Incidental Mutation 'R0281:Duox2'
| ID |
37497 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Duox2
|
| Ensembl Gene |
ENSMUSG00000068452 |
| Gene Name |
dual oxidase 2 |
| Synonyms |
A430065P05Rik |
| MMRRC Submission |
038503-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0281 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
122109728-122128930 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 122122785 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 550
(V550M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000050314
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053734]
|
| AlphaFold |
A0A494BAW1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053734
AA Change: V550M
PolyPhen 2
Score 0.102 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000050314
Gene: ENSMUSG00000068452
AA Change: V550M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:An_peroxidase
|
35 |
560 |
5e-131 |
PFAM |
|
transmembrane domain
|
600 |
622 |
N/A |
INTRINSIC |
|
EFh
|
823 |
851 |
3.7e-5 |
SMART |
|
EFh
|
859 |
887 |
2.09e-4 |
SMART |
|
transmembrane domain
|
1010 |
1032 |
N/A |
INTRINSIC |
|
Pfam:Ferric_reduct
|
1053 |
1202 |
1.8e-22 |
PFAM |
|
Pfam:FAD_binding_8
|
1238 |
1340 |
3.1e-20 |
PFAM |
|
Pfam:NAD_binding_6
|
1346 |
1500 |
1.5e-33 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.9%
|
| Validation Efficiency |
98% (104/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a spontaneous mutation fail to breed and are congenitally hypothyroid (low T4, high TSH), dwarf, and hearing impaired. Anterior pituitaries are dysplastic. Cochlear defects include delayed formation of the inner sulcus and tunnel of Corti and a thickened tectorial membrane. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933430I17Rik |
A |
T |
4: 62,464,304 (GRCm39) |
R374* |
probably null |
Het |
| 5930422O12Rik |
A |
T |
8: 33,919,407 (GRCm39) |
R76* |
probably null |
Het |
| A1cf |
G |
A |
19: 31,923,214 (GRCm39) |
A505T |
probably benign |
Het |
| Abcc5 |
T |
A |
16: 20,241,150 (GRCm39) |
I12F |
probably damaging |
Het |
| Abcf2 |
T |
C |
5: 24,771,562 (GRCm39) |
E555G |
probably damaging |
Het |
| Acan |
A |
T |
7: 78,750,033 (GRCm39) |
E1601D |
probably damaging |
Het |
| Acsbg3 |
T |
A |
17: 57,192,169 (GRCm39) |
Y577* |
probably null |
Het |
| Adam2 |
T |
A |
14: 66,275,055 (GRCm39) |
K559N |
probably benign |
Het |
| Akap11 |
A |
C |
14: 78,747,529 (GRCm39) |
D1619E |
possibly damaging |
Het |
| Ankrd11 |
T |
C |
8: 123,622,307 (GRCm39) |
D515G |
probably benign |
Het |
| Ankrd27 |
T |
A |
7: 35,318,796 (GRCm39) |
N562K |
probably damaging |
Het |
| Atp10b |
T |
C |
11: 43,044,131 (GRCm39) |
I119T |
probably benign |
Het |
| Atr |
T |
C |
9: 95,819,619 (GRCm39) |
I2202T |
probably benign |
Het |
| Bltp2 |
C |
T |
11: 78,162,750 (GRCm39) |
L871F |
possibly damaging |
Het |
| Brd4 |
T |
A |
17: 32,432,514 (GRCm39) |
|
probably benign |
Het |
| Catsperg2 |
C |
T |
7: 29,405,996 (GRCm39) |
C634Y |
possibly damaging |
Het |
| Cep192 |
A |
G |
18: 67,961,553 (GRCm39) |
|
probably benign |
Het |
| Cfap65 |
T |
A |
1: 74,966,230 (GRCm39) |
I366F |
probably damaging |
Het |
| Cnga4 |
G |
T |
7: 105,056,875 (GRCm39) |
R326L |
probably damaging |
Het |
| Cntnap5b |
T |
A |
1: 99,999,878 (GRCm39) |
M212K |
probably benign |
Het |
| Col6a6 |
T |
A |
9: 105,661,315 (GRCm39) |
M265L |
probably benign |
Het |
| Cspg4b |
A |
T |
13: 113,505,677 (GRCm39) |
I727F |
probably damaging |
Het |
| Cyp26b1 |
A |
T |
6: 84,551,538 (GRCm39) |
F417Y |
probably damaging |
Het |
