Incidental Mutation 'R9109:Vmn2r91'
| ID |
692166 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r91
|
| Ensembl Gene |
ENSMUSG00000091206 |
| Gene Name |
vomeronasal 2, receptor 91 |
| Synonyms |
EG665210 |
| MMRRC Submission |
068918-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.072)
|
| Stock # |
R9109 (G1)
|
| Quality Score |
192.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
18305319-18356905 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 18327905 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 500
(I500V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127465
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172359]
|
| AlphaFold |
E9Q2U5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000172359
AA Change: I500V
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: I500V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
462 |
2.2e-38 |
PFAM |
|
Pfam:NCD3G
|
510 |
564 |
6.7e-20 |
PFAM |
|
Pfam:7tm_3
|
597 |
832 |
2.1e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
98% (61/62) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
C |
A |
8: 73,198,923 (GRCm39) |
A110D |
probably benign |
Het |
| 4930407I10Rik |
A |
G |
15: 81,947,615 (GRCm39) |
E504G |
probably benign |
Het |
| 4931406B18Rik |
C |
A |
7: 43,148,702 (GRCm39) |
A170S |
|
Het |
| Apbb2 |
T |
C |
5: 66,609,018 (GRCm39) |
K210E |
probably benign |
Het |
| Arid4a |
C |
A |
12: 71,122,129 (GRCm39) |
L515I |
probably damaging |
Het |
| Atp13a3 |
A |
G |
16: 30,134,716 (GRCm39) |
S1186P |
possibly damaging |
Het |
| Brf1 |
A |
G |
12: 112,927,011 (GRCm39) |
Y500H |
probably damaging |
Het |
| Btaf1 |
A |
G |
19: 36,964,114 (GRCm39) |
Y895C |
probably benign |
Het |
| Cdhr17 |
T |
A |
5: 16,997,909 (GRCm39) |
V47E |
possibly damaging |
Het |
| Cenpf |
T |
C |
1: 189,391,571 (GRCm39) |
T737A |
probably benign |
Het |
| Cmklr1 |
G |
C |
5: 113,752,043 (GRCm39) |
H319Q |
probably benign |
Het |
| Col18a1 |
G |
A |
10: 76,893,204 (GRCm39) |
T1057M |
probably damaging |
Het |
| Col1a2 |
T |
A |
6: 4,515,260 (GRCm39) |
|
probably null |
Het |
| Csmd3 |
A |
C |
15: 47,617,187 (GRCm39) |
H1000Q |
|
Het |
| Cyp4a29 |
T |
A |
4: 115,108,395 (GRCm39) |
M373K |
probably damaging |
Het |
| Dnhd1 |
A |
G |
7: 105,333,173 (GRCm39) |
E215G |
probably damaging |
Het |
| Dusp19 |
T |
C |
2: 80,447,729 (GRCm39) |
M1T |
probably null |
Het |
| Etv4 |
A |
G |
11: 101,664,492 (GRCm39) |
Y253H |
probably benign |
Het |
| Exosc6 |
G |
A |
8: 111,783,513 (GRCm39) |
A171T |
probably damaging |
Het |
| Fam219a |
G |
A |
4: 41,521,870 (GRCm39) |
T70M |
probably damaging |
Het |
| Fau |
G |
A |
19: 6,108,297 (GRCm39) |
R6H |
probably benign |
Het |
| Flrt3 |
T |
C |
2: 140,501,879 (GRCm39) |
D583G |
probably damaging |
Het |
| Gm14443 |
A |
T |
2: 175,011,869 (GRCm39) |
C192* |
probably null |
Het |
| Gm4353 |
T |
A |
7: 115,682,843 (GRCm39) |
N246I |
probably benign |
Het |
| Igfn1 |
A |
G |
1: 135,926,327 (GRCm39) |
L41P |
probably benign |
Het |
| Jakmip3 |
A |
T |
7: 138,622,560 (GRCm39) |
I307F |
probably damaging |
Het |
| Kcnt2 |
T |
A |
1: 140,353,035 (GRCm39) |
V248D |
probably damaging |
Het |
| Kctd14 |
A |
G |
7: 97,107,243 (GRCm39) |
K166R |
probably benign |
Het |
| Kdm5b |
T |
C |
1: 134,528,493 (GRCm39) |
|
probably null |
Het |
| Kif5c |
A |
G |
2: 49,620,151 (GRCm39) |
D461G |
probably damaging |
Het |
| Lpin2 |
T |
C |
17: 71,538,516 (GRCm39) |
|
probably null |
Het |
| Mettl22 |
G |
A |
16: 8,305,231 (GRCm39) |
D295N |
probably damaging |
Het |
| Nox4 |
G |
A |
7: 87,025,448 (GRCm39) |
R525Q |
probably benign |
Het |
| Or10a5 |
A |
T |
7: 106,635,640 (GRCm39) |
I93F |
probably damaging |
Het |
| Or5b95 |
T |
A |
19: 12,658,190 (GRCm39) |
C239* |
probably null |
Het |
| Or5k8 |
A |
T |
16: 58,644,677 (GRCm39) |
Y132N |
probably damaging |
