Incidental Mutation 'R1893:Map4k4'
| ID |
211661 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Map4k4
|
| Ensembl Gene |
ENSMUSG00000026074 |
| Gene Name |
mitogen-activated protein kinase kinase kinase kinase 4 |
| Synonyms |
9430080K19Rik, Nik |
| MMRRC Submission |
039913-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1893 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
39940073-40065470 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 40040717 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 579
(V579E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126961
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163854]
[ENSMUST00000168431]
[ENSMUST00000191964]
[ENSMUST00000192509]
[ENSMUST00000193682]
[ENSMUST00000195259]
[ENSMUST00000195636]
[ENSMUST00000195860]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163854
AA Change: V579E
PolyPhen 2
Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000126961
Gene: ENSMUSG00000026074
AA Change: V579E
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000168431
AA Change: V610E
|
| SMART Domains |
Protein: ENSMUSP00000129796
Gene: ENSMUSG00000026074
AA Change: V610E
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191865
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191964
|
| SMART Domains |
Protein: ENSMUSP00000141235
Gene: ENSMUSG00000026074
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
SCOP:d1i7qa_
|
35 |
139 |
7e-3 |
SMART |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192355
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192509
|
| SMART Domains |
Protein: ENSMUSP00000141665
Gene: ENSMUSG00000026074
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193682
|
| SMART Domains |
Protein: ENSMUSP00000141862
Gene: ENSMUSG00000026074
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
556 |
567 |
N/A |
INTRINSIC |
|
low complexity region
|
590 |
616 |
N/A |
INTRINSIC |
|
low complexity region
|
623 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
680 |
706 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
814 |
N/A |
INTRINSIC |
|
low complexity region
|
824 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
862 |
N/A |
INTRINSIC |
|
CNH
|
903 |
1201 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000195259
AA Change: V579E
|
| SMART Domains |
Protein: ENSMUSP00000142056
Gene: ENSMUSG00000026074
AA Change: V579E
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
824 |
N/A |
INTRINSIC |
|
low complexity region
|
839 |
849 |
N/A |
INTRINSIC |
|
CNH
|
890 |
1188 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000195636
AA Change: V579E
|
| SMART Domains |
Protein: ENSMUSP00000141613
Gene: ENSMUSG00000026074
AA Change: V579E
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
3.4e-97 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
836 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
875 |
888 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
913 |
N/A |
INTRINSIC |
|
CNH
|
954 |
1252 |
1.4e-129 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195860
AA Change: V579E
PolyPhen 2
Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000141400
Gene: ENSMUSG00000026074
AA Change: V579E
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195356
|
| Meta Mutation Damage Score |
0.0581 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 93.0%
|
| Validation Efficiency |
99% (99/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos around day E9.5-10.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
C |
13: 77,415,928 (GRCm39) |
Y674H |
possibly damaging |
Het |
| Aars2 |
G |
A |
17: 45,825,725 (GRCm39) |
R347Q |
probably benign |
Het |
| Abca15 |
A |
T |
7: 119,939,776 (GRCm39) |
M293L |
possibly damaging |
Het |
| Abcb7 |
A |
T |
X: 103,386,142 (GRCm39) |
H97Q |
probably damaging |
Het |
| Aldh1l2 |
G |
T |
10: 83,328,400 (GRCm39) |
N772K |
probably damaging |
Het |
| Ascc2 |
T |
A |
11: 4,622,305 (GRCm39) |
L457Q |
probably benign |
Het |
| Aspm |
T |
A |
1: 139,407,605 (GRCm39) |
I2164N |
probably damaging |
Het |
| Cabs1 |
A |
G |
5: 88,127,894 (GRCm39) |
T182A |
probably benign |
Het |
| Carmil1 |
T |
C |
13: 24,208,446 (GRCm39) |
E833G |
possibly damaging |
Het |
| Ccdc102a |
G |
A |
8: 95,640,171 (GRCm39) |
T41M |
probably damaging |
Het |
| Cimap1c |
A |
G |
9: 56,756,498 (GRCm39) |
Y173H |
probably benign |
Het |
| Clec2h |
T |
C |
6: 128,647,795 (GRCm39) |
V48A |
probably benign |
Het |
| Cpb2 |
G |
A |
14: 75,493,403 (GRCm39) |
V27I |
probably benign |
Het |
| Cr2 |
T |
C |
1: 194,837,495 (GRCm39) |
H1201R |
probably benign |
Het |
| Cyp2d9 |
T |
C |
15: 82,336,807 (GRCm39) |
V52A |
probably damaging |
Het |
| Cyp4a12a |
C |
A |
4: 115,183,864 (GRCm39) |
N223K |
probably benign |
Het |
| Cyp7b1 |
G |
A |
3: 18,150,731 (GRCm39) |
S336L |
possibly damaging |
Het |
| Dnah10 |
T |
C |
5: 124,831,381 (GRCm39) |
V803A |
probably benign |
Het |
| Dnah17 |
T |
A |
11: 117,957,794 (GRCm39) |
T2745S |
probably benign |
Het |
| Ep300 |
T |
A |
15: 81,515,847 (GRCm39) |
|
probably benign |
Het |
| Epha3 |
A |
G |
16: 63,388,762 (GRCm39) |
S829P |
probably damaging |
Het |
| Fads3 |
C |
A |
19: 10,033,868 (GRCm39) |
H418N |
probably benign |
Het |
| Fat1 |
T |
C |
8: 45,476,893 (GRCm39) |
S1980P |
probably damaging |
Het |
| Fgf20 |
T |
C |
8: 40,732,844 (GRCm39) |
E198G |
possibly damaging |
Het |
| Fgl2 |
G |
A |
5: 21,580,669 (GRCm39) |
R337H |
probably benign |
Het |
| Gbp2 |
G |
T |
3: 142,335,933 (GRCm39) |
|
probably benign |
Het |
| Gja10 |
G |
A |
4: 32,601,541 (GRCm39) |
S281L |
probably benign |
Het |
| Gm5422 |
G |
A |
10: 31,125,609 (GRCm39) |
|
noncoding transcript |
Het |
| Gmpr |
T |
A |
13: 45,674,423 (GRCm39) |
D129E |
possibly damaging |
Het |
| Gtf3c4 |
C |
T |
2: 28,724,374 (GRCm39) |
V453I |
possibly damaging |
Het |
| Heatr6 |
T |
C |
11: 83,648,140 (GRCm39) |
V111A |
probably benign |
Het |
| Hipk3 |
G |
A |
2: 104,263,601 (GRCm39) |
R905W |
probably damaging |
Het |
| Hpn |
T |
A |
7: 30,798,773 (GRCm39) |
D103V |
probably damaging |
Het |
| Ipcef1 |
G |
A |
10: 6,850,680 (GRCm39) |
R304W |
probably damaging |
Het |
| Iqcb1 |
A |
G |
16: 36,652,245 (GRCm39) |
D52G |
probably damaging |
Het |
| Klhdc7b |
C |
T |
15: 89,271,898 (GRCm39) |
|
probably null |
Het |
| Klhl1 |
A |
T |
14: 96,477,642 (GRCm39) |
|
probably null |
Het |
| Lrrn1 |
A |
T |
6: 107,545,083 (GRCm39) |
I294F |
possibly damaging |
Het |
| Map3k1 |
A |
T |
13: 111,904,567 (GRCm39) |
F406I |
possibly damaging |
Het |
| Mapre2 |
A |
G |
18: 23,986,774 (GRCm39) |
K62R |
probably damaging |
Het |
| Mdga1 |
A |
T |
17: 30,068,200 (GRCm39) |
Y305N |
probably damaging |
Het |
| Mgl2 |
T |
A |
11: 70,024,993 (GRCm39) |
|
probably null |
Het |
| Mnx1 |
C |
T |
5: 29,682,828 (GRCm39) |
G149D |
unknown |
Het |
| Mtbp |
T |
A |
15: 55,421,064 (GRCm39) |
S17T |
probably benign |
Het |
| Neu3 |
T |
C |
7: 99,472,627 (GRCm39) |
T37A |
possibly damaging |
Het |
| Nr1i3 |
T |
C |
1: 171,044,792 (GRCm39) |
|
probably null |
Het |
| Or10al2 |
A |
T |
17: 37,983,747 (GRCm39) |
K278* |
probably null |
Het |
| Or10g6 |
A |
T |
9: 39,934,270 (GRCm39) |
I194F |
possibly damaging |
Het |
| Or6ae1 |
T |
C |
7: 139,742,734 (GRCm39) |
N43S |
probably damaging |
Het |
| Or9s18 |
T |
A |
13: 65,300,806 (GRCm39) |
M256K |
possibly damaging |
Het |
| Osr2 |
A |
G |
15: 35,300,608 (GRCm39) |
T55A |
possibly damaging |
Het |
| Palld |
A |
G |
8: 61,969,655 (GRCm39) |
V981A |
probably damaging |
Het |
| Pbx1 |
A |
T |
1: 168,030,979 (GRCm39) |
M213K |
possibly damaging |
Het |
| Pcdhb12 |
C |
A |
18: 37,570,136 (GRCm39) |
H427Q |
probably benign |
Het |
| Perm1 |
C |
T |
4: 156,302,340 (GRCm39) |
R295C |
probably benign |
Het |
| Phaf1 |
G |
T |
8: 105,973,133 (GRCm39) |
V248F |
probably damaging |
Het |
| Polm |
T |
C |
11: 5,785,574 (GRCm39) |
T162A |
possibly damaging |
Het |
| Prox1 |
A |
G |
1: 189,892,715 (GRCm39) |
|
probably benign |
Het |
| Ptpn7 |
A |
T |
1: 135,062,641 (GRCm39) |
T127S |
probably benign |
Het |
| Pxk |
C |
T |
14: 8,151,507 (GRCm38) |
R441* |
probably null |
Het |
| Rab21 |
T |
C |
10: 115,126,805 (GRCm39) |
T181A |
probably benign |
Het |
| Rab38 |
A |
T |
7: 88,139,924 (GRCm39) |
T198S |
probably benign |
Het |
| Rnase4 |
C |
G |
14: 51,342,395 (GRCm39) |
Q40E |
possibly damaging |
Het |
| Rnf213 |
T |
A |
11: 119,307,274 (GRCm39) |
W645R |
probably damaging |
Het |
| Rnf8 |
A |
G |
17: 29,840,524 (GRCm39) |
I51M |
probably damaging |
Het |
| Sbpl |
T |
A |
17: 24,172,241 (GRCm39) |
D226V |
unknown |
Het |
| Sdf4 |
T |
G |
4: 156,085,205 (GRCm39) |
I180S |
probably benign |
Het |
| Simc1 |
A |
G |
13: 54,687,528 (GRCm39) |
K99R |
probably damaging |
Het |
| Slc2a4 |
T |
C |
11: 69,837,398 (GRCm39) |
Q49R |
probably damaging |
Het |
| Slco1a4 |
T |
C |
6: 141,780,342 (GRCm39) |
|
probably null |
Het |
| Slco5a1 |
C |
A |
1: 12,964,696 (GRCm39) |
C527F |
probably damaging |
Het |
| Sox6 |
T |
A |
7: 115,143,803 (GRCm39) |
N405I |
probably benign |
Het |
| Sphkap |
G |
A |
1: 83,256,687 (GRCm39) |
P354L |
probably benign |
Het |
| Spi1 |
A |
G |
2: 90,944,702 (GRCm39) |
D149G |
probably benign |
Het |
| Sptan1 |
T |
A |
2: 29,910,472 (GRCm39) |
D1812E |
probably damaging |
Het |
| Sub1 |
A |
T |
15: 11,991,130 (GRCm39) |
V37E |
possibly damaging |
Het |
| Sult2a6 |
T |
C |
7: 13,959,814 (GRCm39) |
T240A |
probably benign |
Het |
| Tacc2 |
A |
G |
7: 130,227,055 (GRCm39) |
S1247G |
probably benign |
Het |
| Taf4 |
T |
C |
2: 179,574,823 (GRCm39) |
D594G |
probably damaging |
Het |
| Tap1 |
T |
G |
17: 34,413,915 (GRCm39) |
D643E |
probably damaging |
Het |
| Ticam1 |
T |
C |
17: 56,578,894 (GRCm39) |
N67S |
probably benign |
Het |
| Tlr6 |
A |
G |
5: 65,110,556 (GRCm39) |
F784L |
probably damaging |
Het |
| Tmprss15 |
A |
G |
16: 78,868,306 (GRCm39) |
V202A |
probably benign |
Het |
| Trp53bp2 |
T |
C |
1: 182,259,193 (GRCm39) |
V82A |
probably benign |
Het |
| Ube2o |
C |
T |
11: 116,439,661 (GRCm39) |
V170I |
possibly damaging |
Het |
| Ube2q2l |
A |
G |
