Incidental Mutation 'R0498:Map4k4'
| ID |
40572 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Map4k4
|
| Ensembl Gene |
ENSMUSG00000026074 |
| Gene Name |
mitogen-activated protein kinase kinase kinase kinase 4 |
| Synonyms |
9430080K19Rik, Nik |
| MMRRC Submission |
038694-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0498 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
39940073-40065470 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 40029338 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glutamine
at position 371
(R371Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141332
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163854]
[ENSMUST00000168431]
[ENSMUST00000191761]
[ENSMUST00000192509]
[ENSMUST00000193682]
[ENSMUST00000195259]
[ENSMUST00000195636]
[ENSMUST00000195860]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
unknown
Transcript: ENSMUST00000163854
AA Change: R371Q
|
| SMART Domains |
Protein: ENSMUSP00000126961
Gene: ENSMUSG00000026074
AA Change: R371Q
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000168431
AA Change: R371Q
|
| SMART Domains |
Protein: ENSMUSP00000129796
Gene: ENSMUSG00000026074
AA Change: R371Q
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191761
AA Change: R371Q
PolyPhen 2
Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000141332
Gene: ENSMUSG00000026074
AA Change: R371Q
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
3.4e-97 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
404 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000192509
AA Change: R371Q
|
| SMART Domains |
Protein: ENSMUSP00000141665
Gene: ENSMUSG00000026074
AA Change: R371Q
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000193682
AA Change: R371Q
|
| SMART Domains |
Protein: ENSMUSP00000141862
Gene: ENSMUSG00000026074
AA Change: R371Q
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
556 |
567 |
N/A |
INTRINSIC |
|
low complexity region
|
590 |
616 |
N/A |
INTRINSIC |
|
low complexity region
|
623 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
680 |
706 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
814 |
N/A |
INTRINSIC |
|
low complexity region
|
824 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
862 |
N/A |
INTRINSIC |
|
CNH
|
903 |
1201 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000195259
AA Change: R371Q
|
| SMART Domains |
Protein: ENSMUSP00000142056
Gene: ENSMUSG00000026074
AA Change: R371Q
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
824 |
N/A |
INTRINSIC |
|
low complexity region
|
839 |
849 |
N/A |
INTRINSIC |
|
CNH
|
890 |
1188 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000195636
AA Change: R371Q
|
| SMART Domains |
Protein: ENSMUSP00000141613
Gene: ENSMUSG00000026074
AA Change: R371Q
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
3.4e-97 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
836 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
875 |
888 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
913 |
N/A |
INTRINSIC |
|
CNH
|
954 |
1252 |
1.4e-129 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000195860
AA Change: R371Q
|
| SMART Domains |
Protein: ENSMUSP00000141400
Gene: ENSMUSG00000026074
AA Change: R371Q
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Meta Mutation Damage Score |
0.1657 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 96.9%
- 20x: 94.4%
|
| Validation Efficiency |
100% (68/68) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos around day E9.5-10.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
A |
T |
7: 40,642,718 (GRCm39) |
D220V |
probably benign |
Het |
| Adgrf2 |
A |
G |
17: 43,025,206 (GRCm39) |
|
probably benign |
Het |
| Aldh18a1 |
