Incidental Mutation 'R5817:Agpat4'
ID 449132
Institutional Source Beutler Lab
Gene Symbol Agpat4
Ensembl Gene ENSMUSG00000023827
Gene Name 1-acylglycerol-3-phosphate O-acyltransferase 4
Synonyms 1500003P24Rik
MMRRC Submission 043397-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5817 (G1)
Quality Score 206
Status Validated
Chromosome 17
Chromosomal Location 12337591-12438532 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) C to T at 12434097 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000127417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024594] [ENSMUST00000164143] [ENSMUST00000167792] [ENSMUST00000170858]
AlphaFold Q8K4X7
Predicted Effect probably benign
Transcript: ENSMUST00000024594
SMART Domains Protein: ENSMUSP00000024594
Gene: ENSMUSG00000023827

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
PlsC 90 212 6.58e-24 SMART
Pfam:Acyltransf_C 241 314 8.8e-29 PFAM
transmembrane domain 335 357 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164143
SMART Domains Protein: ENSMUSP00000128085
Gene: ENSMUSG00000023827

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
PlsC 90 192 1.87e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167792
SMART Domains Protein: ENSMUSP00000127477
Gene: ENSMUSG00000023827

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
PlsC 90 166 1.14e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000167905
Predicted Effect probably benign
Transcript: ENSMUST00000170858
SMART Domains Protein: ENSMUSP00000127417
Gene: ENSMUSG00000023827

