Mutagenetix > Incidental Mutation

Incidental Mutation 'R0323:Lrp2'

25642

Institutional Source

Beutler Lab

Gene Symbol

Lrp2

Ensembl Gene

ENSMUSG00000027070

Gene Name

low density lipoprotein receptor-related protein 2

Synonyms

D230004K18Rik, b2b1625.2Clo, Megalin, Gp330

MMRRC Submission

038533-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0323 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

69254679-69416373 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 69299983 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 3023 (Y3023C)

Ref Sequence

ENSEMBL: ENSMUSP00000079752 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080953]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000080953
AA Change: Y3023C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000079752
Gene: ENSMUSG00000027070
AA Change: Y3023C

Domain	Start	End	E-Value	Type
low complexity region	5	21	N/A	INTRINSIC
LDLa	27	64	5.63e-13	SMART
LDLa	66	105	2.25e-12	SMART
EGF	107	143	2.59e1	SMART
LDLa	107	144	9.29e-14	SMART
LDLa	146	181	6.18e-10	SMART
LDLa	182	219	1.08e-14	SMART
LDLa	221	258	1.05e-12	SMART
LDLa	264	302	1.66e-10	SMART
EGF	310	346	3.23e0	SMART
EGF	350	385	2.32e-1	SMART
LY	414	457	3.88e-3	SMART
LY	458	500	1.17e-6	SMART
LY	501	547	5.96e-13	SMART
LY	548	590	1.94e-12	SMART
LY	591	634	2.66e0	SMART
EGF	661	704	7.76e-3	SMART
LY	732	774	1.76e0	SMART
LY	775	817	3.64e-8	SMART
LY	818	860	1.11e-3	SMART
LY	861	903	2.11e-13	SMART
LY	905	946	9.33e-1	SMART
EGF	972	1013	1.73e0	SMART
LDLa	1024	1061	1.05e-12	SMART
LDLa	1065	1103	4.65e-14	SMART
LDLa	1109	1146	3.63e-16	SMART
LDLa	1149	1186	5.5e-16	SMART
LDLa	1187	1225	1.43e-14	SMART
LDLa	1230	1269	2.1e-12	SMART
LDLa	1271	1308	3.63e-16	SMART
LDLa	1312	1351	4.69e-10	SMART
EGF	1353	1390	9.7e-4	SMART
EGF_CA	1391	1430	6.54e-10	SMART
LY	1457	1501	1.43e-1	SMART
LY	1502	1544	2e-14	SMART
LY	1545	1590	3.03e-14	SMART
LY	1591	1633	5.48e-12	SMART
LY	1635	1677	1.18e-2	SMART
EGF	1704	1742	5.2e-4	SMART
LY	1771	1812	1.68e1	SMART
LY	1813	1856	1.91e-2	SMART
LY	1859	1911	1.88e-10	SMART
LY	1912	1954	7.69e-7	SMART
LY	1955	1994	3e1	SMART
EGF	2022	2060	1.18e-2	SMART
LY	2088	2135	1.14e1	SMART
LY	2136	2182	2.11e-4	SMART
LY	2183	2226	2.22e-12	SMART
LY	2227	2269	1.24e-10	SMART
EGF	2346	2384	2.07e1	SMART
LY	2459	2501	9.91e-10	SMART
LY	2503	2543	1.48e-8	SMART
LY	2544	2586	6.85e-13	SMART
LY	2587	2627	8.13e-1	SMART
EGF_like	2655	2694	3.5e1	SMART
LDLa	2700	2739	2.86e-14	SMART
LDLa	2741	2778	8.09e-14	SMART
LDLa	2780	2820	3.19e-12	SMART
LDLa	2822	2862	6.94e-13	SMART
LDLa	2864	2903	9.29e-14	SMART
LDLa	2907	2947	4.79e-16	SMART
LDLa	2949	2992	8.41e-12	SMART
LDLa	2994	3031	1.08e-14	SMART
LDLa	3033	3072	1.83e-12	SMART
LDLa	3076	3113	1.16e-14	SMART
EGF	3115	3153	8.57e-5	SMART
EGF_CA	3154	3194	3.56e-11	SMART
LY	3221	3263	9.77e-9	SMART
LY	3264	3306	1.22e-9	SMART
LY	3312	3358	5.44e-7	SMART
LY	3359	3401	1.83e-13	SMART
LY	3402	3443	1.41e-5	SMART
EGF	3470	3511	8.91e-3	SMART
LDLa	3513	3552	1.79e-15	SMART
LDLa	3554	3593	9.89e-9	SMART
LDLa	3595	3634	3.07e-14	SMART
LDLa	3636	3675	3.34e-15	SMART
LDLa	3679	3718	1.39e-12	SMART
LDLa	3720	3758	3.83e-15	SMART
LDLa	3760	3797	7.15e-15	SMART
LDLa	3799	3836	2.86e-14	SMART
LDLa	3843	3882	2.38e-11	SMART
LDLa	3884	3924	3.66e-12	SMART
LDLa	3929	3966	1.93e-11	SMART
EGF	3971	4008	6.3e-3	SMART
EGF_CA	4009	4050	1.36e-7	SMART
low complexity region	4072	4084	N/A	INTRINSIC
LY	4136	4178	6.2e-11	SMART
LY	4179	4222	4.32e-10	SMART
LY	4223	4266	3.78e-15	SMART
LY	4267	4306	4.53e1	SMART
EGF	4335	4367	3.46e0	SMART
EGF	4368	4413	1.53e-1	SMART
transmembrane domain	4425	4447	N/A	INTRINSIC
low complexity region	4454	4472	N/A	INTRINSIC
low complexity region	4616	4636	N/A	INTRINSIC

