Mutagenetix > Incidental Mutation

Incidental Mutation 'R8015:Il20rb'

617137

Institutional Source

Beutler Lab

Gene Symbol

Il20rb

Ensembl Gene

ENSMUSG00000044244

Gene Name

interleukin 20 receptor beta

Synonyms

LOC213208, Il20R2, Fndc6

MMRRC Submission

067455-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8015 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

100339772-100368526 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 100356947 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 61 (Y61F)

Ref Sequence

ENSEMBL: ENSMUSP00000096057 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098458]

AlphaFold

E9Q9A6

Predicted Effect

probably damaging
Transcript: ENSMUST00000098458
AA Change: Y61F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000096057
Gene: ENSMUSG00000044244
AA Change: Y61F

Domain	Start	End	E-Value	Type
FN3	30	117	9.09e0	SMART
Pfam:Interfer-bind	131	222	7.6e-9	PFAM
transmembrane domain	228	250	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (51/51)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
PHENOTYPE: Mice homozygous for a knock-out allele display enhanced antigen-specific T cell responses. Mice homozygous for a reporter allele fail to exhibit epidermal hyperplasia in an interleukin-23 (IL-23)-dependent psoriasis mouse model. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alad	A	G	4: 62,430,159 (GRCm39)	V121A	probably damaging	Het
Anapc2	T	A	2: 25,174,688 (GRCm39)	Y684N	probably benign	Het
Atp10a	G	T	7: 58,453,245 (GRCm39)	R808L	probably benign	Het
Best2	A	G	8: 85,735,983 (GRCm39)	V317A	probably damaging	Het
Bmal2	T	C	6: 146,722,088 (GRCm39)	S220P	probably damaging	Het
Cacnb4	A	G	2: 52,354,655 (GRCm39)	L241P	probably damaging	Het
Col6a5	T	C	9: 105,758,940 (GRCm39)	T2089A	possibly damaging	Het
Cttnbp2	G	C	6: 18,426,092 (GRCm39)	A762G	possibly damaging	Het
Defb13	G	T	8: 22,436,828 (GRCm39)	V8F	possibly damaging	Het
Dpp6	C	T	5: 27,022,808 (GRCm39)		probably benign	Het
Fat4	A	G	3: 39,036,065 (GRCm39)	D3239G	possibly damaging	Het
Hmcn1	T	G	1: 150,474,062 (GRCm39)	R4793S	possibly damaging	Het
Hspa1a	T	A	17: 35,189,625 (GRCm39)	Q426L	probably damaging	Het
Hycc2	A	G	1: 58,574,641 (GRCm39)	V300A	possibly damaging	Het
Iqcn	C	T	8: 71,169,441 (GRCm39)	S1177L	probably benign	Het
Itgb1	T	A	8: 129,448,882 (GRCm39)	V496D	possibly damaging	Het
Jakmip1	T	C	5: 37,317,109 (GRCm39)	S102P	unknown	Het
Jmjd8	T	A	17: 26,048,302 (GRCm39)	F108I	probably damaging	Het
Krtap15-1	A	G	16: 88,626,097 (GRCm39)	T55A	possibly damaging	Het
Lce3d	A	T	3: 92,865,810 (GRCm39)		probably benign	Het
Lnpep	C	A	17: 17,766,761 (GRCm39)	V702F	probably damaging	Het
Lox	G	A	18: 52,661,420 (GRCm39)	A218V	probably benign	Het
Mcrs1	T	A	15: 99,146,735 (GRCm39)	K99*	probably null	Het
Mfsd8	G	A	3: 40,801,270 (GRCm39)		probably benign	Het
Msto1	G	T	3: 88,818,863 (GRCm39)	P264Q	probably damaging	Het
Nrp2	C	T	1: 62,784,567 (GRCm39)	R239C	probably damaging	Het
Or2ad1	T	C	13: 21,326,303 (GRCm39)	D308G	probably benign	Het
Or5g25	G	T	2: 85,478,136 (GRCm39)	H176Q	probably damaging	Het
Pate2	A	T	9: 35,581,814 (GRCm39)	H36L	probably damaging	Het
Pate9	A	G	9: 36,446,250 (GRCm39)	V54A	probably benign	Het
Phf20l1	T	G	15: 66,511,797 (GRCm39)	N925K	possibly damaging	Het
Pnliprp2	G	T	19: 58,754,714 (GRCm39)	V253F	probably damaging	Het
Polr2b	A	G	5: 77,484,353 (GRCm39)	D745G	probably damaging	Het
Ptdss1	T	A	13: 67,111,407 (GRCm39)	W158R	possibly damaging	Het
Rcn3	T	A	7: 44,734,331 (GRCm39)	I226F	probably damaging	Het
Rhbdl1	C	G	17: 26,054,825 (GRCm39)	V157L	probably damaging	Het
Slc30a2	A	G	4: 134,074,761 (GRCm39)	T173A	probably benign	Het
Spata16	A	G	3: 26,721,808 (GRCm39)	T110A	probably benign	Het
Specc1l	A	G	10: 75,076,902 (GRCm39)	K53E	probably benign	Het
Speg	G	T	1: 75,392,065 (GRCm39)		probably benign	Het
Spta1	T	A	1: 174,067,737 (GRCm39)	C2055S	probably damaging	Het
Tex14	G	A	11: 87,400,426 (GRCm39)	R406Q	probably benign	Het
Tmem150b	C	T	7: 4,719,327 (GRCm39)	G198S	probably null	Het
Tnfrsf14	T	G	4: 155,011,118 (GRCm39)	Q81P	probably damaging	Het
Txndc17	A	G	11: 72,098,568 (GRCm39)	K40R	probably benign	Het
Ube3a	T	A	7: 58,934,504 (GRCm39)	V560E	probably damaging	Het
Vmn1r14	A	G	6: 57,211,015 (GRCm39)	M198V	probably damaging	Het
Vmn2r23	G	A	6: 123,681,500 (GRCm39)	S136N	probably benign	Het
Vmn2r31	C	T	7: 7,387,199 (GRCm39)	V791I	probably damaging	Het
Wdfy4	T	C	14: 32,829,704 (GRCm39)	Y984C		Het
Zfp386	T	G	12: 116,023,027 (GRCm39)	D248E	probably damaging	Het

