,990,417 (GRCm39) |
T99N |
probably benign |
Het |
| Or5p70 |
A |
T |
7: 107,995,229 (GRCm39) |
K301* |
probably null |
Het |
| Pax6 |
C |
A |
2: 105,526,847 (GRCm39) |
P251Q |
probably benign |
Het |
| Pcdh8 |
C |
T |
14: 80,005,710 (GRCm39) |
A893T |
possibly damaging |
Het |
| Per3 |
A |
T |
4: 151,093,716 (GRCm39) |
V1033E |
probably damaging |
Het |
| Polr1e |
T |
C |
4: 45,019,282 (GRCm39) |
S44P |
probably damaging |
Het |
| Pou4f2 |
T |
A |
8: 79,161,865 (GRCm39) |
H246L |
possibly damaging |
Het |
| Psmd2 |
G |
A |
16: 20,481,429 (GRCm39) |
R828Q |
probably damaging |
Het |
| Ptprq |
A |
G |
10: 107,524,288 (GRCm39) |
S482P |
probably benign |
Het |
| Rbm14 |
G |
T |
19: 4,852,671 (GRCm39) |
|
probably benign |
Het |
| Reln |
T |
C |
5: 22,254,698 (GRCm39) |
D557G |
probably damaging |
Het |
| Rhobtb2 |
A |
G |
14: 70,034,499 (GRCm39) |
I242T |
probably benign |
Het |
| Runx1 |
C |
A |
16: 92,492,629 (GRCm39) |
V5L |
possibly damaging |
Het |
| Shld2 |
G |
A |
14: 33,990,663 (GRCm39) |
T81M |
probably damaging |
Het |
| Slc13a1 |
A |
T |
6: 24,100,339 (GRCm39) |
Y381* |
probably null |
Het |
| Smyd3 |
A |
T |
1: 178,921,961 (GRCm39) |
C180S |
probably damaging |
Het |
| Sntg2 |
T |
A |
12: 30,326,658 (GRCm39) |
|
probably null |
Het |
| Snx19 |
G |
A |
9: 30,344,934 (GRCm39) |
V678I |
probably damaging |
Het |
| Spag5 |
G |
A |
11: 78,195,592 (GRCm39) |
A300T |
probably damaging |
Het |
| Spdl1 |
T |
A |
11: 34,704,154 (GRCm39) |
R560W |
probably damaging |
Het |
| Spen |
T |
C |
4: 141,199,907 (GRCm39) |
T2884A |
probably benign |
Het |
| Spg11 |
G |
A |
2: 121,895,963 (GRCm39) |
Q1752* |
probably null |
Het |
| Srrm4 |
C |
A |
5: 116,613,234 (GRCm39) |
|
probably null |
Het |
| Ssc4d |
A |
G |
5: 135,999,074 (GRCm39) |
L43P |
probably damaging |
Het |
| Sspo |
A |
G |
6: 48,437,813 (GRCm39) |
D1324G |
probably damaging |
Het |
| Tkt |
T |
G |
14: 30,288,982 (GRCm39) |
I238S |
probably damaging |
Het |
| Tmem184b |
A |
T |
15: 79,261,377 (GRCm39) |
N76K |
probably benign |
Het |
| Trpm6 |
A |
G |
19: 18,790,857 (GRCm39) |
M631V |
probably damaging |
Het |
| Ttll6 |
A |
C |
11: 96,024,655 (GRCm39) |
E15A |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,569,296 (GRCm39) |
D27199G |
probably damaging |
Het |
| Ubn2 |
A |
T |
6: 38,464,088 (GRCm39) |
|
probably null |
Het |
| Ubr5 |
A |
C |
15: 38,018,541 (GRCm39) |
I866M |
possibly damaging |
Het |
| Urb1 |
T |
C |
16: 90,550,406 (GRCm39) |
T2149A |
probably benign |
Het |
| Ush2a |
G |
T |
1: 188,529,966 (GRCm39) |
V3252L |
possibly damaging |
Het |
| Usp24 |
A |
G |
4: 106,219,377 (GRCm39) |
|
probably null |
Het |
| Vill |
T |
A |
9: 118,897,502 (GRCm39) |
M259K |
probably damaging |
Het |
| Vldlr |
T |
C |
19: 27,217,290 (GRCm39) |
I411T |
probably damaging |
Het |
| Vmn2r120 |
A |
T |
17: 57,831,887 (GRCm39) |
W301R |
probably damaging |
Het |
| Vps13b |
G |
A |
15: 35,910,946 (GRCm39) |
S3570N |
probably damaging |
Het |
| Vps13c |
T |
C |
9: 67,836,821 (GRCm39) |
V1773A |
probably benign |
Het |
| Vtn |
A |
G |
11: 78,392,400 (GRCm39) |
D326G |
probably benign |
Het |
| Wdr93 |
A |
T |
7: 79,426,511 (GRCm39) |
H592L |
probably damaging |
Het |
| Zdhhc19 |
A |
G |
16: 32,317,953 (GRCm39) |
D94G |
probably damaging |
Het |
| Zfand4 |
A |
T |
6: 116,291,311 (GRCm39) |
E188V |
probably damaging |
Het |
| Zfp523 |
C |
A |
17: 28,420,312 (GRCm39) |
|
probably null |
Het |
| Zfp536 |
T |
C |
7: 37,268,309 (GRCm39) |
D369G |
probably damaging |
Het |
| Zfp608 |
T |
A |
18: 55,121,372 (GRCm39) |
T72S |
probably benign |
Het |
| Zfp804a |
T |
A |
2: 82,088,286 (GRCm39) |
V705E |
probably benign |
Het |
| Zfp974 |
T |
C |
7: 27,625,733 (GRCm39) |
T46A |
probably damaging |
Het |
| Zkscan4 |
C |
T |
13: 21,663,416 (GRCm39) |
Q52* |
probably null |
Het |
|
| Other mutations in Dock3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00940:Dock3
|
APN |
9 |
106,788,576 (GRCm39) |
splice site |
probably benign |
|
|
IGL01067:Dock3
|
APN |
9 |
106,959,572 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01160:Dock3
|
APN |
9 |
106,783,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01290:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01291:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01391:Dock3
|
APN |
9 |
106,784,433 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01399:Dock3
|
APN |
9 |
106,870,670 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01660:Dock3
|
APN |
9 |
106,909,563 (GRCm39) |
splice site |
probably benign |
|
|
IGL01752:Dock3
|
APN |
9 |
106,902,512 (GRCm39) |
splice site |
probably benign |
|
|
IGL01820:Dock3
|
APN |
9 |
106,773,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01908:Dock3
|
APN |
9 |
106,783,861 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02191:Dock3
|
APN |
9 |
106,815,340 (GRCm39) |
missense |
probably benign |
|
|
IGL02227:Dock3
|
APN |
9 |
106,939,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02309:Dock3
|
APN |
9 |
106,790,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Dock3
|
APN |
9 |
106,790,298 (GRCm39) |
splice site |
probably benign |
|
|
IGL02469:Dock3
|
APN |
9 |
106,863,215 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02545:Dock3
|
APN |
9 |
106,939,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02894:Dock3
|
APN |
9 |
106,807,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Dock3
|
APN |
9 |
106,900,944 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03027:Dock3
|
APN |
9 |
106,870,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03068:Dock3
|
APN |
9 |
106,841,958 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03128:Dock3
|
APN |
9 |
106,909,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03161:Dock3
|
APN |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03263:Dock3
|
APN |
9 |
106,807,330 (GRCm39) |
splice site |
probably benign |
|
|
IGL03279:Dock3
|
APN |
9 |
106,788,447 (GRCm39) |
splice site |
probably benign |
|
|
IGL03366:Dock3
|
APN |
9 |
106,882,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
Implosion
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
Squeeze
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Tight
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ANU05:Dock3
|
UTSW |
9 |
106,772,862 (GRCm39) |
missense |
probably benign |
|
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0030:Dock3
|
UTSW |
9 |
106,789,512 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0206:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0208:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0384:Dock3
|
UTSW |
9 |
106,779,094 (GRCm39) |
splice site |
probably benign |
|
|
R0610:Dock3
|
UTSW |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0731:Dock3
|
UTSW |
9 |
106,847,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dock3
|
UTSW |
9 |
106,846,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1350:Dock3
|
UTSW |
9 |
106,791,831 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1393:Dock3
|
UTSW |
9 |
106,788,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1424:Dock3
|
UTSW |
9 |
106,790,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1539:Dock3
|
UTSW |
9 |
106,874,112 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1539:Dock3
|
UTSW |
9 |
106,829,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1571:Dock3
|
UTSW |
9 |
106,815,158 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1682:Dock3
|
UTSW |
9 |
106,851,040 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1795:Dock3
|
UTSW |
9 |
106,902,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1987:Dock3
|
UTSW |
9 |
106,985,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2000:Dock3
|
UTSW |
9 |
106,870,160 (GRCm39) |
splice site |
probably benign |
|
|
R2074:Dock3
|
UTSW |
9 |
106,870,662 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2114:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2265:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2370:Dock3
|
UTSW |
9 |
106,829,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2377:Dock3
|
UTSW |
9 |
106,773,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2385:Dock3
|
UTSW |
9 |
106,868,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Dock3
|
UTSW |
9 |
106,791,740 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3076:Dock3
|
UTSW |
9 |
106,818,725 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3122:Dock3
|
UTSW |
9 |
106,788,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4052:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4294:Dock3
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Dock3
|
UTSW |
9 |
106,939,244 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4664:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4705:Dock3
|
UTSW |
9 |
106,902,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4898:Dock3
|
UTSW |
9 |
106,870,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4898:Dock3
|
UTSW |
9 |
106,807,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Dock3
|
UTSW |
9 |
106,868,354 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4961:Dock3
|
UTSW |
9 |
106,818,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4986:Dock3