Coding Region Coverage

1x: 98.7%
3x: 97.5%
10x: 94.2%
20x: 86.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit lung and kidney epithelial defects, impaired B12 uptake, reduced proliferation of the neuroepithelium resulting in lack of olfactory bulbs, forebrain fusions, ventricular defects, and perinatal lethality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 92 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	A	T	13: 77,446,674 (GRCm39)	T816S	possibly damaging	Het
4930527J03Rik	ACCC	ACC	1: 178,276,503 (GRCm38)		noncoding transcript	Het
4931429P17Rik	A	C	13: 48,114,493 (GRCm39)		noncoding transcript	Het
Abca13	A	C	11: 9,244,701 (GRCm39)	D2188A	probably benign	Het
Accsl	T	A	2: 93,691,425 (GRCm39)	Q351L	probably benign	Het
Acot6	A	C	12: 84,155,953 (GRCm39)	E300D	probably benign	Het
Adgre1	T	A	17: 57,751,060 (GRCm39)	I578N	probably benign	Het
Agbl4	T	C	4: 111,474,419 (GRCm39)	S403P	probably damaging	Het
Agps	T	A	2: 75,724,505 (GRCm39)	Y506*	probably null	Het
Appl1	A	T	14: 26,664,695 (GRCm39)	V446D	possibly damaging	Het
Arcn1	A	T	9: 44,670,356 (GRCm39)	I90N	probably damaging	Het
Aspscr1	G	A	11: 120,569,246 (GRCm39)	V15I	probably damaging	Het
Asxl2	A	G	12: 3,492,487 (GRCm39)	Y24C	probably damaging	Het
Atp8b1	A	G	18: 64,701,323 (GRCm39)	F345S	possibly damaging	Het
Barx1	A	G	13: 48,819,430 (GRCm39)	T243A	probably benign	Het
Bltp1	T	A	3: 36,997,331 (GRCm39)	C1129*	probably null	Het
Bmp2k	A	G	5: 97,235,682 (GRCm39)		probably benign	Het
Cacul1	A	G	19: 60,531,498 (GRCm39)	I257T	probably benign	Het
Chml	A	T	1: 175,514,650 (GRCm39)	F424I	probably benign	Het
Clcn1	A	T	6: 42,287,074 (GRCm39)	E710D	probably damaging	Het
Col1a2	G	A	6: 4,518,822 (GRCm39)		probably benign	Het
Cylc2	T	A	4: 51,228,477 (GRCm39)	S183T	unknown	Het
Dhtkd1	T	A	2: 5,919,699 (GRCm39)	M561L	probably benign	Het
Dnajc13	A	G	9: 104,034,091 (GRCm39)	S2188P	probably damaging	Het
Dyrk1b	C	A	7: 27,884,781 (GRCm39)	Q399K	probably benign	Het
Erc1	T	C	6: 119,597,289 (GRCm39)	K1003E	probably damaging	Het
Ezr	G	A	17: 7,022,164 (GRCm39)	Q105*	probably null	Het
Fam83d	T	A	2: 158,627,467 (GRCm39)	D385E	probably benign	Het
Fbn2	A	G	18: 58,178,389 (GRCm39)	C1950R	probably damaging	Het
Fbxo32	A	T	15: 58,047,605 (GRCm39)	I236N	probably damaging	Het
Fcgr1	T	C	3: 96,193,145 (GRCm39)	E284G	possibly damaging	Het
Foxe3	T	C	4: 114,782,805 (GRCm39)	N136D	probably damaging	Het
Fscn2	A	T	11: 120,258,837 (GRCm39)	I461F	probably damaging	Het
Fsip2	T	C	2: 82,816,240 (GRCm39)	I3991T	probably benign	Het
Galnt15	A	T	14: 31,770,042 (GRCm39)	H249L	probably damaging	Het
Gm10803	T	A	2: 93,394,415 (GRCm39)	Y62*	probably null	Het
Gm20730	G	A	6: 43,058,449 (GRCm39)		probably null	Het
Gm4841	A	G	18: 60,403,718 (GRCm39)	L125S	possibly damaging	Het
Gmpr2	A	G	14: 55,910,203 (GRCm39)	D11G	probably damaging	Het
Gucy1b1	T	A	3: 81,945,463 (GRCm39)		probably null	Het
Hhla1	C	A	15: 65,820,352 (GRCm39)	V133F	probably benign	Het
Hscb	T	C	5: 110,982,556 (GRCm39)	E177G	possibly damaging	Het
Hyal4	A	T	6: 24,756,193 (GRCm39)	N137I	probably benign	Het
Lcp2	A	G	11: 34,004,322 (GRCm39)	D53G	probably damaging	Het
Ldb3	G	A	14: 34,266,002 (GRCm39)	T531I	probably damaging	Het
Llgl2	A	G	11: 115,741,546 (GRCm39)	K559E	probably damaging	Het
Loxhd1	A	G	18: 77,456,833 (GRCm39)	I499V	probably benign	Het
Lrrc59	A	C	11: 94,534,248 (GRCm39)	T269P	probably damaging	Het
Lrriq1	A	T	10: 103,057,150 (GRCm39)	C217S	possibly damaging	Het
Mmrn2	A	T	14: 34,119,991 (GRCm39)	Q287L	probably damaging	Het
Mplkip	A	G	13: 17,871,565 (GRCm39)	I159V	possibly damaging	Het
Napg	C	T	18: 63,120,034 (GRCm39)	R149C	probably damaging	Het
Nrxn1	A	C	17: 91,008,170 (GRCm39)		probably null	Het
Or10ag60	G	A	2: 87,437,841 (GRCm39)	M36I	probably benign	Het
Or1e17	A	T	11: 73,831,773 (GRCm39)	I234F	probably benign	Het
Or6c70	T	A	10: 129,709,936 (GRCm39)	Q230L	probably damaging	Het
Or6d15	A	T	6: 116,559,562 (GRCm39)	V115E	probably damaging	Het
Or6n2	A	G	1: 173,896,893 (GRCm39)	T10A	probably benign	Het
Orc4	A	T	2: 48,827,479 (GRCm39)	V38E	possibly damaging	Het
Palm3	T	A	8: 84,755,349 (GRCm39)	V287D	probably damaging	Het
Pde11a	C	T	2: 75,877,118 (GRCm39)		probably null	Het
Pdss2	T	A	10: 43,248,172 (GRCm39)	H225Q	probably benign	Het
Pkhd1	A	T	1: 20,345,762 (GRCm39)	D2755E	probably benign	Het
Pla2g5	C	T	4: 138,527,967 (GRCm39)	D100N	probably benign	Het
Polrmt	T	C	10: 79,577,832 (GRCm39)	T287A	probably benign	Het
Ppfia2	A	G	10: 106,732,281 (GRCm39)	I943V	possibly damaging	Het
Pth2r	A	C	1: 65,427,775 (GRCm39)	I483L	probably benign	Het
Qrsl1	A	G	10: 43,772,003 (GRCm39)		probably null	Het
Ralgapa1	A	T	12: 55,724,023 (GRCm39)	I1548N	probably damaging	Het
Scn9a	T	C	2: 66,398,475 (GRCm39)	E45G	probably damaging	Het
Sf3b1	T	C	1: 55,058,416 (GRCm39)	I58V	probably damaging	Het
Sh3d19	T	A	3: 86,033,978 (GRCm39)	M777K	probably benign	Het
Shc1	T	C	3: 89,331,020 (GRCm39)	L106P	probably damaging	Het
Skint5	T	C	4: 113,794,818 (GRCm39)	H255R	probably benign	Het
Slc28a3	C	A	13: 58,711,866 (GRCm39)	G487*	probably null	Het
Slc49a4	ACC	AC	16: 35,539,730 (GRCm39)		probably null	Het
Slfn4	A	T	11: 83,077,777 (GRCm39)	R188S	probably damaging	Het
Slitrk5	A	G	14: 111,919,055 (GRCm39)	D893G	probably damaging	Het
Spta1	A	G	1: 174,046,017 (GRCm39)	T1594A	probably damaging	Het
Srarp	G	A	4: 141,160,690 (GRCm39)	Q48*	probably null	Het
Srf	T	C	17: 46,860,415 (GRCm39)	T456A	possibly damaging	Het
Stx2	C	T	5: 129,065,967 (GRCm39)	V230I	probably benign	Het
Tenm4	C	A	7: 96,344,157 (GRCm39)	P250Q	possibly damaging	Het
Tnrc6c	A	G	11: 117,630,707 (GRCm39)	K1023E	probably damaging	Het
Trpc6	A	T	9: 8,610,276 (GRCm39)	H248L	probably damaging	Het
Trpc6	A	G	9: 8,643,537 (GRCm39)	K441E	probably damaging	Het
Uty	T	A	Y: 1,169,979 (GRCm39)	I326F	probably damaging	Het
Vmn1r63	A	G	7: 5,806,335 (GRCm39)	V99A	probably benign	Het
Wnt11	A	G	7: 98,496,590 (GRCm39)	K177E	probably damaging	Het
Wwc1	T	A	11: 35,743,175 (GRCm39)	E882V	probably damaging	Het
Zfhx2	C	A	14: 55,303,436 (GRCm39)	S1516I	possibly damaging	Het
Zmpste24	A	G	4: 120,940,050 (GRCm39)	Y199H	probably damaging	Het

Other mutations in Lrp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Lrp2	APN	2	69,338,123 (GRCm39)	missense	probably damaging	1.00
IGL00594:Lrp2	APN	2	69,316,624 (GRCm39)	missense	probably benign	0.00
IGL00782:Lrp2	APN	2	69,331,989 (GRCm39)	missense	probably benign	0.14
IGL00821:Lrp2	APN	2	69,289,860 (GRCm39)	missense	probably damaging	1.00
IGL00897:Lrp2	APN	2	69,352,225 (GRCm39)	missense	possibly damaging	0.86
IGL01065:Lrp2	APN	2	69,299,780 (GRCm39)	missense	possibly damaging	0.94
IGL01087:Lrp2	APN	2	69,354,417 (GRCm39)	missense	probably damaging	1.00
IGL01095:Lrp2	APN	2	69,322,776 (GRCm39)	nonsense	probably null
IGL01131:Lrp2	APN	2	69,329,583 (GRCm39)	missense	probably damaging	1.00
IGL01350:Lrp2	APN	2	69,341,328 (GRCm39)	missense	probably damaging	0.96
IGL01352:Lrp2	APN	2	69,333,870 (GRCm39)	missense	possibly damaging	0.77
IGL01358:Lrp2	APN	2	69,382,814 (GRCm39)	splice site	probably benign
IGL01375:Lrp2	APN	2	69,308,910 (GRCm39)	splice site	probably benign
IGL01384:Lrp2	APN	2	69,313,846 (GRCm39)	missense	probably damaging	1.00
IGL01384:Lrp2	APN	2	69,284,156 (GRCm39)	missense	probably null	1.00
IGL01411:Lrp2	APN	2	69,312,611 (GRCm39)	missense	probably damaging	1.00
IGL01418:Lrp2	APN	2	69,355,630 (GRCm39)	missense	probably benign
IGL01444:Lrp2	APN	2	69,274,060 (GRCm39)	missense	possibly damaging	0.94
IGL01464:Lrp2	APN	2	69,302,783 (GRCm39)	missense	probably damaging	0.98
IGL01528:Lrp2	APN	2	69,322,804 (GRCm39)	missense	probably damaging	1.00
IGL01663:Lrp2	APN	2	69,259,050 (GRCm39)	missense	probably benign
IGL01761:Lrp2	APN	2	69,311,579 (GRCm39)	missense	possibly damaging	0.85
IGL01780:Lrp2	APN	2	69,316,528 (GRCm39)	missense	possibly damaging	0.66
IGL01994:Lrp2	APN	2	69,313,945 (GRCm39)	missense	probably benign	0.08
IGL02015:Lrp2	APN	2	69,357,922 (GRCm39)	missense	probably benign	0.00
IGL02104:Lrp2	APN	2	69,340,762 (GRCm39)	missense	probably damaging	1.00
IGL02132:Lrp2	APN	2	69,367,960 (GRCm39)	missense	probably benign	0.01
IGL02134:Lrp2	APN	2	69,343,723 (GRCm39)	critical splice acceptor site	probably null
IGL02197:Lrp2	APN	2	69,297,224 (GRCm39)	missense	probably benign	0.01
IGL02212:Lrp2	APN	2	69,281,608 (GRCm39)	missense	probably benign	0.00
IGL02240:Lrp2	APN	2	69,365,390 (GRCm39)	missense	probably benign
IGL02248:Lrp2	APN	2	69,313,152 (GRCm39)	missense	probably damaging	1.00
IGL02369:Lrp2	APN	2	69,294,980 (GRCm39)	missense	probably damaging	1.00
IGL02416:Lrp2	APN	2	69,299,977 (GRCm39)	missense	probably damaging	1.00
IGL02417:Lrp2	APN	2	69,291,649 (GRCm39)	missense	probably damaging	1.00
IGL02458:Lrp2	APN	2	69,352,117 (GRCm39)	missense	probably damaging	0.97
IGL02479:Lrp2	APN	2	69,295,145 (GRCm39)	splice site	probably benign
IGL02508:Lrp2	APN	2	69,333,774 (GRCm39)	missense	probably benign	0.04
IGL02751:Lrp2	APN	2	69,363,806 (GRCm39)	missense	possibly damaging	0.56
IGL02814:Lrp2	APN	2	69,337,080 (GRCm39)	missense	probably damaging	1.00
IGL02867:Lrp2	APN	2	69,382,794 (GRCm39)	missense	possibly damaging	0.67
IGL02889:Lrp2	APN	2	69,382,794 (GRCm39)	missense	possibly damaging	0.67
IGL02943:Lrp2	APN	2	69,285,854 (GRCm39)	missense	possibly damaging	0.86
IGL02948:Lrp2	APN	2	69,318,181 (GRCm39)	missense	probably damaging	1.00
IGL02960:Lrp2	APN	2	69,285,797 (GRCm39)	splice site	probably benign
IGL02990:Lrp2	APN	2	69,271,740 (GRCm39)	missense	possibly damaging	0.56
IGL03027:Lrp2	APN	2	69,367,897 (GRCm39)	missense	probably benign	0.43
IGL03038:Lrp2	APN	2	69,305,808 (GRCm39)	missense	probably damaging	0.99
IGL03064:Lrp2	APN	2	69,313,477 (GRCm39)	missense	probably damaging	0.98
IGL03107:Lrp2	APN	2	69,285,177 (GRCm39)	missense	probably damaging	1.00
IGL03141:Lrp2	APN	2	69,307,370 (GRCm39)	missense	probably damaging	0.99
IGL03154:Lrp2	APN	2	69,379,386 (GRCm39)	missense	probably damaging	1.00
IGL03155:Lrp2	APN	2	69,285,796 (GRCm39)	splice site	probably benign
IGL03163:Lrp2	APN	2	69,331,870 (GRCm39)	nonsense	probably null
IGL03164:Lrp2	APN	2	69,295,043 (GRCm39)	missense	probably damaging	1.00
IGL03169:Lrp2	APN	2	69,353,538 (GRCm39)	missense	probably damaging	1.00
IGL03174:Lrp2	APN	2	69,296,609 (GRCm39)	missense	probably damaging	1.00
IGL03189:Lrp2	APN	2	69,268,822 (GRCm39)	splice site	probably benign
IGL03288:Lrp2	APN	2	69,256,383 (GRCm39)	missense	probably benign	0.02
IGL03350:Lrp2	APN	2	69,268,797 (GRCm39)	missense	probably damaging	1.00
IGL03378:Lrp2	APN	2	69,261,496 (GRCm39)	missense	probably damaging	1.00
casual	UTSW	2	69,329,607 (GRCm39)	missense	probably benign
nonchalant	UTSW	2	69,319,673 (GRCm39)	missense	probably damaging	1.00
Presto	UTSW	2	69,289,875 (GRCm39)	nonsense	probably null
relaxed	UTSW	2	69,365,349 (GRCm39)	missense	probably damaging	1.00
unguarded	UTSW	2	69,296,102 (GRCm39)	missense	probably benign	0.00
Unintended	UTSW	2	69,348,787 (GRCm39)	missense	probably damaging	1.00
BB009:Lrp2	UTSW	2	69,256,371 (GRCm39)	missense	probably benign	0.00
BB019:Lrp2	UTSW	2	69,256,371 (GRCm39)	missense	probably benign	0.00
IGL02835:Lrp2	UTSW	2	69,335,648 (GRCm39)	missense	probably damaging	1.00
IGL03055:Lrp2	UTSW	2	69,288,792 (GRCm39)	missense	probably damaging	1.00
PIT4362001:Lrp2	UTSW	2	69,367,882 (GRCm39)	missense	probably damaging	1.00
PIT4504001:Lrp2	UTSW	2	69,305,747 (GRCm39)	missense	probably damaging	1.00
R0008:Lrp2	UTSW	2	69,346,895 (GRCm39)	missense	probably benign	0.42
R0008:Lrp2	UTSW	2	69,346,895 (GRCm39)	missense	probably benign	0.42
R0044:Lrp2	UTSW	2	69,357,899 (GRCm39)	missense	probably benign	0.01
R0044:Lrp2	UTSW	2	69,357,899 (GRCm39)	missense	probably damaging	0.96
R0048:Lrp2	UTSW	2	69,295,971 (GRCm39)	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69,305,756 (GRCm39)	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69,305,756 (GRCm39)	missense	probably damaging	1.00
R0103:Lrp2	UTSW	2	69,307,384 (GRCm39)	missense	probably benign
R0167:Lrp2	UTSW	2	69,256,002 (GRCm39)	missense	possibly damaging	0.95
R0226:Lrp2	UTSW	2	69,367,907 (GRCm39)	missense	probably null	1.00
R0243:Lrp2	UTSW	2	69,258,974 (GRCm39)	missense	probably benign	0.00
R0308:Lrp2	UTSW	2	69,313,326 (GRCm39)	splice site	probably benign
R0372:Lrp2	UTSW	2	69,365,387 (GRCm39)	missense	probably benign	0.10
R0374:Lrp2	UTSW	2	69,260,651 (GRCm39)	missense	probably damaging	1.00
R0391:Lrp2	UTSW	2	69,290,681 (GRCm39)	splice site	probably benign
R0391:Lrp2	UTSW	2	69,287,202 (GRCm39)	missense	probably damaging	0.99
R0395:Lrp2	UTSW	2	69,263,421 (GRCm39)	missense	possibly damaging	0.89
R0401:Lrp2	UTSW	2	69,309,492 (GRCm39)	missense	probably damaging	0.98
R0471:Lrp2	UTSW	2	69,355,578 (GRCm39)	missense	probably damaging	0.97
R0483:Lrp2	UTSW	2	69,338,145 (GRCm39)	missense	probably damaging	0.99
R0502:Lrp2	UTSW	2	69,341,361 (GRCm39)	missense	probably damaging	1.00
R0542:Lrp2	UTSW	2	69,258,998 (GRCm39)	missense	probably benign	0.00
R0544:Lrp2	UTSW	2	69,322,275 (GRCm39)	missense	probably benign	0.18
R0548:Lrp2	UTSW	2	69,367,982 (GRCm39)	splice site	probably benign
R0593:Lrp2	UTSW	2	69,297,350 (GRCm39)	missense	probably benign
R0608:Lrp2	UTSW	2	69,316,587 (GRCm39)	missense	probably benign	0.02
R0633:Lrp2	UTSW	2	69,278,464 (GRCm39)	missense	probably damaging	1.00
R0691:Lrp2	UTSW	2	69,281,724 (GRCm39)	missense	probably benign	0.19
R0718:Lrp2	UTSW	2	69,341,292 (GRCm39)	missense	probably damaging	1.00
R0737:Lrp2	UTSW	2	69,278,513 (GRCm39)	missense	probably damaging	0.96
R0771:Lrp2	UTSW	2	69,338,334 (GRCm39)	missense	probably damaging	1.00
R0784:Lrp2	UTSW	2	69,348,709 (GRCm39)	missense	probably benign	0.32
R0885:Lrp2	UTSW	2	69,312,697 (GRCm39)	missense	possibly damaging	0.75
R0947:Lrp2	UTSW	2	69,318,182 (GRCm39)	missense	probably damaging	1.00
R1235:Lrp2	UTSW	2	69,354,380 (GRCm39)	missense	probably damaging	1.00
R1293:Lrp2	UTSW	2	69,353,646 (GRCm39)	splice site	probably null
R1301:Lrp2	UTSW	2	69,258,948 (GRCm39)	missense	probably damaging	0.98
R1387:Lrp2	UTSW	2	69,287,262 (GRCm39)	missense	probably damaging	1.00
R1459:Lrp2	UTSW	2	69,313,738 (GRCm39)	missense	probably damaging	0.99
R1459:Lrp2	UTSW	2	69,290,821 (GRCm39)	missense	probably damaging	1.00
R1529:Lrp2	UTSW	2	69,353,526 (GRCm39)	missense	probably damaging	1.00
R1543:Lrp2	UTSW	2	69,331,074 (GRCm39)	missense	probably damaging	1.00
R1546:Lrp2	UTSW	2	69,332,954 (GRCm39)	missense	probably damaging	1.00