| Dhx15 |
A |
T |
5: 52,308,088 (GRCm39) |
M768K |
probably benign |
Het |
| Drc7 |
G |
A |
8: 95,797,881 (GRCm39) |
R433H |
possibly damaging |
Het |
| Elmo2 |
A |
G |
2: 165,138,810 (GRCm39) |
L456P |
probably damaging |
Het |
| Fbxo39 |
T |
C |
11: 72,208,356 (GRCm39) |
I236T |
probably benign |
Het |
| Fezf2 |
A |
G |
14: 12,343,977 (GRCm38) |
C305R |
probably damaging |
Het |
| Fndc3b |
C |
A |
3: 27,511,155 (GRCm39) |
C785F |
probably benign |
Het |
| Gm12253 |
T |
C |
11: 58,330,838 (GRCm39) |
|
probably benign |
Het |
| Gnat2 |
T |
A |
3: 108,002,878 (GRCm39) |
Y95* |
probably null |
Het |
| Gopc |
T |
C |
10: 52,226,774 (GRCm39) |
K220E |
probably damaging |
Het |
| Hectd4 |
G |
A |
5: 121,392,314 (GRCm39) |
D193N |
possibly damaging |
Het |
| Hexa |
G |
A |
9: 59,461,509 (GRCm39) |
|
probably null |
Het |
| Hspa4l |
T |
C |
3: 40,739,840 (GRCm39) |
|
probably benign |
Het |
| Hspa5 |
T |
C |
2: 34,664,332 (GRCm39) |
S301P |
probably damaging |
Het |
| Ice1 |
A |
T |
13: 70,752,166 (GRCm39) |
S1307T |
possibly damaging |
Het |
| Igtp |
T |
C |
11: 58,096,880 (GRCm39) |
L17P |
probably damaging |
Het |
| Itk |
T |
C |
11: 46,244,743 (GRCm39) |
Y225C |
probably damaging |
Het |
| Kifc3 |
A |
G |
8: 95,830,088 (GRCm39) |
V560A |
probably damaging |
Het |
| Lama1 |
A |
G |
17: 68,124,564 (GRCm39) |
N2875D |
probably damaging |
Het |
| Lasp1 |
C |
A |
11: 97,697,677 (GRCm39) |
C32* |
probably null |
Het |
| Lcp2 |
T |
A |
11: 34,019,854 (GRCm39) |
|
probably benign |
Het |
| Lhx9 |
C |
T |
1: 138,760,642 (GRCm39) |
G236D |
probably benign |
Het |
| Lrrc38 |
A |
T |
4: 143,076,979 (GRCm39) |
I81F |
probably damaging |
Het |
| Ly6a |
C |
T |
15: 74,867,236 (GRCm39) |
V94M |
probably benign |
Het |
| Map3k13 |
A |
G |
16: 21,732,907 (GRCm39) |
E503G |
probably damaging |
Het |
| Mertk |
T |
C |
2: 128,624,541 (GRCm39) |
|
probably benign |
Het |
| Mrtfb |
T |
A |
16: 13,230,027 (GRCm39) |
I915N |
probably damaging |
Het |
| Msantd2 |
G |
A |
9: 37,434,515 (GRCm39) |
D252N |
possibly damaging |
Het |
| Mtmr12 |
T |
A |
15: 12,257,792 (GRCm39) |
L290* |
probably null |
Het |
| Myo3a |
T |
C |
2: 22,250,409 (GRCm39) |
I92T |
probably benign |
Het |
| Naglu |
T |
A |
11: 100,964,853 (GRCm39) |
N313K |
probably damaging |
Het |
| Nceh1 |
T |
C |
3: 27,276,953 (GRCm39) |
V92A |
possibly damaging |
Het |
| Ncf4 |
A |
G |
15: 78,135,083 (GRCm39) |
T47A |
probably damaging |
Het |
| Nrp1 |
T |
A |
8: 129,187,164 (GRCm39) |
F403L |
probably damaging |
Het |
| Nxph3 |
T |
C |
11: 95,402,082 (GRCm39) |
T111A |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 58,929,441 (GRCm39) |
E6061V |
probably damaging |
Het |
| Obsl1 |
C |
A |
1: 75,469,571 (GRCm39) |
G1149W |
probably damaging |
Het |
| Or14c39 |
A |
G |
7: 86,344,068 (GRCm39) |
T135A |
probably benign |
Het |
| Or2k2 |
A |
T |
4: 58,784,981 (GRCm39) |
V247E |
probably damaging |
Het |
| Or2p2 |
T |
A |
13: 21,256,544 (GRCm39) |
Y309F |
probably benign |
Het |
| Or5b123 |
A |
G |
19: 13,596,849 (GRCm39) |
T65A |
probably benign |
Het |
| Or5d14 |
C |
T |
2: 87,880,756 (GRCm39) |
V71I |
possibly damaging |
Het |
| Or5p68 |
A |
C |
7: 107,946,121 (GRCm39) |
D22E |
probably benign |
Het |
| Or6c70 |
T |
A |
10: 129,710,415 (GRCm39) |
L70F |
possibly damaging |
Het |
| Pde9a |
T |
C |
17: 31,674,080 (GRCm39) |
V55A |
probably damaging |
Het |
| Pip4k2c |
A |
T |
10: 127,041,690 (GRCm39) |
|
probably null |
Het |
| Plvap |
T |
C |
8: 71,964,026 (GRCm39) |
N112S |
probably damaging |
Het |
| Pop1 |
T |
A |
15: 34,530,004 (GRCm39) |
