Incidental Mutation 'R3878:Vmn1r34'
| ID |
276940 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r34
|
| Ensembl Gene |
ENSMUSG00000091012 |
| Gene Name |
vomeronasal 1 receptor 34 |
| Synonyms |
Gm5991 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
R3878 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
66613807-66614736 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 66614552 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 62
(T62I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153720
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074381]
[ENSMUST00000226262]
[ENSMUST00000226910]
[ENSMUST00000226999]
[ENSMUST00000227332]
[ENSMUST00000228498]
[ENSMUST00000228647]
|
| AlphaFold |
G3XA52 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000074381
AA Change: T62I
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000132900
Gene: ENSMUSG00000091012
AA Change: T62I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
2.2e-54 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226262
AA Change: T62I
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226910
AA Change: T62I
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226999
AA Change: T62I
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227332
AA Change: T62I
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228498
AA Change: T62I
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228647
AA Change: T62I
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700020A23Rik |
C |
T |
2: 130,247,560 (GRCm39) |
T32M |
probably benign |
Het |
| A2ml1 |
T |
C |
6: 128,531,324 (GRCm39) |
S915G |
probably benign |
Het |
| Ablim1 |
T |
C |
19: 57,025,642 (GRCm39) |
|
probably null |
Het |
| Atosb |
T |
G |
4: 43,035,867 (GRCm39) |
H288P |
probably damaging |
Het |
| Cadm2 |
C |
T |
16: 66,612,329 (GRCm39) |
E78K |
probably damaging |
Het |
| Ceacam5 |
C |
T |
7: 17,484,506 (GRCm39) |
P416L |
probably damaging |
Het |
| Chsy3 |
T |
C |
18: 59,542,845 (GRCm39) |
F661S |
probably damaging |
Het |
| Clstn3 |
G |
A |
6: 124,434,901 (GRCm39) |
T338I |
probably damaging |
Het |
| Ctif |
A |
G |
18: 75,653,048 (GRCm39) |
I403T |
probably damaging |
Het |
| Dnaaf9 |
T |
C |
2: 130,620,423 (GRCm39) |
R237G |
possibly damaging |
Het |
| Eprs1 |
T |
A |
1: 185,148,150 (GRCm39) |
|
probably null |
Het |
| Frs2 |
A |
C |
10: 116,914,815 (GRCm39) |
S35A |
probably benign |
Het |
| Gpr155 |
C |
T |
2: 73,198,736 (GRCm39) |
W394* |
probably null |
Het |
| Ift140 |
G |
A |
17: 25,247,918 (GRCm39) |
V259M |
probably benign |
Het |
| Igkv9-124 |
A |
T |
6: 67,919,191 (GRCm39) |
S74T |
probably benign |
Het |
| Krt14 |
C |
T |
11: 100,097,915 (GRCm39) |
V123M |
possibly damaging |
Het |
| Mcm2 |
G |
A |
6: 88,869,990 (GRCm39) |
R60C |
probably damaging |
Het |
| Nebl |
T |
C |
2: 17,398,063 (GRCm39) |
T457A |
possibly damaging |
Het |
| Nlrp4g |
A |
G |
9: 124,349,362 (GRCm38) |
|
noncoding transcript |
Het |
| Nsa2 |
C |
G |
13: 97,268,542 (GRCm39) |
G175A |
probably benign |
Het |
| Or8k40 |
T |
C |
2: 86,584,972 (GRCm39) |
T37A |
probably benign |
Het |
| Pax1 |
A |
T |
2: 147,204,228 (GRCm39) |
|
probably benign |
Het |
| Pdzd2 |
T |
C |
15: 12,376,262 (GRCm39) |
E1291G |
probably benign |
Het |
| Relb |
G |
A |
7: 19,351,769 (GRCm39) |
H115Y |
probably damaging |
Het |
| Rnase10 |
A |
G |
14: 51,246,889 (GRCm39) |
E52G |
probably damaging |
Het |
| Sla2 |
G |
A |
2: 156,717,862 (GRCm39) |
R137C |
probably damaging |
Het |
| Slc14a2 |
C |
T |
18: 78,202,289 (GRCm39) |
V614I |
probably benign |
Het |
| Slc20a2 |
T |
C |
8: 23,058,399 (GRCm39) |
L645P |
possibly damaging |
Het |
| Smoc2 |
A |
G |
17: 14,545,879 (GRCm39) |
D56G |
probably damaging |
Het |
| Szt2 |
A |
G |
4: 118,247,782 (GRCm39) |
S789P |
probably damaging |
Het |
| Tenm2 |
A |
G |
11: 36,030,401 (GRCm39) |
|
probably null |
Het |
| Tm9sf3 |
A |
G |
19: 41,235,152 (GRCm39) |
V169A |
probably damaging |
Het |
| Trbv13-1 |
C |
T |
6: 41,093,322 (GRCm39) |
T86I |
probably benign |
Het |
| Trim24 |
A |
G |
6: 37,941,708 (GRCm39) |
D886G |
probably benign |
Het |
| Trim33 |
A |
G |
3: 103,259,321 (GRCm39) |
I1003M |
probably damaging |
Het |
| Trim37 |
T |
C |
11: 87,096,828 (GRCm39) |
V777A |
probably benign |
Het |
| Ttc7 |
A |
C |
17: 87,678,166 (GRCm39) |
|
probably benign |
Het |
| Ttn |
T |
C |
2: 76,596,364 (GRCm39) |
D11856G |
possibly damaging |
Het |
| Vmn1r226 |
A |
T |
17: 20,908,260 (GRCm39) |
D164V |
possibly damaging |
Het |
| Wapl |
T |
C |
14: 34,414,104 (GRCm39) |
L322P |
probably damaging |
Het |
| Zfp62 |
A |
G |
11: 49,105,960 (GRCm39) |
D17G |
probably damaging |
Het |
|
| Other mutations in Vmn1r34 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00974:Vmn1r34
|
APN |
6 |
66,614,639 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01322:Vmn1r34
|
APN |
6 |
66,613,899 (GRCm39) |
nonsense |
probably null |
|
|
IGL01866:Vmn1r34
|
APN |
6 |
66,614,373 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02389:Vmn1r34
|
APN |
6 |
66,614,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03356:Vmn1r34
|
APN |
6 |
66,613,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0508:Vmn1r34
|
UTSW |
6 |
66,614,392 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0601:Vmn1r34
|
UTSW |
6 |
66,614,648 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1381:Vmn1r34
|
UTSW |
6 |
66,613,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1605:Vmn1r34
|
UTSW |
6 |
66,613,932 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1765:Vmn1r34
|
UTSW |
6 |
66,614,480 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2022:Vmn1r34
|
UTSW |
6 |
66,614,385 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4023:Vmn1r34
|
UTSW |
6 |
66,614,688 (GRCm39) |
missense |
probably benign |
|
|
R4024:Vmn1r34
|
UTSW |
6 |
66,614,688 (GRCm39) |
missense |
probably benign |
|
|
R4025:Vmn1r34
|
UTSW |
6 |
66,614,688 (GRCm39) |
missense |
probably benign |
|
|
R4026:Vmn1r34
|
UTSW |
6 |
66,614,688 (GRCm39) |
missense |
probably benign |
|
|
R4385:Vmn1r34
|
UTSW |
6 |
66,614,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5274:Vmn1r34
|
UTSW |
6 |
66,614,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6182:Vmn1r34
|
UTSW |
6 |
66,614,312 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6629:Vmn1r34
|
UTSW |
6 |
66,614,499 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7143:Vmn1r34
|
UTSW |
6 |
66,614,648 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7689:Vmn1r34
|
UTSW |
6 |
66,613,994 (GRCm39) |
nonsense |
probably null |
|
|
R7956:Vmn1r34
|
UTSW |
6 |
66,614,777 (GRCm39) |
start gained |
probably benign |
|
|
R8031:Vmn1r34
|
UTSW |
6 |
66,614,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9570:Vmn1r34
|
UTSW |
6 |
66,614,718 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0066:Vmn1r34
|
UTSW |
6 |
66,614,459 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1176:Vmn1r34
|
UTSW |
6 |
66,614,109 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCACCAGCATAGAAGATCCTG -3'
(R):5'- GTGCTTAAGGTGAATACACTTTCTG -3'
Sequencing Primer
(F):5'- CCAGCATAGAAGATCCTGTTAATGC -3'
(R):5'- ATTTCCAAGCTGGGCTTG -3'
|
| Posted On |
2015-04-06 |
Incidental Mutation