Het |
| Pecam1 |
G |
T |
11: 106,586,587 (GRCm39) |
N309K |
probably damaging |
Het |
| Pigc |
C |
T |
1: 161,798,032 (GRCm39) |
R5C |
probably benign |
Het |
| Pih1d1 |
T |
C |
7: 44,809,193 (GRCm39) |
V259A |
possibly damaging |
Het |
| Ptpre |
A |
G |
7: 135,271,508 (GRCm39) |
I374M |
probably benign |
Het |
| Rnps1 |
A |
G |
17: 24,637,573 (GRCm39) |
S72G |
unknown |
Het |
| S100pbp |
A |
G |
4: 129,044,847 (GRCm39) |
Y363H |
probably damaging |
Het |
| Sema5a |
A |
G |
15: 32,619,040 (GRCm39) |
T523A |
probably benign |
Het |
| Slc38a8 |
A |
G |
8: 120,212,851 (GRCm39) |
F270S |
possibly damaging |
Het |
| Slc4a1ap |
T |
C |
5: 31,693,538 (GRCm39) |
S491P |
probably damaging |
Het |
| Slc66a2 |
T |
C |
18: 80,300,300 (GRCm39) |
L57P |
probably damaging |
Het |
| Slc7a6 |
T |
C |
8: 106,922,534 (GRCm39) |
V440A |
probably damaging |
Het |
| Sobp |
A |
T |
10: 42,898,902 (GRCm39) |
C228S |
probably damaging |
Het |
| Sox8 |
T |
C |
17: 25,787,813 (GRCm39) |
D212G |
possibly damaging |
Het |
| Specc1 |
A |
G |
11: 62,102,464 (GRCm39) |
|
probably null |
Het |
| Svop |
G |
A |
5: 114,168,231 (GRCm39) |
T456M |
probably benign |
Het |
| Synrg |
A |
G |
11: 83,900,278 (GRCm39) |
D750G |
probably damaging |
Het |
| Syt14 |
C |
A |
1: 192,612,944 (GRCm39) |
E336* |
probably null |
Het |
| Tcp10c |
A |
T |
17: 13,576,650 (GRCm39) |
Q76H |
probably damaging |
Het |
| Tcp11l1 |
C |
T |
2: 104,528,897 (GRCm39) |
V134I |
possibly damaging |
Het |
| Tex51 |
T |
C |
18: 32,594,029 (GRCm39) |
R110G |
possibly damaging |
Het |
| Tle3 |
T |
A |
9: 61,319,562 (GRCm39) |
H443Q |
possibly damaging |
Het |
| Unc13a |
C |
T |
8: 72,108,335 (GRCm39) |
R506Q |
possibly damaging |
Het |
| Vmn2r27 |
T |
C |
6: 124,174,224 (GRCm39) |
Y542C |
possibly damaging |
Het |
| Vmn2r5 |
T |
G |
3: 64,411,411 (GRCm39) |
N386H |
possibly damaging |
Het |
| Wdfy4 |
A |
T |
14: 32,760,704 (GRCm39) |
|
probably null |
Het |
| Zfp709 |
A |
T |
8: 72,644,648 (GRCm39) |
E692D |
possibly damaging |
Het |
| Zglp1 |
A |
T |
9: 20,977,482 (GRCm39) |
L111Q |
probably benign |
Het |
|
| Other mutations in Vmn2r91 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00983:Vmn2r91
|
APN |
17 |
18,325,820 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01121:Vmn2r91
|
APN |
17 |
18,356,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01464:Vmn2r91
|
APN |
17 |
18,327,864 (GRCm39) |
missense |
probably null |
0.00 |
|
IGL02003:Vmn2r91
|
APN |
17 |
18,327,921 (GRCm39) |
missense |
probably benign |
|
|
IGL02709:Vmn2r91
|
APN |
17 |
18,325,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL02795:Vmn2r91
|
APN |
17 |
18,305,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02813:Vmn2r91
|
APN |
17 |
18,356,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02830:Vmn2r91
|
APN |
17 |
18,356,884 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03130:Vmn2r91
|
APN |
17 |
18,330,373 (GRCm39) |
splice site |
probably benign |
|
|
BB006:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB016:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0393:Vmn2r91
|
UTSW |
17 |
18,325,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1142:Vmn2r91
|
UTSW |
17 |
18,356,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1603:Vmn2r91
|
UTSW |
17 |
18,326,405 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1992:Vmn2r91
|
UTSW |
17 |
18,356,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2182:Vmn2r91
|
UTSW |
17 |
18,325,691 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2424:Vmn2r91
|
UTSW |
17 |
18,356,431 (GRCm39) |
nonsense |
probably null |
|
|
R2512:Vmn2r91
|
UTSW |
17 |
18,356,048 (GRCm39) |
missense |
probably benign |
|
|
R2885:Vmn2r91
|
UTSW |
17 |
18,325,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2909:Vmn2r91
|
UTSW |
17 |
18,356,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3009:Vmn2r91
|
UTSW |
17 |
18,325,717 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3079:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3080:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3434:Vmn2r91
|
UTSW |
17 |
18,330,370 (GRCm39) |
splice site |
probably benign |
|
|
R3723:Vmn2r91
|
UTSW |
17 |
18,305,540 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3829:Vmn2r91
|
UTSW |
17 |
18,325,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3845:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3846:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4118:Vmn2r91
|
UTSW |
17 |
18,330,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4285:Vmn2r91
|
UTSW |
17 |
18,356,030 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4729:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4793:Vmn2r91
|
UTSW |
17 |
18,325,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4932:Vmn2r91
|
UTSW |
17 |
18,356,751 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5016:Vmn2r91
|
UTSW |
17 |
18,330,322 (GRCm39) |
nonsense |
probably null |
|
|
R5018:Vmn2r91
|
UTSW |
17 |
18,356,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Vmn2r91
|
UTSW |
17 |
18,356,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5815:Vmn2r91
|
UTSW |
17 |
18,326,464 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6146:Vmn2r91
|
UTSW |
17 |
18,356,518 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6187:Vmn2r91
|
UTSW |
17 |
18,326,888 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6426:Vmn2r91
|
UTSW |
17 |
18,355,865 (GRCm39) |
splice site |
probably null |
|
|
R6450:Vmn2r91
|
UTSW |
17 |
18,305,527 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6767:Vmn2r91
|
UTSW |
17 |
18,327,807 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6986:Vmn2r91
|
UTSW |
17 |
18,356,271 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7112:Vmn2r91
|
UTSW |
17 |
18,325,880 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7178:Vmn2r91
|
UTSW |
17 |
18,356,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7330:Vmn2r91
|
UTSW |
17 |
18,326,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7380:Vmn2r91
|
UTSW |
17 |
18,356,838 (GRCm39) |
nonsense |
probably null |
|
|
R7397:Vmn2r91
|
UTSW |
17 |
18,356,060 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7625:Vmn2r91
|
UTSW |
17 |
18,325,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7739:Vmn2r91
|
UTSW |
17 |
18,356,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7749:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7755:Vmn2r91
|
UTSW |
17 |
18,330,311 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7929:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7981:Vmn2r91
|
UTSW |
17 |
18,327,887 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8211:Vmn2r91
|
UTSW |
17 |
18,326,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8325:Vmn2r91
|
UTSW |
17 |
18,356,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8781:Vmn2r91
|
UTSW |
17 |
18,305,323 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8974:Vmn2r91
|
UTSW |
17 |
18,325,636 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9047:Vmn2r91
|
UTSW |
17 |
18,326,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9048:Vmn2r91
|
UTSW |
17 |
18,356,122 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9211:Vmn2r91
|
UTSW |
17 |
18,356,819 (GRCm39) |
nonsense |
probably null |
|
|
R9555:Vmn2r91
|
UTSW |
17 |
18,325,792 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9616:Vmn2r91
|
UTSW |
17 |
18,356,305 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTGAAGGACATTGAAGTGAG -3'
(R):5'- ACGGGTCTCATCCCTAATTCG -3'
Sequencing Primer
(F):5'- TGAGAGACAAAAAGAGTTTAGGTTG -3'
(R):5'- CCCTAATTCGTAACAATTGGAGG -3'
|
| Posted On |
2021-12-30 |
Incidental Mutation