|
probably null |
Het |
| Ppip5k2 |
T |
C |
1: 97,644,278 (GRCm39) |
H1113R |
possibly damaging |
Het |
| Ptprk |
A |
T |
10: 28,449,388 (GRCm39) |
I962F |
probably damaging |
Het |
| Rad51ap2 |
T |
C |
12: 11,507,043 (GRCm39) |
S322P |
possibly damaging |
Het |
| Rasal1 |
A |
G |
5: 120,812,670 (GRCm39) |
T565A |
probably benign |
Het |
| Rbm15 |
C |
A |
3: 107,238,471 (GRCm39) |
R642S |
probably damaging |
Het |
| Rpsa |
G |
A |
9: 119,960,069 (GRCm39) |
E211K |
possibly damaging |
Het |
| Ryr3 |
A |
G |
2: 112,517,155 (GRCm39) |
S3303P |
probably damaging |
Het |
| Scg2 |
T |
A |
1: 79,413,229 (GRCm39) |
N458I |
possibly damaging |
Het |
| Setx |
A |
G |
2: 29,069,655 (GRCm39) |
T2487A |
probably benign |
Het |
| Slc4a5 |
G |
A |
6: 83,244,549 (GRCm39) |
|
probably benign |
Het |
| Slc8a2 |
T |
A |
7: 15,874,914 (GRCm39) |
D387E |
probably benign |
Het |
| Smarcc2 |
A |
G |
10: 128,310,591 (GRCm39) |
T407A |
probably benign |
Het |
| Snap25 |
A |
G |
2: 136,619,384 (GRCm39) |
D179G |
probably damaging |
Het |
| Socs4 |
T |
C |
14: 47,527,325 (GRCm39) |
S74P |
probably benign |
Het |
| Sp6 |
T |
A |
11: 96,912,751 (GRCm39) |
Y155N |
probably benign |
Het |
| Srrt |
C |
T |
5: 137,294,389 (GRCm39) |
|
probably benign |
Het |
| Steap1 |
C |
T |
5: 5,786,431 (GRCm39) |
M335I |
probably benign |
Het |
| Stra6 |
A |
T |
9: 58,052,772 (GRCm39) |
Y250F |
probably benign |
Het |
| Svil |
T |
C |
18: 5,094,582 (GRCm39) |
S1421P |
probably damaging |
Het |
| Tcea3 |
G |
A |
4: 135,998,677 (GRCm39) |
C317Y |
probably damaging |
Het |
| Tmco6 |
T |
C |
18: 36,870,757 (GRCm39) |
L117S |
probably damaging |
Het |
| Trp53bp1 |
T |
C |
2: 121,100,718 (GRCm39) |
K89E |
probably damaging |
Het |
| Trp63 |
T |
A |
16: 25,583,052 (GRCm39) |
|
probably benign |
Het |
| Ube2d2a |
A |
G |
18: 35,933,185 (GRCm39) |
Y74C |
probably damaging |
Het |
| Usp19 |
T |
G |
9: 108,375,708 (GRCm39) |
F885V |
probably damaging |
Het |
| Utp18 |
T |
A |
11: 93,773,003 (GRCm39) |
|
probably benign |
Het |
| Vmn2r116 |
T |
C |
17: 23,620,387 (GRCm39) |
I707T |
possibly damaging |
Het |
| Vmn2r68 |
T |
A |
7: 84,882,457 (GRCm39) |
|
probably benign |
Het |
| Vmn2r68 |
C |
G |
7: 84,882,466 (GRCm39) |
|
probably null |
Het |
| Zfp318 |
C |
T |
17: 46,723,540 (GRCm39) |
P1848S |
probably benign |
Het |
| Zfp984 |
G |
T |
4: 147,839,722 (GRCm39) |
N376K |
probably benign |
Het |
|
| Other mutations in Duox2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00474:Duox2
|
APN |
2 |
122,114,056 (GRCm39) |
missense |
probably benign |
|
|
IGL00790:Duox2
|
APN |
2 |
122,122,781 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01346:Duox2
|
APN |
2 |
122,117,683 (GRCm39) |
splice site |
probably benign |
|
|
IGL01607:Duox2
|
APN |
2 |
122,122,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01798:Duox2
|
APN |
2 |
122,112,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02000:Duox2
|
APN |
2 |
122,121,190 (GRCm39) |
missense |
probably benign |
|
|
IGL02219:Duox2
|
APN |
2 |
122,125,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02227:Duox2
|
APN |
2 |
122,115,634 (GRCm39) |
splice site |
probably benign |
|
|
IGL02276:Duox2
|
APN |
2 |
122,124,566 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02447:Duox2
|
APN |
2 |
122,127,949 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02806:Duox2
|
APN |
2 |
122,115,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03091:Duox2
|
APN |
2 |
122,119,955 (GRCm39) |
missense |
probably benign |
0.03 |
|
Bedazzled
|
UTSW |
2 |