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency 100% (71/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit changes in brain phospholipid content. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 A G 4: 144,349,497 (GRCm39) I251M probably benign Het
Abcf3 T C 16: 20,367,833 (GRCm39) V63A possibly damaging Het
Ahcyl2 G A 6: 29,890,720 (GRCm39) V292M probably damaging Het
Ahnak2 A T 12: 112,740,437 (GRCm39) F406I probably damaging Het
Aqp7 G A 4: 41,035,510 (GRCm39) T115I probably benign Het
Arhgef5 G A 6: 43,252,038 (GRCm39) D930N probably benign Het
Cc2d2a G A 5: 43,869,760 (GRCm39) R887Q probably damaging Het
Ceacam18 A G 7: 43,291,265 (GRCm39) T236A probably benign Het
Chst15 A T 7: 131,870,873 (GRCm39) Y221N probably damaging Het
Chst15 G A 7: 131,870,876 (GRCm39) L220F probably damaging Het
Cntn2 G A 1: 132,446,486 (GRCm39) T784I probably benign Het
D630003M21Rik A G 2: 158,038,413 (GRCm39) L1011P probably damaging Het
Dync2h1 T A 9: 6,996,905 (GRCm39) D3894V probably damaging Het
Eif1ad19 G T 12: 87,740,201 (GRCm39) D119E probably benign Het
Fam13b T C 18: 34,590,850 (GRCm39) M443V possibly damaging Het
Fam20a T A 11: 109,564,244 (GRCm39) Q503L possibly damaging Het
Ftdc2 T C 16: 58,457,156 (GRCm39) I89V probably benign Het
Gm11677 C T 11: 111,615,537 (GRCm39) noncoding transcript Het
Gm5454 T A 13: 103,493,140 (GRCm39) noncoding transcript Het
Gm5581 A G 6: 131,144,132 (GRCm39) noncoding transcript Het
Gm6619 A G 6: 131,463,400 (GRCm39) I6V unknown Het
Gmcl1 A G 6: 86,691,230 (GRCm39) M255T probably damaging Het
Golm2 T A 2: 121,736,525 (GRCm39) S231T probably benign Het
Gprc5c T A 11: 114,754,450 (GRCm39) C42* probably null Het
Hmcn1 T A 1: 150,613,275 (GRCm39) E1384V possibly damaging Het
Il6 A G 5: 30,223,006 (GRCm39) I91V probably benign Het
Kmt2d A T 15: 98,760,244 (GRCm39) S1005T unknown Het
Map1a A T 2: 121,129,391 (GRCm39) H143L possibly damaging Het
Mical2 A T 7: 111,922,866 (GRCm39) T624S probably benign Het
Msh3 A T 13: 92,422,508 (GRCm39) N549K possibly damaging Het
Ncr1 T A 7: 4,343,894 (GRCm39) I164N possibly damaging Het
Or10ak11 T G 4: 118,687,296 (GRCm39) T115P probably damaging Het
Or51a5 A T 7: 102,771,115 (GRCm39) M292K possibly damaging Het
Or52m1 A G 7: 102,289,585 (GRCm39) N44S probably damaging Het
Or8d2b A G 9: 38,788,673 (GRCm39) D67G probably damaging Het
Palmd T C 3: 116,712,272 (GRCm39) I541M probably benign Het
Pcsk7 A T 9: 45,837,331 (GRCm39) M552L probably benign Het
Plekhh2 A G 17: 84,879,154 (GRCm39) E626G possibly damaging Het
Pole G A 5: 110,460,838 (GRCm39) D1176N probably damaging Het
Polr2f T C 15: 79,035,869 (GRCm39) I110T probably damaging Het
Pomt1 A T 2: 32,138,691 (GRCm39) I436F probably damaging Het
Prag1 A C 8: 36,570,857 (GRCm39) Q480P probably damaging Het
Qars1 C T 9: 108,387,441 (GRCm39) probably benign Het
Ralgapa2 G A 2: 146,175,406 (GRCm39) S1797L probably damaging Het
Rbm26 T C 14: 105,366,039 (GRCm39) T832A probably damaging Het
Rnf169 A G 7: 99,574,976 (GRCm39) S540P probably benign Het
Serpini1 T A 3: 75,520,631 (GRCm39) M76K probably benign Het
Shq1 A G 6: 100,550,681 (GRCm39) L419S probably damaging Het
Slc25a17 G A 15: 81,211,261 (GRCm39) T225M probably damaging Het
Slc6a5 C A 7: 49,606,239 (GRCm39) L716I probably benign Het
Smc1b A G 15: 84,951,984 (GRCm39) V1149A probably damaging Het
Trappc1 A T 11: 69,215,060 (GRCm39) Q26L possibly damaging Het
Trpm2 C A 10: 77,801,814 (GRCm39) G84W probably damaging Het
Ttn G A 2: 76,573,010 (GRCm39) T24215M probably damaging Het
Ubn2 C A 6: 38,456,088 (GRCm39) T337K probably damaging Het
Ubr4 A G 4: 139,196,158 (GRCm39) K1265E probably damaging Het
Vmn1r214 T G 13: 23,219,491 (GRCm39) I328M probably damaging Het
Xcr1 C T 9: 123,684,922 (GRCm39) C280Y possibly damaging Het
Zc3h13 A G 14: 75,565,572 (GRCm39) E895G probably damaging Het
Other mutations in Agpat4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0930:Agpat4 UTSW 17 12,417,723 (GRCm39) missense probably damaging 1.00
R1217:Agpat4 UTSW 17 12,429,203 (GRCm39) missense probably damaging 1.00
R1732:Agpat4 UTSW 17 12,435,615 (GRCm39) missense probably benign 0.00
R2081:Agpat4 UTSW 17 12,370,771 (GRCm39) missense possibly damaging 0.58
R4610:Agpat4 UTSW 17 12,429,264 (GRCm39) splice site probably null
R4766:Agpat4 UTSW 17 12,370,637 (GRCm39) unclassified probably benign
R5091:Agpat4 UTSW 17 12,417,699 (GRCm39) missense probably benign
R7315:Agpat4 UTSW 17 12,429,185 (GRCm39) missense probably damaging 1.00
R7762:Agpat4 UTSW 17 12,429,209 (GRCm39) missense possibly damaging 0.63
R9175:Agpat4 UTSW 17 12,417,669 (GRCm39) missense probably damaging 0.96
R9242:Agpat4 UTSW 17 12,429,186 (GRCm39) missense probably damaging 0.99
R9347:Agpat4 UTSW 17 12,429,168 (GRCm39) missense possibly damaging 0.95
R9367:Agpat4 UTSW 17 12,435,597 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TATGCATGGATTCTGCACCTATCAC -3'
(R):5'- ACCCATGAGAACGGCATCTC -3'

Sequencing Primer
(F):5'- GAACACGGAGCAGCACTGTC -3'
(R):5'- GAGAACGGCATCTCAAACCC -3'
Posted On 2016-12-20