R1550:Lrp2	UTSW	2	69,333,005 (GRCm39)	missense	possibly damaging	0.74
R1590:Lrp2	UTSW	2	69,297,107 (GRCm39)	critical splice donor site	probably null
R1689:Lrp2	UTSW	2	69,333,873 (GRCm39)	missense	probably benign	0.09
R1693:Lrp2	UTSW	2	69,340,762 (GRCm39)	missense	probably damaging	1.00
R1753:Lrp2	UTSW	2	69,326,833 (GRCm39)	missense	possibly damaging	0.87
R1799:Lrp2	UTSW	2	69,333,874 (GRCm39)	missense	probably benign	0.04
R1834:Lrp2	UTSW	2	69,297,224 (GRCm39)	missense	probably benign	0.01
R1921:Lrp2	UTSW	2	69,353,631 (GRCm39)	missense	probably damaging	1.00
R2000:Lrp2	UTSW	2	69,297,434 (GRCm39)	missense	probably damaging	1.00
R2077:Lrp2	UTSW	2	69,338,187 (GRCm39)	missense	probably damaging	1.00
R2092:Lrp2	UTSW	2	69,366,365 (GRCm39)	missense	probably benign	0.25
R2093:Lrp2	UTSW	2	69,366,365 (GRCm39)	missense	probably benign	0.25
R2108:Lrp2	UTSW	2	69,336,968 (GRCm39)	missense	possibly damaging	0.75
R2117:Lrp2	UTSW	2	69,313,729 (GRCm39)	missense	probably benign	0.05
R2122:Lrp2	UTSW	2	69,314,051 (GRCm39)	missense	probably damaging	1.00
R2134:Lrp2	UTSW	2	69,341,411 (GRCm39)	missense	probably damaging	1.00
R2207:Lrp2	UTSW	2	69,297,372 (GRCm39)	missense	possibly damaging	0.94
R2248:Lrp2	UTSW	2	69,341,354 (GRCm39)	missense	probably damaging	1.00
R2264:Lrp2	UTSW	2	69,312,710 (GRCm39)	missense	possibly damaging	0.88
R2316:Lrp2	UTSW	2	69,322,191 (GRCm39)	missense	possibly damaging	0.75
R2513:Lrp2	UTSW	2	69,336,718 (GRCm39)	splice site	probably null
R2984:Lrp2	UTSW	2	69,256,158 (GRCm39)	splice site	probably null
R3085:Lrp2	UTSW	2	69,297,479 (GRCm39)	missense	probably benign	0.05
R3103:Lrp2	UTSW	2	69,262,328 (GRCm39)	missense	probably benign	0.00
R3727:Lrp2	UTSW	2	69,340,773 (GRCm39)	missense	probably damaging	1.00
R3730:Lrp2	UTSW	2	69,294,923 (GRCm39)	missense	probably damaging	0.99
R3730:Lrp2	UTSW	2	69,365,251 (GRCm39)	critical splice donor site	probably null
R3731:Lrp2	UTSW	2	69,294,923 (GRCm39)	missense	probably damaging	0.99
R3731:Lrp2	UTSW	2	69,365,251 (GRCm39)	critical splice donor site	probably null
R3764:Lrp2	UTSW	2	69,326,680 (GRCm39)	missense	probably damaging	1.00
R3768:Lrp2	UTSW	2	69,335,449 (GRCm39)	missense	probably benign	0.34
R3778:Lrp2	UTSW	2	69,339,548 (GRCm39)	missense	probably benign	0.00
R3808:Lrp2	UTSW	2	69,331,892 (GRCm39)	missense	probably damaging	1.00
R3809:Lrp2	UTSW	2	69,331,892 (GRCm39)	missense	probably damaging	1.00
R3813:Lrp2	UTSW	2	69,294,923 (GRCm39)	missense	probably damaging	0.99
R3828:Lrp2	UTSW	2	69,256,356 (GRCm39)	missense	probably benign	0.03
R3852:Lrp2	UTSW	2	69,367,909 (GRCm39)	missense	probably damaging	0.96
R3877:Lrp2	UTSW	2	69,289,816 (GRCm39)	critical splice donor site	probably null
R3877:Lrp2	UTSW	2	69,379,391 (GRCm39)	missense	probably damaging	1.00
R3922:Lrp2	UTSW	2	69,336,720 (GRCm39)	missense	probably benign
R4081:Lrp2	UTSW	2	69,343,617 (GRCm39)	missense	probably damaging	0.98
R4082:Lrp2	UTSW	2	69,343,617 (GRCm39)	missense	probably damaging	0.98
R4118:Lrp2	UTSW	2	69,260,606 (GRCm39)	critical splice donor site	probably null
R4193:Lrp2	UTSW	2	69,297,487 (GRCm39)	missense	probably damaging	1.00
R4284:Lrp2	UTSW	2	69,310,438 (GRCm39)	missense	possibly damaging	0.95
R4322:Lrp2	UTSW	2	69,256,335 (GRCm39)	nonsense	probably null
R4352:Lrp2	UTSW	2	69,262,526 (GRCm39)	critical splice donor site	probably null
R4407:Lrp2	UTSW	2	69,332,861 (GRCm39)	missense	probably damaging	1.00
R4408:Lrp2	UTSW	2	69,297,513 (GRCm39)	missense	probably benign	0.09
R4416:Lrp2	UTSW	2	69,357,575 (GRCm39)	missense	probably benign	0.18
R4426:Lrp2	UTSW	2	69,336,692 (GRCm39)	missense	probably benign	0.00
R4510:Lrp2	UTSW	2	69,310,406 (GRCm39)	missense	possibly damaging	0.58
R4511:Lrp2	UTSW	2	69,310,406 (GRCm39)	missense	possibly damaging	0.58
R4553:Lrp2	UTSW	2	69,343,629 (GRCm39)	missense	probably benign	0.13
R4591:Lrp2	UTSW	2	69,366,419 (GRCm39)	missense	probably damaging	1.00
R4612:Lrp2	UTSW	2	69,288,771 (GRCm39)	nonsense	probably null
R4622:Lrp2	UTSW	2	69,290,693 (GRCm39)	missense	possibly damaging	0.87
R4632:Lrp2	UTSW	2	69,319,473 (GRCm39)	splice site	probably null
R4633:Lrp2	UTSW	2	69,291,761 (GRCm39)	missense	probably benign	0.16
R4636:Lrp2	UTSW	2	69,266,983 (GRCm39)	missense	possibly damaging	0.93
R4657:Lrp2	UTSW	2	69,297,337 (GRCm39)	missense	probably damaging	1.00
R4667:Lrp2	UTSW	2	69,319,642 (GRCm39)	missense	probably benign	0.02
R4712:Lrp2	UTSW	2	69,336,895 (GRCm39)	missense	probably damaging	1.00
R4713:Lrp2	UTSW	2	69,318,310 (GRCm39)	missense	probably damaging	1.00
R4720:Lrp2	UTSW	2	69,311,517 (GRCm39)	missense	probably damaging	0.99
R4732:Lrp2	UTSW	2	69,363,899 (GRCm39)	missense	probably benign
R4733:Lrp2	UTSW	2	69,363,899 (GRCm39)	missense	probably benign
R4777:Lrp2	UTSW	2	69,312,608 (GRCm39)	missense	probably damaging	1.00
R4779:Lrp2	UTSW	2	69,290,059 (GRCm39)	missense	possibly damaging	0.75
R4786:Lrp2	UTSW	2	69,368,300 (GRCm39)	missense	probably damaging	1.00
R4842:Lrp2	UTSW	2	69,299,755 (GRCm39)	missense	probably benign	0.06
R4845:Lrp2	UTSW	2	69,339,585 (GRCm39)	missense	possibly damaging	0.71
R4846:Lrp2	UTSW	2	69,309,457 (GRCm39)	missense	probably damaging	1.00
R4938:Lrp2	UTSW	2	69,302,712 (GRCm39)	missense	probably damaging	0.98
R4951:Lrp2	UTSW	2	69,366,332 (GRCm39)	missense	probably damaging	1.00
R4990:Lrp2	UTSW	2	69,311,732 (GRCm39)	missense	probably benign	0.01
R5075:Lrp2	UTSW	2	69,296,102 (GRCm39)	missense	probably benign	0.00
R5078:Lrp2	UTSW	2	69,331,874 (GRCm39)	missense	possibly damaging	0.93
R5102:Lrp2	UTSW	2	69,319,502 (GRCm39)	missense	probably damaging	0.98
R5124:Lrp2	UTSW	2	69,331,834 (GRCm39)	missense	probably damaging	0.97
R5131:Lrp2	UTSW	2	69,260,686 (GRCm39)	missense	possibly damaging	0.74
R5141:Lrp2	UTSW	2	69,382,693 (GRCm39)	splice site	probably null
R5223:Lrp2	UTSW	2	69,354,397 (GRCm39)	missense	probably damaging	0.99
R5236:Lrp2	UTSW	2	69,287,163 (GRCm39)	splice site	probably null
R5267:Lrp2	UTSW	2	69,379,322 (GRCm39)	missense	possibly damaging	0.83
R5290:Lrp2	UTSW	2	69,343,698 (GRCm39)	missense	probably damaging	1.00
R5333:Lrp2	UTSW	2	69,355,572 (GRCm39)	missense	probably benign	0.01
R5355:Lrp2	UTSW	2	69,285,182 (GRCm39)	nonsense	probably null
R5356:Lrp2	UTSW	2	69,295,052 (GRCm39)	missense	possibly damaging	0.74
R5369:Lrp2	UTSW	2	69,289,904 (GRCm39)	missense	probably benign	0.04
R5486:Lrp2	UTSW	2	69,267,809 (GRCm39)	missense	probably benign	0.04
R5554:Lrp2	UTSW	2	69,382,768 (GRCm39)	missense	possibly damaging	0.92
R5584:Lrp2	UTSW	2	69,281,632 (GRCm39)	missense	probably damaging	1.00
R5585:Lrp2	UTSW	2	69,294,968 (GRCm39)	missense	possibly damaging	0.77
R5587:Lrp2	UTSW	2	69,329,607 (GRCm39)	missense	probably benign
R5605:Lrp2	UTSW	2	69,353,643 (GRCm39)	missense	probably damaging	1.00
R5637:Lrp2	UTSW	2	69,302,762 (GRCm39)	missense	probably damaging	1.00
R5647:Lrp2	UTSW	2	69,350,258 (GRCm39)	missense	probably null	0.80
R5686:Lrp2	UTSW	2	69,341,405 (GRCm39)	missense	possibly damaging	0.88
R5691:Lrp2	UTSW	2	69,332,897 (GRCm39)	missense	probably damaging	1.00
R5724:Lrp2	UTSW	2	69,281,726 (GRCm39)	missense	probably damaging	0.99
R5726:Lrp2	UTSW	2	69,339,491 (GRCm39)	missense	probably damaging	1.00
R5743:Lrp2	UTSW	2	69,297,221 (GRCm39)	missense	probably damaging	1.00
R5777:Lrp2	UTSW	2	69,285,869 (GRCm39)	missense	probably damaging	1.00
R5841:Lrp2	UTSW	2	69,310,497 (GRCm39)	missense	probably benign	0.00
R5892:Lrp2	UTSW	2	69,273,120 (GRCm39)	missense	probably benign
R5951:Lrp2	UTSW	2	69,326,667 (GRCm39)	splice site	probably null
R5974:Lrp2	UTSW	2	69,289,892 (GRCm39)	missense	probably damaging	1.00
R5980:Lrp2	UTSW	2	69,365,349 (GRCm39)	missense	probably damaging	1.00
R6046:Lrp2	UTSW	2	69,337,098 (GRCm39)	missense	probably damaging	1.00
R6113:Lrp2	UTSW	2	69,313,901 (GRCm39)	missense	possibly damaging	0.76
R6146:Lrp2	UTSW	2	69,341,345 (GRCm39)	missense	probably benign	0.00
R6177:Lrp2	UTSW	2	69,340,763 (GRCm39)	frame shift	probably null
R6180:Lrp2	UTSW	2	69,333,868 (GRCm39)	missense	possibly damaging	0.85
R6219:Lrp2	UTSW	2	69,299,822 (GRCm39)	missense	probably damaging	1.00
R6228:Lrp2	UTSW	2	69,312,710 (GRCm39)	missense	possibly damaging	0.88
R6265:Lrp2	UTSW	2	69,296,684 (GRCm39)	missense	probably damaging	1.00
R6312:Lrp2	UTSW	2	69,267,025 (GRCm39)	missense	probably damaging	1.00
R6337:Lrp2	UTSW	2	69,268,811 (GRCm39)	missense	probably damaging	1.00
R6376:Lrp2	UTSW	2	69,313,787 (GRCm39)	missense	probably benign	0.02
R6385:Lrp2	UTSW	2	69,326,128 (GRCm39)	missense	probably benign	0.22
R6429:Lrp2	UTSW	2	69,291,631 (GRCm39)	missense	probably damaging	1.00
R6458:Lrp2	UTSW	2	69,335,500 (GRCm39)	missense	probably benign	0.00
R6524:Lrp2	UTSW	2	69,266,983 (GRCm39)	missense	possibly damaging	0.93
R6555:Lrp2	UTSW	2	69,339,647 (GRCm39)	missense	probably benign	0.00
R6594:Lrp2	UTSW	2	69,270,267 (GRCm39)	missense	possibly damaging	0.58
R6599:Lrp2	UTSW	2	69,299,749 (GRCm39)	missense	probably damaging	1.00
R6655:Lrp2	UTSW	2	69,284,202 (GRCm39)	missense	probably benign	0.01
R6718:Lrp2	UTSW	2	69,314,124 (GRCm39)	missense	probably benign	0.09
R6736:Lrp2	UTSW	2	69,278,555 (GRCm39)	missense	probably benign	0.02
R6738:Lrp2	UTSW	2	69,288,832 (GRCm39)	missense	probably damaging	0.97
R6799:Lrp2	UTSW	2	69,314,248 (GRCm39)	missense	probably damaging	1.00
R6846:Lrp2	UTSW	2	69,348,787 (GRCm39)	missense	probably damaging	1.00
R6856:Lrp2	UTSW	2	69,343,612 (GRCm39)	missense	probably damaging	1.00
R6861:Lrp2	UTSW	2	69,343,721 (GRCm39)	missense	possibly damaging	0.77
R6888:Lrp2	UTSW	2	69,354,485 (GRCm39)	missense	probably damaging	0.98
R6897:Lrp2	UTSW	2	69,340,846 (GRCm39)	missense	probably benign
R6902:Lrp2	UTSW	2	69,289,847 (GRCm39)	missense	probably damaging	1.00
R6908:Lrp2	UTSW	2	69,302,709 (GRCm39)	missense	probably damaging	1.00
R6918:Lrp2	UTSW	2	69,319,649 (GRCm39)	missense	probably damaging	1.00
R6989:Lrp2	UTSW	2	69,302,799 (GRCm39)	missense	probably damaging	1.00
R7022:Lrp2	UTSW	2	69,313,552 (GRCm39)	missense	probably damaging	1.00
R7025:Lrp2	UTSW	2	69,313,372 (GRCm39)	missense	possibly damaging	0.90
R7026:Lrp2	UTSW	2	69,352,131 (GRCm39)	missense	probably damaging	0.97
R7138:Lrp2	UTSW	2	69,296,089 (GRCm39)	missense	possibly damaging	0.94
R7145:Lrp2	UTSW	2	69,285,152 (GRCm39)	critical splice donor site	probably null
R7150:Lrp2	UTSW	2	69,318,395 (GRCm39)	missense	probably damaging	0.99
R7165:Lrp2	UTSW	2	69,336,917 (GRCm39)	missense	probably damaging	0.99
R7174:Lrp2	UTSW	2	69,263,416 (GRCm39)	missense	probably benign	0.11
R7204:Lrp2	UTSW	2	69,302,877 (GRCm39)	missense	probably benign	0.25
R7275:Lrp2	UTSW	2	69,289,875 (GRCm39)	nonsense	probably null
R7278:Lrp2	UTSW	2	69,316,696 (GRCm39)	missense	probably damaging	1.00
R7296:Lrp2	UTSW	2	69,312,725 (GRCm39)	missense	probably benign	0.04
R7315:Lrp2	UTSW	2	69,322,166 (GRCm39)	missense	probably damaging	0.98
R7342:Lrp2	UTSW	2	69,309,634 (GRCm39)	missense	possibly damaging	0.95
R7351:Lrp2	UTSW	2	69,278,486 (GRCm39)	missense	probably damaging	1.00
R7352:Lrp2	UTSW	2	69,302,741 (GRCm39)	missense	probably benign	0.04
R7366:Lrp2	UTSW	2	69,314,150 (GRCm39)	missense	probably damaging	1.00
R7373:Lrp2	UTSW	2	69,331,036 (GRCm39)	missense	probably damaging	1.00
R7446:Lrp2	UTSW	2	69,290,018 (GRCm39)	missense	probably damaging	0.99
R7446:Lrp2	UTSW	2	69,262,557 (GRCm39)	missense	probably damaging	1.00
R7451:Lrp2	UTSW	2	69,343,677 (GRCm39)	missense	probably damaging	1.00
R7492:Lrp2	UTSW	2	69,367,925 (GRCm39)	missense	probably damaging	0.99
R7571:Lrp2	UTSW	2	69,346,747 (GRCm39)	missense	probably damaging	1.00
R7638:Lrp2	UTSW	2	69,307,352 (GRCm39)	critical splice donor site	probably null
R7664:Lrp2	UTSW	2	69,337,076 (GRCm39)	missense	probably damaging	1.00
R7686:Lrp2	UTSW	2	69,319,581 (GRCm39)	missense	probably damaging	1.00
R7711:Lrp2	UTSW	2	69,309,687 (GRCm39)	critical splice acceptor site	probably null
R7737:Lrp2	UTSW	2	69,326,782 (GRCm39)	missense	possibly damaging	0.77
R7763:Lrp2	UTSW	2	69,333,732 (GRCm39)	missense	probably damaging	0.99
R7775:Lrp2	UTSW	2	69,331,883 (GRCm39)	missense	possibly damaging	0.74
R7824:Lrp2	UTSW	2	69,331,883 (GRCm39)	missense	possibly damaging	0.74
R7840:Lrp2	UTSW	2	69,295,128 (GRCm39)	missense	probably damaging	0.98
R7878:Lrp2	UTSW	2	69,338,153 (GRCm39)	missense	probably damaging	1.00
R7878:Lrp2	UTSW	2	69,338,154 (GRCm39)	missense	probably damaging	1.00
R7895:Lrp2	UTSW	2	69,288,823 (GRCm39)	missense	probably damaging	0.97
R7898:Lrp2	UTSW	2	69,271,710 (GRCm39)	missense	probably benign	0.00
R7912:Lrp2	UTSW	2	69,259,016 (GRCm39)	missense	probably benign	0.03
R7923:Lrp2	UTSW	2	69,268,732 (GRCm39)	missense	possibly damaging	0.75
R7932:Lrp2	UTSW	2	69,256,371 (GRCm39)	missense	probably benign	0.00
R7940:Lrp2	UTSW	2	69,262,541 (GRCm39)	missense	possibly damaging	0.91
R7954:Lrp2	UTSW	2	69,333,867 (GRCm39)	missense	possibly damaging	0.61
R8007:Lrp2	UTSW	2	69,336,849 (GRCm39)	missense	probably benign	0.02
R8084:Lrp2	UTSW	2	69,339,713 (GRCm39)	missense	probably damaging	0.97
R8087:Lrp2	UTSW	2	69,278,473 (GRCm39)	missense	probably damaging	1.00
R8090:Lrp2	UTSW	2	69,295,089 (GRCm39)	missense	possibly damaging	0.94
R8110:Lrp2	UTSW	2	69,336,797 (GRCm39)	missense	probably benign
R8129:Lrp2	UTSW	2	69,260,624 (GRCm39)	missense	possibly damaging	0.75
R8155:Lrp2	UTSW	2	69,313,342 (GRCm39)	missense	possibly damaging	0.74
R8182:Lrp2	UTSW	2	69,319,673 (GRCm39)	missense	probably damaging	1.00
R8239:Lrp2	UTSW	2	69,311,611 (GRCm39)	nonsense	probably null
R8247:Lrp2	UTSW	2	69,261,431 (GRCm39)	missense	possibly damaging	0.76
R8327:Lrp2	UTSW	2	69,322,268 (GRCm39)	missense	probably damaging	1.00
R8355:Lrp2	UTSW	2	69,346,828 (GRCm39)	missense	probably damaging	0.99
R8404:Lrp2	UTSW	2	69,344,585 (GRCm39)	nonsense	probably null
R8427:Lrp2	UTSW	2	69,281,641 (GRCm39)	missense	probably damaging	0.97
R8463:Lrp2	UTSW	2	69,322,250 (GRCm39)	missense	probably damaging	1.00
R8502:Lrp2	UTSW	2	69,344,585 (GRCm39)	nonsense	probably null
R8529:Lrp2	UTSW	2	69,330,986 (GRCm39)	missense	probably damaging	0.96
R8673:Lrp2	UTSW	2	69,302,804 (GRCm39)	missense	probably damaging	1.00
R8698:Lrp2	UTSW	2	69,288,767 (GRCm39)	missense	probably benign	0.37
R8698:Lrp2	UTSW	2	69,278,583 (GRCm39)	missense	probably benign	0.39
R8708:Lrp2	UTSW	2	69,289,957 (GRCm39)	missense	probably damaging	1.00
R8716:Lrp2	UTSW	2	69,274,138 (GRCm39)	missense	probably benign	0.04
R8723:Lrp2	UTSW	2	69,316,648 (GRCm39)	missense	probably damaging	1.00
R8787:Lrp2	UTSW	2	69,382,745 (GRCm39)	missense	probably damaging	1.00
R8903:Lrp2	UTSW	2	69,379,382 (GRCm39)	missense	possibly damaging	0.68
R8944:Lrp2	UTSW	2	69,341,348 (GRCm39)	missense	probably damaging	1.00
R9069:Lrp2	UTSW	2	69,331,996 (GRCm39)	missense	probably damaging	1.00
R9076:Lrp2	UTSW	2	69,350,260 (GRCm39)	missense	probably benign	0.01
R9155:Lrp2	UTSW	2	69,291,713 (GRCm39)	nonsense	probably null
R9173:Lrp2	UTSW	2	69,299,731 (GRCm39)	missense	probably damaging	1.00
R9254:Lrp2	UTSW	2	69,333,891 (GRCm39)	missense	probably benign	0.09
R9256:Lrp2	UTSW	2	69,341,303 (GRCm39)	missense	probably benign	0.03
R9291:Lrp2	UTSW	2	69,310,379 (GRCm39)	missense	probably damaging	1.00
R9335:Lrp2	UTSW	2	69,258,983 (GRCm39)	missense	probably benign	0.01
R9357:Lrp2	UTSW	2	69,336,917 (GRCm39)	missense	probably damaging	0.99
R9368:Lrp2	UTSW	2	69,357,979 (GRCm39)	missense	probably damaging	0.99
R9453:Lrp2	UTSW	2	69,288,832 (GRCm39)	missense	probably damaging	1.00
R9546:Lrp2	UTSW	2	69,287,165 (GRCm39)	critical splice donor site	probably null
R9554:Lrp2	UTSW	2	69,261,497 (GRCm39)	missense	probably damaging	1.00
R9597:Lrp2	UTSW	2	69,260,703 (GRCm39)	missense	probably benign	0.02
R9601:Lrp2	UTSW	2	69,289,928 (GRCm39)	missense	probably damaging	1.00
R9623:Lrp2	UTSW	2	69,307,423 (GRCm39)	missense	probably benign	0.09
RF016:Lrp2	UTSW	2	69,339,549 (GRCm39)	missense	probably benign
X0011:Lrp2	UTSW	2	69,350,342 (GRCm39)	missense	probably damaging	1.00
X0023:Lrp2	UTSW	2	69,266,944 (GRCm39)	missense	probably damaging	0.99
Z1176:Lrp2	UTSW	2	69,338,225 (GRCm39)	missense	possibly damaging	0.88
Z1176:Lrp2	UTSW	2	69,310,386 (GRCm39)	missense	possibly damaging	0.66
Z1177:Lrp2	UTSW	2	69,326,812 (GRCm39)	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69,302,797 (GRCm39)	missense	probably benign	0.03
Z1177:Lrp2	UTSW	2	69,281,624 (GRCm39)	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69,339,633 (GRCm39)	missense	probably benign	0.00
Z1177:Lrp2	UTSW	2	69,331,985 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGTTACAGACAGTCCCCATCTCG -3'
(R):5'- TTATGCAGCCACCAGCAACAGG -3'

Sequencing Primer
(F):5'- TTGTCACACCGGAACTGATGAG -3'
(R):5'- CAGCAACAGGGGAATTCATGC -3'

Posted On

2013-04-16