Incidental Mutation 'R4747:Vmn2r1'
ID 357164
Institutional Source Beutler Lab
Gene Symbol Vmn2r1
Ensembl Gene ENSMUSG00000027824
Gene Name vomeronasal 2, receptor 1
Synonyms V2r83, EG56544
MMRRC Submission 042029-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R4747 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 63988968-64016905 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 63989267 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 69 (I69V)
Ref Sequence ENSEMBL: ENSMUSP00000029406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029406]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000029406
AA Change: I69V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000029406
Gene: ENSMUSG00000027824
AA Change: I69V

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 86 504 6e-92 PFAM
Pfam:NCD3G 546 599 2.4e-17 PFAM
Pfam:7tm_3 632 866 4.1e-48 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 95 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402D24Rik A G 1: 63,795,568 (GRCm39) probably benign Het
Acadvl G T 11: 69,903,334 (GRCm39) N340K probably damaging Het
Adgrl4 T A 3: 151,213,077 (GRCm39) N372K probably benign Het
Adh1 G A 3: 137,994,642 (GRCm39) G321S probably damaging Het
Ankrd26 G T 6: 118,504,718 (GRCm39) N730K probably benign Het
Aoc2 A T 11: 101,219,646 (GRCm39) probably null Het
Arhgef4 A G 1: 34,762,355 (GRCm39) E537G unknown Het
Ccdc7b T C 8: 129,904,716 (GRCm39) V118A probably benign Het
Ccdc88b T A 19: 6,833,509 (GRCm39) R219W probably damaging Het
Ccdc97 T C 7: 25,418,348 (GRCm39) probably null Het
Cfhr4 A T 1: 139,625,922 (GRCm39) C792S probably damaging Het
Ciao3 A T 17: 25,999,327 (GRCm39) Y247F probably benign Het
Cnot1 T C 8: 96,501,310 (GRCm39) N86S probably benign Het
Comp T C 8: 70,829,352 (GRCm39) C310R probably damaging Het
Crtc2 A T 3: 90,167,518 (GRCm39) N281Y probably damaging Het
Cryl1 T C 14: 57,550,559 (GRCm39) K102E probably damaging Het
Csf2ra G A 19: 61,214,491 (GRCm39) R225* probably null Het
Dao A T 5: 114,150,693 (GRCm39) D99V probably benign Het
Dgkd A G 1: 87,861,889 (GRCm39) T815A probably damaging Het
Dhrs7 T C 12: 72,699,892 (GRCm39) T247A probably benign Het
Dnah7c G C 1: 46,572,328 (GRCm39) D934H probably damaging Het
Dnajc15 T C 14: 78,081,896 (GRCm39) Y82C probably benign Het
Dnajc4 T C 19: 6,966,872 (GRCm39) Q152R probably damaging Het
Dsc1 T C 18: 20,227,615 (GRCm39) K541R probably damaging Het
Elp4 G A 2: 105,624,952 (GRCm39) R196C probably damaging Het
Epha8 GC G 4: 136,666,006 (GRCm39) probably null Het
Ercc6 T C 14: 32,291,864 (GRCm39) V1076A probably benign Het
Fgd4 T C 16: 16,241,793 (GRCm39) Y677C probably damaging Het
Fndc3b C A 3: 27,483,114 (GRCm39) C1028F probably damaging Het
Folr1 T A 7: 101,513,184 (GRCm39) D37V probably damaging Het
Gabrr3 T A 16: 59,268,277 (GRCm39) probably null Het
Garem1 C A 18: 21,263,000 (GRCm39) V605L probably benign Het
