Incidental Mutation 'IGL02811:Oas3'
ID360582
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oas3
Ensembl Gene ENSMUSG00000032661
Gene Name2'-5' oligoadenylate synthetase 3
SynonymsOasl10, 2'-5' oligoadenylate synthetase-like 10
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL02811
Quality Score
Status
Chromosome5
Chromosomal Location120753098-120777661 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 120764322 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 636 (E636D)
Ref Sequence ENSEMBL: ENSMUSP00000035588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044833]
Predicted Effect unknown
Transcript: ENSMUST00000044833
AA Change: E636D
SMART Domains Protein: ENSMUSP00000035588
Gene: ENSMUSG00000032661
AA Change: E636D

DomainStartEndE-ValueType
Pfam:OAS1_C 159 341 6.3e-83 PFAM
Pfam:OAS1_C 610 795 3.1e-78 PFAM
Pfam:NTP_transf_2 831 920 4.5e-11 PFAM
Pfam:OAS1_C 954 1136 9e-85 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166703
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c20 C T 13: 4,512,683 R90H possibly damaging Het
BC048679 A T 7: 81,495,189 probably benign Het
Chd6 T C 2: 160,990,301 R984G probably damaging Het
Cobl A G 11: 12,253,285 I1139T possibly damaging Het
Coq3 A G 4: 21,900,273 R167G probably damaging Het
Crim1 A G 17: 78,350,701 K670E possibly damaging Het
Crtac1 T C 19: 42,333,911 E130G probably damaging Het
Dcbld1 A G 10: 52,319,973 T426A probably benign Het
Dimt1 T C 13: 106,947,667 probably benign Het
Dnal1 G A 12: 84,131,392 probably null Het
Fes T C 7: 80,379,841 Y631C probably damaging Het
Hemk1 A T 9: 107,331,551 V149E probably benign Het
Itga6 T C 2: 71,826,732 V397A probably damaging Het
Kmt2c A T 5: 25,315,028 L2028* probably null Het
Krt33b C A 11: 100,029,569 C86F probably benign Het
Lmx1a A G 1: 167,791,374 I101V probably benign Het
Mlh1 A G 9: 111,271,514 V4A probably benign Het
Mroh2b A G 15: 4,915,236 I440V possibly damaging Het
Mrpl35 A G 6: 71,818,820 Y28H probably benign Het
Olfm4 T A 14: 80,021,673 S454T probably damaging Het
Olfr597 T C 7: 103,320,933 I174T probably benign Het
Olfr724 T A 14: 49,960,133 probably benign Het
Otoa G T 7: 121,118,655 G365V possibly damaging Het
Pdgfrl G T 8: 40,976,968 R124L probably damaging Het
Rcbtb2 T A 14: 73,174,411 V380E probably damaging Het
Rufy2 A G 10: 63,000,327 D345G probably damaging Het
Shq1 A T 6: 100,630,984 I322N probably damaging Het
Skint4 C A 4: 112,087,003 T4K possibly damaging Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Tbc1d5 A G 17: 50,800,121 I469T probably damaging Het
Thoc3 T C 13: 54,460,175 R319G probably benign Het
Tmem63a A G 1: 180,965,783 I507M probably damaging Het
Usp40 A T 1: 87,995,736 I271N probably damaging Het
Vps13d T C 4: 145,131,765 D2157G possibly damaging Het
Vwa8 T A 14: 78,994,459 V586D probably benign Het
Other mutations in Oas3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00547:Oas3 APN 5 120777442 splice site probably benign
IGL01095:Oas3 APN 5 120772889 missense probably damaging 1.00
IGL01835:Oas3 APN 5 120766128 nonsense probably null
IGL02006:Oas3 APN 5 120769235 missense probably benign 0.00
IGL03194:Oas3 APN 5 120758953 missense probably damaging 1.00
R0066:Oas3 UTSW 5 120758875 missense probably damaging 1.00
R0195:Oas3 UTSW 5 120756145 missense probably damaging 1.00
R0196:Oas3 UTSW 5 120756145 missense probably damaging 1.00
R0197:Oas3 UTSW 5 120756145 missense probably damaging 1.00
R0445:Oas3 UTSW 5 120756145 missense probably damaging 1.00
R0523:Oas3 UTSW 5 120766144 missense unknown
R0592:Oas3 UTSW 5 120771149 missense probably damaging 1.00
R0946:Oas3 UTSW 5 120769063 missense unknown
R1354:Oas3 UTSW 5 120770000 missense possibly damaging 0.94
R1642:Oas3 UTSW 5 120777574 missense possibly damaging 0.90
R1681:Oas3 UTSW 5 120769908 missense probably benign 0.22
R1844:Oas3 UTSW 5 120759980 missense probably damaging 0.99
R1981:Oas3 UTSW 5 120761835 splice site probably benign
R2443:Oas3 UTSW 5 120777488 missense probably benign 0.35
R2902:Oas3 UTSW 5 120758917 missense probably damaging 1.00
R3034:Oas3 UTSW 5 120771056 missense probably damaging 1.00
R4565:Oas3 UTSW 5 120771039 missense probably damaging 1.00
R4692:Oas3 UTSW 5 120769355 missense probably benign 0.03
R4723:Oas3 UTSW 5 120766256 missense unknown
R4812:Oas3 UTSW 5 120761147 unclassified probably benign
R5288:Oas3 UTSW 5 120756990 missense probably damaging 1.00
R5343:Oas3 UTSW 5 120756238 missense possibly damaging 0.70
R5494:Oas3 UTSW 5 120761644 missense unknown
R5688:Oas3 UTSW 5 120758802 missense probably benign 0.31
R5894:Oas3 UTSW 5 120756954 missense probably damaging 1.00
R5921:Oas3 UTSW 5 120769981 missense probably damaging 1.00
R6037:Oas3 UTSW 5 120769319 missense probably benign 0.41
R6037:Oas3 UTSW 5 120769319 missense probably benign 0.41
R6066:Oas3 UTSW 5 120772924 missense probably damaging 0.97
R6104:Oas3 UTSW 5 120761693 missense unknown
R6134:Oas3 UTSW 5 120769048 missense unknown
R6255:Oas3 UTSW 5 120771230 missense probably benign 0.04
R6257:Oas3 UTSW 5 120761135 unclassified probably benign
R6776:Oas3 UTSW 5 120758874 missense probably damaging 1.00
R8022:Oas3 UTSW 5 120756966 missense possibly damaging 0.91
R8137:Oas3 UTSW 5 120777500 missense probably benign 0.07
RF006:Oas3 UTSW 5 120774100 missense probably damaging 1.00
X0024:Oas3 UTSW 5 120761728 missense unknown
Posted On2015-12-18