Incidental Mutation 'R6527:Steap4'
ID |
521954 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Steap4
|
Ensembl Gene |
ENSMUSG00000012428 |
Gene Name |
STEAP family member 4 |
Synonyms |
Tnfaip9, Tiarp |
MMRRC Submission |
044653-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.115)
|
Stock # |
R6527 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
5 |
Chromosomal Location |
8010472-8032213 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 8028502 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Leucine to Histidine
at position 360
(L360H)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000111081
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000115421]
|
AlphaFold |
Q923B6 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000115421
AA Change: L360H
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000111081 Gene: ENSMUSG00000012428 AA Change: L360H
Domain | Start | End | E-Value | Type |
Pfam:F420_oxidored
|
21 |
107 |
2.3e-16 |
PFAM |
transmembrane domain
|
203 |
225 |
N/A |
INTRINSIC |
Pfam:Ferric_reduct
|
247 |
395 |
2.6e-14 |
PFAM |
transmembrane domain
|
416 |
438 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 97.9%
- 20x: 93.7%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] PHENOTYPE: Mice homozygous for a knock-out allele exhibit adipose accumulation, oxidative stress, increased liver weight, lower metabolic rate, hypoactivity, insulin resistance, glucose intolerance, mild hyperglycemia and dyslipidemia. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 53 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1110002E22Rik |
A |
G |
3: 137,773,288 (GRCm39) |
T826A |
probably damaging |
Het |
Abca16 |
T |
A |
7: 120,076,995 (GRCm39) |
I686N |
possibly damaging |
Het |
Abcb6 |
T |
C |
1: 75,154,132 (GRCm39) |
|
probably null |
Het |
Adgrl3 |
A |
C |
5: 81,935,364 (GRCm39) |
E1299A |
probably damaging |
Het |
Amd2 |
A |
C |
10: 35,586,802 (GRCm39) |
Y252D |
probably damaging |
Het |
Cfap74 |
A |
G |
4: 155,506,722 (GRCm39) |
|
probably null |
Het |
Dhx29 |
G |
T |
13: 113,069,076 (GRCm39) |
K135N |
probably damaging |
Het |
Dlg5 |
T |
A |
14: 24,240,516 (GRCm39) |
D245V |
possibly damaging |
Het |
Dscaml1 |
C |
T |
9: 45,623,482 (GRCm39) |
Q83* |
probably null |
Het |
Dsp |
T |
A |
13: 38,379,849 (GRCm39) |
L1599Q |
probably damaging |
Het |
Duox2 |
A |
G |
2: 122,125,095 (GRCm39) |
V369A |
probably benign |
Het |
Flacc1 |
T |
C |
1: 58,731,572 (GRCm39) |
M1V |
probably null |
Het |
Gbe1 |
T |
A |
16: 70,230,560 (GRCm39) |
|
probably null |
Het |
Gm7298 |
A |
G |
6: 121,746,669 (GRCm39) |
K600R |
probably benign |
Het |
Heatr4 |
C |
T |
12: 84,026,537 (GRCm39) |
G240E |
probably damaging |
Het |
Jakmip2 |
A |
G |
18: 43,689,589 (GRCm39) |
V651A |
possibly damaging |
Het |
Jam3 |
C |
T |
9: 27,066,640 (GRCm39) |
R8Q |
unknown |
Het |
Letm2 |
A |
G |
8: 26,082,522 (GRCm39) |
|
probably benign |
Het |
Lmod3 |
T |
C |
6: 97,224,339 (GRCm39) |
D494G |
probably benign |
Het |
Mast2 |
T |
C |
4: 116,172,136 (GRCm39) |
D604G |
probably damaging |
Het |
Mif4gd |
C |
T |
11: 115,500,101 (GRCm39) |
|
probably null |
Het |
Msr1 |
T |
C |
8: 40,077,274 (GRCm39) |
E112G |
possibly damaging |
Het |
Mtus2 |
A |
G |
5: 148,214,408 (GRCm39) |
|
probably null |
Het |
Muc4 |
A |
G |
16: 32,753,433 (GRCm38) |
H1103R |
probably benign |
Het |
Nudt14 |
T |
A |
12: 112,898,507 (GRCm39) |
I198F |
possibly damaging |
Het |
Or11j4 |
T |
A |
14: 50,630,885 (GRCm39) |
L224* |
probably null |
Het |
Or13p3 |
T |
A |
4: 118,567,045 (GRCm39) |
F147Y |
possibly damaging |
Het |
Or1n1b |
T |
C |
2: 36,780,594 (GRCm39) |
T89A |
probably benign |
Het |
Osbpl8 |
T |
C |
10: 111,129,066 (GRCm39) |
I884T |
probably benign |
Het |
Podxl2 |
T |
C |
6: 88,819,912 (GRCm39) |
N550S |
probably damaging |
Het |
Ppp1r9a |
A |
G |
6: 5,045,949 (GRCm39) |
Y151C |
probably damaging |
Het |
Prss42 |
T |
C |
9: 110,629,924 (GRCm39) |
V226A |
possibly damaging |
Het |
Psmd12 |
A |
G |
11: 107,379,794 (GRCm39) |
I116V |
probably damaging |
Het |
Psme4 |
A |
C |
11: 30,782,175 (GRCm39) |
I872L |
probably benign |
Het |
Rab11fip1 |
A |
T |
8: 27,664,420 (GRCm39) |
V65E |
probably damaging |
Het |
Ros1 |
T |
C |
10: 52,019,473 (GRCm39) |
N700S |
possibly damaging |
Het |
Slc15a4 |
G |
A |
5: 127,673,773 (GRCm39) |
T547M |
probably damaging |
Het |
Slfn3 |
T |
A |
11: 83,103,932 (GRCm39) |
C268S |
probably benign |
Het |
Smc5 |
T |
C |
19: 23,205,554 (GRCm39) |
Q794R |
probably benign |
Het |
Sqor |
A |
G |
2: 122,651,206 (GRCm39) |
Y434C |
probably damaging |
Het |
Sycp1 |
A |
G |
3: 102,806,203 (GRCm39) |
V496A |
probably benign |
Het |
Tmem161b |
T |
G |
13: 84,420,383 (GRCm39) |
M128R |
probably benign |
Het |
Tmem59l |
T |
C |
8: 70,938,775 (GRCm39) |
E102G |
probably damaging |
Het |
Tnks |
A |
T |
8: 35,340,247 (GRCm39) |
V457D |
probably benign |
Het |
Tomt |
A |
G |
7: 101,549,599 (GRCm39) |
Y230H |
probably damaging |
Het |
Trim37 |
A |
G |
11: 87,080,910 (GRCm39) |
N561D |
probably damaging |
Het |
V1ra8 |
T |
A |
6: 90,180,295 (GRCm39) |
I166K |
probably damaging |
Het |
Vmn1r56 |
A |
G |
7: 5,199,575 (GRCm39) |
V14A |
probably benign |
Het |
Vsig8 |
T |
C |
1: 172,387,925 (GRCm39) |
V5A |
possibly damaging |
Het |
Vwa8 |
A |
T |
14: 79,184,653 (GRCm39) |
S384C |
possibly damaging |
Het |
Wwc1 |
C |
T |
11: 35,744,264 (GRCm39) |
E853K |
probably benign |
Het |
Zfp984 |
T |
C |
4: 147,840,381 (GRCm39) |
N157D |
probably benign |
Het |
Zzef1 |
G |
A |
11: 72,765,816 (GRCm39) |
D1448N |
probably benign |
Het |
|
Other mutations in Steap4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00596:Steap4
|
APN |
5 |
8,026,979 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00827:Steap4
|
APN |
5 |
8,026,712 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01481:Steap4
|
APN |
5 |
8,026,858 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02378:Steap4
|
APN |
5 |
8,026,741 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03058:Steap4
|
APN |
5 |
8,025,664 (GRCm39) |
missense |
probably benign |
0.00 |
PIT4362001:Steap4
|
UTSW |
5 |
8,030,337 (GRCm39) |
missense |
probably benign |
0.03 |
R0329:Steap4
|
UTSW |
5 |
8,025,829 (GRCm39) |
missense |
possibly damaging |
0.92 |
R0546:Steap4
|
UTSW |
5 |
8,025,870 (GRCm39) |
missense |
probably damaging |
0.99 |
R0637:Steap4
|
UTSW |
5 |
8,028,398 (GRCm39) |
splice site |
probably benign |
|
R0638:Steap4
|
UTSW |
5 |
8,027,030 (GRCm39) |
splice site |
probably benign |
|
R0651:Steap4
|
UTSW |
5 |
8,030,348 (GRCm39) |
nonsense |
probably null |
|
R0881:Steap4
|
UTSW |
5 |
8,030,388 (GRCm39) |
missense |
probably benign |
|
R1167:Steap4
|
UTSW |
5 |
8,026,520 (GRCm39) |
missense |
probably benign |
0.34 |
R1543:Steap4
|
UTSW |
5 |
8,025,902 (GRCm39) |
splice site |
probably benign |
|
R1889:Steap4
|
UTSW |
5 |
8,025,892 (GRCm39) |
missense |
probably damaging |
1.00 |
R3803:Steap4
|
UTSW |
5 |
8,026,979 (GRCm39) |
missense |
probably damaging |
1.00 |
R3811:Steap4
|
UTSW |
5 |
8,027,017 (GRCm39) |
missense |
probably benign |
0.18 |
R3885:Steap4
|
UTSW |
5 |
8,030,494 (GRCm39) |
missense |
probably damaging |
1.00 |
R3887:Steap4
|
UTSW |
5 |
8,030,494 (GRCm39) |
missense |
probably damaging |
1.00 |
R4051:Steap4
|
UTSW |
5 |
8,030,404 (GRCm39) |
missense |
probably damaging |
1.00 |
R4208:Steap4
|
UTSW |
5 |
8,030,404 (GRCm39) |
missense |
probably damaging |
1.00 |
R5016:Steap4
|
UTSW |
5 |
8,026,699 (GRCm39) |
nonsense |
probably null |
|
R5302:Steap4
|
UTSW |
5 |
8,025,547 (GRCm39) |
nonsense |
probably null |
|
R5951:Steap4
|
UTSW |
5 |
8,025,769 (GRCm39) |
missense |
probably benign |
0.00 |
R6136:Steap4
|
UTSW |
5 |
8,028,562 (GRCm39) |
missense |
probably damaging |
0.99 |
R6631:Steap4
|
UTSW |
5 |
8,026,995 (GRCm39) |
nonsense |
probably null |
|
R6964:Steap4
|
UTSW |
5 |
8,025,568 (GRCm39) |
missense |
probably damaging |
1.00 |
R7055:Steap4
|
UTSW |
5 |
8,026,858 (GRCm39) |
missense |
probably damaging |
1.00 |
R7408:Steap4
|
UTSW |
5 |
8,028,453 (GRCm39) |
missense |
probably benign |
0.07 |
R7692:Steap4
|
UTSW |
5 |
8,026,976 (GRCm39) |
missense |
probably benign |
0.32 |
R8205:Steap4
|
UTSW |
5 |
8,026,795 (GRCm39) |
missense |
possibly damaging |
0.65 |
R8861:Steap4
|
UTSW |
5 |
8,025,672 (GRCm39) |
missense |
probably benign |
0.00 |
R9287:Steap4
|
UTSW |
5 |
8,026,683 (GRCm39) |
missense |
probably benign |
0.05 |
R9423:Steap4
|
UTSW |
5 |
8,026,720 (GRCm39) |
missense |
probably damaging |
0.99 |
R9504:Steap4
|
UTSW |
5 |
8,030,538 (GRCm39) |
missense |
probably benign |
0.00 |
R9531:Steap4
|
UTSW |
5 |
8,028,424 (GRCm39) |
missense |
probably benign |
0.20 |
R9566:Steap4
|
UTSW |
5 |
8,025,646 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
Predicted Primers |
PCR Primer
(F):5'- AGAGGTGTGTTTCAGTTCCCC -3'
(R):5'- CTGCCTGTCAGTGTCTGAGTTC -3'
Sequencing Primer
(F):5'- TCCCCTTGGAAGAGTAAAGTAGAAG -3'
(R):5'- CGAACTGCTAATGATGTGACTAG -3'
|
Posted On |
2018-06-06 |