Mutagenetix > Incidental Mutation

Incidental Mutation 'R3830:Ptges3l'

473800

Institutional Source

Beutler Lab

Gene Symbol

Ptges3l

Ensembl Gene

ENSMUSG00000097487

Gene Name

prostaglandin E synthase 3 like

Synonyms

1110069E20Rik, 1700113I22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.192) question?

Stock #

R3830 (G1)

Quality Score

Status

Not validated

Chromosome

Chromosomal Location

101418812-101425333 bp(-) (GRCm38)

Type of Mutation

makesense

DNA Base Change (assembly)

T to C at 101421617 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Tryptophan at position 67 (*67W)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040561] [ENSMUST00000070395] [ENSMUST00000093933] [ENSMUST00000103102] [ENSMUST00000107252] [ENSMUST00000107257] [ENSMUST00000107259]

AlphaFold

Q9D9A7

Predicted Effect

probably benign
Transcript: ENSMUST00000040561

SMART Domains

Protein: ENSMUSP00000042151
Gene: ENSMUSG00000035007

Domain	Start	End	E-Value	Type
low complexity region	43	75	N/A	INTRINSIC
coiled coil region	80	102	N/A	INTRINSIC
coiled coil region	165	201	N/A	INTRINSIC
low complexity region	327	338	N/A	INTRINSIC
RUN	540	602	2.77e-21	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000070395

SMART Domains

Protein: ENSMUSP00000067912
Gene: ENSMUSG00000075528

Domain	Start	End	E-Value	Type
Pfam:tRNA-synt_2c	8	101	1.5e-8	PFAM
tRNA_SAD	196	239	1.43e-6	SMART
low complexity region	276	293	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000093933

SMART Domains

Protein: ENSMUSP00000091465
Gene: ENSMUSG00000097487

Domain	Start	End	E-Value	Type
Pfam:CS	6	80	8.7e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000103102

SMART Domains

Protein: ENSMUSP00000099391
Gene: ENSMUSG00000097487

Domain	Start	End	E-Value	Type
Pfam:CS	6	80	7.3e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000107252

SMART Domains

Protein: ENSMUSP00000102873
Gene: ENSMUSG00000097487

Domain	Start	End	E-Value	Type
Pfam:CS	6	80	9.6e-9	PFAM
low complexity region	141	149	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000107257

SMART Domains

Protein: ENSMUSP00000102878
Gene: ENSMUSG00000097239

Domain	Start	End	E-Value	Type
Pfam:tRNA-synt_2c	91	214	1.4e-8	PFAM
tRNA_SAD	309	352	1.43e-6	SMART
low complexity region	389	406	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000107259

SMART Domains

Protein: ENSMUSP00000102880
Gene: ENSMUSG00000097239

Domain	Start	End	E-Value	Type
Pfam:tRNA-synt_2c	109	232	3.4e-9	PFAM
tRNA_SAD	327	370	1.43e-6	SMART
low complexity region	407	424	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125472

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133240

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140123

Predicted Effect

probably null
Transcript: ENSMUST00000149706
AA Change: *67W

SMART Domains

Protein: ENSMUSP00000116399
Gene: ENSMUSG00000097487
AA Change: *67W

Domain	Start	End	E-Value	Type
SCOP:d1ejfa_	2	41	6e-11	SMART
PDB:1EJF\|B	2	56	2e-13	PDB

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150957

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185077

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.7%
20x: 96.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agpat5	A	G	8: 18,879,605	E250G	probably benign	Het
Aox4	A	T	1: 58,255,511	T960S	probably damaging	Het
Bach2	T	A	4: 32,563,150	L539H	probably damaging	Het
Capn1	A	T	19: 5,994,847	L465Q	probably damaging	Het
Cd300c	A	G	11: 114,959,627	F117L	probably benign	Het
Cep104	T	G	4: 153,984,943	M207R	probably damaging	Het
Chd2	A	G	7: 73,491,415	Y577H	possibly damaging	Het
Col4a1	C	A	8: 11,209,650	G1341V	probably damaging	Het
Cspg4	T	G	9: 56,897,621	D1905E	probably damaging	Het
Dhx37	T	C	5: 125,431,613	K86R	probably benign	Het
Drd2	T	A	9: 49,402,143	V204D	probably damaging	Het
Gclc	A	T	9: 77,791,960	I520L	probably benign	Het
Gpat3	A	G	5: 100,884,386	D183G	probably benign	Het
Gpat4	G	A	8: 23,180,155	P286L	probably damaging	Het
Gprin3	T	C	6: 59,353,633	E563G	probably benign	Het
Grm8	A	T	6: 27,761,229	L332*	probably null	Het
Grpel1	T	A	5: 36,469,483	N36K	probably benign	Het
Hecw1	C	T	13: 14,346,058	S198N	probably benign	Het
Kcna2	T	C	3: 107,104,796	I231T	probably benign	Het
Lpcat1	T	C	13: 73,489,093	I114T	possibly damaging	Het
Mast4	G	T	13: 102,738,811	H1350N	probably damaging	Het
Ncor2	T	C	5: 125,118,692		probably benign	Het
Ntn1	C	G	11: 68,385,793	D110H	probably damaging	Het
Olfr222	G	T	11: 59,571,601	N46K	probably damaging	Het
Pigb	T	C	9: 73,017,473	N468S	probably benign	Het
Pik3r2	G	A	8: 70,770,421	R452C	probably benign	Het
Plekhg1	A	G	10: 3,873,400	T123A	probably damaging	Het
Rgs12	G	A	5: 34,966,015	V381M	possibly damaging	Het
Rrm2	G	T	12: 24,708,599	A47S	probably benign	Het
Rsg1	C	T	4: 141,218,589	R148C	probably damaging	Het
Six2	G	T	17: 85,685,187	S296Y	probably damaging	Het
Slc5a12	T	A	2: 110,632,736	C392*	probably null	Het
Snx5	A	T	2: 144,254,901		probably null	Het
Svep1	A	G	4: 58,096,177	L1481P	probably damaging	Het
Tspan18	T	C	2: 93,220,108	I57V	probably benign	Het
Ube3b	C	A	5: 114,399,951	Q368K	probably damaging	Het
Zfhx4	A	T	3: 5,401,209	K2142N	probably damaging	Het
Zfp729a	A	T	13: 67,619,878	F744Y	probably damaging	Het

Other mutations in Ptges3l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00851:Ptges3l	APN	11	101423790	missense	possibly damaging	0.62
IGL01955:Ptges3l	APN	11	101423818	missense	possibly damaging	0.94
R1183:Ptges3l	UTSW	11	101421905	missense	possibly damaging	0.79
R1450:Ptges3l	UTSW	11	101421905	missense	possibly damaging	0.93
R2513:Ptges3l	UTSW	11	101424042	missense	possibly damaging	0.81
R4846:Ptges3l	UTSW	11	101419184	unclassified	probably benign
R4965:Ptges3l	UTSW	11	101424622	start codon destroyed	probably null	0.32
R7430:Ptges3l	UTSW	11	101423815	missense	possibly damaging	0.90

Predicted Primers

Posted On

2017-04-14