122,117,602 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
Birthday
|
UTSW |
2 |
122,112,352 (GRCm39) |
missense |
probably benign |
|
|
gregorian
|
UTSW |
2 |
122,119,826 (GRCm39) |
nonsense |
probably null |
|
|
julian
|
UTSW |
2 |
122,119,813 (GRCm39) |
missense |
probably benign |
0.08 |
|
mayan
|
UTSW |
2 |
122,115,064 (GRCm39) |
missense |
probably benign |
0.00 |
|
minor
|
UTSW |
2 |
122,111,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
oaf
|
UTSW |
2 |
122,125,657 (GRCm39) |
missense |
probably damaging |
0.98 |
|
paltry
|
UTSW |
2 |
122,113,541 (GRCm39) |
critical splice donor site |
probably null |
|
|
promethius
|
UTSW |
2 |
122,126,862 (GRCm39) |
missense |
probably benign |
|
|
Recruit
|
UTSW |
2 |
122,114,378 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
schlemiel
|
UTSW |
2 |
122,120,044 (GRCm39) |
missense |
probably null |
0.89 |
|
stumblebum
|
UTSW |
2 |
122,115,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Two-bit
|
UTSW |
2 |
122,111,483 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0049:Duox2
|
UTSW |
2 |
122,127,167 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R0244:Duox2
|
UTSW |
2 |
122,122,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0378:Duox2
|
UTSW |
2 |
122,115,064 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0383:Duox2
|
UTSW |
2 |
122,122,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0442:Duox2
|
UTSW |
2 |
122,119,813 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0524:Duox2
|
UTSW |
2 |
122,112,317 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0560:Duox2
|
UTSW |
2 |
122,122,035 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0562:Duox2
|
UTSW |
2 |
122,120,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0645:Duox2
|
UTSW |
2 |
122,123,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0704:Duox2
|
UTSW |
2 |
122,115,249 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0963:Duox2
|
UTSW |
2 |
122,117,653 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1254:Duox2
|
UTSW |
2 |
122,113,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1442:Duox2
|
UTSW |
2 |
122,112,232 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1473:Duox2
|
UTSW |
2 |
122,117,602 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R1489:Duox2
|
UTSW |
2 |
122,123,877 (GRCm39) |
missense |
probably benign |
|
|
R1738:Duox2
|
UTSW |
2 |
122,123,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1748:Duox2
|
UTSW |
2 |
122,117,532 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1809:Duox2
|
UTSW |
2 |
122,114,378 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1843:Duox2
|
UTSW |
2 |
122,122,739 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1903:Duox2
|
UTSW |
2 |
122,125,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1962:Duox2
|
UTSW |
2 |
122,127,853 (GRCm39) |
splice site |
probably null |
|
|
R2069:Duox2
|
UTSW |
2 |
122,117,589 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2073:Duox2
|
UTSW |
2 |
122,125,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2074:Duox2
|
UTSW |
2 |
122,125,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2075:Duox2
|
UTSW |
2 |
122,125,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2085:Duox2
|
UTSW |
2 |
122,111,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3123:Duox2
|
UTSW |
2 |
122,111,554 (GRCm39) |
splice site |
probably benign |
|
|
R3907:Duox2
|
UTSW |
2 |
122,113,541 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4572:Duox2
|
UTSW |
2 |
122,112,207 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4614:Duox2
