Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02811:Oas3'

360582

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oas3

Ensembl Gene

ENSMUSG00000032661

Gene Name

2'-5' oligoadenylate synthetase 3

Synonyms

Oasl10, 2'-5' oligoadenylate synthetase-like 10

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL02811

Quality Score

Status

Chromosome

Chromosomal Location

120753098-120777661 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 120764322 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 636 (E636D)

Ref Sequence

ENSEMBL: ENSMUSP00000035588 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044833]

AlphaFold

Q8VI93

Predicted Effect

unknown
Transcript: ENSMUST00000044833
AA Change: E636D

SMART Domains

Protein: ENSMUSP00000035588
Gene: ENSMUSG00000032661
AA Change: E636D

Domain	Start	End	E-Value	Type
Pfam:OAS1_C	159	341	6.3e-83	PFAM
Pfam:OAS1_C	610	795	3.1e-78	PFAM
Pfam:NTP_transf_2	831	920	4.5e-11	PFAM
Pfam:OAS1_C	954	1136	9e-85	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000166703

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1c20	C	T	13: 4,512,683	R90H	possibly damaging	Het
BC048679	A	T	7: 81,495,189		probably benign	Het
Chd6	T	C	2: 160,990,301	R984G	probably damaging	Het
Cobl	A	G	11: 12,253,285	I1139T	possibly damaging	Het
Coq3	A	G	4: 21,900,273	R167G	probably damaging	Het
Crim1	A	G	17: 78,350,701	K670E	possibly damaging	Het
Crtac1	T	C	19: 42,333,911	E130G	probably damaging	Het
Dcbld1	A	G	10: 52,319,973	T426A	probably benign	Het
Dimt1	T	C	13: 106,947,667		probably benign	Het
Dnal1	G	A	12: 84,131,392		probably null	Het
Fes	T	C	7: 80,379,841	Y631C	probably damaging	Het
Hemk1	A	T	9: 107,331,551	V149E	probably benign	Het
Itga6	T	C	2: 71,826,732	V397A	probably damaging	Het
Kmt2c	A	T	5: 25,315,028	L2028*	probably null	Het
Krt33b	C	A	11: 100,029,569	C86F	probably benign	Het
Lmx1a	A	G	1: 167,791,374	I101V	probably benign	Het
Mlh1	A	G	9: 111,271,514	V4A	probably benign	Het
Mroh2b	A	G	15: 4,915,236	I440V	possibly damaging	Het
Mrpl35	A	G	6: 71,818,820	Y28H	probably benign	Het
Olfm4	T	A	14: 80,021,673	S454T	probably damaging	Het
Olfr597	T	C	7: 103,320,933	I174T	probably benign	Het
Olfr724	T	A	14: 49,960,133		probably benign	Het
Otoa	G	T	7: 121,118,655	G365V	possibly damaging	Het
Pdgfrl	G	T	8: 40,976,968	R124L	probably damaging	Het
Rcbtb2	T	A	14: 73,174,411	V380E	probably damaging	Het
Rufy2	A	G	10: 63,000,327	D345G	probably damaging	Het
Shq1	A	T	6: 100,630,984	I322N	probably damaging	Het
Skint4	C	A	4: 112,087,003	T4K	possibly damaging	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Tbc1d5	A	G	17: 50,800,121	I469T	probably damaging	Het
Thoc3	T	C	13: 54,460,175	R319G	probably benign	Het
Tmem63a	A	G	1: 180,965,783	I507M	probably damaging	Het
Usp40	A	T	1: 87,995,736	I271N	probably damaging	Het
Vps13d	T	C	4: 145,131,765	D2157G	possibly damaging	Het
Vwa8	T	A	14: 78,994,459	V586D	probably benign	Het

Other mutations in Oas3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00547:Oas3	APN	5	120777442	splice site	probably benign
IGL01095:Oas3	APN	5	120772889	missense	probably damaging	1.00
IGL01835:Oas3	APN	5	120766128	nonsense	probably null
IGL02006:Oas3	APN	5	120769235	missense	probably benign	0.00
IGL03194:Oas3	APN	5	120758953	missense	probably damaging	1.00
R0066:Oas3	UTSW	5	120758875	missense	probably damaging	1.00
R0195:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0196:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0197:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0445:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0523:Oas3	UTSW	5	120766144	missense	unknown
R0592:Oas3	UTSW	5	120771149	missense	probably damaging	1.00
R0946:Oas3	UTSW	5	120769063	missense	unknown
R1354:Oas3	UTSW	5	120770000	missense	possibly damaging	0.94
R1642:Oas3	UTSW	5	120777574	missense	possibly damaging	0.90
R1681:Oas3	UTSW	5	120769908	missense	probably benign	0.22
R1844:Oas3	UTSW	5	120759980	missense	probably damaging	0.99
R1981:Oas3	UTSW	5	120761835	splice site	probably benign
R2443:Oas3	UTSW	5	120777488	missense	probably benign	0.35
R2902:Oas3	UTSW	5	120758917	missense	probably damaging	1.00
R3034:Oas3	UTSW	5	120771056	missense	probably damaging	1.00
R4565:Oas3	UTSW	5	120771039	missense	probably damaging	1.00
R4692:Oas3	UTSW	5	120769355	missense	probably benign	0.03
R4723:Oas3	UTSW	5	120766256	missense	unknown
R4812:Oas3	UTSW	5	120761147	unclassified	probably benign
R5288:Oas3	UTSW	5	120756990	missense	probably damaging	1.00
R5343:Oas3	UTSW	5	120756238	missense	possibly damaging	0.70
R5494:Oas3	UTSW	5	120761644	missense	unknown
R5688:Oas3	UTSW	5	120758802	missense	probably benign	0.31
R5894:Oas3	UTSW	5	120756954	missense	probably damaging	1.00
R5921:Oas3	UTSW	5	120769981	missense	probably damaging	1.00
R6037:Oas3	UTSW	5	120769319	missense	probably benign	0.41
R6037:Oas3	UTSW	5	120769319	missense	probably benign	0.41
R6066:Oas3	UTSW	5	120772924	missense	probably damaging	0.97
R6104:Oas3	UTSW	5	120761693	missense	unknown
R6134:Oas3	UTSW	5	120769048	missense	unknown
R6255:Oas3	UTSW	5	120771230	missense	probably benign	0.04
R6257:Oas3	UTSW	5	120761135	unclassified	probably benign
R6776:Oas3	UTSW	5	120758874	missense	probably damaging	1.00
R8022:Oas3	UTSW	5	120756966	missense	possibly damaging	0.91
R8137:Oas3	UTSW	5	120777500	missense	probably benign	0.07
R8967:Oas3	UTSW	5	120758842	missense	probably damaging	0.99
R9124:Oas3	UTSW	5	120774105	missense	probably damaging	1.00
R9287:Oas3	UTSW	5	120754689	missense	probably damaging	1.00
RF006:Oas3	UTSW	5	120774100	missense	probably damaging	1.00
X0024:Oas3	UTSW	5	120761728	missense	unknown

Posted On

2015-12-18