Incidental Mutation 'R8958:Grm7'
ID 682161
Institutional Source Beutler Lab
Gene Symbol Grm7
Ensembl Gene ENSMUSG00000056755
Gene Name glutamate receptor, metabotropic 7
Synonyms 6330570A01Rik, Gpr1g, mGlu7a receptor, mGluR7, E130018M02Rik
MMRRC Submission 068794-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8958 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 110622542-111544191 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 111472783 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 36 (S36L)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071076] [ENSMUST00000172951] [ENSMUST00000174018]
AlphaFold Q68ED2
Predicted Effect possibly damaging
Transcript: ENSMUST00000071076
AA Change: S874L

PolyPhen 2 Score 0.516 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000064404
Gene: ENSMUSG00000056755
AA Change: S874L

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 3e-108 PFAM
Pfam:Peripla_BP_6 144 371 3e-11 PFAM
Pfam:NCD3G 519 569 1.2e-13 PFAM
Pfam:7tm_3 602 847 5.1e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172951
AA Change: S874L

PolyPhen 2 Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000133957
Gene: ENSMUSG00000056755
AA Change: S874L

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 1.7e-103 PFAM
Pfam:Peripla_BP_6 144 487 1e-12 PFAM
Pfam:NCD3G 519 569 1.2e-17 PFAM
Pfam:7tm_3 600 848 1.4e-87 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000173001
AA Change: S36L

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000174018
SMART Domains Protein: ENSMUSP00000134635
Gene: ENSMUSG00000056755

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 176 4.9e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000174310
AA Change: S26L