|
UTSW |
2 |
122,120,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4675:Duox2
|
UTSW |
2 |
122,111,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4770:Duox2
|
UTSW |
2 |
122,115,397 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4817:Duox2
|
UTSW |
2 |
122,126,996 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4931:Duox2
|
UTSW |
2 |
122,127,236 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5138:Duox2
|
UTSW |
2 |
122,128,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5288:Duox2
|
UTSW |
2 |
122,125,617 (GRCm39) |
missense |
probably benign |
|
|
R5344:Duox2
|
UTSW |
2 |
122,112,352 (GRCm39) |
missense |
probably benign |
|
|
R5385:Duox2
|
UTSW |
2 |
122,125,617 (GRCm39) |
missense |
probably benign |
|
|
R5386:Duox2
|
UTSW |
2 |
122,125,617 (GRCm39) |
missense |
probably benign |
|
|
R5493:Duox2
|
UTSW |
2 |
122,111,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5632:Duox2
|
UTSW |
2 |
122,111,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5742:Duox2
|
UTSW |
2 |
122,115,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6228:Duox2
|
UTSW |
2 |
122,117,674 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6380:Duox2
|
UTSW |
2 |
122,111,483 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6398:Duox2
|
UTSW |
2 |
122,126,851 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6409:Duox2
|
UTSW |
2 |
122,115,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6527:Duox2
|
UTSW |
2 |
122,125,095 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6596:Duox2
|
UTSW |
2 |
122,115,819 (GRCm39) |
missense |
probably benign |
|
|
R6719:Duox2
|
UTSW |
2 |
122,114,867 (GRCm39) |
splice site |
probably null |
|
|
R6981:Duox2
|
UTSW |
2 |
122,121,708 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7036:Duox2
|
UTSW |
2 |
122,110,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7073:Duox2
|
UTSW |
2 |
122,119,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7105:Duox2
|
UTSW |
2 |
122,120,033 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7127:Duox2
|
UTSW |
2 |
122,122,430 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7259:Duox2
|
UTSW |
2 |
122,125,657 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7698:Duox2
|
UTSW |
2 |
122,111,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Duox2
|
UTSW |
2 |
122,113,948 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8103:Duox2
|
UTSW |
2 |
122,117,535 (GRCm39) |
missense |
probably benign |
|
|
R8231:Duox2
|
UTSW |
2 |
122,120,044 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8439:Duox2
|
UTSW |
2 |
122,128,636 (GRCm39) |
missense |
probably benign |
|
|
R8712:Duox2
|
UTSW |
2 |
122,119,826 (GRCm39) |
nonsense |
probably null |
|
|
R8887:Duox2
|
UTSW |
2 |
122,120,044 (GRCm39) |
missense |
probably null |
0.89 |
|
R8909:Duox2
|
UTSW |
2 |
122,126,862 (GRCm39) |
missense |
probably benign |
|
|
R9022:Duox2
|
UTSW |
2 |
122,110,919 (GRCm39) |
makesense |
probably null |
|
|
R9350:Duox2
|
UTSW |
2 |
122,115,729 (GRCm39) |
nonsense |
probably null |
|
|
R9727:Duox2
|
UTSW |
2 |
122,116,998 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Duox2
|
UTSW |
2 |
122,126,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Duox2
|
UTSW |
2 |
122,123,933 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGCGGGATAAGTAAGTCACAGACG -3'
(R):5'- AGACAGCCTCCACAGGTCTTGATG -3'
Sequencing Primer
(F):5'- GTCTGAGTCCGAGAATCCTTAC -3'
(R):5'- TTGATGCCAGGGGCCTAC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation