Incidental Mutation 'R4839:Nwd2'
ID 371617
Institutional Source Beutler Lab
Gene Symbol Nwd2
Ensembl Gene ENSMUSG00000090061
Gene Name NACHT and WD repeat domain containing 2
Synonyms 3110047P20Rik, B830017A01Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R4839 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 63806446-63967889 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 63962893 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 826 (I826F)
Ref Sequence ENSEMBL: ENSMUSP00000124712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159584] [ENSMUST00000162166]
AlphaFold Q6P5U7
Predicted Effect possibly damaging
Transcript: ENSMUST00000159584
AA Change: I826F

PolyPhen 2 Score 0.918 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000124712
Gene: ENSMUSG00000090061
AA Change: I826F

DomainStartEndE-ValueType
Pfam:DUF4062 42 145 1.5e-8 PFAM
Blast:AAA 408 691 3e-29 BLAST
WD40 939 995 1.06e2 SMART
WD40 998 1037 8.96e-2 SMART
Blast:WD40 1091 1126 9e-19 BLAST
Blast:WD40 1129 1170 1e-17 BLAST
Blast:WD40 1220 1260 3e-16 BLAST
WD40 1263 1302 3.4e-2 SMART
WD40 1347 1385 2.65e1 SMART
WD40 1386 1425 1.58e2 SMART
Blast:WD40 1466 1507 3e-19 BLAST
Blast:WD40 1606 1644 4e-18 BLAST
Blast:KR 1686 1730 2e-16 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000162166
Predicted Effect probably benign
Transcript: ENSMUST00000162757
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik T A 17: 9,226,845 (GRCm39) S467T probably benign Het
2310030G06Rik A T 9: 50,652,023 (GRCm39) Y68* probably null Het
Abat T G 16: 8,401,512 (GRCm39) probably benign Het
Abca2 C T 2: 25,330,921 (GRCm39) S1203F probably damaging Het
Adam22 G A 5: 8,186,813 (GRCm39) P436L probably damaging Het
Ak3 A C 19: 29,025,132 (GRCm39) L33R probably damaging Het
Arhgap11a A T 2: 113,672,374 (GRCm39) I198K probably damaging Het
Arl14epl A T 18: 47,065,544 (GRCm39) K103M possibly damaging Het
Atg16l1 T A 1: 87,693,896 (GRCm39) N65K probably damaging Het
Btnl2 G A 17: 34,584,260 (GRCm39) W394* probably null Het
Cacna1e C A 1: 154,296,804 (GRCm39) R1687L probably damaging Het
Cacna1g G T 11: 94,350,433 (GRCm39) R471S probably benign Het
Cdh13 A T 8: 119,578,587 (GRCm39) R205* probably null Het
Cdkl3 A T 11: 51,895,861 (GRCm39) Y36F probably damaging Het
Cep290 T A 10: 100,344,648 (GRCm39) N488K probably damaging Het
Cep350 A T 1: 155,804,240 (GRCm39) C948S probably benign Het
Cep70 A G 9: 99,178,138 (GRCm39) K446R probably benign Het
Cfap70 T C 14: 20,475,597 (GRCm39) T375A probably damaging Het
Cfhr1 A G 1: 139,487,871 (GRCm39) L9S probably damaging Het
Chrm4 T A 2: 91,757,952 (GRCm39) M120K probably damaging Het
Col1a1 A G 11: 94,840,921 (GRCm39) probably null Het
