Incidental Mutation 'R2336:Or10al4'
ID 246572
Institutional Source Beutler Lab
Gene Symbol Or10al4
Ensembl Gene ENSMUSG00000063994
Gene Name olfactory receptor family 10 subfamily AL member 4
Synonyms Olfr120, MOR263-3, GA_x6K02T2PSCP-2184981-2185946
MMRRC Submission 040323-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R2336 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 38036890-38037882 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38037689 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 258 (Y258F)
Ref Sequence ENSEMBL: ENSMUSP00000146861 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077498] [ENSMUST00000207771]
AlphaFold Q8VFQ2
Predicted Effect probably benign
Transcript: ENSMUST00000077498
AA Change: Y267F

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000094931
Gene: ENSMUSG00000063994
AA Change: Y267F

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 50 320 1e-5 PFAM
Pfam:7tm_1 56 305 6e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207771
AA Change: Y258F

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)
Meta Mutation Damage Score 0.2504 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 100% (38/38)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430110L20Rik T A 1: 181,055,206 (GRCm39) noncoding transcript Het
Arhgap21 G A 2: 20,884,862 (GRCm39) R772C probably damaging Het
Arid2 A G 15: 96,260,430 (GRCm39) E393G probably damaging Het
Atrn C T 2: 130,799,874 (GRCm39) T417I probably damaging Het
Baiap3 T C 17: 25,469,378 (GRCm39) K173R probably damaging Het
Bdp1 A T 13: 100,189,510 (GRCm39) N1497K probably damaging Het
Ceacam5 T C 7: 17,481,300 (GRCm39) V349A probably benign Het
Chrnd T C 1: 87,122,615 (GRCm39) F132S probably damaging Het
Ddx42 A G 11: 106,121,976 (GRCm39) M164V possibly damaging Het
Dtwd2 A G 18: 49,833,320 (GRCm39) probably benign Het
Eprs1 T A 1: 185,143,571 (GRCm39) probably benign Het
Fut8 A G 12: 77,459,730 (GRCm39) probably benign Het
Gabrr3 C T 16: 59,250,313 (GRCm39) T104M probably damaging Het
Gcat G A 15: 78,915,180 (GRCm39) R16H probably benign Het
Gnb2 A T 5: 137,527,460 (GRCm39) W125R probably damaging Het
Grik4 C T 9: 42,477,651 (GRCm39) D512N probably damaging Het
Hnf4g T C 3: 3,706,284 (GRCm39) F60L probably benign Het
Lrp6 A G 6: 134,484,546 (GRCm39) I359T probably damaging Het
Lrrfip2 A G 9: 111,051,283 (GRCm39) D325G probably damaging Het
Mttp A T 3: 137,821,856 (GRCm39) I222K possibly damaging Het
Myom1 A T 17: 71,330,189 (GRCm39) H107L possibly damaging Het
Obi1 G A 14: 104,716,318 (GRCm39) P685L probably damaging Het
Or2r11 A G 6: 42,437,663 (GRCm39) C97R probably damaging Het
Ppfia3 T C 7: 45,006,121 (GRCm39) probably null Het
Prokr2 A T 2: 132,223,359 (GRCm39) M61K probably damaging Het
Ptk2 A G 15: 73,137,965 (GRCm39) C502R probably damaging Het
Rbm25 T A 12: 83,698,192 (GRCm39) W172R probably damaging Het
Rdh16f1 A G 10: 127,624,624 (GRCm39) K154R probably benign Het
Rnf213 G A 11: 119,305,430 (GRCm39) E554K probably benign Het
St3gal6 A T 16: 58,314,067 (GRCm39) I22K probably damaging Het
Tut7 G T 13: 59,946,868 (GRCm39) P585Q probably damaging Het
Usp43 G A 11: 67,782,258 (GRCm39) R387* probably null Het
Vmn2r106 T C 17: 20,488,470 (GRCm39) N643S probably benign Het
Zdbf2 G T 1: 63,342,623 (GRCm39) R334L probably benign Het
Zfp868 G T 8: 70,066,558 (GRCm39) probably null Het
Other mutations in Or10al4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01402:Or10al4 APN 17 38,037,193 (GRCm39) missense probably benign 0.08
IGL01925:Or10al4 APN 17 38,037,002 (GRCm39) missense probably benign 0.18
IGL02901:Or10al4 APN 17 38,037,311 (GRCm39) missense probably damaging 1.00
PIT4687001:Or10al4 UTSW 17 38,037,082 (GRCm39) missense probably benign 0.01
R1645:Or10al4 UTSW 17 38,037,229 (GRCm39) missense probably benign 0.01
R2218:Or10al4 UTSW 17 38,037,145 (GRCm39) missense probably damaging 0.97
R4613:Or10al4 UTSW 17 38,037,587 (GRCm39) missense probably damaging 1.00
R5237:Or10al4 UTSW 17 38,037,268 (GRCm39) missense probably damaging 1.00
R5880:Or10al4 UTSW 17 38,037,545 (GRCm39) missense probably benign 0.09
R6187:Or10al4 UTSW 17 38,037,032 (GRCm39) missense probably damaging 0.99
R9083:Or10al4 UTSW 17 38,037,060 (GRCm39) missense probably damaging 1.00
R9479:Or10al4 UTSW 17 38,036,986 (GRCm39) missense probably damaging 0.99
R9647:Or10al4 UTSW 17 38,037,796 (GRCm39) missense probably damaging 1.00
Z1088:Or10al4 UTSW 17 38,036,983 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATGAGGCTGCAATCTTCGTG -3'
(R):5'- GTAAATTCTCATTAGCCAGCAGC -3'

Sequencing Primer
(F):5'- AGGCTGCAATCTTCGTGACAGTAG -3'
(R):5'- ATTGCCAGAGGTTTCTTCAGACTCAG -3'
Posted On 2014-10-30