Other mutations in Il20rb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01490:Il20rb	APN	9	100,355,207 (GRCm39)	missense	probably damaging	1.00
IGL02943:Il20rb	APN	9	100,348,305 (GRCm39)	missense	probably benign	0.00
IGL03368:Il20rb	APN	9	100,341,174 (GRCm39)	utr 3 prime	probably benign
IGL03396:Il20rb	APN	9	100,341,251 (GRCm39)	missense	probably damaging	0.99
IGL03412:Il20rb	APN	9	100,357,049 (GRCm39)	missense	probably benign	0.00
R0157:Il20rb	UTSW	9	100,355,132 (GRCm39)	missense	probably damaging	1.00
R4591:Il20rb	UTSW	9	100,357,043 (GRCm39)	missense	possibly damaging	0.61
R4948:Il20rb	UTSW	9	100,343,592 (GRCm39)	splice site	probably benign
R5622:Il20rb	UTSW	9	100,368,371 (GRCm39)	missense	probably benign	0.15
R6448:Il20rb	UTSW	9	100,356,986 (GRCm39)	missense	probably benign	0.03
R7013:Il20rb	UTSW	9	100,343,481 (GRCm39)	missense	probably benign	0.10
R7502:Il20rb	UTSW	9	100,350,479 (GRCm39)	missense	probably damaging	0.98
R7916:Il20rb	UTSW	9	100,348,304 (GRCm39)	missense	probably benign	0.01
R8234:Il20rb	UTSW	9	100,341,263 (GRCm39)	missense	probably benign	0.01
R9143:Il20rb	UTSW	9	100,356,936 (GRCm39)	missense	probably damaging	1.00
R9381:Il20rb	UTSW	9	100,343,541 (GRCm39)	missense	possibly damaging	0.60
R9450:Il20rb	UTSW	9	100,355,055 (GRCm39)	missense	possibly damaging	0.47
R9595:Il20rb	UTSW	9	100,368,311 (GRCm39)	missense	possibly damaging	0.91
R9727:Il20rb	UTSW	9	100,357,001 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGGTCTCTCAAACCCATTAAC -3'
(R):5'- TTGTCACAAAGGCACAAGTG -3'

Sequencing Primer
(F):5'- CCATTAACACTAAGGGGTGGACTG -3'
(R):5'- ACAGTCACTGTTGATGAACCTG -3'

Posted On

2020-01-23