Gbp7 A T 3: 142,248,778 (GRCm39) D347V probably damaging Het
Gdpd4 A G 7: 97,610,840 (GRCm39) T87A possibly damaging Het
Gm12258 C A 11: 58,750,422 (GRCm39) H532Q probably damaging Het
Herc2 A G 7: 55,756,141 (GRCm39) E727G possibly damaging Het
Hfm1 G A 5: 107,065,389 (GRCm39) H97Y probably benign Het
Idua G T 5: 108,828,902 (GRCm39) R335L probably damaging Het
Ifi207 A G 1: 173,556,633 (GRCm39) S702P probably benign Het
Kif16b A T 2: 142,699,346 (GRCm39) V78D probably damaging Het
Klra17 T A 6: 129,849,232 (GRCm39) D114V probably damaging Het
Krt76 A G 15: 101,794,180 (GRCm39) S481P probably damaging Het
Lhfpl5 A G 17: 28,798,950 (GRCm39) D153G probably damaging Het
Med21 T A 6: 146,550,700 (GRCm39) D70E possibly damaging Het
Mroh3 A T 1: 136,113,237 (GRCm39) M739K probably benign Het
Myo1a A G 10: 127,550,307 (GRCm39) E549G probably damaging Het
Neu1 A G 17: 35,153,359 (GRCm39) D294G possibly damaging Het
Nmur2 A T 11: 55,931,105 (GRCm39) I202K probably benign Het
Nop2 T A 6: 125,114,057 (GRCm39) D174E probably benign Het
Ogfr A T 2: 180,236,216 (GRCm39) H267L probably damaging Het
Or10p1 G T 10: 129,444,053 (GRCm39) A99E possibly damaging Het
Or5m8 A G 2: 85,822,271 (GRCm39) T37A probably damaging Het
P2ry13 T A 3: 59,117,308 (GRCm39) I157F probably benign Het
Pank4 T C 4: 155,063,989 (GRCm39) V660A probably damaging Het
Pax6 C A 2: 105,526,847 (GRCm39) P251Q probably benign Het
Pcdhb13 T C 18: 37,577,868 (GRCm39) Y749H probably damaging Het
Pcdhga3 C A 18: 37,809,799 (GRCm39) Q751K probably benign Het
Pcnt C T 10: 76,272,299 (GRCm39) E186K possibly damaging Het
Pecam1 A T 11: 106,575,072 (GRCm39) F613I probably benign Het
Pias2 T C 18: 77,240,488 (GRCm39) *615Q probably null Het
Plb1 A T 5: 32,507,003 (GRCm39) M1193L probably benign Het
Pomgnt1 T C 4: 116,013,396 (GRCm39) L506P probably damaging Het
Qrfp T C 2: 31,698,852 (GRCm39) T27A probably damaging Het
Relb C A 7: 19,361,847 (GRCm39) probably null Het
Resf1 A T 6: 149,228,392 (GRCm39) E479D probably damaging Het
Rgl1 G T 1: 152,400,450 (GRCm39) C685* probably null Het
Ric8b A G 10: 84,753,628 (GRCm39) Y8C probably benign Het
Rrp36 G A 17: 46,980,893 (GRCm39) A161V possibly damaging Het
Samd9l G A 6: 3,375,504 (GRCm39) Q586* probably null Het
Sbf1 C T 15: 89,186,916 (GRCm39) D821N probably damaging Het
Septin8 G C 11: 53,427,545 (GRCm39) A255P probably damaging Het
Skp2 T C 15: 9,113,927 (GRCm39) T329A possibly damaging Het
Slc15a2 C T 16: 36,592,498 (GRCm39) V220M probably damaging Het
Slc25a11 T A 11: 70,536,782 (GRCm39) T63S possibly damaging Het
Sowahc T C 10: 59,058,983 (GRCm39) I373T probably benign Het
Sptbn2 T A 19: 4,798,182 (GRCm39) M1969K probably benign Het
St14 G A 9: 31,015,053 (GRCm39) T315M possibly damaging Het
Tagap G A 17: 8,151,030 (GRCm39) R284H probably benign Het
Tdpoz3 T A 3: 93,733,476 (GRCm39) S50R possibly damaging Het
Thoc5 A G 11: 4,854,187 (GRCm39) D182G probably damaging Het
Tinag A G 9: 76,904,238 (GRCm39) V395A probably benign Het
Tmc8 A G 11: 117,683,550 (GRCm39) S702G probably benign Het
Tmem202 A G 9: 59,426,477 (GRCm39) S230P possibly damaging Het
Tmem203 T C 2: 25,145,764 (GRCm39) V28A probably benign Het
Traf3ip1 A T 1: 91,455,479 (GRCm39) S647C probably damaging Het
Tram1 A T 1: 13,659,870 (GRCm39) I26N probably damaging Het
Ttc6 A T 12: 57,721,478 (GRCm39) D989V possibly damaging Het
Ttll6 A G 11: 96,036,372 (GRCm39) T334A possibly damaging Het
Ttn A T 2: 76,750,086 (GRCm39) D3654E probably damaging Het
Ufd1 T G 16: 18,639,832 (GRCm39) V112G probably damaging Het
Usp9y A T Y: 1,391,284 (GRCm39) Y629N possibly damaging Het
Zfp180 A T 7: 23,805,246 (GRCm39) Y555F probably damaging Het
Zfp438 T C 18: 5,214,403 (GRCm39) N185S probably benign Het
Zfp445 C T 9: 122,686,215 (GRCm39) V15I possibly damaging Het
Zfp462 A G 4: 55,013,476 (GRCm39) E1814G probably benign Het
Other mutations in Vmn2r1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Vmn2r1 APN 3 64,012,389 (GRCm39) nonsense probably null
IGL00335:Vmn2r1 APN 3 64,012,809 (GRCm39) missense probably damaging 0.96
IGL01509:Vmn2r1 APN 3 64,010,466 (GRCm39) missense probably benign 0.03
IGL01641:Vmn2r1 APN 3 64,011,924 (GRCm39) missense probably benign 0.19
IGL01656:Vmn2r1 APN 3 63,989,274 (GRCm39) missense probably damaging 0.96
IGL01927:Vmn2r1 APN 3 63,989,105 (GRCm39) missense probably benign 0.01
IGL02093:Vmn2r1 APN 3 64,012,130 (GRCm39) missense probably benign
IGL02146:Vmn2r1 APN 3 64,012,104 (GRCm39) missense probably benign 0.39
IGL02186:Vmn2r1 APN 3 63,989,138 (GRCm39) missense probably benign 0.01
IGL02320:Vmn2r1 APN 3 63,989,180 (GRCm39) missense possibly damaging 0.61
IGL02423:Vmn2r1 APN 3 63,997,665 (GRCm39) missense probably benign 0.00
IGL02709:Vmn2r1 APN 3 64,012,355 (GRCm39) missense probably benign 0.24
R0034:Vmn2r1 UTSW 3 63,997,435 (GRCm39) missense probably damaging 1.00
R0064:Vmn2r1 UTSW 3 64,012,209 (GRCm39) missense possibly damaging 0.76
R0152:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0305:Vmn2r1 UTSW 3 63,997,087 (GRCm39) missense probably damaging 1.00
R0314:Vmn2r1 UTSW 3 63,993,980 (GRCm39) missense probably damaging 1.00
R0317:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0465:Vmn2r1 UTSW 3 63,989,180 (GRCm39) missense possibly damaging 0.61
R1144:Vmn2r1 UTSW 3 63,997,541 (GRCm39) missense probably damaging 1.00
R1163:Vmn2r1 UTSW 3 63,994,046 (GRCm39) missense probably benign 0.03
R1448:Vmn2r1 UTSW 3 64,008,734 (GRCm39) missense probably damaging 1.00
R1491:Vmn2r1 UTSW 3 63,997,034 (GRCm39) missense probably damaging 1.00
R1543:Vmn2r1 UTSW 3 63,996,994 (GRCm39) missense probably damaging 1.00
R1611:Vmn2r1 UTSW 3 64,011,958 (GRCm39) nonsense probably null
R1676:Vmn2r1 UTSW 3 63,997,603 (GRCm39) nonsense probably null
R1727:Vmn2r1 UTSW 3 63,989,163 (GRCm39) missense probably benign
R1851:Vmn2r1 UTSW 3 64,008,926 (GRCm39) missense probably benign 0.32
R3080:Vmn2r1 UTSW 3 63,997,205 (GRCm39) missense probably damaging 1.00
R3790:Vmn2r1 UTSW 3 63,994,185 (GRCm39) critical splice donor site probably null
R4111:Vmn2r1 UTSW 3 63,997,176 (GRCm39) missense probably benign 0.23
R4689:Vmn2r1 UTSW 3 64,012,074 (GRCm39) missense possibly damaging 0.94
R4970:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5033:Vmn2r1 UTSW 3 64,012,501 (GRCm39) missense probably damaging 1.00
R5086:Vmn2r1 UTSW 3 63,997,418 (GRCm39) missense probably benign 0.00
R5112:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5385:Vmn2r1 UTSW 3 64,008,819 (GRCm39) missense possibly damaging 0.89
R5629:Vmn2r1 UTSW 3 64,012,538 (GRCm39) missense possibly damaging 0.87
R5762:Vmn2r1 UTSW 3 63,997,474 (GRCm39) missense probably benign 0.24
R5867:Vmn2r1 UTSW 3 64,011,990 (GRCm39) missense probably benign
R5893:Vmn2r1 UTSW 3 63,993,974 (GRCm39) missense probably damaging 1.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6290:Vmn2r1 UTSW 3 64,012,873 (GRCm39) missense probably benign 0.02
R6443:Vmn2r1 UTSW 3 64,012,374 (GRCm39) missense possibly damaging 0.78
R6464:Vmn2r1 UTSW 3 64,008,766 (GRCm39) missense probably benign
R6826:Vmn2r1 UTSW 3 64,012,567 (GRCm39) nonsense probably null
R6874:Vmn2r1 UTSW 3 64,012,376 (GRCm39) missense probably damaging 1.00
R6882:Vmn2r1 UTSW 3 63,997,529 (GRCm39) missense possibly damaging 0.64
R6983:Vmn2r1 UTSW 3 63,989,118 (GRCm39) missense probably benign
R7010:Vmn2r1 UTSW 3 64,012,146 (GRCm39) missense probably benign 0.19
R7144:Vmn2r1 UTSW 3 63,997,362 (GRCm39) missense probably damaging 1.00
R7341:Vmn2r1 UTSW 3 64,012,877 (GRCm39) makesense probably null
R7510:Vmn2r1 UTSW 3 63,993,922 (GRCm39) missense probably damaging 1.00
R7557:Vmn2r1 UTSW 3 63,997,475 (GRCm39) missense probably damaging 0.99
R7895:Vmn2r1 UTSW 3 63,997,130 (GRCm39) missense possibly damaging 0.90
R8108:Vmn2r1 UTSW 3 64,010,471 (GRCm39) missense probably damaging 0.98
R8209:Vmn2r1 UTSW 3 63,997,199 (GRCm39) missense possibly damaging 0.64
R8365:Vmn2r1 UTSW 3 63,994,034 (GRCm39) missense possibly damaging 0.80
R8514:Vmn2r1 UTSW 3 63,993,942 (GRCm39) missense probably benign 0.11
R8554:Vmn2r1 UTSW 3 63,997,334 (GRCm39) missense probably damaging 0.98
R8980:Vmn2r1 UTSW 3 64,010,501 (GRCm39) missense
R9140:Vmn2r1 UTSW 3 63,997,465 (GRCm39) missense probably benign 0.05
R9239:Vmn2r1 UTSW 3 64,011,959 (GRCm39) missense probably damaging 0.99
R9441:Vmn2r1 UTSW 3 64,012,674 (GRCm39) missense probably damaging 1.00
R9549:Vmn2r1 UTSW 3 63,997,493 (GRCm39) missense probably benign 0.17
R9771:Vmn2r1 UTSW 3 63,997,559 (GRCm39) missense possibly damaging 0.79
X0065:Vmn2r1 UTSW 3 63,997,678 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCAGCAGACAGATAAGCTTAGC -3'
(R):5'- CTGCATAACAGGTTTCAGAAGAAC -3'

Sequencing Primer
(F):5'- AGCTTAGCTTTAGGATTTCTTGC -3'
(R):5'- AGTCTGAGTAGCAGCCCTTAACTG -3'
Posted On 2015-11-11