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
PHENOTYPE: Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam17 A T 12: 21,399,934 (GRCm39) N157K possibly damaging Het
Adck2 T C 6: 39,560,848 (GRCm39) V412A probably benign Het
Adgrb3 C T 1: 25,865,190 (GRCm39) V11I possibly damaging Het
Arhgef17 T C 7: 100,579,019 (GRCm39) D643G probably damaging Het
Arvcf A G 16: 18,221,376 (GRCm39) Q597R probably damaging Het
Brdt T C 5: 107,525,877 (GRCm39) V910A probably benign Het
Cachd1 A G 4: 100,851,283 (GRCm39) D1167G probably benign Het
Ccdc187 A C 2: 26,165,577 (GRCm39) S860A probably benign Het
Ccdc28a T C 10: 18,089,926 (GRCm39) I113M probably benign Het
Cdc5l T C 17: 45,704,127 (GRCm39) N699S probably benign Het
Cenpf A T 1: 189,385,350 (GRCm39) I2310K possibly damaging Het
Ch25h A T 19: 34,452,414 (GRCm39) I38N probably benign Het
Chrdl2 C A 7: 99,670,129 (GRCm39) P84Q probably damaging Het
Cltc A T 11: 86,586,403 (GRCm39) Y1673N possibly damaging Het
Cr1l C G 1: 194,812,243 (GRCm39) G27R probably damaging Het
Crebbp G A 16: 4,031,172 (GRCm39) probably benign Het
Dync1h1 G A 12: 110,586,805 (GRCm39) E929K probably benign Het
E2f7 C A 10: 110,601,615 (GRCm39) P324Q probably damaging Het
Eif3b A G 5: 140,411,194 (GRCm39) D215G probably benign Het
Ephb1 A G 9: 102,072,614 (GRCm39) I55T probably damaging Het
Fbxw14 A T 9: 109,107,810 (GRCm39) L188Q probably damaging Het
Foxg1 T C 12: 49,431,944 (GRCm39) S226P probably damaging Het
Gbe1 T C 16: 70,275,210 (GRCm39) F337L probably damaging Het
Glg1 A T 8: 111,899,116 (GRCm39) C716* probably null Het
Gp1ba C G 11: 70,531,730 (GRCm39) probably benign Het
H2-M5 T A 17: 37,299,520 (GRCm39) I167F probably damaging Het
H3c6 T C 13: 23,746,421 (GRCm39) H40R possibly damaging Het
Hycc1 A G 5: 24,169,934 (GRCm39) C472R probably benign Het
Il18rap C T 1: 40,582,177 (GRCm39) T366M probably benign Het
Ino80 C T 2: 119,213,862 (GRCm39) R1236H probably damaging Het
Ism1 T A 2: 139,573,995 (GRCm39) I115N possibly damaging Het
Kdm4a A G 4: 117,999,573 (GRCm39) S950P probably benign Het
Lama5 T C 2: 179,835,592 (GRCm39) T1254A probably benign Het
Lipo2 T A 19: 33,698,361 (GRCm39) K339* probably null Het
Lrrc7 T C 3: 157,946,138 (GRCm39) K187R probably benign Het
Mkrn2os G C 6: 115,562,317 (GRCm39) S215R probably benign Het
Myzap G T 9: 71,457,485 (GRCm39) D303E possibly damaging Het
Naa11 T C 5: 97,540,084 (GRCm39) N25D probably damaging Het
Naip5 T A 13: 100,354,117 (GRCm39) K1149* probably null Het
Obscn C T 11: 58,964,158 (GRCm39) V3083M probably damaging Het
Or10d1 T C 9: 39,484,091 (GRCm39) T155A probably benign Het
Or4k48 T C 2: 111,476,070 (GRCm39) T91A possibly damaging Het
Parn T A 16: 13,466,322 (GRCm39) E241D possibly damaging Het
Pax1 T A 2: 147,210,517 (GRCm39) probably null Het
Pclo A T 5: 14,725,369 (GRCm39) E1409V unknown Het
Pclo A G 5: 14,763,056 (GRCm39) Y3843C unknown Het
Ppp2r3d A T 9: 101,088,634 (GRCm39) M563K probably benign Het
Prdm1 T G 10: 44,316,729 (GRCm39) K623Q probably damaging Het
Ptpn13 T C 5: 103,698,973 (GRCm39) V1152A probably benign Het
Ptx3 G A 3: 66,128,391 (GRCm39) A151T probably benign Het
Rab11fip1 T C 8: 27,644,940 (GRCm39) S282G possibly damaging Het
Ros1 G T 10: 51,972,190 (GRCm39) N1641K probably damaging Het
Syne1 T C 10: 5,181,768 (GRCm39) K4189R probably benign Het
Tcf3 T C 10: 80,246,091 (GRCm39) K611E probably damaging Het
Tmem215 A G 4: 40,474,376 (GRCm39) Q151R probably benign Het
Trappc8 T C 18: 21,003,667 (GRCm39) I254V probably benign Het
Trim46 T C 3: 89,143,760 (GRCm39) D556G probably damaging Het
Wdr97 A T 15: 76,245,694 (GRCm39) E1310D Het
Zfp513 C A 5: 31,356,825 (GRCm39) R487L probably damaging Het
Zmpste24 C A 4: 120,944,508 (GRCm39) E97* probably null Het
Other mutations in Grm7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01729:Grm7 APN 6 111,223,145 (GRCm39) missense probably benign 0.14
IGL02058:Grm7 APN 6 111,335,278 (GRCm39) missense probably damaging 1.00
IGL02650:Grm7 APN 6 111,335,919 (GRCm39) missense probably damaging 1.00
IGL02892:Grm7 APN 6 111,230,981 (GRCm39) missense probably damaging 0.99
IGL03074:Grm7 APN 6 111,472,604 (GRCm39) splice site probably null
IGL03185:Grm7 APN 6 110,623,183 (GRCm39) missense possibly damaging 0.84
Appropriated UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
Consumed UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
Devoured UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
Ravaged UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
shaky UTSW 6 111,472,752 (GRCm39) nonsense probably null
PIT4651001:Grm7 UTSW 6 110,623,050 (GRCm39) missense probably benign
R0539:Grm7 UTSW 6 111,336,055 (GRCm39) splice site probably benign
R0622:Grm7 UTSW 6 111,335,457 (GRCm39) missense probably damaging 1.00
R1356:Grm7 UTSW 6 111,335,985 (GRCm39) missense probably damaging 1.00
R1762:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1783:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1785:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1816:Grm7 UTSW 6 111,472,752 (GRCm39) nonsense probably null
