Incidental Mutation 'R9432:Magi1'
| ID |
713013 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi1
|
| Ensembl Gene |
ENSMUSG00000045095 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| Synonyms |
Baiap1, Gukmi1, AIP3, BAP1, WWP3 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.561)
|
| Stock # |
R9432 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
93652436-94260898 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 93660058 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 1179
(I1179T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000086730
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055224]
[ENSMUST00000089317]
[ENSMUST00000093769]
[ENSMUST00000203519]
[ENSMUST00000203688]
[ENSMUST00000204347]
[ENSMUST00000204532]
|
| AlphaFold |
Q6RHR9 |
| PDB Structure |
X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6 [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055224
AA Change: I1082T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000062085
Gene: ENSMUSG00000045095
AA Change: I1082T
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
348 |
380 |
2.88e-9 |
SMART |
|
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
|
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
|
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
|
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
|
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
|
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
|
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000089317
AA Change: I1179T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000086730
Gene: ENSMUSG00000045095
AA Change: I1179T
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
|
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
|
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000093769
AA Change: I963T
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000091283
Gene: ENSMUSG00000045095
AA Change: I963T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
|
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
|
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
|
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
|
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203519
AA Change: I1094T
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000145244
Gene: ENSMUSG00000045095
AA Change: I1094T
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
360 |
392 |
2.88e-9 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
|
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
|
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
|
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
|
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
|
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203688
AA Change: I963T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000145515
Gene: ENSMUSG00000045095
AA Change: I963T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
|
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
|
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
|
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000204347
AA Change: I1191T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000144881
Gene: ENSMUSG00000045095
AA Change: I1191T
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
|
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
|
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204532
|
| SMART Domains |
Protein: ENSMUSP00000144769
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
|
WW
|
74 |
106 |
5.8e-13 |
SMART |
|
WW
|
133 |
165 |
1.7e-11 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
|
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(165) : Targeted(2) Gene trapped(163)
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
T |
C |
5: 109,884,917 (GRCm39) |
R314G |
unknown |
Het |
| Abca13 |
G |
A |
11: 9,244,559 (GRCm39) |
V2141M |
probably benign |
Het |
| Abcc10 |
G |
A |
17: 46,634,710 (GRCm39) |
A431V |
possibly damaging |
Het |
| Acod1 |
A |
G |
14: 103,292,414 (GRCm39) |
R313G |
probably damaging |
Het |
| Adam3 |
G |
T |
8: 25,193,928 (GRCm39) |
S361R |
probably damaging |
Het |
| Ahcyl2 |
C |
T |
6: 29,768,874 (GRCm39) |
T113M |
possibly damaging |
Het |
| Ano8 |
C |
A |
8: 71,933,561 (GRCm39) |
R577L |
unknown |
Het |
| Arhgef7 |
T |
A |
8: 11,869,646 (GRCm39) |
S653R |
probably damaging |
Het |
| Atp10a |
G |
A |
7: 58,469,418 (GRCm39) |
V1090I |
possibly damaging |
Het |
| Birc6 |
A |
G |
17: 74,966,216 (GRCm39) |
M4048V |
probably benign |
Het |
| C3 |
G |
A |
17: 57,530,950 (GRCm39) |
P384S |
probably damaging |
Het |
| Camkk1 |
A |
T |
11: 72,928,757 (GRCm39) |
E432V |
probably damaging |
Het |
| Celsr3 |
T |
A |
9: 108,726,032 (GRCm39) |
V3087D |
probably benign |
Het |
| Ckap4 |
A |
G |
10: 84,363,543 (GRCm39) |
S507P |
probably damaging |
Het |
| Coq6 |
G |
A |
12: 84,420,464 (GRCm39) |
M471I |
probably benign |
Het |
| Csmd2 |
C |
A |
4: 128,171,004 (GRCm39) |
H332Q |
|
Het |
| Cxcr1 |
T |
A |
1: 74,231,231 (GRCm39) |
N264Y |
probably damaging |
Het |
| Dchs2 |
C |
A |
3: 83,036,032 (GRCm39) |
R260S |
possibly damaging |
Het |
| Elmod2 |
C |
A |
8: 84,057,761 (GRCm39) |
A41S |
possibly damaging |
Het |
| Emilin2 |
G |
A |
17: 71,581,781 (GRCm39) |
T315I |
probably benign |
Het |
| Eml1 |
A |
G |
12: 108,482,842 (GRCm39) |
N487S |
probably benign |
Het |
| Epn1 |
G |
T |
7: 5,096,369 (GRCm39) |
R221L |
probably benign |
Het |
| Faah |
A |
G |
4: 115,874,772 (GRCm39) |
V28A |
probably benign |
Het |
| Fbl |
G |
A |
7: 27,876,689 (GRCm39) |
R230H |
probably benign |
Het |
| Fsip2 |
C |
T |
2: 82,805,907 (GRCm39) |
S742F |
probably damaging |
Het |
| Gm5460 |
A |
G |
14: 33,767,769 (GRCm39) |
D184G |
possibly damaging |
Het |
| Gpatch2l |
T |
C |
12: 86,307,408 (GRCm39) |
V262A |
probably damaging |
Het |
| Grin2c |
A |
T |
11: 115,142,052 (GRCm39) |
L789* |
probably null |
Het |
| H1f0 |
C |
T |
15: 78,912,947 (GRCm39) |
P9L |
probably damaging |
Het |
| Hectd4 |
A |
G |
5: 121,460,864 (GRCm39) |
T948A |
probably benign |
Het |
| Herc2 |
G |
A |
7: 55,780,932 (GRCm39) |
G1199D |
probably damaging |
Het |
| Hoxb7 |
G |
T |
11: 96,177,617 (GRCm39) |
A22S |
possibly damaging |
Het |
| Ifih1 |
T |
A |
2: 62,439,618 (GRCm39) |
I519F |
probably damaging |
Het |
| Ifit1bl1 |
T |
A |
19: 34,571,498 (GRCm39) |
I320F |
possibly damaging |
Het |
| Iqgap2 |
T |
C |
13: 95,774,261 (GRCm39) |
T1320A |
probably benign |
Het |
| Kat2a |
A |
G |
11: 100,602,178 (GRCm39) |
V192A |
probably damaging |
Het |
| Kat6b |
A |
C |
14: 21,672,077 (GRCm39) |
H329P |
probably damaging |
Het |
| Klhl29 |
A |
G |
12: 5,260,056 (GRCm39) |
L54P |
probably benign |
Het |
| Kntc1 |
A |
T |
5: 123,925,112 (GRCm39) |
I1142F |
possibly damaging |
Het |
| Lipo3 |
A |
G |
19: 33,533,864 (GRCm39) |
Y323H |
probably damaging |
Het |
| Lmtk3 |
G |
A |
7: 45,441,994 (GRCm39) |
V351I |
probably damaging |
Het |
| Lrrc8b |
T |
C |
5: 105,633,888 (GRCm39) |
S787P |
probably benign |
Het |
| Mapk11 |
T |
C |
15: 89,028,631 (GRCm39) |
D269G |
probably benign |
Het |
| Mfsd13a |
T |
G |
19: 46,354,868 (GRCm39) |
I15R |
probably benign |
Het |
| Myo1h |
G |
A |
5: 114,499,366 (GRCm39) |
V143I |
possibly damaging |
Het |
| Naaladl1 |
T |
C |
19: 6,156,917 (GRCm39) |
I187T |
possibly damaging |
Het |
| Nos1 |
G |
A |
5: 118,034,871 (GRCm39) |
V416M |
probably damaging |
Het |
| Or14a256 |
G |
A |
7: 86,265,065 (GRCm39) |
R263C |
possibly damaging |
Het |
| Or14j8 |
A |
G |
17: 38,263,559 (GRCm39) |
S119P |
probably damaging |
Het |
| Or8k30 |
T |
G |
2: 86,338,914 (GRCm39) |
I37S |
probably benign |
Het |
| Pcdh15 |
A |
G |
10: 74,460,170 (GRCm39) |
T1373A |
probably damaging |
Het |
| Pcdh18 |
T |
G |
3: 49,699,667 (GRCm39) |
M932L |
probably damaging |
Het |
| Pcdhb15 |
T |
A |
18: 37,608,683 (GRCm39) |
H638Q |
probably benign |
Het |
| Pcdhb19 |
A |
G |
18: 37,630,628 (GRCm39) |
E141G |
possibly damaging |
Het |
| Pds5b |
T |
G |
5: 150,693,256 (GRCm39) |
L656R |
probably damaging |
Het |
| Plcl1 |
T |
C |
1: 55,445,587 (GRCm39) |
L14P |
probably benign |
Het |
| Pzp |
A |
T |
6: 128,499,128 (GRCm39) |
I173N |
|
Het |
| Rnf123 |
C |
T |
9: 107,937,008 (GRCm39) |
R849H |
probably damaging |
Het |
| Sfrp5 |
T |
C |
19: 42,188,225 (GRCm39) |
D198G |
probably damaging |
Het |
| Sftpb |
G |
C |
6: 72,283,843 (GRCm39) |
A147P |
probably benign |
Het |
| Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
| Slc30a6 |
A |
G |
17: 74,719,699 (GRCm39) |
T220A |
possibly damaging |
Het |
| Slc5a3 |
T |
A |
16: 91,874,615 (GRCm39) |
V224D |
probably benign |
Het |
| Smad5 |
T |
A |
13: 56,875,417 (GRCm39) |
Y202N |
probably benign |
Het |
| Smok2b |
A |
G |
17: 13,453,881 (GRCm39) |
I14V |
probably damaging |
Het |
| Tas2r108 |
T |
A |
6: 40,471,121 (GRCm39) |
I199K |
probably damaging |
Het |
| Tcea2 |
A |
G |
2: 181,322,227 (GRCm39) |
I10V |
probably damaging |
Het |
| Tfg |
G |
A |
16: 56,524,868 (GRCm39) |
R113* |
probably null |
Het |
| Tubb4a |
A |
T |
17: 57,388,034 (GRCm39) |
L331I |
probably benign |
Het |
| Ugt2b37 |
A |
G |
5: 87,402,046 (GRCm39) |
V195A |
probably damaging |
Het |
| Umad1 |
A |
G |
6: 8,401,096 (GRCm39) |
H55R |
unknown |
Het |
| Vmn1r176 |
A |
T |
7: 23,534,743 (GRCm39) |
Y137N |
probably damaging |
Het |
| Vmn1r44 |
T |
A |
6: 89,870,473 (GRCm39) |
M73K |
possibly damaging |
Het |
| Vmn2r112 |
A |
G |
17: 22,821,233 (GRCm39) |
T69A |
|
Het |
| Vmn2r59 |
A |
T |
7: 41,696,254 (GRCm39) |
Y163N |
probably damaging |
Het |
| Vps13c |
T |
A |
9: 67,830,137 (GRCm39) |
D1514E |
probably benign |
Het |
| Vsir |
A |
G |
10: 60,193,732 (GRCm39) |
D65G |
possibly damaging |
Het |
| Ypel3 |
A |
T |
7: 126,379,262 (GRCm39) |
M112L |
probably benign |
Het |
| Zfp26 |
T |
A |
9: 20,347,830 (GRCm39) |
K911N |
probably damaging |
Het |
| Zfp362 |
C |
T |
4: 128,670,980 (GRCm39) |
R346Q |
probably damaging |
Het |
| Zfp595 |
A |
T |
13: 67,465,407 (GRCm39) |
Y288* |
probably null |
Het |
| Zfyve28 |
G |
T |
5: 34,400,633 (GRCm39) |
Q22K |
possibly damaging |
Het |
| Zswim4 |
T |
G |
8: 84,963,539 (GRCm39) |
D32A |
probably damaging |
Het |
|
| Other mutations in Magi1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01376:Magi1
|
APN |
6 |
94,260,074 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01457:Magi1
|
APN |
6 |
93,724,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Magi1
|
APN |
6 |
93,663,605 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01724:Magi1
|
APN |
6 |
93,769,381 (GRCm39) |
splice site |
probably null |
|
|
IGL01967:Magi1
|
APN |
6 |
93,685,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01984:Magi1
|
APN |
6 |
93,685,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02074:Magi1
|
APN |
6 |
93,722,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02098:Magi1
|
APN |
6 |
93,655,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02225:Magi1
|
APN |
6 |
93,671,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02522:Magi1
|
APN |
6 |
93,655,617 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02659:Magi1
|
APN |
6 |
93,762,591 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02900:Magi1
|
APN |
6 |
93,663,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0007:Magi1
|
UTSW |
6 |
93,722,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Magi1
|
UTSW |
6 |
93,724,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Magi1
|
UTSW |
6 |
93,671,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1487:Magi1
|
UTSW |
6 |
93,685,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1497:Magi1
|
UTSW |
6 |
93,724,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1502:Magi1
|
UTSW |
6 |
93,671,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2042:Magi1
|
UTSW |
6 |
93,732,026 (GRCm39) |
missense |
probably benign |
|
|
R2132:Magi1
|
UTSW |
6 |
93,674,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2331:Magi1
|
UTSW |
6 |
93,662,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Magi1
|
UTSW |
6 |
93,722,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3076:Magi1
|
UTSW |
6 |
93,734,668 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3551:Magi1
|
UTSW |
6 |
93,676,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4005:Magi1
|
UTSW |
6 |
93,678,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4455:Magi1
|
UTSW |
6 |
93,762,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4670:Magi1
|
UTSW |
6 |
93,663,624 (GRCm39) |
splice site |
probably null |
|
|
R4671:Magi1
|
UTSW |
6 |
93,657,768 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4839:Magi1
|
UTSW |
6 |
93,671,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Magi1
|
UTSW |
6 |
93,660,072 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5147:Magi1
|
UTSW |
6 |
93,724,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Magi1
|
UTSW |
6 |
93,769,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5724:Magi1
|
UTSW |
6 |
93,722,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Magi1
|
UTSW |
6 |
93,657,852 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5846:Magi1
|
UTSW |
6 |
93,662,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Magi1
|
UTSW |
6 |
93,685,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5912:Magi1
|
UTSW |
6 |
93,685,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6112:Magi1
|
UTSW |
6 |
93,722,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6115:Magi1
|
UTSW |
6 |
93,685,051 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6351:Magi1
|
UTSW |
6 |
93,920,210 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6355:Magi1
|
UTSW |
6 |
94,260,177 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6457:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Magi1
|
UTSW |
6 |
93,676,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6613:Magi1
|
UTSW |
6 |
93,722,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6661:Magi1
|
UTSW |
6 |
93,920,289 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6755:Magi1
|
UTSW |
6 |
93,685,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6909:Magi1
|
UTSW |
6 |
93,674,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7180:Magi1
|
UTSW |
6 |
93,792,731 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7224:Magi1
|
UTSW |
6 |
93,660,070 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7447:Magi1
|
UTSW |
6 |
93,722,562 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7517:Magi1
|
UTSW |
6 |
93,685,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7537:Magi1
|
UTSW |
6 |
93,685,091 (GRCm39) |
nonsense |
probably null |
|
|
R7549:Magi1
|
UTSW |
6 |
93,685,095 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7566:Magi1
|
UTSW |
6 |
93,655,308 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7805:Magi1
|
UTSW |
6 |
93,659,927 (GRCm39) |
missense |
probably benign |
|
|
R8022:Magi1
|
UTSW |
6 |
93,674,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8290:Magi1
|
UTSW |
6 |
94,260,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Magi1
|
UTSW |
6 |
93,681,330 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8762:Magi1
|
UTSW |
6 |
93,792,789 (GRCm39) |
nonsense |
probably null |
|
|
R8894:Magi1
|
UTSW |
6 |
93,663,586 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8974:Magi1
|
UTSW |
6 |
93,674,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9225:Magi1
|
UTSW |
6 |
93,762,511 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R9277:Magi1
|
UTSW |
6 |
93,920,234 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9300:Magi1
|
UTSW |
6 |
93,724,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9393:Magi1
|
UTSW |
6 |
93,659,890 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9402:Magi1
|
UTSW |
6 |
94,260,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9567:Magi1
|
UTSW |
6 |
93,659,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9567:Magi1
|
UTSW |
6 |
93,655,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCTGGTAAGACACTGGTG -3'
(R):5'- TCTCATGGCTCCATCCTGAG -3'
Sequencing Primer
(F):5'- CTCTGGAGACAAGCTCATGGAGTC -3'
(R):5'- TCCATCCTGAGCAGTAGGAG -3'
|
| Posted On |
2022-05-16 |
Incidental Mutation