Col3a1 T C 1: 45,362,963 (GRCm39) probably null Het
Csrnp3 A T 2: 65,852,375 (GRCm39) R256* probably null Het
Dbf4 T A 5: 8,458,263 (GRCm39) K190* probably null Het
Dnah10 A T 5: 124,850,196 (GRCm39) I1573F probably damaging Het
Dock8 A G 19: 25,146,858 (GRCm39) I1446V probably benign Het
Dst G T 1: 34,229,943 (GRCm39) R2187M probably damaging Het
Ece2 C T 16: 20,449,918 (GRCm39) R257C probably damaging Het
Espn A G 4: 152,222,961 (GRCm39) Y306H probably damaging Het
Fkbpl G A 17: 34,864,839 (GRCm39) M202I probably benign Het
Fn1 A G 1: 71,681,242 (GRCm39) L362P probably damaging Het
Ganc A C 2: 120,290,304 (GRCm39) R880S probably benign Het
Gucy1b2 A T 14: 62,685,695 (GRCm39) L90Q probably damaging Het
Hcn1 T A 13: 118,062,246 (GRCm39) I504N unknown Het
Hdac2 C A 10: 36,873,462 (GRCm39) T352K probably benign Het
Hip1 T C 5: 135,455,172 (GRCm39) probably null Het
Hspa13 G A 16: 75,562,169 (GRCm39) S10L probably damaging Het
Ipo5 T C 14: 121,157,450 (GRCm39) I96T probably benign Het
Isl1 T C 13: 116,438,220 (GRCm39) Y264C probably damaging Het
Izumo1 T C 7: 45,275,657 (GRCm39) I322T probably benign Het
Kars1 A C 8: 112,729,158 (GRCm39) V183G possibly damaging Het
Lrrc15 C A 16: 30,093,086 (GRCm39) M84I probably benign Het
Magi1 A T 6: 93,671,177 (GRCm39) V796E probably damaging Het
Matn4 G T 2: 164,242,896 (GRCm39) D67E probably benign Het
Mertk A G 2: 128,624,496 (GRCm39) M636V probably damaging Het
Mettl27 C A 5: 134,963,266 (GRCm39) P126T probably damaging Het
Mfrp T A 9: 44,013,432 (GRCm39) H52Q possibly damaging Het
Mrgprb8 T G 7: 48,038,656 (GRCm39) I109R probably benign Het
Mroh2a G A 1: 88,165,666 (GRCm39) G512S probably damaging Het
Ncoa7 T A 10: 30,598,655 (GRCm39) R89S possibly damaging Het
Nfkb2 G T 19: 46,296,006 (GRCm39) E170D probably benign Het
Nin G T 12: 70,137,325 (GRCm39) H84N possibly damaging Het
Or10d1 A G 9: 39,484,441 (GRCm39) M38T probably benign Het
Or14c43 T C 7: 86,115,117 (GRCm39) F166S probably damaging Het
Or1j11 G A 2: 36,312,012 (GRCm39) V201I probably benign Het
Or4l15 C T 14: 50,197,646 (GRCm39) M294I probably benign Het
Or52a5b T C 7: 103,416,961 (GRCm39) I214M possibly damaging Het
Or5k3 A G 16: 58,969,393 (GRCm39) Y60C probably damaging Het
Or5p73 T C 7: 108,064,938 (GRCm39) S136P probably benign Het
Otof C T 5: 30,576,748 (GRCm39) R168H probably damaging Het
Pcdha6 T C 18: 37,101,485 (GRCm39) V226A possibly damaging Het
Pggt1b T C 18: 46,391,166 (GRCm39) I200V possibly damaging Het
Ppat G A 5: 77,098,811 (GRCm39) Q41* probably null Het
Ppfibp2 A T 7: 107,342,192 (GRCm39) H27L probably damaging Het
Rbm27 T A 18: 42,460,510 (GRCm39) I775N probably damaging Het
Rnf40 C T 7: 127,191,812 (GRCm39) R349* probably null Het
Rtp3 A T 9: 110,818,544 (GRCm39) W46R probably damaging Het
Sass6 C T 3: 116,403,949 (GRCm39) R196W probably damaging Het
Sel1l A T 12: 91,799,932 (GRCm39) D131E probably benign Het
Slain2 T C 5: 73,106,066 (GRCm39) S234P probably damaging Het
Slc47a1 C T 11: 61,264,176 (GRCm39) probably null Het
Sp140 CAGAAGAAG CAGAAG 1: 85,538,529 (GRCm39) probably benign Het
Spata31e2 T C 1: 26,724,440 (GRCm39) T247A probably benign Het
Spef2 A T 15: 9,713,264 (GRCm39) Y369* probably null Het
Spred2 T A 11: 19,948,233 (GRCm39) M76K possibly damaging Het
Svs5 T A 2: 164,078,806 (GRCm39) D367V probably benign Het
Tasor2 G A 13: 3,634,807 (GRCm39) P667S probably damaging Het
Tefm A T 11: 80,027,947 (GRCm39) D270E probably benign Het
Tfcp2l1 C A 1: 118,597,194 (GRCm39) P425H probably benign Het
Thbd A T 2: 148,248,591 (GRCm39) C426S probably damaging Het
Timm10b T A 7: 105,333,219 (GRCm39) D968E probably damaging Het
Tle2 C T 10: 81,413,518 (GRCm39) T119I probably damaging Het
Tnik T A 3: 28,650,224 (GRCm39) Y446N possibly damaging Het
Tpr T A 1: 150,324,948 (GRCm39) L2400* probably null Het
Trrap T C 5: 144,782,402 (GRCm39) F3328S probably damaging Het
Vldlr G A 19: 27,215,465 (GRCm39) C154Y probably damaging Het
Vmn1r79 T G 7: 11,910,361 (GRCm39) M81R probably benign Het
Vps13d T C 4: 144,812,000 (GRCm39) T3305A possibly damaging Het
Wdr62 T C 7: 29,970,111 (GRCm39) E232G probably damaging Het
Wdr62 T A 7: 29,940,890 (GRCm39) I843F probably benign Het
Zfp747l1 T C 7: 126,984,179 (GRCm39) S308G probably benign Het
Zfp873 T A 10: 81,896,353 (GRCm39) H361Q probably damaging Het
Zfp949 A C 9: 88,452,047 (GRCm39) H539P probably damaging Het
Other mutations in Nwd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00325:Nwd2 APN 5 63,962,818 (GRCm39) missense probably benign
IGL01111:Nwd2 APN 5 63,964,643 (GRCm39) missense probably damaging 1.00
IGL01152:Nwd2 APN 5 63,963,872 (GRCm39) missense possibly damaging 0.74
IGL01307:Nwd2 APN 5 63,965,626 (GRCm39) missense possibly damaging 0.95
IGL01449:Nwd2 APN 5 63,962,937 (GRCm39) missense probably damaging 1.00
IGL01624:Nwd2 APN 5 63,964,153 (GRCm39) missense probably damaging 1.00
IGL01997:Nwd2 APN 5 63,961,938 (GRCm39) missense probably damaging 0.99
IGL02007:Nwd2 APN 5 63,962,042 (GRCm39) missense possibly damaging 0.87
IGL02143:Nwd2 APN 5 63,948,996 (GRCm39) splice site probably null
IGL02184:Nwd2 APN 5 63,963,020 (GRCm39) missense probably damaging 1.00
IGL02379:Nwd2 APN 5 63,962,644 (GRCm39) missense probably damaging 1.00
IGL02489:Nwd2 APN 5 63,962,570 (GRCm39) missense probably damaging 1.00
IGL02580:Nwd2 APN 5 63,965,512 (GRCm39) missense probably damaging 0.99