A |
G |
19: 40,562,716 (GRCm39) |
V219A |
probably benign |
Het |
| Anapc10 |
A |
G |
8: 80,501,610 (GRCm39) |
D126G |
probably benign |
Het |
| Ap1m2 |
T |
C |
9: 21,207,129 (GRCm39) |
*426W |
probably null |
Het |
| Arhgap21 |
A |
G |
2: 20,867,928 (GRCm39) |
I865T |
probably damaging |
Het |
| Armc8 |
A |
G |
9: 99,379,345 (GRCm39) |
V527A |
probably damaging |
Het |
| Asic5 |
A |
T |
3: 81,913,778 (GRCm39) |
|
probably benign |
Het |
| Baz2b |
A |
C |
2: 59,732,340 (GRCm39) |
|
probably benign |
Het |
| Bpifa5 |
T |
C |
2: 154,009,169 (GRCm39) |
V237A |
probably damaging |
Het |
| Brip1 |
T |
A |
11: 86,088,745 (GRCm39) |
K52I |
possibly damaging |
Het |
| Cacna1g |
T |
C |
11: 94,350,685 (GRCm39) |
I387V |
probably damaging |
Het |
| Cbr4 |
A |
G |
8: 61,948,107 (GRCm39) |
I135V |
probably benign |
Het |
| Ccdc66 |
C |
T |
14: 27,222,197 (GRCm39) |
|
probably null |
Het |
| Cubn |
G |
A |
2: 13,449,078 (GRCm39) |
T999M |
probably damaging |
Het |
| Dnai3 |
G |
T |
3: 145,787,119 (GRCm39) |
D305E |
possibly damaging |
Het |
| Dpp8 |
C |
T |
9: 64,953,077 (GRCm39) |
|
probably benign |
Het |
| Dsg1b |
T |
C |
18: 20,542,390 (GRCm39) |
S966P |
possibly damaging |
Het |
| Erp27 |
T |
C |
6: 136,896,862 (GRCm39) |
|
probably benign |
Het |
| Fat4 |
A |
T |
3: 39,034,786 (GRCm39) |
I2813L |
probably benign |
Het |
| Fhod1 |
G |
A |
8: 106,056,488 (GRCm39) |
R1101C |
probably damaging |
Het |
| Hoxc9 |
T |
C |
15: 102,892,359 (GRCm39) |
S191P |
probably damaging |
Het |
| Izumo4 |
T |
C |
10: 80,540,030 (GRCm39) |
|
probably null |
Het |
| Kalrn |
C |
T |
16: 33,875,261 (GRCm39) |
D104N |
possibly damaging |
Het |
| Kank4 |
A |
T |
4: 98,667,873 (GRCm39) |
D191E |
probably benign |
Het |
| Kbtbd11 |
A |
G |
8: 15,077,605 (GRCm39) |
E68G |
probably benign |
Het |
| Kdr |
C |
T |
5: 76,119,798 (GRCm39) |
V654I |
probably benign |
Het |
| Klra1 |
A |
T |
6: 130,349,782 (GRCm39) |
|
probably null |
Het |
| Kmt2e |
T |
A |
5: 23,683,970 (GRCm39) |
Y373* |
probably null |
Het |
| Lepr |
A |
T |
4: 101,602,889 (GRCm39) |
M226L |
probably benign |
Het |
| Lrp1b |
T |
A |
2: 41,348,417 (GRCm39) |
I800F |
probably benign |
Het |
| Lta4h |
T |
C |
10: 93,307,833 (GRCm39) |
|
probably benign |
Het |
| Map3k7 |
T |
C |
4: 31,974,814 (GRCm39) |
|
probably benign |
Het |
| Mgat4f |
A |
G |
1: 134,318,610 (GRCm39) |
I461V |
possibly damaging |
Het |
| Mme |
A |
G |
3: 63,253,487 (GRCm39) |
I444V |
probably damaging |
Het |
| Mms19 |
C |
T |
19: 41,938,212 (GRCm39) |
R582Q |
possibly damaging |
Het |
| Mtss1 |
A |
G |
15: 58,817,286 (GRCm39) |
S502P |
probably damaging |
Het |
| Myo3a |
G |
T |
2: 22,467,441 (GRCm39) |
A232S |
possibly damaging |
Het |
| Nwd2 |
G |
T |
5: 63,963,686 (GRCm39) |
W1090L |
probably damaging |
Het |
| Or4k15 |
A |
C |
14: 50,364,750 (GRCm39) |
T239P |
probably damaging |
Het |
| Or8b12 |
G |
A |
9: 37,657,550 (GRCm39) |
G40E |
probably damaging |
Het |
| Pcm1 |
G |
A |
8: 41,746,806 (GRCm39) |
S1335N |
probably benign |
Het |
| Pdzph1 |
A |
G |
17: 59,280,825 (GRCm39) |
F486L |
probably benign |
Het |
| Piezo2 |
T |
C |
18: 63,235,245 (GRCm39) |
K552R |
possibly damaging |
Het |
| Plekhs1 |
T |
A |
19: 56,469,536 (GRCm39) |
|
probably null |
Het |
| Pprc1 |
C |
T |
19: 46,060,007 (GRCm39) |
Q1514* |
probably null |
Het |
| Ralgapa1 |
T |
C |
12: 55,736,576 (GRCm39) |
T1831A |
possibly damaging |
Het |
| Rnpep |
G |
T |
1: 135,193,090 (GRCm39) |
D455E |
probably damaging |
Het |
| Rpgrip1 |
T |
A |
14: 52,368,771 (GRCm39) |
|
probably benign |
Het |
| Saxo1 |
A |
T |
4: 86,397,133 (GRCm39) |
M135K |
possibly damaging |
Het |
| Serpina12 |
T |
C |
12: 104,002,048 (GRCm39) |
T223A |
probably damaging |
Het |
| Serpinb3a |
A |
G |
1: 106,974,880 (GRCm39) |
F218L |
probably damaging |
Het |
| Serpinb9f |
T |
G |
13: 33,509,990 (GRCm39) |
|
probably benign |
Het |
| Spata33 |
A |
G |
8: 123,948,662 (GRCm39) |
D98G |
probably benign |
Het |
| Stard13 |
T |
A |
5: 150,975,942 (GRCm39) |
Y742F |
probably damaging |
Het |
| Tecta |
A |
G |
9: 42,288,910 (GRCm39) |
Y552H |
probably damaging |
Het |
| Tie1 |
A |
T |
4: 118,336,358 (GRCm39) |
|
probably benign |
Het |
| Tmem161a |
A |
G |
8: 70,633,623 (GRCm39) |
T254A |
probably benign |
Het |
| Tmem30a |
G |
T |
9: 79,681,376 (GRCm39) |
Y264* |
probably null |
Het |
| Tmem87a |
A |
T |
2: 120,224,946 (GRCm39) |
I105K |
probably benign |
Het |
| Tnrc6b |
A |
T |
15: 80,742,920 (GRCm39) |
D51V |
probably damaging |
Het |
| Trgc3 |
T |
A |
13: 19,445,262 (GRCm39) |
M70K |
probably damaging |
Het |
| Trpc4 |
T |
C |
3: 54,198,632 (GRCm39) |
F519L |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,539,925 (GRCm39) |
T26027A |
probably damaging |
Het |
| Vmn1r198 |
A |
C |
13: 22,539,144 (GRCm39) |
H121P |
probably damaging |
Het |
| Vps33a |
A |
G |
5: 123,709,024 (GRCm39) |
F64L |
probably benign |
Het |
| Zfp1008 |
T |
C |
13: 62,755,201 (GRCm39) |
N39S |
probably damaging |
Het |
| Zfp994 |
A |
T |
17: 22,419,882 (GRCm39) |
C356S |
probably damaging |
Het |
|
| Other mutations in Map4k4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00328:Map4k4
|
APN |
1 |
40,043,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00417:Map4k4
|
APN |
1 |
40,053,692 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00516:Map4k4
|
APN |
1 |
40,053,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01545:Map4k4
|
APN |
1 |
40,053,389 (GRCm39) |
splice site |
probably benign |
|
|
IGL02092:Map4k4
|
APN |
1 |
40,063,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02092:Map4k4
|
APN |
1 |
40,025,943 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02570:Map4k4
|
APN |
1 |
40,019,739 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02626:Map4k4
|
APN |
1 |
40,053,257 (GRCm39) |
splice site |
probably benign |
|
|
IGL02993:Map4k4
|
APN |
1 |
40,053,348 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03178:Map4k4
|
APN |
1 |
40,025,853 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
tank
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02835:Map4k4
|
UTSW |
1 |
40,049,760 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0496:Map4k4
|
UTSW |
1 |
40,045,982 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0588:Map4k4
|
UTSW |
1 |
40,044,024 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Map4k4
|
UTSW |
1 |
40,042,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Map4k4
|
UTSW |
1 |
40,043,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Map4k4
|
UTSW |
1 |
40,060,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1615:Map4k4
|
UTSW |
1 |
40,045,990 (GRCm39) |
splice site |
probably benign |
|
|
R1763:Map4k4
|
UTSW |
1 |
40,039,917 (GRCm39) |
splice site |
probably benign |
|
|
R1800:Map4k4
|
UTSW |
1 |
40,062,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1893:Map4k4
|
UTSW |
1 |
40,040,717 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2411:Map4k4
|
UTSW |
1 |
40,046,656 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2851:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
|
R2852:Map4k4
|
UTSW |
1 |
40,039,915 (GRCm39) |
splice site |
probably benign |
|
|
R2987:Map4k4
|
UTSW |
1 |
40,025,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3087:Map4k4
|
UTSW |
1 |
40,060,242 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3688:Map4k4
|
UTSW |
1 |
40,024,331 (GRCm39) |
splice site |
probably null |
|
|
R4075:Map4k4
|
UTSW |
1 |
40,062,622 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4304:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4564:Map4k4
|
UTSW |
1 |
40,028,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4569:Map4k4
|
UTSW |
1 |
40,039,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4613:Map4k4
|
UTSW |
1 |
40,056,351 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4715:Map4k4
|
UTSW |
1 |
40,058,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Map4k4
|
UTSW |
1 |
40,043,076 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4926:Map4k4
|
UTSW |
1 |
40,056,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4943:Map4k4
|
UTSW |
1 |
40,058,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5033:Map4k4
|
UTSW |
1 |
40,046,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5177:Map4k4
|
UTSW |
1 |
40,025,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5297:Map4k4
|
UTSW |
1 |
40,001,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5844:Map4k4
|
UTSW |
1 |
40,039,036 (GRCm39) |
splice site |
probably benign |
|
|
R5952:Map4k4
|
UTSW |
1 |
40,039,082 (GRCm39) |
unclassified |
probably benign |
|
|
R6111:Map4k4
|
UTSW |
1 |
40,050,822 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6125:Map4k4
|
UTSW |
1 |
40,043,125 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6838:Map4k4
|
UTSW |
1 |
40,015,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6927:Map4k4
|
UTSW |
1 |
40,050,842 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7008:Map4k4
|
UTSW |
1 |
40,028,131 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7164:Map4k4
|
UTSW |
1 |
40,013,132 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7195:Map4k4
|
UTSW |
1 |
40,058,829 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7352:Map4k4
|
UTSW |
1 |
40,001,387 (GRCm39) |
missense |
unknown |
|
|
R7589:Map4k4
|
UTSW |
1 |
40,060,251 (GRCm39) |
nonsense |
probably null |
|
|
R7816:Map4k4
|
UTSW |
1 |
40,053,368 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7869:Map4k4
|
UTSW |
1 |
40,013,204 (GRCm39) |
missense |
unknown |
|
|
R8013:Map4k4
|
UTSW |
1 |
40,001,372 (GRCm39) |
missense |
unknown |
|
|
R8145:Map4k4
|
UTSW |
1 |
40,039,694 (GRCm39) |
missense |
|
|
|
R8154:Map4k4
|
UTSW |
1 |
40,060,302 (GRCm39) |
nonsense |
probably null |
|
|
R8254:Map4k4
|
UTSW |
1 |
40,045,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8266:Map4k4
|
UTSW |
1 |
40,050,813 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8375:Map4k4
|
UTSW |
1 |
40,063,801 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8487:Map4k4
|
UTSW |
1 |
40,028,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8699:Map4k4
|
UTSW |
1 |
40,015,910 (GRCm39) |
missense |
unknown |
|
|
R8726:Map4k4
|
UTSW |
1 |
40,043,142 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8907:Map4k4
|
UTSW |
1 |
40,058,770 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8956:Map4k4
|
UTSW |
1 |
40,039,840 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8963:Map4k4
|
UTSW |
1 |
40,039,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9091:Map4k4
|
UTSW |
1 |
40,042,923 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9234:Map4k4
|
UTSW |
1 |
40,029,261 (GRCm39) |
missense |
unknown |
|
|
R9270:Map4k4
|
UTSW |
1 |
40,042,923 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9438:Map4k4
|
UTSW |
1 |
40,045,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9689:Map4k4
|
UTSW |
1 |
40,058,722 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9771:Map4k4
|
UTSW |
1 |
40,025,877 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGTCAGTAGCCCCATGAAGGGAAC -3'
(R):5'- CCAGGAACGTGAAGCCATCTAGTG -3'
Sequencing Primer
(F):5'- AACTGGGTGTTCCCATTGG -3'
(R):5'- AGCAGGGTGTCTGATGTGAAC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation