|Institutional Source||Beutler Lab|
|Gene Name||cytohesin 1 interacting protein|
|Synonyms||A130053M09Rik, Pscdbp, Cybr, Cbp|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7703 (G1)|
|Chromosomal Location||58129137-58195532 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 58147908 bp|
|Amino Acid Change||Valine to Alanine at position 148 (V148A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000028175 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000028175]|
|Predicted Effect||probably damaging
AA Change: V148A
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: V148A
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]
PHENOTYPE: Mice homozygous for a null allele display impaired trafficking and/or cell adhesion of immune system cells. Mice homozygous for a reporter allele show normal immune cell development and function; however, mutant hematopoietic stems cells have impaired repopulating activity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cytip||
(F):5'- CGCTGTGTATGCTGCATTC -3'
(R):5'- TAGCTCCGCTCATACTAGACG -3'
(F):5'- GCATTCTTGTGCACCACAGAC -3'
(R):5'- CCTAAAGCCTCTTTGATAGCGAAGG -3'