IGL02682:Nwd2 APN 5 63,962,021 (GRCm39) missense probably damaging 1.00
IGL02682:Nwd2 APN 5 63,962,020 (GRCm39) missense probably benign 0.03
IGL02891:Nwd2 APN 5 63,882,570 (GRCm39) missense possibly damaging 0.91
IGL03135:Nwd2 APN 5 63,963,338 (GRCm39) missense probably damaging 1.00
IGL03149:Nwd2 APN 5 63,963,338 (GRCm39) missense probably damaging 1.00
R0113:Nwd2 UTSW 5 63,965,241 (GRCm39) missense probably damaging 1.00
R0172:Nwd2 UTSW 5 63,963,712 (GRCm39) missense probably benign 0.44
R0196:Nwd2 UTSW 5 63,963,694 (GRCm39) missense probably benign 0.37
R0239:Nwd2 UTSW 5 63,957,467 (GRCm39) missense probably benign 0.01
R0239:Nwd2 UTSW 5 63,957,467 (GRCm39) missense probably benign 0.01
R0309:Nwd2 UTSW 5 63,964,561 (GRCm39) missense probably damaging 1.00
R0311:Nwd2 UTSW 5 63,962,341 (GRCm39) missense probably damaging 0.99
R0335:Nwd2 UTSW 5 63,962,116 (GRCm39) missense probably benign 0.00
R0384:Nwd2 UTSW 5 63,963,025 (GRCm39) missense probably benign 0.11
R0496:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0497:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0498:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0505:Nwd2 UTSW 5 63,962,454 (GRCm39) missense probably damaging 1.00
R0655:Nwd2 UTSW 5 63,948,928 (GRCm39) missense possibly damaging 0.73
R0762:Nwd2 UTSW 5 63,957,757 (GRCm39) missense probably benign 0.33
R0835:Nwd2 UTSW 5 63,957,473 (GRCm39) missense probably damaging 0.99
R0926:Nwd2 UTSW 5 63,965,234 (GRCm39) missense probably damaging 0.99
R0948:Nwd2 UTSW 5 63,964,655 (GRCm39) missense probably damaging 1.00
R1015:Nwd2 UTSW 5 63,964,154 (GRCm39) missense probably damaging 1.00
R1086:Nwd2 UTSW 5 63,963,917 (GRCm39) missense probably damaging 1.00
R1186:Nwd2 UTSW 5 63,807,367 (GRCm39) utr 5 prime probably benign
R1305:Nwd2 UTSW 5 63,902,540 (GRCm39) missense probably damaging 0.97
R1542:Nwd2 UTSW 5 63,964,318 (GRCm39) missense probably damaging 1.00
R1548:Nwd2 UTSW 5 63,957,525 (GRCm39) missense probably benign 0.00
R1553:Nwd2 UTSW 5 63,957,848 (GRCm39) missense probably benign 0.00
R1636:Nwd2 UTSW 5 63,964,900 (GRCm39) missense probably damaging 1.00
R1658:Nwd2 UTSW 5 63,964,589 (GRCm39) missense probably damaging 1.00
R1763:Nwd2 UTSW 5 63,965,614 (GRCm39) missense probably benign
R1800:Nwd2 UTSW 5 63,962,917 (GRCm39) missense probably benign 0.15
R1813:Nwd2 UTSW 5 63,962,753 (GRCm39) missense probably benign 0.00
R1861:Nwd2 UTSW 5 63,962,197 (GRCm39) missense probably damaging 0.96
R1889:Nwd2 UTSW 5 63,965,009 (GRCm39) missense possibly damaging 0.49
R1896:Nwd2 UTSW 5 63,962,753 (GRCm39) missense probably benign 0.00
R1919:Nwd2 UTSW 5 63,963,523 (GRCm39) missense probably damaging 1.00