6: 136,378,825 (GRCm39) |
S2P |
possibly damaging |
Het |
| Vmn1r177 |
G |
A |
7: 23,565,573 (GRCm39) |
T101I |
probably benign |
Het |
| Vmn2r68 |
A |
T |
7: 84,883,867 (GRCm39) |
Y79* |
probably null |
Het |
| Wdr35 |
A |
C |
12: 9,035,994 (GRCm39) |
Y255S |
probably benign |
Het |
| Zfp507 |
A |
T |
7: 35,502,052 (GRCm39) |
|
probably benign |
Het |
| Zfp688 |
G |
A |
7: 127,018,409 (GRCm39) |
R239C |
probably damaging |
Het |
| Zfp74 |
T |
A |
7: 29,635,470 (GRCm39) |
|
probably null |
Het |
| Zfp932 |
A |
G |
5: 110,157,069 (GRCm39) |
N223D |
possibly damaging |
Het |
|
| Other mutations in Map4k4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00328:Map4k4
|
APN |
1 |
40,043,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00417:Map4k4
|
APN |
1 |
40,053,692 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00516:Map4k4
|
APN |
1 |
40,053,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01545:Map4k4
|
APN |
1 |
40,053,389 (GRCm39) |
splice site |
probably benign |
|
|
IGL02092:Map4k4
|
APN |
1 |
40,063,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02092:Map4k4
|
APN |
1 |
40,025,943 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02570:Map4k4
|
APN |
1 |
40,019,739 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02626:Map4k4
|
APN |
1 |
40,053,257 (GRCm39) |
splice site |
probably benign |
|
|
IGL02993:Map4k4
|
APN |
1 |
40,053,348 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03178:Map4k4
|
APN |
1 |
40,025,853 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
tank
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02835:Map4k4
|
UTSW |
1 |
40,049,760 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0496:Map4k4
|
UTSW |
1 |
40,045,982 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0498:Map4k4
|
UTSW |
1 |
40,029,338 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0588:Map4k4
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Map4k4
|
UTSW |
1 |
40,042,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Map4k4
|
UTSW |
1 |
40,043,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Map4k4
|
UTSW |
1 |
40,060,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1615:Map4k4
|
UTSW |
1 |
40,045,990 (GRCm39) |
splice site |
probably benign |
|
|
R1763:Map4k4
|
UTSW |
1 |
40,039,917 (GRCm39) |
splice site |
probably benign |
|
|
R1800:Map4k4
|
UTSW |
1 |
40,062,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2411:Map4k4
|
UTSW |
1 |
40,046,656 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2851:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
|
R2852:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
|
R2987:Map4k4
|
UTSW |
1 |
40,025,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3087:Map4k4
|
UTSW |
1 |
40,060,242 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3688:Map4k4
|
UTSW |
1 |
40,024,331 (GRCm39) |
splice site |
probably null |
|
|
R4075:Map4k4
|
UTSW |
1 |
40,062,622 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4304:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4564:Map4k4
|
UTSW |
1 |
40,028,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4569:Map4k4
|
UTSW |
1 |
40,039,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4613:Map4k4
|
UTSW |
1 |
40,056,351 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4715:Map4k4
|
UTSW |
1 |
40,058,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Map4k4
|
UTSW |
1 |
40,043,076 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4926:Map4k4
|
UTSW |
1 |
40,056,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4943:Map4k4
|
UTSW |
1 |
40,058,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5033:Map4k4
|
UTSW |
1 |
40,046,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5177:Map4k4
|
UTSW |
1 |
40,025,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5297:Map4k4
|
UTSW |
1 |
40,001,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5844:Map4k4
|
UTSW |
1 |
40,039,036 (GRCm39) |
splice site |
probably benign |
|
|
R5952:Map4k4
|
UTSW |
1 |
40,039,082 (GRCm39) |
unclassified |
probably benign |
|
|
R6111:Map4k4
|
UTSW |
1 |
40,050,822 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6125:Map4k4
|
UTSW |
1 |
40,043,125 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6838:Map4k4
|
UTSW |
1 |
40,015,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6927:Map4k4
|
UTSW |
1 |
40,050,842 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7008:Map4k4
|
UTSW |
1 |
40,028,131 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7164:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7195:Map4k4
|
UTSW |
1 |
40,058,829 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7352:Map4k4
|
UTSW |
1 |
40,001,387 (GRCm39) |
missense |
unknown |
|
|
R7589:Map4k4
|
UTSW |
1 |
40,060,251 (GRCm39) |
nonsense |
probably null |
|
|
R7816:Map4k4
|
UTSW |
1 |
40,053,368 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7869:Map4k4
|
UTSW |
1 |
40,013,204 (GRCm39) |
missense |
unknown |
|
|
R8013:Map4k4
|
UTSW |
1 |
40,001,372 (GRCm39) |
missense |
unknown |
|
|
R8145:Map4k4
|
UTSW |
1 |
40,039,694 (GRCm39) |
missense |
|
|
|
R8154:Map4k4
|
UTSW |
1 |
40,060,302 (GRCm39) |
nonsense |
probably null |
|
|
R8254:Map4k4
|
UTSW |
1 |
40,045,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8266:Map4k4
|
UTSW |
1 |
40,050,813 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8375:Map4k4
|
UTSW |
1 |
40,063,801 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8487:Map4k4
|
UTSW |
1 |
40,028,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8699:Map4k4
|
UTSW |
1 |
40,015,910 (GRCm39) |
missense |
unknown |
|
|
R8726:Map4k4
|
UTSW |
1 |
40,043,142 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8907:Map4k4
|
UTSW |
1 |
40,058,770 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8956:Map4k4
|
UTSW |
1 |
40,039,840 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8963:Map4k4
|
UTSW |
1 |
40,039,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9091:Map4k4
|
UTSW |
1 |
40,042,923 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9234:Map4k4
|
UTSW |
1 |
40,029,261 (GRCm39) |
missense |
unknown |
|
|
R9270:Map4k4
|
UTSW |
1 |
40,042,923 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9438:Map4k4
|
UTSW |
1 |
40,045,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9689:Map4k4
|
UTSW |
1 |
40,058,722 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9771:Map4k4
|
UTSW |
1 |
40,025,877 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCTACTAACATGGAGCCGTGTC -3'
(R):5'- AGGGACTTCACATCTGAGTTAAGG -3'
Sequencing Primer
(F):5'- AACATGGAGCCGTGTCTTCTAATTC -3'
(R):5'- TGACTGGAGATAGCCATAATGAGTTC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation