Mutagenetix > Incidental Mutations

Incidental Mutation 'R5974:Olfr1434'

471657

Institutional Source

Beutler Lab

Gene Symbol

Olfr1434

Ensembl Gene

ENSMUSG00000095640

Gene Name

olfactory receptor 1434

Synonyms

MOR214-4, Olfr1433, MOR214-4, GA_x6K02T2RE5P-2618516-2619454, GA_x6K02T2RE5P-2610001-2610414

MMRRC Submission

044157-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

R5974 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

12279854-12285626 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 12283836 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 263 (S263P)

Ref Sequence

ENSEMBL: ENSMUSP00000146411 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000207186] [ENSMUST00000207915] [ENSMUST00000208197]

AlphaFold

Q7TQR9

Predicted Effect

probably damaging
Transcript: ENSMUST00000087814
AA Change: S263P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000085115
Gene: ENSMUSG00000095640
AA Change: S263P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	308	9.2e-55	PFAM
Pfam:7tm_1	42	307	2.5e-18	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000207186
AA Change: S263P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Predicted Effect

probably benign
Transcript: ENSMUST00000207915

Predicted Effect

probably damaging
Transcript: ENSMUST00000208197
AA Change: S263P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.6%
20x: 92.6%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg3l2	G	T	18: 67,421,259	L458M	probably damaging	Het
Anapc4	T	C	5: 52,845,400	L261P	probably damaging	Het
Aqp6	A	G	15: 99,601,436	Y10C	probably benign	Het
Ccnb1ip1	A	T	14: 50,792,205	N133K	probably benign	Het
Clip4	A	T	17: 71,831,247	H433L	probably damaging	Het
Cntnap5c	T	A	17: 57,876,485	M62K	probably benign	Het
Col12a1	A	G	9: 79,682,127	S1049P	probably damaging	Het
Col15a1	C	T	4: 47,258,683	T358I	probably benign	Het
Coro7	A	T	16: 4,631,889	D645E	possibly damaging	Het
Ctnnal1	C	A	4: 56,817,067	W585L	probably damaging	Het
Ctnnd1	C	A	2: 84,620,915	E114*	probably null	Het
Daam2	T	A	17: 49,464,473	S882C	probably damaging	Het
Des	T	A	1: 75,362,984	S329T	probably benign	Het
Dido1	T	C	2: 180,671,497	D994G	probably benign	Het
Dock3	A	G	9: 106,994,062	V547A	probably damaging	Het
Ebf4	G	A	2: 130,365,564	A643T	probably damaging	Het
Ect2	C	A	3: 27,144,963	E194*	probably null	Het
Epb41l2	A	G	10: 25,441,815	I77V	possibly damaging	Het
Fat3	A	T	9: 16,006,528		probably null	Het
Fbn2	T	G	18: 58,048,920	D1803A	probably damaging	Het
Fbxo10	T	C	4: 45,040,631	E858G	probably benign	Het
Fbxo24	C	T	5: 137,619,650	R284Q	probably benign	Het
Fsip2	T	A	2: 82,963,313	I425N	possibly damaging	Het
Fut9	A	C	4: 25,620,090	Y241*	probably null	Het
Galr2	A	G	11: 116,283,026	S161G	possibly damaging	Het
Gcc2	T	A	10: 58,258,243	L14I	probably damaging	Het
Gm11127	A	T	17: 36,056,785	D220E	probably benign	Het
Hdac11	G	A	6: 91,173,214	V332I	probably benign	Het
Hdac7	T	C	15: 97,802,072		probably null	Het
Kif16b	C	T	2: 142,857,381	G93D	probably damaging	Het
Krtap11-1	C	A	16: 89,570,768	C121F	possibly damaging	Het
Lacc1	T	C	14: 77,035,077	Q93R	probably damaging	Het
Lama1	T	C	17: 67,773,727	F1250S	probably benign	Het
Lmbrd2	A	G	15: 9,172,115	E332G	probably benign	Het
Lrp2	C	A	2: 69,459,548	C3649F	probably damaging	Het
Map1a	T	C	2: 121,304,376	V1653A	probably benign	Het
Mrpl1	T	C	5: 96,231,794		probably null	Het
Myo1b	A	G	1: 51,778,373	S577P	probably damaging	Het
Nedd4	T	A	9: 72,743,638		probably null	Het
Negr1	T	A	3: 157,069,286	V213E	probably damaging	Het
Nlk	T	G	11: 78,590,966	Q223P	probably benign	Het
Ntn5	A	G	7: 45,691,424	H162R	probably damaging	Het
Nupl2	T	C	5: 24,167,402	S63P	probably damaging	Het
Obscn	C	A	11: 59,076,547	D477Y	probably damaging	Het
Olfr101	A	T	17: 37,300,338	I28N	possibly damaging	Het
Olfr1037	T	C	2: 86,084,881	S299G	probably benign	Het
Pabpn1	A	G	14: 54,897,160	T280A	probably damaging	Het
Per3	A	T	4: 151,042,737	V109E	possibly damaging	Het
Pira2	A	C	7: 3,841,577	V485G	probably benign	Het
Pknox2	A	G	9: 36,936,322	L133P	probably damaging	Het
Pros1	A	C	16: 62,900,667	N195T	probably damaging	Het
Rffl	T	C	11: 82,806,151	K289E	probably damaging	Het
Ripk1	T	A	13: 34,030,101	Y475*	probably null	Het
Ryr2	A	G	13: 11,714,511		probably null	Het
Sgk1	T	A	10: 21,996,249	N241K	probably damaging	Het
Skint1	T	A	4: 112,019,319	S146T	probably benign	Het
Sox30	G	T	11: 45,981,073	D252Y	probably damaging	Het
Syngap1	A	G	17: 26,963,038	Y1002C	probably damaging	Het
Tiam2	A	G	17: 3,414,809	D271G	possibly damaging	Het
Ticam1	T	C	17: 56,271,178	T306A	probably benign	Het
Tmem252	A	G	19: 24,674,268	E67G	probably benign	Het
Tnxb	T	G	17: 34,685,707	F1149V	probably damaging	Het
Ubr4	A	G	4: 139,421,078		probably null	Het
Unc50	A	G	1: 37,437,209	D150G	probably benign	Het
Ywhag	A	C	5: 135,911,629	L37R	probably damaging	Het
Zfp296	T	C	7: 19,577,937	L123P	probably benign	Het
Zfp418	G	T	7: 7,182,200	Q387H	possibly damaging	Het
Zfp882	T	C	8: 71,913,155	F53L	probably damaging	Het

Other mutations in Olfr1434

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01933:Olfr1434	APN	19	12283705	missense	probably damaging	1.00
IGL02415:Olfr1434	APN	19	12283498	missense	probably benign	0.44
IGL02731:Olfr1434	APN	19	12283842	missense	probably damaging	0.99
IGL02803:Olfr1434	APN	19	12283983	missense	possibly damaging	0.94
IGL03050:Olfr1434	UTSW	19	12283512	missense	probably benign
R0432:Olfr1434	UTSW	19	12283903	missense	probably damaging	1.00
R2209:Olfr1434	UTSW	19	12283860	missense	probably benign	0.41
R3710:Olfr1434	UTSW	19	12283086	missense	probably damaging	1.00
R4724:Olfr1434	UTSW	19	12283096	missense	probably damaging	1.00
R5133:Olfr1434	UTSW	19	12283306	missense	possibly damaging	0.96
R6544:Olfr1434	UTSW	19	12283155	missense	probably damaging	1.00
R7225:Olfr1434	UTSW	19	12283467	missense	probably benign	0.00
R7320:Olfr1434	UTSW	19	12283816	missense	possibly damaging	0.72
R7467:Olfr1434	UTSW	19	12283475	nonsense	probably null
R7900:Olfr1434	UTSW	19	12283341	missense	probably damaging	1.00
R8719:Olfr1434	UTSW	19	12283428	missense	probably benign	0.13
R9135:Olfr1434	UTSW	19	12283444	missense	probably damaging	1.00
R9324:Olfr1434	UTSW	19	12283575	missense	probably benign	0.30

Predicted Primers

PCR Primer
(F):5'- CAATGACACTTTCTTTGCACATGTC -3'
(R):5'- TCTCACATGGTGTTGTAGTGAAATC -3'

Sequencing Primer
(F):5'- GCACATGTCCTACTTGTCATATTAAC -3'
(R):5'- AATCTTATCTCTTACCTTAGCTGCAG -3'

Posted On

2017-03-31