Incidental Mutation 'R0465:Vmn2r1'
ID 41556
Institutional Source Beutler Lab
Gene Symbol Vmn2r1
Ensembl Gene ENSMUSG00000027824
Gene Name vomeronasal 2, receptor 1
Synonyms V2r83, EG56544
MMRRC Submission 038665-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R0465 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 63988968-64016905 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 63989180 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 40 (S40P)
Ref Sequence ENSEMBL: ENSMUSP00000029406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029406]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000029406
AA Change: S40P

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000029406
Gene: ENSMUSG00000027824
AA Change: S40P

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 86 504 6e-92 PFAM
Pfam:NCD3G 546 599 2.4e-17 PFAM
Pfam:7tm_3 632 866 4.1e-48 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.2%
Validation Efficiency 100% (71/71)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre4 T A 17: 56,092,137 (GRCm39) probably benign Het
Ankrd13a T A 5: 114,942,295 (GRCm39) I526N probably damaging Het
Aox1 G A 1: 58,101,366 (GRCm39) V446I probably damaging Het
Arid1b G A 17: 5,046,535 (GRCm39) G441D possibly damaging Het
Bdkrb2 A T 12: 105,558,118 (GRCm39) N120Y possibly damaging Het
Bud31 G A 5: 145,083,396 (GRCm39) V80I probably damaging Het
Camkmt T A 17: 85,738,950 (GRCm39) F225L probably damaging Het
Carf T C 1: 60,171,142 (GRCm39) M200T probably damaging Het
Carmil3 T C 14: 55,737,318 (GRCm39) L767P probably damaging Het
Cdk14 T A 5: 5,143,019 (GRCm39) R237S probably damaging Het
Cdx2 C A 5: 147,243,283 (GRCm39) K170N possibly damaging Het
Cfap65 G A 1: 74,956,043 (GRCm39) R1093C possibly damaging Het
Cnot8 T A 11: 58,004,886 (GRCm39) V195E probably damaging Het
Copa T C 1: 171,945,872 (GRCm39) F936S probably damaging Het
Cstdc1 A G 2: 148,625,345 (GRCm39) N93S probably benign Het
Dnai1 T A 4: 41,629,988 (GRCm39) probably null Het
Dsel T C 1: 111,789,992 (GRCm39) N181S probably benign Het
Enpp7 A G 11: 118,879,607 (GRCm39) N87S probably damaging Het
Fads1 C T 19: 10,160,429 (GRCm39) P5L probably benign Het
G3bp1 T C 11: 55,389,452 (GRCm39) F383L probably damaging Het
Gm12695 T C 4: 96,673,312 (GRCm39) Y29C probably damaging Het
Gm5592 T A 7: 40,805,481 (GRCm39) probably benign Het
Gmnc T G 16: 26,781,702 (GRCm39) N109T probably damaging Het
Gstcd A G 3: 132,688,905 (GRCm39) I615T probably benign Het
Hal A C 10: 93,352,146 (GRCm39) K646Q probably benign Het
Hbs1l A G 10: 21,227,940 (GRCm39) I472V probably null Het
Ift27 A T 15: 78,057,958 (GRCm39) probably benign Het
Iqub A T 6: 24,503,783 (GRCm39) I163N probably damaging Het
Isg20l2 T A 3: 87,838,987 (GRCm39) V66E probably benign Het
Itgb4 T C 11: 115,870,582 (GRCm39) M137T probably damaging Het
Lca5 T A 9: 83,277,920 (GRCm39) K475* probably null Het
Lyve1 A G 7: 110,452,034 (GRCm39) probably null Het
Map3k19 T C 1: 127,766,264 (GRCm39) D220G probably damaging Het
Mdn1 T A 4: 32,699,204 (GRCm39) probably benign Het
Mmp15 T C 8: 96,094,626 (GRCm39) W167R probably damaging Het
Ms4a13 A G 19: 11,149,957 (GRCm39) C135R probably benign Het
Myh1 A G 11: 67,101,243 (GRCm39) H673R possibly damaging Het
Myrf G C 19: 10,195,526 (GRCm39) T428S probably benign Het
Oas2 A G 5: 120,873,120 (GRCm39) I645T probably damaging Het
Or52s6 A T 7: 103,092,042 (GRCm39) F96Y possibly damaging Het
Pard3b T G 1: 62,250,877 (GRCm39) probably benign Het
Patj T A 4: 98,423,744 (GRCm39) probably null Het
Pcare A G 17: 72,057,155 (GRCm39) C841R probably benign Het
Pkd1l3 C G 8: 110,350,281 (GRCm39) D375E possibly damaging Het
Pkd1l3 G A 8: 110,350,295 (GRCm39) S380N probably benign Het
Rab34 C A 11: 78,081,337 (GRCm39) C67* probably null Het
Rimbp3 T C 16: 17,029,644 (GRCm39) S1023P possibly damaging Het
Rnf148 T C 6: 23,654,684 (GRCm39) N104S probably benign Het
Rpa1 T C 11: 75,203,921 (GRCm39) T288A probably damaging Het
Scn9a A G 2: 66,357,340 (GRCm39) L976P probably damaging Het
Serpina12 T A 12: 104,004,104 (GRCm39) D176V probably benign Het
Sik1 C T 17: 32,073,996 (GRCm39) V10I possibly damaging Het
Sntb1 C A 15: 55,612,672 (GRCm39) R302L probably benign Het
Stambp A G 6: 83,547,321 (GRCm39) I56T probably benign Het
Tac2 A G 10: 127,565,039 (GRCm39) probably benign Het
Tecta A T 9: 42,270,714 (GRCm39) I1198K possibly damaging Het
Tfip11 C T 5: 112,481,130 (GRCm39) R369C probably benign Het
Tnpo1 A G 13: 99,021,142 (GRCm39) I79T probably damaging Het
Ttll5 A T 12: 85,980,100 (GRCm39) N895Y probably benign Het
Ube2u T A 4: 100,389,293 (GRCm39) probably benign Het
Ubxn4 G A 1: 128,190,641 (GRCm39) E256K probably benign Het
Vmn2r100 G A 17: 19,751,792 (GRCm39) V612I probably damaging Het
Vmn2r59 G T 7: 41,696,332 (GRCm39) H137N probably benign Het
Vsig10l T C 7: 43,116,866 (GRCm39) V467A probably damaging Het
Vwde A G 6: 13,215,805 (GRCm39) probably benign Het
Xrra1 T A 7: 99,528,578 (GRCm39) D139E probably benign Het
Zc3h15 T C 2: 83,494,159 (GRCm39) probably benign Het
Zfhx4 C T 3: 5,310,716 (GRCm39) probably benign Het
Zscan18 A G 7: 12,509,413 (GRCm39) probably benign Het
Other mutations in Vmn2r1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Vmn2r1 APN 3 64,012,389 (GRCm39) nonsense probably null
IGL00335:Vmn2r1 APN 3 64,012,809 (GRCm39) missense probably damaging 0.96
IGL01509:Vmn2r1 APN 3 64,010,466 (GRCm39) missense probably benign 0.03
IGL01641:Vmn2r1 APN 3 64,011,924 (GRCm39) missense probably benign 0.19
IGL01656:Vmn2r1 APN 3 63,989,274 (GRCm39) missense probably damaging 0.96
IGL01927:Vmn2r1 APN 3 63,989,105 (GRCm39) missense probably benign 0.01
IGL02093:Vmn2r1 APN 3 64,012,130 (GRCm39) missense probably benign
IGL02146:Vmn2r1 APN 3 64,012,104 (GRCm39) missense probably benign 0.39
IGL02186:Vmn2r1 APN 3 63,989,138 (GRCm39) missense probably benign 0.01
IGL02320:Vmn2r1 APN 3 63,989,180 (GRCm39) missense possibly damaging 0.61
IGL02423:Vmn2r1 APN 3 63,997,665 (GRCm39) missense probably benign 0.00
IGL02709:Vmn2r1 APN 3 64,012,355 (GRCm39) missense probably benign 0.24
R0034:Vmn2r1 UTSW 3 63,997,435 (GRCm39) missense probably damaging 1.00
R0064:Vmn2r1 UTSW 3 64,012,209 (GRCm39) missense possibly damaging 0.76
R0152:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0305:Vmn2r1 UTSW 3 63,997,087 (GRCm39) missense probably damaging 1.00
R0314:Vmn2r1 UTSW 3 63,993,980 (GRCm39) missense probably damaging 1.00
R0317:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R1144:Vmn2r1 UTSW 3 63,997,541 (GRCm39) missense probably damaging 1.00
R1163:Vmn2r1 UTSW 3 63,994,046 (GRCm39) missense probably benign 0.03
R1448:Vmn2r1 UTSW 3 64,008,734 (GRCm39) missense probably damaging 1.00
R1491:Vmn2r1 UTSW 3 63,997,034 (GRCm39) missense probably damaging 1.00
R1543:Vmn2r1 UTSW 3 63,996,994 (GRCm39) missense probably damaging 1.00
R1611:Vmn2r1 UTSW 3 64,011,958 (GRCm39) nonsense probably null
R1676:Vmn2r1 UTSW 3 63,997,603 (GRCm39) nonsense probably null
R1727:Vmn2r1 UTSW 3 63,989,163 (GRCm39) missense probably benign
R1851:Vmn2r1 UTSW 3 64,008,926 (GRCm39) missense probably benign 0.32
R3080:Vmn2r1 UTSW 3 63,997,205 (GRCm39) missense probably damaging 1.00
R3790:Vmn2r1 UTSW 3 63,994,185 (GRCm39) critical splice donor site probably null
R4111:Vmn2r1 UTSW 3 63,997,176 (GRCm39) missense probably benign 0.23
R4689:Vmn2r1 UTSW 3 64,012,074 (GRCm39) missense possibly damaging 0.94
R4747:Vmn2r1 UTSW 3 63,989,267 (GRCm39) missense probably benign 0.00
R4970:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5033:Vmn2r1 UTSW 3 64,012,501 (GRCm39) missense probably damaging 1.00
R5086:Vmn2r1 UTSW 3 63,997,418 (GRCm39) missense probably benign 0.00
R5112:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5385:Vmn2r1 UTSW 3 64,008,819 (GRCm39) missense possibly damaging 0.89
R5629:Vmn2r1 UTSW 3 64,012,538 (GRCm39) missense possibly damaging 0.87
R5762:Vmn2r1 UTSW 3 63,997,474 (GRCm39) missense probably benign 0.24
R5867:Vmn2r1 UTSW 3 64,011,990 (GRCm39) missense probably benign
R5893:Vmn2r1 UTSW 3 63,993,974 (GRCm39) missense probably damaging 1.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6290:Vmn2r1 UTSW 3 64,012,873 (GRCm39) missense probably benign 0.02
R6443:Vmn2r1 UTSW 3 64,012,374 (GRCm39) missense possibly damaging 0.78
R6464:Vmn2r1 UTSW 3 64,008,766 (GRCm39) missense probably benign
R6826:Vmn2r1 UTSW 3 64,012,567 (GRCm39) nonsense probably null
R6874:Vmn2r1 UTSW 3 64,012,376 (GRCm39) missense probably damaging 1.00
R6882:Vmn2r1 UTSW 3 63,997,529 (GRCm39) missense possibly damaging 0.64
R6983:Vmn2r1 UTSW 3 63,989,118 (GRCm39) missense probably benign
R7010:Vmn2r1 UTSW 3 64,012,146 (GRCm39) missense probably benign 0.19
R7144:Vmn2r1 UTSW 3 63,997,362 (GRCm39) missense probably damaging 1.00
R7341:Vmn2r1 UTSW 3 64,012,877 (GRCm39) makesense probably null
R7510:Vmn2r1 UTSW 3 63,993,922 (GRCm39) missense probably damaging 1.00
R7557:Vmn2r1 UTSW 3 63,997,475 (GRCm39) missense probably damaging 0.99
R7895:Vmn2r1 UTSW 3 63,997,130 (GRCm39) missense possibly damaging 0.90
R8108:Vmn2r1 UTSW 3 64,010,471 (GRCm39) missense probably damaging 0.98
R8209:Vmn2r1 UTSW 3 63,997,199 (GRCm39) missense possibly damaging 0.64
R8365:Vmn2r1 UTSW 3 63,994,034 (GRCm39) missense possibly damaging 0.80
R8514:Vmn2r1 UTSW 3 63,993,942 (GRCm39) missense probably benign 0.11
R8554:Vmn2r1 UTSW 3 63,997,334 (GRCm39) missense probably damaging 0.98
R8980:Vmn2r1 UTSW 3 64,010,501 (GRCm39) missense
R9140:Vmn2r1 UTSW 3 63,997,465 (GRCm39) missense probably benign 0.05
R9239:Vmn2r1 UTSW 3 64,011,959 (GRCm39) missense probably damaging 0.99
R9441:Vmn2r1 UTSW 3 64,012,674 (GRCm39) missense probably damaging 1.00
R9549:Vmn2r1 UTSW 3 63,997,493 (GRCm39) missense probably benign 0.17
R9771:Vmn2r1 UTSW 3 63,997,559 (GRCm39) missense possibly damaging 0.79
X0065:Vmn2r1 UTSW 3 63,997,678 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGATTTCAAGGCCCCTGATTGAGAC -3'
(R):5'- TTCGCCCACCACCTGAATTGAC -3'

Sequencing Primer
(F):5'- GGCGCTTCACTAAAACGTG -3'
(R):5'- CAAGAAAGAAGATGGCTTACCC -3'
Posted On 2013-05-23