R1823:Grm7 UTSW 6 111,184,730 (GRCm39) missense probably benign 0.17
R1864:Grm7 UTSW 6 111,057,384 (GRCm39) missense probably benign 0.03
R1894:Grm7 UTSW 6 111,335,568 (GRCm39) missense probably benign
R1987:Grm7 UTSW 6 110,891,472 (GRCm39) missense probably damaging 1.00
R1993:Grm7 UTSW 6 111,184,769 (GRCm39) missense probably benign 0.13
R2138:Grm7 UTSW 6 110,623,098 (GRCm39) missense probably damaging 1.00
R2214:Grm7 UTSW 6 111,335,958 (GRCm39) missense probably damaging 1.00
R2289:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2296:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2339:Grm7 UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
R2847:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2849:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2879:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2884:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2921:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R2923:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R3014:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3015:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3703:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3713:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3963:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4009:Grm7 UTSW 6 111,472,683 (GRCm39) missense probably damaging 1.00
R4091:Grm7 UTSW 6 110,891,301 (GRCm39) missense probably damaging 1.00
R4131:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4132:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4161:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 0.99
R4329:Grm7 UTSW 6 110,891,325 (GRCm39) missense probably damaging 1.00
R4357:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4359:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4379:Grm7 UTSW 6 111,223,335 (GRCm39) missense probably benign 0.05
R4379:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4380:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4514:Grm7 UTSW 6 111,335,265 (GRCm39) missense possibly damaging 0.81
R4518:Grm7 UTSW 6 110,891,507 (GRCm39) splice site probably null
R4647:Grm7 UTSW 6 110,891,344 (GRCm39) nonsense probably null
R4714:Grm7 UTSW 6 111,057,383 (GRCm39) missense possibly damaging 0.52
R4775:Grm7 UTSW 6 110,891,332 (GRCm39) missense probably damaging 1.00
R4957:Grm7 UTSW 6 111,335,824 (GRCm39) missense probably damaging 1.00
R5056:Grm7 UTSW 6 111,057,404 (GRCm39) missense probably damaging 0.99
R5062:Grm7 UTSW 6 110,623,097 (GRCm39) missense probably damaging 1.00
R5256:Grm7 UTSW 6 111,335,182 (GRCm39) missense probably benign 0.01
R5431:Grm7 UTSW 6 111,335,387 (GRCm39) missense probably benign
R6026:Grm7 UTSW 6 111,478,500 (GRCm39) nonsense probably null
R6174:Grm7 UTSW 6 111,223,258 (GRCm39) missense probably benign
R6305:Grm7 UTSW 6 111,335,626 (GRCm39) missense probably damaging 1.00
R6318:Grm7 UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
R6440:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 1.00
R6519:Grm7 UTSW 6 111,184,713 (GRCm39) missense probably benign 0.00
R6531:Grm7 UTSW 6 111,335,386 (GRCm39) missense probably benign 0.29
R6888:Grm7 UTSW 6 111,335,314 (GRCm39) missense possibly damaging 0.79
R6949:Grm7 UTSW 6 111,472,690 (GRCm39) missense probably damaging 1.00
R6949:Grm7 UTSW 6 110,623,265 (GRCm39) missense probably benign 0.03
R6989:Grm7 UTSW 6 111,184,766 (GRCm39) missense probably damaging 1.00
R7076:Grm7 UTSW 6 111,335,113 (GRCm39) missense probably benign 0.04
R7203:Grm7 UTSW 6 111,335,530 (GRCm39) missense possibly damaging 0.94
R7208:Grm7 UTSW 6 111,335,530 (GRCm39) missense possibly damaging 0.94
R7217:Grm7 UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
R7257:Grm7 UTSW 6 110,623,079 (GRCm39) missense probably damaging 1.00
R7297:Grm7 UTSW 6 110,622,974 (GRCm39) missense probably benign 0.16
R7470:Grm7 UTSW 6 111,478,476 (GRCm39) missense
R7567:Grm7 UTSW 6 111,335,722 (GRCm39) missense probably damaging 0.96
R7806:Grm7 UTSW 6 111,223,314 (GRCm39) nonsense probably null
R8018:Grm7 UTSW 6 111,184,737 (GRCm39) missense probably benign 0.01
R8076:Grm7 UTSW 6 111,543,000 (GRCm39) missense probably damaging 1.00
R8409:Grm7 UTSW 6 110,891,297 (GRCm39) missense probably benign 0.02
R8420:Grm7 UTSW 6 111,057,315 (GRCm39) missense probably benign
R8523:Grm7 UTSW 6 111,223,280 (GRCm39) missense possibly damaging 0.76
R8816:Grm7 UTSW 6 111,230,966 (GRCm39) missense possibly damaging 0.46
R9135:Grm7 UTSW 6 111,472,729 (GRCm39) missense probably benign 0.39
R9207:Grm7 UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
R9210:Grm7 UTSW 6 110,622,869 (GRCm39) missense probably benign 0.01
R9438:Grm7 UTSW 6 111,231,077 (GRCm39) missense possibly damaging 0.94
R9448:Grm7 UTSW 6 111,335,193 (GRCm39) missense probably benign 0.01
Z1176:Grm7 UTSW 6 111,335,451 (GRCm39) missense probably damaging 1.00
Z1176:Grm7 UTSW 6 111,335,110 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CACACCCTATCTGCGGTCATTG -3'
(R):5'- TCTACAAGGCAAGCTTACTCC -3'

Sequencing Primer
(F):5'- TGTGTTTCCTAGCTCTACATACAAAC -3'
(R):5'- GGCAAGCTTACTCCACAGAG -3'
Posted On 2021-08-31