R1922:Nwd2 UTSW 5 63,951,585 (GRCm39) missense probably benign
R2258:Nwd2 UTSW 5 63,962,499 (GRCm39) missense probably benign 0.00
R2292:Nwd2 UTSW 5 63,962,917 (GRCm39) missense probably benign 0.15
R2504:Nwd2 UTSW 5 63,961,717 (GRCm39) missense probably benign 0.02
R2869:Nwd2 UTSW 5 63,957,671 (GRCm39) missense probably benign 0.00
R2869:Nwd2 UTSW 5 63,957,671 (GRCm39) missense probably benign 0.00
R2958:Nwd2 UTSW 5 63,963,325 (GRCm39) missense probably benign 0.01
R3034:Nwd2 UTSW 5 63,957,446 (GRCm39) missense probably damaging 1.00
R3422:Nwd2 UTSW 5 63,882,536 (GRCm39) missense possibly damaging 0.46
R3423:Nwd2 UTSW 5 63,957,504 (GRCm39) missense probably damaging 1.00
R3439:Nwd2 UTSW 5 63,961,895 (GRCm39) missense probably benign 0.00
R4193:Nwd2 UTSW 5 63,964,808 (GRCm39) missense probably damaging 1.00
R4254:Nwd2 UTSW 5 63,963,889 (GRCm39) missense possibly damaging 0.74
R4384:Nwd2 UTSW 5 63,963,914 (GRCm39) missense probably damaging 1.00
R4707:Nwd2 UTSW 5 63,951,665 (GRCm39) missense probably damaging 1.00
R4713:Nwd2 UTSW 5 63,961,803 (GRCm39) missense probably benign 0.00
R4735:Nwd2 UTSW 5 63,965,594 (GRCm39) missense probably benign 0.34
R4744:Nwd2 UTSW 5 63,964,310 (GRCm39) missense probably damaging 1.00
R4795:Nwd2 UTSW 5 63,962,776 (GRCm39) missense probably benign 0.21
R4835:Nwd2 UTSW 5 63,965,189 (GRCm39) missense probably benign 0.00
R4896:Nwd2 UTSW 5 63,962,151 (GRCm39) missense probably damaging 1.00
R5017:Nwd2 UTSW 5 63,807,484 (GRCm39) utr 5 prime probably benign
R5170:Nwd2 UTSW 5 63,963,380 (GRCm39) missense probably damaging 0.99
R5312:Nwd2 UTSW 5 63,963,415 (GRCm39) nonsense probably null
R5330:Nwd2 UTSW 5 63,963,859 (GRCm39) missense probably benign 0.02
R5331:Nwd2 UTSW 5 63,963,859 (GRCm39) missense probably benign 0.02
R5419:Nwd2 UTSW 5 63,965,051 (GRCm39) missense probably benign 0.11
R5434:Nwd2 UTSW 5 63,964,991 (GRCm39) missense probably benign 0.00
R5445:Nwd2 UTSW 5 63,962,681 (GRCm39) missense probably damaging 1.00
R5761:Nwd2 UTSW 5 63,882,573 (GRCm39) missense probably damaging 1.00
R5788:Nwd2 UTSW 5 63,965,114 (GRCm39) missense probably benign 0.00
R5907:Nwd2 UTSW 5 63,963,326 (GRCm39) missense probably damaging 0.99
R5959:Nwd2 UTSW 5 63,965,413 (GRCm39) missense probably benign 0.32
R6002:Nwd2 UTSW 5 63,962,143 (GRCm39) missense probably benign
R6027:Nwd2 UTSW 5 63,965,563 (GRCm39) missense possibly damaging 0.65
R6082:Nwd2 UTSW 5 63,962,374 (GRCm39) missense possibly damaging 0.96
R6163:Nwd2 UTSW 5 63,963,131 (GRCm39) missense probably benign 0.00
R6172:Nwd2 UTSW 5 63,964,249 (GRCm39) missense probably damaging 0.98
R6334:Nwd2 UTSW 5 63,957,596 (GRCm39) missense possibly damaging 0.95
R6447:Nwd2 UTSW 5 63,964,898 (GRCm39) missense probably benign 0.41
R6649:Nwd2 UTSW 5 63,882,527 (GRCm39) missense possibly damaging 0.89
R6855:Nwd2 UTSW 5 63,961,794 (GRCm39) missense probably benign 0.00
R7034:Nwd2 UTSW 5 63,962,258 (GRCm39) missense probably damaging 1.00
R7168:Nwd2 UTSW 5 63,964,837 (GRCm39) missense probably benign 0.04
R7326:Nwd2 UTSW 5 63,957,752 (GRCm39) missense probably damaging 1.00
R7561:Nwd2 UTSW 5 63,964,434 (GRCm39) nonsense probably null
R7576:Nwd2 UTSW 5 63,964,736 (GRCm39) missense probably benign 0.00
R7580:Nwd2 UTSW 5 63,965,624 (GRCm39) missense probably benign 0.05
R7723:Nwd2 UTSW 5 63,965,347 (GRCm39) missense possibly damaging 0.69
R7769:Nwd2 UTSW 5 63,961,847 (GRCm39) missense probably damaging 0.99
R8293:Nwd2 UTSW 5 63,962,663 (GRCm39) missense probably benign 0.05
R8517:Nwd2 UTSW 5 63,948,925 (GRCm39) missense probably damaging 1.00
R8782:Nwd2 UTSW 5 63,882,540 (GRCm39) missense probably damaging 1.00
R8792:Nwd2 UTSW 5 63,963,047 (GRCm39) missense probably damaging 0.97
R8888:Nwd2 UTSW 5 63,963,241 (GRCm39) missense probably damaging 1.00
R8895:Nwd2 UTSW 5 63,963,241 (GRCm39) missense probably damaging 1.00
R8901:Nwd2 UTSW 5 63,963,685 (GRCm39) missense probably damaging 1.00
R8913:Nwd2 UTSW 5 63,963,440 (GRCm39) missense possibly damaging 0.80
R8920:Nwd2 UTSW 5 63,948,863 (GRCm39) missense probably damaging 1.00
R9052:Nwd2 UTSW 5 63,961,773 (GRCm39) missense probably damaging 1.00
R9362:Nwd2 UTSW 5 63,961,747 (GRCm39) missense probably benign 0.23
R9368:Nwd2 UTSW 5 63,962,306 (GRCm39) missense probably damaging 0.99
R9377:Nwd2 UTSW 5 63,957,740 (GRCm39) missense probably damaging 1.00
R9430:Nwd2 UTSW 5 63,964,665 (GRCm39) missense probably damaging 1.00
R9655:Nwd2 UTSW 5 63,964,568 (GRCm39) nonsense probably null
R9661:Nwd2 UTSW 5 63,957,780 (GRCm39) missense probably damaging 0.97
R9736:Nwd2 UTSW 5 63,951,600 (GRCm39) missense probably damaging 1.00
R9793:Nwd2 UTSW 5 63,964,232 (GRCm39) missense probably damaging 1.00
R9795:Nwd2 UTSW 5 63,964,232 (GRCm39) missense probably damaging 1.00
RF020:Nwd2 UTSW 5 63,963,066 (GRCm39) nonsense probably null
X0023:Nwd2 UTSW 5 63,964,306 (GRCm39) missense probably damaging 0.99
Z1176:Nwd2 UTSW 5 63,963,500 (GRCm39) missense probably damaging 1.00
Z1176:Nwd2 UTSW 5 63,882,540 (GRCm39) missense probably damaging 1.00
Z1177:Nwd2 UTSW 5 63,964,669 (GRCm39) nonsense probably null
Z1177:Nwd2 UTSW 5 63,962,327 (GRCm39) missense possibly damaging 0.60
Predicted Primers PCR Primer
(F):5'- AGAGATGCACACAATCCTGGC -3'
(R):5'- TTCCTGCGAGTAGTTGTAAGCC -3'

Sequencing Primer
(F):5'- CAATCCTGGCAGATTACTTTCTAGGG -3'
(R):5'- TAAGCCAGTTCTATGTCGGCAAG -3'
Posted On 2016-03-01