|
UTSW |
9 |
106,809,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5054:Dock3
|
UTSW |
9 |
106,815,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5065:Dock3
|
UTSW |
9 |
106,832,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Dock3
|
UTSW |
9 |
106,868,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5101:Dock3
|
UTSW |
9 |
106,846,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Dock3
|
UTSW |
9 |
106,810,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Dock3
|
UTSW |
9 |
106,863,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5257:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5273:Dock3
|
UTSW |
9 |
106,777,904 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5322:Dock3
|
UTSW |
9 |
106,779,028 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5482:Dock3
|
UTSW |
9 |
106,855,937 (GRCm39) |
nonsense |
probably null |
|
|
R5553:Dock3
|
UTSW |
9 |
106,868,309 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5631:Dock3
|
UTSW |
9 |
106,832,898 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5739:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5838:Dock3
|
UTSW |
9 |
106,772,687 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5888:Dock3
|
UTSW |
9 |
106,901,002 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5960:Dock3
|
UTSW |
9 |
106,788,554 (GRCm39) |
nonsense |
probably null |
|
|
R5974:Dock3
|
UTSW |
9 |
106,871,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6116:Dock3
|
UTSW |
9 |
106,809,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Dock3
|
UTSW |
9 |
106,841,998 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6176:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6219:Dock3
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6238:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6266:Dock3
|
UTSW |
9 |
106,841,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Dock3
|
UTSW |
9 |
106,785,631 (GRCm39) |
missense |
probably benign |
|
|
R6531:Dock3
|
UTSW |
9 |
106,844,415 (GRCm39) |
missense |
probably benign |
|
|
R6567:Dock3
|
UTSW |
9 |
106,773,946 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6572:Dock3
|
UTSW |
9 |
106,866,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6620:Dock3
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6726:Dock3
|
UTSW |
9 |
107,036,651 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Dock3
|
UTSW |
9 |
106,779,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Dock3
|
UTSW |
9 |
106,841,916 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7320:Dock3
|
UTSW |
9 |
106,772,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7357:Dock3
|
UTSW |
9 |
106,882,568 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7423:Dock3
|
UTSW |
9 |
106,844,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7426:Dock3
|
UTSW |
9 |
106,772,782 (GRCm39) |
missense |
probably benign |
|
|
R7439:Dock3
|
UTSW |
9 |
106,900,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Dock3
|
UTSW |
9 |
106,866,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7470:Dock3
|
UTSW |
9 |
106,882,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Dock3
|
UTSW |
9 |
106,785,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8047:Dock3
|
UTSW |
9 |
106,870,208 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8308:Dock3
|
UTSW |
9 |
106,790,371 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8837:Dock3
|
UTSW |
9 |
106,774,539 (GRCm39) |
missense |
probably benign |
|
|
R8862:Dock3
|
UTSW |
9 |
106,855,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8952:Dock3
|
UTSW |
9 |
106,850,958 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9230:Dock3
|
UTSW |
9 |
106,807,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Dock3
|
UTSW |
9 |
106,818,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9272:Dock3
|
UTSW |
9 |
106,774,569 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9344:Dock3
|
UTSW |
9 |
106,870,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Dock3
|
UTSW |
9 |
106,901,035 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9764:Dock3
|
UTSW |
9 |
106,959,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9766:Dock3
|
UTSW |
9 |
106,788,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Dock3
|
UTSW |
9 |
106,863,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATGTTAGTTTTGGCTAGCAAGTC -3'
(R):5'- GCACTACTATAGATTACAGCAGATGC -3'
Sequencing Primer
(F):5'- TTGGCTAGCAAGTCATACAAAAACTC -3'
(R):5'- AGATGCTTGGCCCCATTAGAGATTC -3'
|
| Posted On |
2015-12-29 |
Incidental Mutation